circLARP4 hsa_circ_0003222; hsa_circRNA_101057 12 50848096-50855130 + hg19 LATS1 GCTCCCTTTCCCAATGGTAGTTTTGTGAATGGCTTTAATTCGCCAGGATCTTATAAAACAAATGCTGCTGCTATGAATATGGGTCGACCATTCCAAAAAAATCGTGTGAAGCCTCAGTTTAGGTCATCTGGTGGTTCAGAACACTCAACAGAGGGCTCTGTATCCTTGGGGGATGGACAGTTGAACAGATATAGTTCAAGAAACTTTCCAGCTGAACGGCATAACCCCACAGTAACTGGGCATCAGGAGCAAACTTACCTTCAGAAGGAGACTTCCACTTTGCAGGTGGAACAGAATGGGGACTATGGTAGGGGCAG exonic gastric cancer Microarray; in vitro knockdown; in vitro overexpression; dual luciferase reporter assay; RIP; FISH; etc. GES-1 and GC cell lines (SGC-7901, MKN-45, MKN-28, HGC-27, MGC-803, AGS, BGC-823) cytoplasm down-regulated miR-424-5p LATS1 N/A N/A Increased miR-424 expression or decreased LATS1 expression was associated with pathological stage and unfavorable prognosis of GC patients. Ectopic expression of miR-424 promoted proliferation and invasion of GC cells by targeting LATS1 gene. Furthermore, circLARP4 was mainly localized in the cytoplasm and inhibited biological behaviors of GC cells by sponging miR-424. The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients. 28893265 2017 Molecular Cancer Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression N/A hsa_circ_0005836 N/A 14 39623414-39627606 - hg19 TRAPPC6B GTTTACAAAAGATACTGCAAGGTTCAAGGATGAGTTAGATATCATGAAGTTCATTTGTAAAGATTTTTGGACTACGGTATTCAAGAAACAAATCGACAATCTAAGGACAAATCATCAGGGCATCTATGTACTTCAGGACAACAAATTTCGCCTGCTTACTCAGATGTCTGCAGGAAAACAGTATTTAGAACATGCATCTAAG N/A active pulmonary tuberculosis RNA-seq; qRT-PCR Peripheral blood mononuclear cells N/A down-regulated N/A N/A N/A N/A They found for the first time that hsa_circ_0005836 and hsa_circ_0009128 were significantly down-regulated in the PBMCs of APTB compared with HC. It indicates hsa_circ_0005836 might serve as a novel potential biomarker for TB infection. 28846924 2017 Mol Immunol. The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. N/A hsa_circ_0009128 N/A 16 11815432-11830089 - hg19 TXNDC11 TCGAGCAAAAGATGTGATAATACCAGCAAAGCCACCTGTCAGCTTTTTCTCCTTGAGGTCTCCAGTCCTTGACCTCTTCCAGGGGCAGCTGGATTATGCAGAGTACGTTCGACGGGATTCAGAGGTGGTACTGCTCTTCTTCTATGCCCCTTGGTGTGGACAGTCCATCGCTGCCAGGGCAGAAATTGAGCAAGCAGCAAGTCGGCTTTCAGATCAGGTGTTGTTTGTGGCAATTAACTGTTGGTGGAACCAGGGGAAATGCAGAAAACAGAAACACTTCTTTTATTTTCCTGTAATATATCTGTATCATCGGAGTTTTGGACCAATCGAATACAAAGGCCCCATGAGTGCTGTTTACATTGAGAAGTTTGTCCGCCGGGTGATGAAACCACTTCTCTACATCCCATCTCAATCAGAATTACTAGATTTTCTCTCAAACTACGAGCCTGGAGTACTCGGGTACTTTGAGTTCAGTGGCTCACCCCAGCCTCCTGGTTATTTGACCTTCTTCACCTCAGCATTACATTCATTAAAGAAAG N/A active pulmonary tuberculosis RNA-seq; qRT-PCR Peripheral blood mononuclear cells N/A down-regulated N/A N/A N/A N/A They found for the first time that hsa_circ_0005836 and hsa_circ_0009128 were significantly down-regulated in the PBMCs of APTB compared with HC. It indicates hsa_circ_0005836 might serve as a novel potential biomarker for TB infection. 28846924 2017 Mol Immunol. The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. N/A circ-SMARCA5 hsa_circ_0001445 4 144464662-144465125 + hg19 SMARCA5 GGAGGCTTGTGGATCAGAATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACATGGAGCAACACATGTGTTTGCTTCAAAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGAGGTGCAAAGAAGACTGCAGAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCACTTAGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGAGAAGACTATAGAGAAAAACAAAAG exonic prostate cancer qRT-PCR; in vitro knockdown; etc. LNCaP cell,22RV1, DU145, PC-3,WPMY-1 N/A up-regulated N/A N/A N/A N/A Circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues and significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. 28765045 2017 Biochem Biophys Res Commun. Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer. N/A circ-ABCB10 hsa_circ_0008717 1 229665945-229678118 - hg19 ABCB10 TTTTTTGTCTCACCTAATCTGGCCACCTTTGTTTTGAGCGTGGTGCCTCCAGTGTCAATCATTGCTGTAATTTATGGGCGATATCTACGGAAACTGACCAAAGTCACTCAGGATTCCCTGGCACAAGCCACTCAGCTAGCTGAGGAACGTATTGGAAATGTAAGAACTGTTCGAGCTTTTGGGAAAGAAATGACTGAAATCGAGAAATATGCCAGCAAAGTGGACCATGTAATGCAGTTAGCAAGGAAAGAGGCATTCGCCCGGGCTGGTTTCTTTGGAGCAACTGGGCTCTCCGGAAACCTGATCGTGCTTTCTGTCCTGTACAAAGGAGGGCTGCTGATGGGCAGTGCCCACATGACCGTGGGTGAACTCTCTTCCTTCCTAATGTATGCTTTCTGGGTTGGAATAAGCATTGGAGGTCTGAGCTCTTTCTACTCGGAGCTGATGAAAGGACTGGGTGCAGGGGGGCGCCTCTGGGAGCTCCTGGAGAGAGAGCCCAAGCTGCCTTTTAACGAGGGGGTCATCTTAAATGAGAAAAGCTTCCAGGGTGCTTTGGAGTTTAAGAACGTGCATTTTGCCTATCCAGCTCGCCCAGAGGTGCCCATATTTCAGGATTTCAGCCTTTCCATTCCGTCAGGATCTGTCACGGCACTGGTTGGCCCAAGTGGTTCTGGCAAATCAACAGTGCTTTCACTCCTGCTGAGGTTGTACGACCCTGCTTCTG N/A breast cancer Mircroarray; qRT-PCR; in vitro knockdown; luciferase reporter assay; etc. MCF-7, MDAMB-231, MDA-MB-468, MDA-MB-453,MCF-10A N/A up-regulated miR-1271 N/A N/A N/A circ-ABCB10 was significantly up-regulated in breast cancer tissue.In vitro, loss-of-function experiments showed circ-ABCB10 knockdown suppressed the proliferation and increased apoptosis of breast cancer cells.Results reveal the important regulatory role of circ-ABCB10 through sponging miR-1271. 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0008945 hsa_circRNA_008945 14 51208299-51211083 - hg19 NIN CTGCACAGATGTCCCGATCTCTCTGACTTCCAGCAAAAAATCTCTAGTGTTCTAAGCTACAACGAAAAACTGCTGAAAGAAAAGGAAGCTCTGAGTGAGGAATTAAATAGCTGTGTCGATAAGTTGGCAAAATCAAGTCTTTTAGAGCATAGAATTGCGACGATGAAGCAGGAACAGAAATCCTGGGAACATCAGAGTGCGAGCTTAAAGTCACAGCTGGTGGCTTCTCAGGAAAAGGTTCAGAATTTAGAAGACACCGTGCAGAATGTAAACCTGCAAATGTCCCGGATGAAATCTGACCTACGAGTGACTCAGCAGGAAAAGGAGGCTTTAAAACAAGAAGTGATGTCTTTACATAAGCAACTTCAGAATGCTGGTGGCAAG exonic breast cancer Microarray; qRT-PCR breast cancer tissue N/A up-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0000732 hsa_circRNA_101939; hsa_circ_000220 17 1540002-1540356 - hg19 SCARF1 GCCAGCGAGAGATGGAGCTACCGTGTCCAGGATGAAGCTGCAGGTCTGGGGGACACTGACCAGCTTGGGCTCCACGCTGCCCTGCCGTTCCCTCAGCTCCCACAAGCTACCCTGGGTGACAGTCTCACATCACGACCCGGAGGTCCCCTTCAACCACAGCTTCATCGAGCCGCCCTCTGCCGGCTGGGCCACTGATGACTCCTTCTCATCCGATCCTGAGTCTGGAGAGGCAGATGAGGTTCCTGCCTACTGTGTGCCACCCCAAGAAG exonic breast cancer Microarray; qRT-PCR breast cancer tissue N/A up-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0000098 hsa_circRNA_100291; hsa_circ_001351 1 101372407-101387397 + hg19 SLC30A7 CTTAGGCTTGATTTCCGACTCTTTTCACATGTTTTTCGATAGCACTGCCATTTTGGCTGGACTGGCAGCTTCTGTTATTTCAAAATGGAGAGATAATGATGCTTTCTCCTATGGGTATGTTAGAGCGGAAGTTCTGGCTGGCTTTGTCAATGGCCTATTTTTGATCTTCACTGCTTTTTTTATTTTCTCAGAAGGAGTTGAGAGAGCATTAGCCCCTCCAGATGTCCACCATGAGAGACTGCTTCTTGTTTCCATTCTTGGGTTTGTGGTAAACCTAATAGGAATATTTGTTTTCAAACATGGAGGTCATGGACATTCTCATGGCTCTGGCCACGGACACAGTCATTCCCTCTTTAATGGTGCTCTAGATCAGGCACATGGCCATGTCGATCATTGCCATAGCCATGAAGTGAAACATGGTGCTGCACATAGCCATGATCATGCTCATGGACATGGACACTTTCATTCTCATGATGGCCCGTCCTTAAAAGAAACAACAGGACCCAGCAGACAGATTTTACAAGGTGTATTTTTACATATCCTAGCAGATACACTTGGAAGTATTGGTGTAATTGCTTCTGCCATCATGATGCAAAATTTTGGTCTGATGATAGCAGATCCTATCTGTTCAATTCTTATAGCCATTCTTATAGTTGTAAG exonic breast cancer Microarray; qRT-PCR breast cancer tissue N/A up-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0001721 hsa_circRNA_104423; hsa_circ_000457 7 90355880-90356126 + hg19 CDK14 ATATGTGTCACAAAGATGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGACACAGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCTCCACTGGCAAAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCG exonic breast cancer Microarray; qRT-PCR breast cancer tissue N/A up-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0000911 hsa_circRNA_103584; hsa_circ_000268 19 17448965-17449496 - hg19 GTPBP3 CTGCCTGAGGGCCTGCCGCCGCTGCGCCTCTGTTTCCGCGTGGATAAGGTCCGCCAGCCCCTCCACTTCGGTCAGGTTCAGCTTCCCATTGGCGAACGCCCGTCTGGTGAACTCGCCTGCCTCCGCCGGTCGAAGCCCTGGCACGCTGCCTGCAGGAAGGTCCCAGTCTGACACCCCCTGGTCCCCACCCAGGCCCATTGGGAGGACCAAGCATCTCACCCAACGCTGCAACTCACCCAAGGCCTGCAGGACGCCGCTCACCACTGCCGGGCCTCCATGCACGTGGAACTCCACGCAGTCCTCACCGGTGAAACTCTGGGGACCTAATGTGACAGACAGGTGACAGGAGGACAGCACAGCCAGTGCAAACCCTTGGAAGGGGGAAACTGAGTCATGGGACCTACAGGAGGCTCGGAACCTGGGGACCCTCACCTGGGAACCAGAGCACCAGTGCGCGGTCCAGAGGCTCCCCGGAGCGGGGATCGCTGAGCAGGCGCAGGCTGGCGTGGCGAGCAAGGGGCAGGTCTCGGG exonic breast cancer Microarray; qRT-PCR breast cancer tissue N/A down-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0018293 hsa_circRNA_100588 10 47164293-47166311 - hg19 None GGCTTAGGAACCAAGGAGGGTGTCATCATTGAGATCCTGGCCTCTCGGACCAAGAACCAGCTGCGGGAGATAATGAAGGCGTATGAGGAAGGTAAGGGGTGGCACAGATGGAGGGGCTCAGGAGTGGCCACAAGCTTTGGCAGCCTGGCAGGGAACAAGGATCAAGAATTAACCTGGGCCACACTAGAAAGGACCCTTTGGGGACTTTTTTACCCACAGGTGCTGAGCACCTACCGTATGCCAAGATCTGTGCCTGATGGTGACACTGAACATGATTCAGACTTGATCTGTAAGCTCACCAGCTCCTCTTACAGGGGAGAGAGGCCTGTGACCAACTAAAATCTCTGCCCTTGAGGACTGTGGTAGTAGGGGGTGTGGACCCCAGGCTAGCAGAGGCCAGTCAGTCCTCCACATCATGTACCTAGTGGGGAGTTTTCCTGGAGGCTTTGGCTTTGCCAAGCCTTGAGATGAAATGGAGCTTGGTTGGCAGCCCCTAGCCTGGCTCTCTGACCTGGTCCATCTTGTGCTTTGAGCTTGGTTGGGTACGCATGTCGCTTCTAGTTGTGAAGCACCACCCAGGCGACAGCCACTTGGACACCCGGGCATTGCATCCATGCCCTGTGCCAAGGACTTTCTTTCCTAGAAGGCTTTAATAAGGAGAAGTATGGGGAACAGGGCTGGAAGGAGGAAAGCAGGCCCCGGGTAGGCTGTGGGCCTCTGCTTGTGCCTCATGGTCCTGTTTCCCTGCAGACTATGGGTCCAGCCTGGAGGAGGACATCCAAGCAGACACAAGTGGCTACCTGGAGAGGATCCTGGTGTGCCTCCTGCAGGTGTCACAGCCTAGGCTCTTGGGAGTGCCTTGGTTTGGGAGTCCCAACAGCTCCACCCCAGGGAGCAGCCCTTGAATAGCGCCACAAGAGTCAGGGTAGGGGCATGGGATAGCCCAGCAGCCAGGGCTCATTGGGTGTGTCTCAGCATGGTTAGAGGGTCCCAACTGCAGAGCCCCCACACCTGTCCTTACTCAGCCATGTGAGAGCATCCTGGAAGCGGGAGGAGAGCAGGTCCTTCGTGCAGGCCTCATGCCAGGCACTTTGCTTACCTTAGCTCACTGAATCCGCCAAGCCTTATGAGGCAGTCCTTACCACCCCCATTGTACAAATGAGGAAACCAAGGGCTGAAGAGAATAACTGGCTTGTCGAAGTTTCCACAGCCAAAGAGCAGCAGAGCCATGCCTGCCCTCCAAGCCCAGGATCCCCCCTGTGCCCTTAATGCTCTGGTCAGCTGGCCTGCCTTACAGAGCCACCTCCTCTGTTCCTAGGGCAGCAGGGATGATGTGAGCAGCTTTGTGGACCCAGGACTGGCCCTCCAAGACGCACAGGTGAGGCTGCGCCCAGCCGGCCATGTGGCCCCACCCCCTGCCATCTGGACTCCGGCTCCTCTGCCCACGGGGGCTTTCTCTGACACTGGGCTGGGACCCACCCAGCTCAGCTCCCTATAGGCCTTTGTCCTGTGGTGTCTGGGGAGGAGAGTGAGGGTGTTGGGAGACTCGGGAGGAAGGAGTGTGACTTGGGGGTGGGGGAGCACTAAAGCTCTGTCCTGGCAGGAACAGCCCATGAACCCGGGGGCGCTAGGCCCCAGTGCTGGACACAGGTGTCCGGGTCTCTGTAGGTCTGCCTGCTGGCAGAGGGAAGTCTGGGGACCAGGCAGTTCCTAGAGCAGCTTGTGGCCCAGGATAGAGAAAATATTCTAAGCCAGAGCTGCTAGAGAAAGGGGAGCTCCCTGTCAGAGACGACCAAGCAGGGGAGCATGCTGGCCTGGCAGAGTGGACAGGGCCAGGCCATGGCCACAGCTCTGGGACTCTGGGGCTCAGTCCCTCACCTCCCTGGTCTCCCTCACTGGCTTATTGTGGGTGTCCCAATGCTAGGATCTGTATGCGGCAGGCGAGAAGATTCGTGGGACTGATGAGATGAAATTCATCACCATCCTGTGCACGCGCAGTGCCACTCACCTGCTGAGAG exonic breast cancer Microarray; qRT-PCR breast cancer tissue N/A down-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0001283 hsa_circRNA_001283; hsa_circ_000939 3 39108038-39130809 + hg19 WDR48 TAATATCTGCTTCTTCTGACACGACAGTAAAAGTATGGAATGCACACAAGGGATTTTGCATGTCAACATTAAGGACACATAAGGATTACGTAAAGGCCTTAGCATATGCCAAGGATAAAGAACTAGTAGCATCAGCTGGGTTGGACAGACAAATATTCCTTTGGGATGTGAATACTCTAACAGCATTGACTGCCTCAAATAACACTGTCACAACTTCTTCTTTAAGTGGAAACAAAGATTCCATTTATAGCCTGGCCATGAATCAACTGGGAACAATCATTGTATCAGGGTCCACTGAAAAGGTGTTACGGGTATGGGATCCAAGAACATGTGCAAAACTAATGAAGCTTAAAGGGCACACGGATAATGTGAAGGCATTGCTATTAAACAGAGATGGCACGCAATGCCTGTCAGGCAGTTCTGATGGGACAATTCGCCTTTGGTCCCTTGGCCAGCAGAGATGTATAGCAACATACCGAGTCCATGATGAAGGTGTTTGGGCGCTGCAAGTCAATGATGCCTTCACACATGTGTATTCTGGTGGAAGGGACAGGAAGATTTATTGTACAGACCTAAGAAACCCTGACATTCGGGTGCTAATTTGTGAAGAAAAAGCACCAGTTCTCAAGATGGAGCTTGATAGATCAGCTGATCCTCCTCCTGCAATTTGGGTTGCAACAACTAAGTCTACAGTAAATAAATGGACTTTGAAAGGAATTCATAATTTTAGAGCCTCTGGAGATTATGACAATGACTGTACAAATCCTATAACACCTCTTTGTACACAACCTGACCAGGTTATTAAAGGGGGTGCTAGTATTATTCAGTGCCACATTCTTAATGATAAGAGACATATATTAACCAAAGATACCAATAATAATGTGGCATATTGGGATGTATTGAAGGCATGTAAAGTTGAAGATCTGGGCAAAGTGGATTTTGAAGATGAAATTAAGAAAAGATTTAAAATGGTGTATGTGCCAAATTGGTTCTCAGTAGACTTAAAAACAGGGATGTTAACTATTACTTTGGATGAAAGTGATTGTTTTGCTGCCTGGGTTTCTGCAAAAGATGCTGGTTTCAGCAGCCCTGATGGGTCAGATCCAAAATTGAATTTAGGAGGACTTTTACTCCAAGCACTCCTGGAATATTGGCCTAGAACACATGTGAATCCAATGGATGAAGAGGAAAATGAAGTAAACCATGTAAATGGGGAGCAGGAGAACCGAGTGCAGAAGGGAAATGGATATTTTCAAGTGCCCCCACATACACCCGTGATCTTTGGTGAAGCTGGAGGTCGCACACTGTTCAGGCTGCTCTGCCGAGATTCCGGGGGTGAGACTGAGTCTATGCTTCTTAATGAAACAGTGCCACAATGGGTAATTGACATCACTGTGGAT exonic breast cancer Microarray; qRT-PCR breast cancer tissue N/A down-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0000893 hsa_circ_000261 19 12790270-12791139 - hg19 DHPS ATCGAGAAGAAGCTGGAACCACTGTCACAGGATGAAGACCAGCACGCGGACCTGACCCAGAGCCGCCGCCCACTTACCAGCTGCACCATTTTCCTGGGATATACATCCAACCTCATCAGTTCAGGCATCCGTGAGACCATTCGCTACCTTGTGCAGCACAACATGGTGGACGTATTGGTGACCACAGCTGGCGGCGTGGAGGAAGACCTCATCAAGTGCCTGGCGCCCACATACTTGGGCGAGTTTAGCCTCAGGGGGAAGGAGCTCCGGGAGAACGGGATCAATAGGATCGGAAACCTGCTGGTGCCCAATGAGAATTACTGCAAGTTTGAGGACTGGCTGATGCCCATTCTGGACCAGATGGTGATGGAGCAGAACACAGAGGGTGTAAAGTGGACGCCTTCTAAGATGATCGCCCGGCTGGGCAAGGAGATCAACAACCCAGAGTCCGTGTATTACTGGGCCCAGAAG N/A breast cancer Microarray; qRT-PCR breast cancer tissue N/A down-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A hsa_circ_0000981 hsa_circRNA_001506; hsa_circ_001506 2 20240809-20240905 - hg19 LAPTM4A GTAGTCTCCCACTATTTTATATCTTTGTTACTTCAAGTAAGACAATCTTAAATATGAGAGGACATCTAGAGATTGTGCTAAGATTGCGTCGTGATG intronic breast cancer Microarray; qRT-PCR breast cancer tissue N/A down-regulated N/A N/A N/A N/A N/A 28744405 2017.7.1 Am J Cancer Res. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 N/A circDENND4C hsa_circ_0005684; hsa_circRNA_005684 9 19286766-19305525 + hg19 DENND4C AGTTCTATATGAAGGGAAAGAACGGCTTATTCCAGGATGTGAAGTGATCCTAGCCACACCCTATGGTCGCTGTGCCAATGTCAACAATAGTTCAACTACTTCACAAAGAATCTTTATCACTTATCGAAGGGCTCCTCCAGTTCGACCCCAGAATTCCTTGGCTGTAACTGATATCTGTGTTATTGTAACCAGTAAAGGAGAAACTCCTCCTCATACCTTCTGCAAAGTTGACAAAAACTTAAATTGTGGAATGGTAAGAATAAAGTTTTCATCTTCAAAGTTTCATATGAAACCAAAAAGGGATACGTTTTGGATTCCTGTTTACTGTTGGGTATATACTCACATTTTATATTTTCATGATGCTTGTTTTTATTTTTCCTAATTTTTATGATTTGTAATAATTTTTAAAGTCCTATCCCATGATTTATAATAATTTCATCTTTAAGTCAGGGATATTTTTGAGGGAGTAAATCCTAATATTGTCTGTGTTACATTAACAAAGGTTTTATTCACTTTTGGATTTCAGTGGTGTCTTCAGGGACAACTGTGGGGTTAGAGTGGGTAGAAGCTCTCCTTACATTCATTTATTCATTCATTCATTCATTTGTTTGCTTTTTTTATTTTTTTGAGACAGGGTCTTGCTTTGTCGCCCAGGCTGGAGTACAGTGGTGCAATCACAGCTCACTGCAGCCTTGACCCCCCACCAGGCTCAAGTGATCTTCCCACCTTAGCCTCCCGAGTAGCTGGGACTACAGGATAGTAGAGACAGGGTTTCATCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTTAAGTGATCCACCTCCCTTGGCCTCCCAAAGTGTTGGAATTACAGGCGTGAGCCACCATGCCCGGCCTGTTTTTGTTTTTGAGACAGGGTCTCCTTAAGTTGCCCAGGATGCTCCTGAACTCTAGGGCTCAAGAGAAAATATTGCAGTTTTGCATACTTATTTTTTTTTTTCAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGTCTCAGCCTCCCAGGTAGCTGGGGCTACGGGCGTGCGCCACTACGCCCACCTAATTTTGTATGTTTAGTAGAGATGAGGTTTCACCATGTTGGTTGGCCAGGATGGTCTTGATCTCTTGACCTTGTGATCCACCTGCCTCAGCTTCCCAAAGTGCTGGGATTACAGGCGCAAGCCACCACACCCAATCCATGCATACTTACTCTTTAAAAGGACTGTAGTGAAGAAGAAAATGAACATAAATGTTTGATTCATAGTTTTTAAAGACTACAGCTTACTTTTGGTTCAGATTTACTTTGAAAAATATCTTCAGGTCAAACTAATATTAGCTTAATGTTGTATAGGCGGAGATGACAAATGCACCCAGAACAATTAGTGAAGACAGGGTTGCCTCTGGAGGTGATGACCTCATAGTCCTCCAGTGACCCAAGTCTTCCCCAATTTGGGCTCCAGTGCACACTCCGTTTTGTGCTGTGTCTTACAAGAAGGGGCAATCTCTGAGTGATTGTGAAATTCTAAATCTTTTGAAATGGCCTTCATATCAGTTTGATTTTTGTAGCATTGTTTTCTTACTCTCTTATTTTAGTGTTCTGAACTTCATGCTTTGCTGTATTTTATACTGCATAGTTCATTATATAAACGTTTTAAATAGACTCTTCTGAGTAAATAAATGAATCTTTAGTTGGTATCCAACAAAATCAATTTCTTTTCACTCTTTTGTCTTTTTTATAAACCTAATTCATGTTTTACAGTGGGGTTCCAGCGTGTTTCTGTGTTATAAGAAGTCTGTACCTGCTTCAAATGCAATAGCATATAAGGCTGGTAAGTGAGTTAAAAAAAATTGTCTCAATTGCTATAGTTATTGGTGCATATTAACATTTGGCTAAAAGAGATAAAGTATGCTCCCTTACATAGTTTGTAGAATTGATCTATTCATAAAATTATCTATAATTTTAGCATATAAAGATATGTGTTTTCTTAAATACATATACAAGATATATTAATACCCCCACCAAACATGCTGTTAATTTAATTTAAACATTTATCTAAAGCAAACATATGTGGAATAAACATTCAAGCTTTTGGTCTACGTTAATAGACTTAACAGTATAATGGAAAGTTGCTGACTCTCTGACCTTTTATATTTTGGCAATCAGAAAGGTGTCAAACTGCGTCTTTACTTCTTATATTTCCTTCTCTTATCTCTTTGTGTCTGATTTGAAACCACATGTTACTTGCCATGAAAGGTGGACTTGCTTCCTTTCTCCTTTGTTGCAAAGAATCAGCTATATGGAGGAGAGGAGGGCCTGAGAAACTTTTCTGCCATGAAGTGTTTGAGAAATCTATCGCCACATTCTTACTGCACATTAAAGTGTCAAGGGCTGTAAAGATTTAAGTGTCACGTCTTCATTCCACTGGTATGGTGGGATAAAAACTGAAAATACAGGTATGCTCCAGTTGTAAATAGAAAAGATACTGGAATACTTCTTTGTGAAAAGAAGCAGTGCTAATTACTATTTGATTATGCACAGTTCTTGAAATAAAGTTTTACTTCAGGGAAGTCAGGCAAATTCATATCCAAAAAATCGTGATTTTCATAAAAACATTCATACTAATGAACCAAACCATTTAATTTATAATATAAAAATAATGGCAACGACTAACGTATAAAATTCAGTATCATTTTAAAATCTGATACTGTAGGCTGGGCATGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGAGTGAGGCGGGCAGATCGCTTGAGGCCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACGCATCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCACGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGTGACAAAGCAAGATCCTGTCTCAAAAAAAAAAAAAAAAAGTGATACTGTTAATACTGCTGTAATATGTTGATTATGTGTGATGTCCTTTTTTTGTTGTTGTTGTTGTTTTTGGTGGAGAAAAGATATCACTTAAAAAACTTATAGAAAGAAACTGTACCAAAGTATTCAGTTATTTGATATGAGACACTTATTTTAGAATAGAGAGTTTTAGATACTGAATTTGGGCTCAAAATTCTACTACTGATTTTGAAGTTTTTCACTTAGAGATGGTCTATATATTGATGACCTTAGAGGCTAATGAACAGATGCCATGTAGCTAATTTATTCTGTGGGTCTTCATTGTGGTTCTCAAAGTGTCACTTGCTCCTACTTTCTGGGTCTCACATACTCTGTACTTAGTCACAGTGTTTCTGTCTCATTTACTTTTCATGTTGCATGCCTTTTACACTGCTTCCCTCTTAAGATGAGTTTAGGGGCTGTGATAATTTCTGTTGCCTCAGCATTATTTCATAACACTTGTCTCTTCCCTGAATTTTTCACAGAAGACTAACTGAAATAGTTGGTAAATTTTTCTGTATGTTTCTTACCATTTTCCACAAGGTGTTGGCATGTGTAGAAGAAAATACATTAAGATTGGTGATCAAGATTGGTTGAATGGAATCTCAACTAGTATATTAATACATTTTAAATGTTACAATGAACTGTAAATTCATGGGTAAAATATCAGGGGTAAACTTATTTTAGTTTCTGTTATAGCAAGGGGGAAATCAATTTTAAAATACCACACAAGTATTGCCATGAAATTCGGCATTAAAATATTCCATTAATACCTATCATATGCAATTTATGGAAAAGTAACTATTTAAAAAATTTATTGTTGTCTCATTCTTCAAAAGGTTTAATTTTTAGATATCCAGAAGAGGACTATGAGTCATTTCCACTCTCAGAATCAGATGTACCTCTTTTCTGCCTTCCTATGGGAGCTACTATTGAGTGCTGGGATCCTGAAACCAAATATCCACTTCCAGTTTTTTCAACTTTTGTCTTGACAGGTTCTTCAGCCAAAAAGGTATATGGAGCTGCCATTCAGTTTTATGAACCTTACTCTCGGGAACTTCTATCAGAGAAACAGCTTATGCACCTGGGCTTGTTGACGCCTGTGGAGAGAAAAATGGTCTCCAAATCCATCAATACAAACAAATGCATTTGTTTACTCTCACACTGGCCTTTTTTTGAAGCTTTTAGGAAATTTCTTATGTTTATCTACAAACTTTCTGTGTCTGGACCACATCCTCTTCCCATTGAAAAGCACATTTCACATTTTATGCAAAACATCCCTTTTCCTTCACCACAAAGACCGAGAATCCTTGTCCAGCTGTCAGTCCATGATGCATTAATATTATCACAGCCAGTTTCTACACCTTTACCACTAAGTGGAGCCAACTTTAGCACCTTGCTAATGAATCTGGGTCCTGAGAATTGTGCAACACTGCTGCTCTTTGTTTTACTTGAGAGTAAAATTCTGCTGCATTCTCTTAGGCCAGCTGTCTTGACTGGGGTAGCTGAAGCTGTTGTAGCTATGATCTTTCCATTTCAGTGGCAATGCCCATATATTCCCCTTTGTCCTCTTTCACTGGCTGCAGTGCTTAGTGCACCTTTACCATTTATAGTTGGAGTTGACTCAAGGTATTTTGATCTTCATGACCCACCACAAGATGTTGTTTGCATTGACTTGGATACGAACATGTTATATGT exonic breast cancer qRT-PCR; in vitro knockdown; western blot; etc. MCF-7 and MDA-MB-231 cell lines N/A up-regulated N/A N/A N/A N/A In breast cancer cells, circDENND4C was increased under hypoxic conditions and decreased after knocking-down HIF1¦Á. In addition, knocking-down circDENND4C inhibited proliferation of breast cancer cells in a hypoxic environment. Finally, tumors with a large size had higher circDENND4C expression levels than those of small size. Conclusion: CircDENND4C is a HIF1¦Á-associated circRNA promoting the proliferation of breast cancer cells under hypoxia. 28739726 2017.8 Anticancer Res. HIF1¦Á-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment N/A hsa_circRNA_100338 hsa_circ_0000130 1 151611363-151611595 + hg19 SNX27 GAACCACGTGAATGTTGAGGGGGCGACACACAAGCAGGTGGTGGACCTGATTCGAGCAGGCGAGAAGGAATTGATCTTGACAGTGTTATCTGTACCTCCTCATGAGGCAGATAACCTAGATCCCAGTGACGACTCGTTGGGACAATCATTTTATGATTACACAGAAAAGCAAGCAGTGCCCATATCGGTCCCCAGATACAAACATGTGGAGCAGAATGGTGAGAAGTTTGTG exonic hepatocellular carcinoma Mircroarray; qRT-PCR; dual luciferase reporter assay; in vitro overexpression; etc. HCC tissues and paired pericancerous tissues N/A up-regulated miR-141-3p N/A N/A N/A High expression of circRNA_100338, one of the upregulated circRNAs in HCC, is closely correlated with a low cumulative survival rate and metastatic progression in HCC patients with hepatitis B. Furthermore, our in silico and experimental analyses identified miR-141-3p as a direct target of circRNA_100338. Thus, circRNA_100338 functions as an endogenous sponge for miR-141-3p in HCC. In addition, we identified the crucial antagonistic roles of circRNA_100338 and miR-141-3p in the regulation of invasive potential in liver cancer cells. Overall, the differential expression of multiple circRNAs in HCC tissues and their clinical significance in hepatitis B-related HCC patients as revealed by our study suggests that circRNA_100338 is a potentially valuable biomarker for HCC diagnosis and target for HCC therapeutics. 28710406 2017.7 Sci Rep. Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma N/A hsa_circRNA_104075 hsa_circ_0075736 6 17669523-17669777 - hg19 NUP153 GCACCAGTTAGAAGACAAATGAAAGCTAAGCAACTCAGTGCACAATCTTACGGTGTGACCAGTTCAACAGCTCGGCGAATATTGCAGTCTTTAGAGAAGATGTCAAGCCCTTTAGCGGATGCAAAAAGAATTCCATCCATTGTTTCTTCTCCTCTGAATTCT exonic hepatocellular carcinoma Microarray; qRT-PCR HCC tissues and paired pericancerous tissues N/A up-regulated N/A N/A N/A N/A N/A 28710406 2017.7 Sci Rep. Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma N/A hsa_circ_0020397 hsa_circRNA_100722 10 128768965-128926028 + hg19 DOCK1 CTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTCCAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAAAATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACCTTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGTGGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAACATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGGGTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAACAGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGCGATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGTTAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGTCAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGCTGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAGCTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAAATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACACGTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGGACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAAGTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATCCATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCAGCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGATCGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGACCATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGACCGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAAGGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGATTCTGAACTCATT exonic colorectal cancer qRT-PCR; dual luciferase reporter assay; in vitro knockdown; in vitro overexpression; western blot; etc. normal human colonic epithelial cells (CCD 841 CoN) and colorectal cell lines (LoVo, HCT116, SW480 and SW620) N/A up-regulated miR-138 TERT; PD-L1 N/A N/A Although hsa_circ_0020397 did not influence miR-138 expression per se, hsa_circ_0020397 did inhibit miR-138 activity, as examined via the expression of miR-138 targets TERT and PD-L1. Control treatments with plasmids overexpressing linear hsa_circ_0020397 did not have these effects. Hsa_circ_0020397 promoted cell viability and invasion of CRC cells and inhibited their apoptosis, whereas miR-138 had the opposite effect. Nevertheless, hsa_circ_0020397 antagonized miR-138 suppression of cell growth. When TERT or PD-L1 expression was suppressed with siRNAs, the above functions of hsa_circ_0020397 were attenuated, suggesting that hsa_circ_0020397 can regulate CRC cell viability, apoptosis and invasion by promoting the expression of miR-138 target genes. 28707774 2017.9 Cell Biol Int. Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1 N/A hsa_circ_000839 hsa_circ_0000497; hsa_circRNA_101280 13 78293666-78327493 + hg19 SLAIN1 GTTATACATTGGCTCTTCAAAGACGTTCACCTCATCAGAGAAATCCCTGACTCCTTTGCAGTGGTGTAGACATGTCCTAGATAACCCAACTCCTGAGATGGAAGCAGCGAGACGTTCCCTGTGCTTTAGACTGGAGCAAGGTTACACTTCCAGGGGCTCCCCACTCAGTCCCCAGTCATCTATCGACAGTGAGCTGAGTACTTCAGAATTGGAGGATGATTCTATCTCCATGGGATATAAATTACAGGACCTCACTGATGTTCAGATCATGGCTCGTCTGCAAGAAGAAAGTCTCAGGCAAGATTATGCTTCTACTTCAGCATCTGTATCAAGACATAGTTCCAGTGTGTCATTGAGTTCAGGAAAAAAAGGGACATGTAGTGATCAAGAATATGACCAATACAGTCTGGAGGATGAAGAGGAATTTGATCATTTGCCACCACCTCAGCCTCGTCTTCCAAGATGTTCCCCTTTCCAAAGAGGAATTCCCCATTCACAGACTTTCTCCAGCATTCGGGAGTGTAGGAGGAGCCCCAGTTCCCAGTATTTTCCTTCAAATAATTACCAGCAGCAACAGTATTATTCACCTCAAGCCCAAACTCCAGATCAGCAACCAAATAGGACCAATGGAGATAAGCTCCGAAGAAGTATGCCTAACCTAGCCCGGATGCCAAGTACAACTGCCATTAGTAGCAACATTAGTTCTCCGGTCACCGTGCGAAATAGTCAGAGTTTTGACTCAAGCTTGCATGGAGCTGGAAATGGAATTTCAAGAATACAATCTTGTA exonic hepatocellular carcinoma qRT-PCR; western blot; dual luciferase reporter assay; etc. Huh7 and HepG2 HCC cell lines; hepatocellular cancer tissues N/A up-regulated miR-200b RhoA N/A N/A Our data establish that miR-200b is expressed at a relatively low level in hepatocellular carcinoma ( p < 0.001). RhoA and circ_000839 are expressed at a relatively high level in hepatocellular carcinoma ( p < 0.001, respectively). Our mechanistic data indicate that RhoA is a direct target of miR-200b ( p < 0.001), binding of which affects the expression of invasion and migration in hepatocellular carcinoma cell lines ( p < 0.05). And correlation analysis showed that miR-200b was inversely correlated with RhoA and circ_000839 ( p = 0.012, p = 0.002, respectively), while RhoA was positively correlated with circ_000839 ( p < 0.001). Taken together, our data suggest that miR-200b could mediate RhoA gene and circ_000839 to form endogenous competition. And this is a direction for the association study of miR-200b and RhoA in the future. 28695771 2017.7 Tumour Biol. MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 N/A circRNA-MYLK hsa_circ_0002768; hsa_circRNA_103450 3 123471177-123512691 - hg19 MYLK ACCATGGGGGATGTGAAGCTGGTTGCCTCGTCACACATTTCCAAAACCTCCCTCAGTGTGGATCCCTCAAGAGTTGACTCCATGCCCCTGACAGAGGCCCCTGCTTTCATTTTGCCCCCTCGGAACCTCTGCATCAAAGAAGGAGCCACCGCCAAGTTCGAAGGGCGGGTCCGGGGTTACCCAGAGCCCCAGGTGACATGGCACAGAAACGGGCAACCCATCACCAGCGGGGGCCGCTTCCTGCTGGATTGCGGCATCCGGGGGACTTTCAGCCTTGTGATTCATGCTGTCCATGAGGAGGACAGGGGAAAGTATACCTGTGAAGCCACCAATGGCAGTGGTGCTCGCCAGGTGACAGTGGAGTTGACAGTAGAAG exonic bladder cancer Microarray; qRT-PCR; in vitro knockdown; in vitro overexpression; in vivo overexpression; RIP; dual luciferase reporter assay; FISH; western blot; northern blot; qRT-PCR; etc. bladder cancer cell lines EJ, T24, 5673£¬BIU-87 normal bladder epithelial cell line SV-HUC-1; 293T cell N/A up-regulated miR-29a VEGFA N/A N/A circRNA-MYLK and VEGFA were significantly up-regulated and co-expressed in BC. Importantly, circRNA-MYLK levels were related to the progression of stage and grade of BC. Mechanistically, we demonstrated that circRNA-MYLK could directly bind to miR-29a and relieve suppression for target VEGFA, which activated VEGFA/VEGFR2 signaling pathway. Functionally, we found that ectopically expressing circRNA-MYLK accelerated cell proliferation, migration, tube formation of HUVEC and rearranged cytoskeleton. Moreover, up-regulating circRNA-MYLK promoted epithelial-mesenchymal transition. Whereas circRNA-MYLK knockdown decreased cell proliferation, motility, and induced apoptosis. Finally, up-regulating circRNA-MYLK promoted the growth, angiogenesis and metastasis of BC xenografts. 28687357 2017.9.10 Cancer Lett. Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway N/A hsa_circ_0013958 hsa_circRNA_100323 1 147131074-147131890 - hg19 ACP6 GTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGTGTCAGAAAGAAG exonic lung adenocarcinoma Microarray; qRT-PCR; in vitro knockdown; in vitro overexpression; western blot; luciferase reporter assay; FISH; etc. LAC tissues, A549 and H1299 cells and plasma cytoplasm up-regulated miR-134 CCND1 N/A N/A Hsa_circ_0013958 was further confirmed to be up-regulated in all of the LAC tissues, cells and plasma. In addition, hsa_circ_0013958 levels were associated with TNM stage (P = 0.009) and lymphatic metastasis (P = 0.006). The area under the receiver operating characteristic curve was 0.815 (95% confidence interval = 0.727-0.903; P < 0.001). In addition, to further illustrate the bioactivities of hsa_circ_0013958 in LAC, siRNA-mediated inhibition of hsa_circ_0013958 was performed in vitro. The results showed that hsa_circ_0013958 promoted cell proliferation and invasion and inhibited cell apoptosis in LAC. Moreover, hsa_circ_0013958 was identified as a sponge of miR-134, and thus it up-regulated oncogenic cyclin D1, which plays a pivotal role in the development of non-small cell lung cancer. 28685964 2017.7 FEBS J. hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma N/A hsa_circRNA_100269 hsa_circ_0013048 1 82302569-82372915 + hg19 LPHN2 ATATGAAGATCAATGATGCAGACTGATGGTTTTGATGAAGCTGGGCATTTATAACTAGATTCATTAAGGAATACAAAGAAAATACTTAAAGGGATCAATAATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTGTAATCAGCTTCTTACCAAATACAGAAGGTTTCAGCAGAGCAGCTTTACCATTTGGGCTGGTGAGGCGAGAATTATCCTGTGAAGGTTATTCTATAGATCTGCGATGCCCGGGCAGTGATGTCATCATGATTGAGAGCGCTAACTATGGTCGGACGGATGACAAGATTTGTGATGCTGACCCATTTCAGATGGAGAATACAGACTGCTACCTCCCCGATGCCTTCAAAATTATGACTCAAAG exonic gastric cancer qRT-PCR; dual luciferase assay; in vitro overexpression; etc. human colorectal cancer cell lines, namely, AGS,MKN28, MKN45, BGC823, MGC803, SGC7901, and GES1 N/A down-regulated miR-630 N/A N/A N/A The expression levels of circRNA_100269 and its linear isomer LPHN2 mRNA were found to be downregulated (p<0.01) in GC tissues. The target miRNA was predicted to be miR-630, whose expression was upregulated (p<0.01) and found to be negatively correlated with that of circRNA_100269 (r = -0.688) in GC tissues. Moreover, direct interaction of circRNA_100269 and miR-630 was confirmed through dual-luciferase assays. Overexpressing the circRNA_100269 plasmid inhibited cell proliferation (p<0.05). Furthermore, transfection of miR-630 mimics into cell lines overexpressing circRNA_100269 blocked the function of circRNA_100269 (p<0.05). Thus, circRNA_100269 level was downregulated in GC and correlated negatively with that of miR-630. Taken together, our results suggest that circRNA_100269 and miR-630 comprise a novel pathway that regulates proliferation of GC cells. 28657541 2017.7 Aging (Albany NY). CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630 N/A circ-Amotl1 hsa_circ_0004214; hsa_circRNA_100937 11 94532555-94533477 + hg19 AMOTL1 TTGAAGATCCTCTTTGTAACTTCCACTCCCCAAACTTCCTGAGGATCTCAGAGGTGGAAATGAGAGGTTCCGAGGATGCGGCAGCTGGAACAGTATTGCAGCGGCTGATCCAGGAACAACTGCGGTATGGCACCCCAACCGAGAACATGAACTTGCTGGCCATTCAGCACCAGGCCACAGGGAGTGCAGGACCAGCCCATCCTACAAACAACTTTTCTTCCACGGAAAACCTCACTCAAGAAGACCCACAAATGGTCTACCAGTCAGCACGCCAAGAACCGCAGGGTCAAGAACACCAGGTGGACAATACGGTGATGGAGAAACAGGTCCGGTCCACGCAGCCTCAGCAGAACAACGAGGAACTGCCCACTTACGAGGAGGCCAAAGCACAGTCGCAGTTCTTCAGGGGGCAGCAGCAGCAGCAACAGCAGCAGGGGGCGGTGGGCCATGGTTACTACATGGCAGGGGGCACCAGTCAGAAGTCCCGAACTGAGGGGAGGCCCACTGTGAACCGTGCCAACAGTGGACAGGCGCATAAGGACGAGGCGCTGAAGGAACTGAAGCAGGGCCACGTCCGCTCGCTCAGCGAGAGAATCATGCAGCTGTCCCTGGAGAGGAATGGGGCCAAGCAACACCTTCCCGGCTCGGGGAATGGAAAGGGCTTCAAAGTAGGAGGGGGGCCCTCCCCTGCCCAGCCTGCAGGTAAAGTGCTGGACCCTCGGGGTCCTCCACCTGAGTACCCCTTCAAGACCAAGCAAATGATGTCCCCAGTCAGCAAGACCCAGGAGCACGGACTTTTTTATGGTGACCAGCACCCCGGGATGCTCCACGAGATGGTCAAGCCCTACCCTGCTCCTCAGCCTGTGAGAACAGATGTGGCCGTCCTGCGGTACCAGCCACCCCCTGAGTATGGGGTAACGAG exonic breast cancer qRT-PCR; in vitro knockdown; in vitro overexpression; in vivo overexpression; western blot; IHC; pull down; northern blot; etc. MDA-MB-231 cells nucleus up-regulated N/A N/A c-myc; EGF; c-myb; NF1; AKT N/A Circ-Amotl1 is highly expressed in patient tumor samples and cancer cell lines. Single-cell inoculations using circ-Amotl1-transfected tumor cells showed a 30-fold increase in proliferative capacity relative to control. Agarose colony-formation assays similarly revealed a 142-fold increase. Tumor-take rate in nude mouse xenografts using 6-day (219 cells) and 3-day (9 cells) colonies were 100%, suggesting tumor-forming potential of every cell. Subcutaneous single-cell injections led to the formation of palpable tumors in 41% of mice, with tumor sizes >1 cm3 in 1 month. We further found that this potent tumorigenicity was triggered through interactions between circ-Amotl1 and c-myc. A putative binding site was identified in silico and tested experimentally. Ectopic expression of circ-Amotl1 increased retention of nuclear c-myc, appearing to promote c-myc stability and upregulate c-myc targets. Expression of circ-Amotl1 also increased the affinity of c-myc binding to a number of promoters. 28622299 2017.9 Cell Death Differ. A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation N/A hsa_circ_0003159 N/A 7 81689743-81746489 - hg19 CACNA2D1 CCTGAGAAAAATGACAGTGAGCCAGGCAGCCAGAGGATAAAACCTGTTTTCATTGAAGATGCTAATTTTGGACGACAAATATCTTATCAGCACGCAGCAGTCCATATTCCTACTGACATCTATGAGGGCTCAACAATTGTGTTAAATGAACTCAACTGGACAAGTGCCTTAGATGAAGTTTTCAAAAAGAATCGCGAGGAAGACCCTTCATTATTGTGGCAGGTTTTTGGCAGTGCCACTGGCCTAGCTCGATATTATCCAGCTTCACCATGGGTTGATAATAGTAGAACTCCAAATAAGATTGACCTTTATGATGTACGCAGAAGACCATGGTACATCCAAGGAGCTGCATCTCCTAAAGACATGCTTATTCTGGTGGATGTGAGTGGAAGTGTTAGTGGATTGACACTTAAACTGATCCGAACATCTGTCTCCGAAATGTTAGAAACCCTCTCAGATGATGATTTCGTGAATGTAGCTTCA N/A gastric cancer qRT-PCR fresh gastric cancer tissues and adjacent non-tumorous tissues N/A down-regulated N/A N/A N/A N/A Compared with paired adjacent non-tumorous tissues, hsa_circ_0003159 expression was significantly down-regulated in gastric cancer tissues. What is more, we found that hsa_circ_0003159 expression levels were significantly negatively associated with gender, distal metastasis, and tumor-node-metastasis stage. 28618205 2017.7.15 J Clin Lab Anal. Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance N/A circMTO1 hsa_circ_0007874; hsa_circRNA_104135 6 74175931-74176329 + hg19 MTO1 GTCAGATGTCATGTAATCCTTCCTTTGGTGGCATCGGAAAGGGACATTTAATGAGGGAAGTAGATGCCTTGGATGGCCTGTGTTCTCGCATCTGTGACCAGTCTGGTGTACATTATAAAGTATTAAACCGGCGTAAGGGACCAGCTGTGTGGGGTCTGAGAGCTCAGATTGATAGGAAACTCTATAAACAGAACATGCAGAAAGAAATCTTGAATACACCACTGCTTACTGTTCAGGAGGGAGCTGTAGAAGATCTTATTCTTACAGAACCAGAGCCTGAACACACTGGGAAATGCCGTGTCAGTGGGGTTGTTTTGG exonic hepatocellular carcinoma Microarray; qRT-PCR; RIP; ISH; FISH; in vitro knockdown; in vitro overexpression; in vivo knockdown; etc. HCC and paired adjacent liver tissues; HCC cell lines HepG2, SMMC-7721,QGY-7701, and SK-Hep1 cytoplasm down-regulated miR-9 p21 N/A N/A Expression profile revealed that circMTO1 was significantly down-regulated in HCC tissues. HCC patients with low circMTO1 expression had shortened survival. By using a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells, we identified miR-9 as the circMTO1-associated miRNA. Silencing of circMTO1 in HCC could down-regulate p21, the target of oncogenic miR-9, resulting in the promotion of HCC cell proliferation and invasion. In addition, the tumor-promoting effect of circMTO1 silencing was blocked by miR9 inhibitor. Intratumoral administration of cholesterol-conjugated circMTO1 siRNA promoted tumor growth in HCC-bearing mice in vivo. 28520103 2017.10 Hepatology Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression N/A hsa_circ_0001895 hsa_circRNA_104945; hsa_circ_000760 9 134305476-134308181 + hg19 PRRC2B GCAGATCGGGAGCGGTGCCGAGAAAAATTTCCTTACTAGATGACATTTCATCGCAATGTCCGATCGTTTGGGGCAAATTACCAAGGGCAAGGATGGGAAAAGCAAGTACTCGACTCTCAGCCTGTTTGATAAGTATAAAGGAAAATCAGTAGACGCGATTAGATCCTCAGTTATTCCTAGACATGGCTTACAGAGTCTTGGGAAAGTTGCTGCAGCCCGGCGCATGCCACCGCCTGCAAACCTGCCAAGCTTGAAGTCTGAAAACAAAGGAAACGACCCCAACATCGTGATAGTACCCAAGGACGGGACGGGATGGGCAAACAAGCAGGATCAGCAAGACCCAAAGAG exonic gastric cancer qRT-PCR healthy gastric mucosa and gastric dysplasia tissues; normal human gastric mucosa epithelial cell line (GES-1) and gastric cancer cell lines (AGS, BGC-823, HGC-27, MGC-803, and SGC-7901) N/A down-regulated N/A N/A N/A N/A Hsa_circ_0001895 expression levels in gastric cancer cell lines were all significantly downregulated than those in normal gastric epithelial GES-1 cells. Besides, compared with healthy control tissues, it was downregulated not only in 69.8% (67/96) gastric cancer tissues but also in gastric precancerous lesions. Moreover, hsa_circ_0001895expression levels were significantly correlated with cell differentiation, Borrmann type, and tissue carcino-embryonic antigen expression. 28443463 2017.4 Tumour Biol. Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances N/A hsa_circRNA_100290 hsa_circ_0013339 1 101372407-101379362 + hg19 SLC30A7 CTTAGGCTTGATTTCCGACTCTTTTCACATGTTTTTCGATAGCACTGCCATTTTGGCTGGACTGGCAGCTTCTGTTATTTCAAAATGGAGAGATAATGATGCTTTCTCCTATGGGTATGTTAGAGCGGAAGTTCTGGCTGGCTTTGTCAATGGCCTATTTTTGATCTTCACTGCTTTTTTTATTTTCTCAGAAGGAGTTGAGAGAGCATTAGCCCCTCCAGATGTCCACCATGAGAGACTGCTTCTTGTTTCCATTCTTGGGTTTGTGGTAAACCTAATAGGAATATTTGTTTTCAAACATGGAGGTCATGGACATTCTCATGGCTCTGGCCACGGACACAGTCATTCCCTCTTTAATGGTGCTCTAGATCAGGCACATGGCCATGTCGATCATTGCCATAGCCATGAAGTGAAACATGGTGCTGCACATAGCCATGATCATGCTCATGGACATGGACACTTTCATTCTCATG exonic oral squamous cell carcinomas Microarray; in vitro knockdown; in vivo knockdown; luciferase reporter assay; western blot; IHC; etc. OSCC tissue and paired non-cancerous matched tissue; human OSCC cell lines SCC9, CAL27 and HN4 N/A up-regulated miR-29 CDK6 N/A N/A circRNA_100290 was upregulated and co-expressed with CDK6 in OSCC tissue. Knockdown of circRNA_100290 decreased expression of CDK6 and inhibited proliferation of OSCC cell lines in vitro and in vivo. Via luciferase reporter assays, circRNA_100290 was observed to directly bind to miR-29 family members. Further EGFP/RFP reporter assays showed that CDK6 was the direct target of miR-29b. Taken together, we conclude that circRNA_100290 may function as a competing endogenous RNA to regulate CDK6 expression through sponging up miR-29b family members. 28368401 2017.8 Oncogene circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family N/A hsa_circRNA_100876 hsa_circ_0023404 11 71668272-71671937 + hg19 RNF121 GTTGATATGTCAGATCTCTCTCCAGAAGAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAAT exonic non small cell lung cancer qRT-PCR tumor tissues and adjacent nontumorous tissues N/A up-regulated N/A N/A N/A N/A The expression level of circRNA_100876 was significantly elevated in NSCLC tissues when compared with their adjacent nontumorous tissues (P=0.000). Moreover, there was a close correlation between the circRNA_100876 up-regulation expression and lymph node metastasis (P=0.001) and tumor staging (P=0.001) in NSCLC. In addition, Kaplan-Meier survival analysis demonstrated that the overall survival time of NSCLC patients with high circRNA_100876 expression was significantly shorter than those patients with low circRNA_100876 expression (P=0.000). 28343871 2017.5 Pathol Res Pract. Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value N/A hsa_circ_0004277 hsa_circRNA_100526 10 1125950-1126416 + hg19 WDR37 TACGTAGAGAAATCGACACTCTTAATGAACGTTTAGCTGCTGAAGGACAAGCGATTGATGGAGCAGAGCTGAGTAAGGGCCAACTCAAAACAAAAGCCAGTCACAGCACCAGCCAGCTCTCCCAGAAACTGAAGACCACTTACAAGGCTTCCACCAGCAAG exonic acute myeloid leukemia Microarray; qRT-PCR mononuclear cells from BM aspirates of AML patients and healthy controls N/A down-regulated N/A N/A N/A N/A A downregulated circRNA, hsa_circ_0004277, was characterized and functionally evaluated in a cohort of 115 human samples, thus offering a potential diagnostic marker and treatment target in AML. Interestingly, we found chemotherapy could significantly restore the expression of hsa_circ_0004277, indicating the increasing level of hsa_circ_0004277 was associated with successful treatment. Furthermore, a detailed circRNA-miRNA-mRNA interaction network was presented for hsa_circ_0004277, allowing us to better understand its underlying mechanisms for function in AML. 28282919 2017.3.9 Int J Mol Sci. Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis N/A hsa_circ_0035381 hsa_circRNA_101525 15 55621921-55634000 + hg19 PIGB TTTTTTTGCCAGTTGTGCTCCTGGTTCACATGGTATTGCTGTACCAGAACCCTTACAAACACCATGGAAACTGTTCTCACTATAATTGCTCTTTTCTACTATCCTTTGGAAGGTTCAAAGTCTATGAACAGTGTCAAATACTCATCCCTGGTGGCACTTGCCTTCATAATTCGTCCCACAGCTGTCATTCTGTGGACACCTTTGCTCTTCAGACATTTCTGTCAAGAACCAAGAAAGCTTGATCTTATTCTACATCATTTTTTACCTGTAGGCTTTGTTACTTTGAGTTTGTCTCTGATGATTGATCGTATTTTTTTTGGCCAATGGACTCTGGTTCAATTTAATTTTTTGAAATTTAACGTGCTGCAGAACTGGGGAACATTTTATGGTTCTCATCCATGGCACTGGTACTTCAGTCAAGGATTTCCAGTTATCTTGGGTACTCACTTACCCTTCTTTATTCATGGCTGCTATCTAGCACCAAAGAGATACCGGATACTTTTGGTGACTGTGCTGTGGACACTGCTTGTTTATAGCATGTTGAGCCACAAAGAATTCAGGTTTATTTATCCAGTTTTACCATTCTGTATGGTGTTCTGTG exonic acute myeloid leukemia Microarray; qRT-PCR mononuclear cells from BM aspirates of AML patients and healthy controls N/A up-regulated N/A N/A N/A N/A Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression.qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile. 28282919 2017.3.9 Int J Mol Sci. Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis N/A hsa_circ_0004136 hsa_circRNA_104134 6 73713630-73751785 + hg19 KCNQ5 TTTTCTCCTTGTCTTTGGTTGCTTGATTTTGTCAGTGTTTTCTACCATCCCTGAGCACACAAAATTGGCCTCAAGTTGCCTCTTGATCCTGGAGTTCGTGATGATTGTCGTCTTTGGTTTGGAGTTCATCATTCGAATCTGGTCTGCGGGTTGCTGTTGTCGATATAGAGGATGGCAAGGAAGACTGAGGTTTGCTCGAAAGCCCTTCTGTGTTATAG exonic acute myeloid leukemia Microarray; qRT-PCR mononuclear cells from BM aspirates of AML patients and healthy controls N/A up-regulated N/A N/A N/A N/A Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression.qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile. 28282919 2017.3.9 Int J Mol Sci. Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis N/A hsa_circ_0058058 hsa_circRNA_102913 2 216177220-216190861 + hg19 ATIC CCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTTGCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCTCGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAG exonic acute myeloid leukemia Microarray; qRT-PCR mononuclear cells from BM aspirates of AML patients and healthy controls N/A up-regulated N/A N/A N/A N/A Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression.qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile. 28282919 2017.3.9 Int J Mol Sci. Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis N/A hsa_circ_0017446 hsa_circRNA_100527 10 1125950-1132297 + hg19 WDR37 TACGTAGAGAAATCGACACTCTTAATGAACGTTTAGCTGCTGAAGGACAAGCGATTGATGGAGCAGAGCTGAGTAAGGGCCAACTCAAAACAAAAGCCAGTCACAGCACCAGCCAGCTCTCCCAGAAACTGAAGACCACTTACAAGGCTTCCACCAGCAAGATTGTCTCCAGCTTTAAGACCACGACATCGAGAGCTGCCTGCCAGCTCGTGAAGGAGTACATCGGCCACCGGGACGGCATCTGGGATGTCAGCGTGGCCAAGACACAGCCAGTGGTGCTCGGGACTGCATCAGCCGATCACACGGCTTTGCTGTGGAGCATAGAGACAGGGAAGTGCCTAGTCAAGTACGCAGGCCACGTGGGCTCAG exonic acute myeloid leukemia Microarray; qRT-PCR mononuclear cells from BM aspirates of AML patients and healthy controls N/A down-regulated N/A N/A N/A N/A Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression.qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile. 28282919 2017.3.9 Int J Mol Sci. Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis N/A circCCDC66 N/A 3 56592970-56594028 N/A hg19 CCDC66 GACGACGACAAAAACAATTAGAGCATCAGGAAACAGTACTGCTGGAGCACCCTTTCA exonic colon cancer RNA-seq; RT-PCR; qRT-PCR; Sanger sequecning; in vitro knockdown; in vitro overexpression; in vivo knockdown; etc. matched normal and tumor colon tissue; HCT116,HT-29, Caco-2, LS123 cells cytoplasm up-regulated miR-33b; miR-93; miR-185 MYC(miR-33b; miR-93) N/A N/A RNA-Seq data from matched normal and tumor colon tissue samples identified numerous circRNAs specifically elevated in cancer cells, several of which were verified by quantitative RT-PCR. CircCCDC66 expression was elevated in polyps and colon cancer and was associated with poor prognosis. Gain-of-function and loss-of-function studies in colorectal cancer cell lines demonstrated that circCCDC66 controlled multiple pathological processes, including cell proliferation, migration, invasion, and anchorage-independent growth. In-depth characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft and orthotopic mouse models, respectively. 28249903 2017.5 Cancer Res. Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis N/A circCCNB1 N/A 5 69174877-69175537 N/A hg19 CCNB1 AGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAATGGAATAATTGTGTGCCCAAGAAGATGCTG exonic colon cancer RNA-seq; qRT-PCR matched normal and tumor colon tissue N/A up-regulated N/A N/A N/A N/A Differential expression of the circRNA candidates was quantified in 48 pairs of colorectal tumors and corresponding adjacent non-tumor tissues. Among the investigated circRNA candidates, circCCDC66_10_8, circCCNB1_7_6, and circCDK13_2_2 were significantly elevated in the colorectal tumor tissues. 28249903 2017.5 Cancer Res. Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis N/A circCDK13 N/A 7 39987599-39988258 N/A hg19 CDK13 TCCCATGCTGCCTGAAGATAAAGAAGCTGATAGACGGTCTGGAAAATCCCGAAGCAGAAGCCCGTATTCATC exonic colon cancer RNA-seq; qRT-PCR matched normal and tumor colon tissue N/A up-regulated N/A N/A N/A N/A Differential expression of the circRNA candidates was quantified in 48 pairs of colorectal tumors and corresponding adjacent non-tumor tissues. Among the investigated circRNA candidates, circCCDC66_10_8, circCCNB1_7_6, and circCDK13_2_2 were significantly elevated in the colorectal tumor tissues. 28249903 2017.5 Cancer Res. Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis N/A circZKSCAN1 hsa_circ_0001727; hsa_circRNA_104435; hsa_circ_000017 7 99621041-99621930 + hg19 ZKSCAN1 GAATAGTAAAGAAACACATCATAAAACCTCCCAGGACATAAAGGTGAGCACAGACCCTGTTTGGATCAAGTCAGTTCCTGGAGCCTGAATGATGACTGCTGAATCACGGGAAGCCACGGGTCTGTCCCCACAGGCTGCACAGGAGAAGGATGGTATCGTAATAGTGAAGGTGGAAGAGGAAGATGAGGAAGACCACATGTGGGGGCAGGATTCCACCCTACAGGACACGCCTCCTCCAGACCCAGAGATATTCCGCCAACGCTTCAGGCGCTTCTGTTACCAGAACACTTTTGGGCCCCGAGAGGCTCTCAGTCGGCTGAAGGAACTTTGTCATCAGTGGCTGCGGCCAGAAATAAACACCAAGGAACAGATCCTGGAGCTTCTGGTGCTAGAGCAGTTTCTTTCCATCCTGCCCAAGGAGCTCCAGGTCTGGCTGCAGGAATACCGCCCCGATAGTGGAGAGGAGGCCGTGACCCTTCTAGAAGACTTGGAGCTTGATTTATCAGGACAACAGGTCCCAGGTCAAGTTCATGGACCTGAGATGCTCGCAAGGGGGATGGTGCCTCTGGATCCAGTTCAGGAGTCCTCGAGCTTTGACCTTCATCACGAGGCCACCCAGTCCCACTTCAAACATTCGTCTCGGAAACCCCGCCTCTTACAGTCACGAG exonic hepatocellular carcinoma RT-PCR; in vitro knockdown; in vivo knockdown; in vitro overexpression; in vivo overexpression; western blot; FISH; RNA-seq; qRT-PCR etc. hepatocellular carcinoma tissue and paired adjacent nontumorous tissues; human normal liver L02 cell line and the HCC cell lines (Huh7, SMMC-7721, BEL-7402, HepG2, and Hep3B) cytoplasm down-regulated N/A N/A N/A N/A Expression of both ZKSCAN1mRNA and circZKSCAN1 was significantly lower in the HCC samples compared with that in matched adjacent nontumorous tissues. The low expression level of ZKSCAN1 was only associated with tumor size, while the cirZKSCAN1 levels varied in patients with different tumor numbers, cirrhosis, vascular invasion, or microscopic vascular invasion, as well as with the tumor grade. Silencing both ZKSCAN1mRNA and circZKSCAN1 promoted cell proliferation, migration, and invasion. In contrast, overexpression of both forms of RNA repressed HCC progression in vivo and in vitro. Silencing or overexpression of both forms of RNA did not interfere with each other. RNA-seq revealed a very different molecular basis for the observed effects; ZKSCAN1mRNA mainly regulated cellular metabolism, while circZKSCAN1 mediated several cancer-related signaling pathways, suggesting a nonredundant role for ZKSCAN1mRNA and circRNA. 28211215 2017.4 Mol Oncol. ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways. N/A hsa_circ_0000190 hsa_circRNA_000190; hsa_circ_002125 1 224553580-224559125 + hg19 CNIH4 TGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCTGTTGCCACTTGGAATATATATCGATACATTATGGTGCCGAGTGGTAACATGGGAGTGTTTGATCCAACAGAAATACACAATCGAGGGCAGCTGAAGTCACACATGAAAGAAGCCATGATCAAGCTTGGTTTCCACTTGCTCTGCTTCTTCATGTATCTTTATAG exonic gastric cancer Microarray; qRT-PCR paired gastric cancer tissues and adjacent non-tumor tissues N/A down-regulated N/A N/A N/A N/A Hsa_circ_0000190 is down-regulated in gastric cancer tissues and plasma samples from patients with gastric cancer.Hsa_circ_0000190 levels are correlated with tumor diameter, lymphatic metastasis, distal metastasis, and TNM stage.Hsa_circ_0000190 may be a novel biomarker for the diagnosis of gastric cancer. 28130019 2017.3 Clin Chim Acta. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer N/A circ-BANP hsa_circ_0003098; hsa_circRNA_101902 16 88037900-88071617 + hg19 BANP CGTCGTCCCCCAGACTACAGTAATACTCAACAATGATCGGCAGAACGCCATTGTAGCCAAGATGGAAGACCCCTTGAGCAACAGGGCACCGGATTCCCTGGAAAATGTCATTAGCAACGCTGTGCCTGGGCGTCGGCAGAACACCATTGTGGTGAAGGTGCCGGGCCAAGAAGACAGCCACCACGAGGACGGGGAGAGCGGCTCGGAGGCCAGCGACTCTGTGTCCAGCTGTGGGCAGGCGGGCAGTCAGAGCATCGGGAGCAACGTCACGCTCATCACCCTGAACTCGGAAGAGGACTACCCCAATGGCACCTGGCTGGGCGACGAGAACAACCCCGAGATGCGGGTACGCTGCGCCATCATCCCCTCCGACATGCTGCACATCAGCACCAACTGCCGCACGGCCGAGAAGATGGCGCTCACGCTGCTGGACTACCTCTTCCACCGCGAGGTGCAGGCTGTGTCCAACCTCTCGGGGCAGGGCAAGCACGGGAAGAAGCAGCTGGACCCGCTCACCATCTACGGCATCCGGTGTCACCTTTTCTATAAATTTGGCATCACAGAATCCGACTGGTACCGAATCAAGCAGAGCATCGACTCCAAGTGCCGCACGGCGTGGCGGCGCAAGCAGCGGGGCCAGAGCCTGGCGGTCAAGAGCTTCTCGCGGAGAACGCCCAACTCGTCCTCCTACTGCCCTTCAGAGCCGATGATGAGCACCCCACCTCCTGCCAGCGAGCTCCCGCAGCCACAGCCGCAGCCGCAGGCCCTGCACTACGCGCTGGCCAACGCACAGCAGGTGCAGATCCACCAGATCGGAGAAGACGGACAGGTGCAAGTAATCCCACAGGGACACCTCCACATCGCCCAGGTGCCGCAGGGGGAGCAAGTCCAGATCACGCAGGACAGCGAGGGCAACCTCCAGATCCATCACGTGGGGCAGGACGGTCAG exonic colorectal cancer Microarray; RT-PCR; qRT-PCR; in vitro knockdown; ISH; western blot; etc. paired CRC cancerous and adjacent normal tissues; HCT116 and HT29 cells cytoplasm up-regulated N/A N/A p-Akt N/A Circ-BANP was overexpressed in CRC cancerous tissues. Knockdown of circ-BANP with siRNA significantly attenuate the proliferation of CRC cells. In summary, our findings demonstrated that dysregulated circ-BANP appears to have an important role in CRC cells and could serve as a prognostic and therapeutic marker for CRC. 28103507 2017.4 Biomed Pharmacother. Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer N/A circHIAT1 hsa_circRNA_000096; hsa_circ_0000096; hsa_circ_001013 1 100515464-100535241 + hg19 HIAT1 CCTCAAGGAATAGGTTCTCCTAGTGTCTATCATGCAGTTATCGTCATCTTTTTGGAGTTTTTTGCTTGGGGACTATTGACAGCACCCACCTTGGTGGTATTACATGAAACCTTTCCTAAACATACATTTCTGATGAACGGCTTAATTCAAGGAGTAAAGGGTTTGTTGTCATTCCTTAGTGCCCCGCTTATTGGTGCTCTTTCTGATGTTTGGGGCCGAAAATCCTTCTTGCTGCTAACGGTGTTTTTCACATGTGCCCCAATTCCTTTAATGAAGATCAGCCCATGGTGGTACTTTGCTGTTATCTCTGTTTCTGGGGTTTTTGCAGTGACTTTTTCTGTGGTATTTGCATACGTAGCAGATATAACCCAAGAGCATGAAAGAAGTATGGCTTATGGACTGGTTTCAGCAACATTTGCTGCAAGTTTAGTCACCAGTCCTGCAATTGGAGCTTATCTTGGACGAGTATATGGGGACAGCTTGGTGGTGGTCTTAGCTACAGCAATAGCTTTGCTAGATATTTGTTTTATCCTTGTTGCTGTGCCAGAGTCGTTGCCTGAGAAAATGCGGCCAGCATCCTGGGGAGCACCCATTTCCTGGGAACAAGCTGACCCTTTTGCGTCCTTAAAAAAAGTCGGCCAAGATTCCATAGTGCTGCTGATCTGCATTACAGTGTTTCTCTCCTACCTACCGGAGGCAGGCCAATATTCCAGCTTTTTTTTATACCTCAGACAGATAATGAAATTTTCACCAGAAAGTGTTGCAGCGTTTATAGCAGTCCTTGGCATTCTTTCCATTATTGCACAG exonic clear cell renal cell carcinoma qRT-PCR; in vitro overexpression; in vitro knockdown; luciferase reporter assay; western blot; pull down; CRISPR-Cas9; ChIP; in vivo overexpression; etc. OSRC-2,SW-839,Caki-1,ACHN cells N/A down-regulated miR-195-5p; miR-29a-3p; miR-29c-3p CDC42 N/A N/A CircHIAT1 was down-regulated in ccRCCs tissues. Targeting AR could suppress ccRCC cell progression via increasing circHIAT1 expression. ChIP assay and luciferase assay demonstrated that AR suppressed circHIAT1 expression via regulating its host gene,HIAT1 expression at the transcriptional level. The consequences of AR-suppressed circHIAT1 resulted in deregulating miR-195-5p/29a-3p/29c-3p expressions, which increased CDC42 expression to enhance ccRCC cell migration and invasion. Increasing this newly identified signal via circHIAT1 suppressed AR-enhanced ccRCC cell migration and invasion. Together, these results suggested that circHIAT1 functioned as a metastatic inhibitor to suppress AR-enhanced ccRCC cell migration and invasion. 28089832 2017.5 Cancer Lett. Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals N/A hsa_circ_0000069 hsa_circRNA_100213; hsa_circ_001061 1 47745912-47748131 - hg19 STIL GTCTTCCCAAAAGTTATCTTCTGGGAAGATGCCAATACATGATCACGACTCTGGTGTTGAAGATGAAGATTTTTCTCCAAGACCAATTCCTAGTCCTCATCCAGTGAGTCAGAAGATTTCTAAGATCCAACCATCAGTTCCTGAACTTTCACTTGTGTTGGATGGCAATTTCATAGAATCAAACCCTCTGCCTACTCCATTGGAAATGGTGAATAATGAAAATCCTCCTTTGATTAACCACTTGGAACACTTGAAGCCATTGCAACCCCAGCTTTATGATGAGAAACACAGTCCAGAAGTTGAAGCTGGAGAGCCTTCCTTGAGAGGAATACCAAATCAGTTAAACCAGGATAAACCAGCTCTTTTGAGACACTGCAAAGTAAGACAGCCACCTGCCTATAAGAAAGGGAACCCCCATACCAGGAACAGTATTAAACCATCTTCTCATAATGGGCCATCTCATGATATATTTGAAAAGCTCCAAACAGTTTCTGCTGGAAATGTACAAAACGAAGAGTATCCTATAAGACCCTCCACACTTAATTCTAGGCAGTCTTCTCTTGCCCCGCAGTCCCAACCACACGATTTTGTTTTTTCACCCCATAATTCAGGAAGACCAATGGAACTTCAGATACCTACTCCCCCACTGCCATCTTACTGTTCCACAAACGTTTGCAGGTGTTGTCAGCATCATAGTCATATTCAATATAGTCCGCTAAATTCTTGGCAAGGAGCAAACACAGTTGGATCCATTCAAGATGTCCAGTCTGAAGCCCTTCAAAAGCATTCATTATTTCACCCAAGTGGATGTCCAGCCCTGTACTGTAATGCATTCTGTTCTTCAAGTAGTCCTATAGCCTTGAGACCTCAGGGAGATATGGGCAGTTGTTCTCCCCACAGCAATATTGAACCATCGCCTGTGGCAAGACCGCCTTCACATATGGACTTATGTAACCCACAGCCTTGCACAGTGTGCATGCACACACCCAAGACTGAGTCAGATAATGGAATGATGGGACTATCTCCAGATGCATATCGGTTCCTCACAGAACAAGACAGACAGCTAAGACTACTTCAGGCACAG exonic colorectal cancer qRT-PCR; in vitro knockdown; etc. 30 paired CRC tissues and adjacent noncancerous tissues; human CRC cell lines (HT-29, LoVo, HCT-116 and SW480) and normal intestinal epithelial cell line (HCO) N/A up-regulated N/A N/A N/A N/A Hsa_circ_0000069 was high expressed in CRC tissues and correlated with patients' age and tumor, node, metastasis (TNM stage (P<0.05). Furthermore, functional analysis revealed that hsa_circ_0000069 knockdown could notably inhibit cell proliferation, migration, and invasion, and induce G0/G1 phase arrest of cell cycle in vitro. 28003761 2016.12 Onco Targets Ther. Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer N/A circPVT1 N/A 8 128902834- 128903244 + hg19 PVT1 N/A N/A gastric cancer RNA-seq; qRT-PCR; luciferase reporter assay; in vitro knockdown; etc. paired cancer specimens and adjacent normal tissues; MGC-803,AGS cells and HEK-293T cells cytoplasm up-regulated miR-125 E2F2 N/A N/A The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus. circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC. Our findings suggest that circPVT1 is a novel proliferative factor and prognostic marker in GC. 27986464 2017.3 Cancer Lett. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastriccancer Yuan et al. produced a commentary regarding this published article, of which the AUC of circPVT1 expression was thought to be below 0.7 in GC and circPVT1 could not be considered as an index for determining the prognosis of GC patients. After that, Huang et al. responded to this commentary and admitted that the AUC level was indeed relatively low for circPVT1 expression in GC patients, and TCGA clinical data were utilized to validate this low AUC level in GC patients. Zhu et al. thought the detailed description of how to obtain circRNA sequencing data for circPVT1 expression in GC was necessary and the primer sequence of circPVT1 was needed to be definitely confirmed. hsa_circ_0067934 hsa_circRNA_103510 3 170013698-170015181 + hg19 PRKCI TTATTTTGGAAAAACAAATTCGCATACCACGTTCTCTGTCTGTAAAAGCTGCAAGTGTTCTGAAGAGTTTTCTTAATAAGGACCCTAAGGAACGATTGGGTTGTCATCCTCAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCGAAATGTTGATTGGGATATG exonic esophageal squamous cell carcinoma qRT-PCR; in vitro knockdown; FISH; western blot; etc. paired ESCC tissues and adjacent normal tissues; TE-13, ECA-109 and HEEC cells cytoplasm up-regulated N/A N/A N/A N/A Hsa_circ_0067934 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues. The high expression level of hsa_circ_0067934 was associated with poor differentiation (P = 0.025), I-II T stage (P = 0.04), and I-II TNM stage (P = 0.021). The in vitro silence of hsa_circ_0067934 by siRNA inhibited the proliferation and migration of ESCC cells and blocked cell cycle progression. Cell fraction analyses and fluorescence in situ hybridization detected that hsa_circ_0067934 was mostly located in the cytoplasm. 27752108 2016.10 Sci Rep. Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation N/A ciRS-7 hsa_circ_0001946; CDR1as; hsa_circRNA_105055; Cdr1as X 139865339-139866824 + hg19 CDR1 GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG antisense hepatocellular carcinoma qRT-PCR; western blot; Sanger sequencing HCC tumor tissues and non-tumor tissues N/A no change miR-7 p70S6K N/A N/A The expression levels of ciRS-7 were comparable between HCC and matched non-tumor tissues. However, the highly ciRS-7 expression in HCC tissues was significantly correlated with hepatic MVI, AFP level and younger age and thus partly related with the deterioration of HCC. Especially, ciRS-7 was one of the independent factors of hepatic MVI. These data suggested that ciRS-7 may be a promising biomarker of hepatic MVI and a novel therapy target for restraining MVI. 27614453 2017.1 J Cancer Res Clin Oncol. The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma N/A cZNF292 hsa_circ_0004383 6 87920168-87928449 + hg19 ZNF292 GCTTGCCCCAGAACACACACTATAGAGCAGATGCAGTAGCCACAAATAACTTTGTGGGGATCTAGTAGCTCCCTTAAAGAATGAGGTGAGGCAGGCTGAAGCGGGCGGATCACGAGGTCAAGAGATCAAGACCATCCTGGCTGACAAGGTGAAACGCCGTCTCTACTAAAAATACAAAAAGTAGCCAGGCTTGGTGGCGGGCGTCTGTAGTCCCAACTACACGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCTGTGAGCCGAGATCATGCCACTGCATTCCAGCCTGGGGAACAGAACAAGACTCTGTCTCAAAAACAAACAAACAAACAAAGAATGAGGTGAGGCATGTAGCACCCACAGAGCCTGTGTCTGATCTCAGTGGGAGATCTTGGGTCATCACTCAGCCCTAGCTAGTTGCCATGCTGGGATGTGGGCCCAAAGTTGCCAATTTTTTTTGTTTTAAAAGAAAAGCCAGAAACCCAAGTTTTTATGTAAAATATATGACTTCTAAATATTAGAAACTAATTCAAATACTTTTTGAACAATGTGCACATCAAAACATCCATGAGCCACTAGTTTATGAACACACACATATACTCACTAGTGTAGTCCCTTCTGGTATGGTGGAGTGTGTCTTTAATATATGACTCCTTTCAGTATCCTCAACTCTGAATCATCTTGCTCCTCTTTGAATAACTTCAGTTCGTGGGCCACCACCTGTCTCAGGAGGCCAACTTGTTCTGTTTTTGGTTTACTCTAATGGTTTGGTAGTTCTGTCTTATAGGAAACAGGAAAGTGTCTCTTTTAAACTTCAACCTAGTGGTCCTGGTATGACCTGTGAGACACACAGAATAAAATTAACTCCTCTCTTATGTGACAAGCCTCTAGATTTGTGAATTTGGCTAATTTAATCTAAAATTTAATCCAAATTTTAAAAATTGGATTTACAAGTCAATTTTTATTTCTCCAGAAATGTATCACATAGTAGTTAAGAATGAACACTCTGAAGTCAGACTATGAGGATTTGAATCCCTTCTCTGCCTTTCCTAGCTCTGTGGTCTTATGGCTTTTTATTTCACTACTTTTGGTTAGTTAATTTTTAATATAAGCATATTACTATAATTTACCTAATTACTGAATAGGTAGTACATGTAAAGCTCTTAGAACAACGCCTAGCACATGGTAAATATTCAGTAAATATTATTTAGTATCCAGATAAAGCATCCCTAGTTCCATCAGTCATTCATCAAAAAACAGTTTTAAATTTTCTTACCATATTTTTCTTACAGGTTACTCATTAATGGAAGCAATATGGTGCATTGCAGGAAGACATTTAGGTTTTGTTCCTTGTCTTTTCCCCTCTATGCCATCTCCCCCCAACTCATCTTCAAACCAGATTACAGTGACATTTATCTTTGTCTGTTCATATGTGTATAAATATAAATATATGTGTATAGACATTCATTCATTCTTGAAGGGGTGTCGTAACAAAAACCATTGGTTTAATGGGGAAAAAAGTGTAGGACTTTGGTCAGATGCCAGTCGCAAGTACCAGGTCCCCAAGTCTGTCCAACTTGGCTACAATGTTAGGGGTTCTCACAACCCCCTCCTCAGGGTCAGTAATTTGCTAGAATAACTCACAGAACTCAGGAAAATGCTATACTTACTATTACAAGGTATTATAAAGGATACAAATGAACAGCCAGATGAAGAAGTACCTAGGGTGAGATCTGAAAGGGTTCCAAGCACCAGAGCCTGTCTCTGTGGAGTTGGGATGTGCCACCTTCCCAGCACATGGATGTGTTTTCCAACTCAGAAGCTCTTAGACTACTGTTGTTTAGGAGGTCTTGTGGAGTACATAGCCATGATTGATCAGATCATTGGCCATTGGTGATTGGGTTCAATCTCTGCCCCTTTACCTCCTGCAAGACTGGGGGGTGGGGCTACAAGTTCCATCTCTCTAATCATGGCATGGTCTTTGTAGTGACCAGTCCCTGTCTTAAAGCTATCTAGAAGCTCCTCAGCCTAATGTTATCTCATTAACATGAAAAAGACACTTACGTAGATTTCAAGGGTTTTAGGAGCTTTGTGCTAAGAACCTAGGACAAAGACCAGTTATTTTTTATTATACCATACTTGTATGCCTGCCAGTGGCACAAACTGAATTCAAAGACTGGTCATGAATCTTAACATCCCTTTTGATTGAATGGTTGCATCATTGAATTCCAAATTTTCTTGTATAATCTTTCCTAGTTCATGTTGGTTCAACCAGGAACTAATCCCAGGTTTTAATTGCTCTAATCAAAATCACCATGCAAGAGAATGTTTTCATTTCTAGCAGTCCATAGTTCTCTGTCATTGTCCTCTGAATCATCTAGCTGGTCAAAAGATTGGAGAGTATAACCATTTCAGATCCATAAGAAATATAAGTTCTTCTTTATTTGAGGGCTGTTTAGAAGAAAGTTAAGAATTCTTCTGTGTAGGGGTCAAAAGAAAACTTCCCTTCATCCTCTGAAGGTTCACTGAAAATCACCTGACAAACAGCAGATTAATAGGAGAAATGGCATACAGATTTATTAATGAAAGGGAGGTGGGGAAATGTGGGTGATTTTAGAGGAGGGTTGTAAATTATTTTTAGGGGAATTCAATGGACTTGAACATACAGTGGCCTGGGACAAAGTCTATTGAGCCTGCTAAGCATTCAGTGGTTTGTGACAAAAGTCTGGCTAGGTGTGTTGACAGACTTCCGTCTTCCTGCCCTATGAGTTCAGTTAATGAAAACTCAGGGAGGGGACTGTTAGAAATGCTTATTCCCGGTGCCACAAAGAAATAGCACTCAAACATAAATTTAATTTTCACAGAAAGGCAATTTTTACTTTCTGCGGAAAGGGTGCTCCTTGCAGATGGAACAATGGTGAGACCACACCCGGACAGGGGAGGGGAAGGAGTTCTTGTTCCTGACGCAGGTATCCCCTACTGCTGTGTCATTCCTGTATTGGCTAGGGTTGGCCCGCACAGTCTAAGCTAATTCCAACTGGCTATTTTAAAAAGAGCAGGGGGTATGAGCCAGAGTGGTAGGGTGAGTAGTTTGGCGGGAAGGATGGTTAGAAACAGGTAACTAAAGGTGACTTAGGTCAGAGCAGGTGACCAGGGGTGACTCAGGTAAAGCAGGTGACCGGGATGAGTCAGGATGGACCAGGTGACCAGGGAACAGATGTGAACTACTGATTAGGACTGGTGGGAAAGTTGTTTACTGAAACTTAGAAGCAAGGGGGTGAAGAGAACCAGGAAGCTAAACTTTAAAATGGAGAATCAAAGAATAAGAGAGCTGAACATACTGACATACTGATTCTTTGAAGAGAAACTTGGGGTTCACTATATTTAACAGGATCAAAGGTAATTTTCTTCTTCTTTGGTGGGCCTGGACTTTAGACAGATAAGGAAACTTCACAGAACAACTTCATACTGTGTTTTGCGAGAAAGAGGATCAAGAGATGGGAAGAAACAGGGGAAGGTCGGAGAGACTCTGAGGCTGCTTCTTCAGCATGTCAAAGTGCCACAGTTTGGGGTATCAGTTTCTGAGCCCCAGCACCTGCAAAAGTGAGTCTCTGGATTGGGATTATATGTATAATAGTGACATGATTAGGCAAATAAAAGGCTTTAATTTCTGTGTTTACATCGAAGCTGAATAATCTTGGATATAATGTAGGCAGCTTGGGTATAATGTAGGCAGCTTCATCTCATGACCAGCTACAATGTCATTTGTTCATCATTACATTTAACAATGCCAAGAGGGTACAGAAACATGGATTCCCCTCTTCCCCAGCATCTCTGTCCCTGCTTGGAACTTAAAAGATCAGGAATAGCTTTACCTTTGGGTTTCATGTGGATTGAGCTAAGGAACTTATCTCTGGTTGTTTTTATCCTCACGTAGAATCTATTTTGTACCATGAAGGTTTGGGATATAATGGGATTGTGAGGTGAGGTGCAAGTGTGGATGAGAGCAAATTTGTTTCAGGGTTCATCTGGGAAAGATTGCAGTGTTTTTTCCTGGATATCTGAGAAACACGTTTTTCCACTTCAACTTTACTGAGAAATTTTGCTGTGGAGTTGGTTTTGGACCTAGTTGAGTATCCCCCGACACCCCATCCTACATCCTGCACTGTGGCTGCAGGTTTTCTGTCCTTTCTGTCTCTAGCAATCAGTATTTGCCCTCACTTCTTAGGGGGAAAGGAAAGGAAAGGATTAGTTGAGAGCCAAGGTCTGTGAATATATGGCTACTCAGTCGGTGAGTAGTTATTTTGTTGCCCTTTAGTTTACCAGCTTACTTTTTCTATTGCTTTCGTCTAATCACTTACTAATTCTGTTAGTTGGAAGTTAGTAGAGAGGTCAAGGTAGTAAGTGCTTTGGTAGTAGAATACAATCCCCCCCACCCCTTCCCTCCCTCCAGTTTTTAAAAGTGCTTCTGTATGCCAGAGGATACAGGCCCTCAGGAAATTTTTTTTTCCTTCAATACCCTATTTTCTAGGAAAAGAAACCTGAATTTCCATATGTTTGATTAAATGAGTCTTAAACCCTGAAGTGTGGAGAGGACCAATTGTGGCAGTCTTCTGTGTTATAAAAACATTTAATTAGAATCTCTCTTCATTTAGCATAACTATAGAACCTTTTAGGTAAGAGTCTTAACATGTGTGTTTCTGTATAACTTATCTTTCCATTATCTCCCATCTCTTATTCAGTAAGATAAATAGCATCTTTTAAAGTAATTCTGATGAGGTAAATTTAAAATATTCACTTAATTGAAAGATGAGAAATATTTTTAATTAAAAAAACACTATTACAAAAATTACTTAACCTTATAATAATTCTTTAATATCTTTAATGTTGATTTTTATATGTTGAAAGTCTTTGGATGACTTTTTAATTGCTAGTGCTTGTCAAAAAATTATTAATTTGTATGTACTGTTATTTTTTTATGGACTGAAAAAGGACACGTCTTTGCTGACCATACATGATTTATTTTGTTGTTCAATATTGAATTTTCTGCTGCTTCTACGAGAAATAGAAAACAGATATTATTTCAAATTCTTCACTGCATGCCTGGTCAACTGTTACTTGCTCAGATGTCTTTTTAAAATAACTTTTAAAACTTACTAGGGAATAGAGGAGATAACTCTTGCCCTATTTAAAACTAGCCTTGATGAAATTATGCTGTTGCTGGATGAATTAATACTAATCTTTTCTCCTACAGAGAGCTGCCAAAAATATGACTATGACTTTATTTCATTTAATATTTTAATCAATATAAACTACTTTTTGTTTTTATAAATAAAAATCTGTATTTTTCAAAATTTTTCAGGAAAAAACAGCTGATGAGTCAATGTATATTTTGATTTACATTTTGAATACTTTTTATTATTCCTTCCAAAACAGACACTCCTAGAATATGCAGAGAAATGGAAAACTTCAGAAGATCCTTTACCTTTATTGGAGGTATACACAGTGGCTATCCAAAGTTATGTTAAAGCCCGACCTTATCTTACCTCTGAATGTGAAAATGTAGCCTTGGTTCTGGAACGCTTGGCATTAAGCTGTGTTGAACTTTTACTGTGTCTGCCTGTTGAGTTATCAGATAAACAGTGGGAACAATTTCAGACACTGGTGCAGGTAGCTCATGAAAAGCTGATGGAGAATGGCAGCTGTGAATTGCATTTTTTAGCTACTCTAGCTCAAGAGACTGGGGTGTGGAAAAACCCGGTACTGTGCACTATTCTTTCCCAGGAACCATTGGATAAGGATAAAG intronic glioma in vitro knockdown; qRT-PCR; western blot; luciferase reporter assay; etc. human glioma U87MG and U251 cell lines N/A N/A N/A N/A N/A N/A cZNF292 silencing suppresses tube formation by inhibiting glioma cell proliferation and cell cycle progression. Cell cycle progression in human glioma U87MG and U251 cells was halted at S/G2/M phase via the Wnt/¦Â-catenin signaling pathway and related genes such as PRR11, Cyclin A, p-CDK2, VEGFR-1/2, p-VEGFR-1/2 and EGFR. The results suggest that cZNF292 silencing plays an important role in the tube formation process and has potential for application as a therapeutic target and biomarker in glioma. 27613831 2016.9 Oncotarget Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/¦Â-catenin signaling pathway N/A circTCF25 hsa_circ_0041103; hsa_circRNA_101922 16 89962397-89967202 + hg19 TCF25 AGAGAGCGCTGTACAGCATGGAATGTGCGTTCCACCCCCTGTTCAGTCTCACCAGTGGGGCCTGCCGGCTGGATTACCGCAGACCCGAGAACAGGAGCTTCTACCTGGCCCTCTACAAGCAGATGAGCTTCCTGGAGAAGCGAGGCTGCCCGCGCACGGCGCTGGAGTACTGCAAGCTCATCCTGAGTCTCGAGCCGGATGAGGACCCCCTCTGCATGCTGCTGCTCATCGACCACCTGGCCTTGCGGGCCCGGAACTACGAGTACCTGATCCGCCTCTTCCAGGAGTGGGAGGCTCATCGGAACCTGTCCCAGCTCCCTAATTTTGCCTTCTCTGTTCCACTGGCGTATTTCCTGCTGAGCCAGCAGACAGACCTCCCTGAGTGTGAGCAGAGCTCTGCCAGGCAGAAGGCCTCTCTCCTGATACAGCAGGCGCTCACCATGTTCCCTGGAG exonic bladder carcinoma Microarray; qRT-PCR; in vitro overexpression; western blot; IHC; etc. paired bladder carcinoma tissue and matched para-carcinoma tissue; T24 and EJ cells N/A up-regulated miR-103a-3p; miR-107 CDK6 N/A N/A CircTCF25 was highly expressed in bladder cancer compared to control. Over-expression of circTCF25 showed that up-regulating circTCF25 could inhibit miR-103a-3p and miR-107 expressions, increase CDK6 protein level, and promote proliferation and migration of EJ and T24 cells. Compared to the adjacent tissues, we found that the circTCF25 and CDK6 were highly expressed in bladder carcinoma tissues, while, miR-103a-3p and miR-107 were lowly expressed in bladder cancer.In conclusion, CircTCF25 might play an important regulatory role via the miR-103a-3p and miR-107 in bladder cancer development. 27484176 2016.8 Sci Rep. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma N/A circZFR hsa_circ_0072088; hsa_circRNA_103809 5 32379220-32388780 - hg19 ZFR CCCTTACGTCGTCCTGACTCATCTGATGACCGTTATGTAATGACAAAACATGCCACCATTTATCCAACTGAAGAGGAGTTACAGGCAGTTCAGAAAATTGTTTCTATTACTGAACGTGCTTTAAAACTCGTTTCAGACAGTTTGTCTGAACATGAGAAGAACAAGAACAAAGAGGGAGATGATAAGAAAGAGGGAGGTAAAGACAGAGCTTTGAAAGGAGTTTTGCGAGTGGGAGTATTGGCAAAAGGATTACTTCTCCGAGGAGATAGAAATGTCAACCTTGTTTTGCTGTGCTCAGAGAAACCTTCAAAGACATTATTAAGCCGTATTGCAGAAAACCTACCCAAACAGCTTGCTGTTATAAGCCCTGAGAAGTATGACATAAAATGTGCTGTATCTGAAGCGGCAATAATTTTGAATTCATGTGTGGAACCCAAAATGCAAGTCACTATCACACTGACATCTCCAATTATTCGAGAAGAGAACATGAGGGAAGGAGATGTAACCTCGGGTATGGTGAAAGACCCACCGGACGTCTTGGACAGGCAAAAATGCCTTGACGCTCTGGCTGCTCTACGCCACGCTAAGTGGTTCCAGGCTAGAGCTAATGGTCTGCAGTCCTGTGTGATTATCATACGCATTCTTCGAGACCTCTGTCAGCGAGTTCCAACTTGGTCTGATTTTCCAAGCTGG exonic bladder carcinoma Microarray; qRT-PCR paired bladder carcinoma tissue and matched para-carcinoma tissue N/A up-regulated N/A N/A N/A N/A N/A 27484176 2016.8 Sci Rep. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma N/A circPTK2 hsa_circ_0005273; hsa_circRNA_104700 8 141710989-141716304 - hg19 PTK2 CCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTG exonic bladder carcinoma Microarray; qRT-PCR paired bladder carcinoma tissue and matched para-carcinoma tissue N/A up-regulated N/A N/A N/A N/A N/A 27484176 2016.8 Sci Rep. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma N/A circBC048201 hsa_circ_0061265; hsa_circRNA_103108 21 15456270-15456465 + hg19 BC048201 AAATCCCAAGTTGACCGTCAAGTCCAACGCTCGCTGCAGACATCTAGTGGACCCGGCGCTCGCGGACGGAAGCGGACAGACCTAGTTGGATCCTTATCCCACCAATCTGGCCCACCTTTGCTGCCATCTAACTCCGCTGACCGGCCCACCGTTCCTCCACTGTTCGCTGGTTGACCCGGGCAGCGGAGAGAGGAG exonic bladder carcinoma Microarray; qRT-PCR paired bladder carcinoma tissue and matched para-carcinoma tissue N/A up-regulated N/A N/A N/A N/A N/A 27484176 2016.8 Sci Rep. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma N/A circFAM169A hsa_circ_0007158; hsa_circRNA_103890 5 74109664-74137504 - hg19 FAM169A AGGATGGCATTCCCTGTGGATATGCTGGAAAATTGCAGCCATGAGGAATTGGAAAATTCTGCTGAAGATTACATGTCAGATTTAAGGTGTGGGGACCCTGAAAATCCAGAGTGTTTTTCTCTTCTCAATATTACGATTCCTATTAGCCTGTCAAATGTAGGCTTTGTACCTCTTTATGGTGGAGATCAGACCCAGAAAATTCTTGCTCTCTTTGCACCTGAAGATTCACTGACAGCTGTGGCACTTTACCTTGCTGATCAGTGGTGGGCTATTGATGATATTGTGAAAACATCTGTTCCTTCAAGAGAGGGGCTTAAGCAGGTGAGCACTCTTGGGGAGAGAGTGGTTCTGTATGTTCTGAATCGAATTATTTATAGAAAACAGGAAATGGAGAGAAATGAGATCCCATTCCTGTGTCATAGCAGTACTGATTATGCTAAGATTCTGTGGAAGAAAGGAGAGGCCATTGGGTTTTATTCAGTTAAGCCTACAGGAAGCATATGTGCCTCTTTTCTTACCCAAAGTTACCAATTGCCAGTTCTTGATACAATGTTTCTAAGAAAGAAATACAGAGGTAAAGATTTTGGGCTTCACATGCTGGAGGACTTTGTTGATTCCTTTACAGAAGATGCGCTTGGCTTGCGGTATCCACTGTCTTCTCTCATGTATACAG exonic bladder carcinoma Microarray; qRT-PCR paired bladder carcinoma tissue and matched para-carcinoma tissue N/A down-regulated N/A N/A N/A N/A N/A 27484176 2016.8 Sci Rep. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma N/A circTRIM24 hsa_circ_0082582; hsa_circRNA_104503 7 138203933-138255748 + hg19 TRIM24 AGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGGAGCAGCTGAAGCTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTATAGAAGAAGCTTTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAAATCAGATCCAAAACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAGAAATAAATAAAAAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAGTGGCTGGACTCTCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCAAACGACTGATTACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTGATCCTAGTTTCTGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATCCTGTCGTGGAACAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTACGGCTCCAGCATATGCAGCAACAGGTAATGGCTCAGAGGCAACAGGTGCAACGGAGGCCAGCACCTGTGGGTTTACCAAACCCTAGAATGCAGGGGCCCATCCAGCAACCTTCCATCTCTCATCAGCAACCGCCTCCACGTTTGATAAACTTTCAGAATCACAGCCCCAAACCCAATGGACCAGTTCTTCCTCCTCATCCTCAACAACTGAGATATCCACCAAACCAGAACATACCACGACAAGCAATAAAGCCAAACCCCCTACAGATGGCTTTCTTGGCTCAACAAGCCATAAAACAGTGGCAGATCAGCAGTGGACAGGGAACCCCATCAACTACCAACAGCACATCCTCTACTCCTTCCAGCCCCACGATTACTAGTGCAGCAGGATATGATGGAAAGGCTTTTGGTTCACCTATGATCGATTTGAGCTCACCAGTGGGAGGGTCTTATAATCTTCCCTCTCTTCCGGAT exonic bladder carcinoma Microarray; qRT-PCR paired bladder carcinoma tissue and matched para-carcinoma tissue N/A down-regulated N/A N/A N/A N/A N/A 27484176 2016.8 Sci Rep. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma N/A hsa_circRNA_104983 hsa_circ_0089974 X 17705861-17710588 + hg19 NHS CCGTCTCCAACCTGGACATAGAGAGTAAGCTGAGTGTGTACTACCGCGCCCCGTGGCACCAGCAGCGCAACATCTTCCTCCCAGCCACAAGGCCACCCTGCGTGGAGGAGCTGCACCGCCACGCCCGGCAGAGCCTGCAAGCCCTGCGCAGAGAACACCGGAGCCGGAGCGATCGCCGAGAGCAAAGAGCAGCTGCCCCCCTTTCCATTGCAGCTCCTCCACTGCCAGCCTACCCTCCAGCTCACAGCCAGAGGAGGCGTGAGTTTAAGGACCGTCACTTTTTAACG exonic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A up-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_001059 hsa_circ_0000554; hsa_circ_001059 14 74551677-74551959 + hg19 LIN52 ATGGCGTCTCCCACAGACGGTAAGAGCCGGCTTAGAGATCTTTGCCTGCAGCCTCCTTCTTTGCTCTACTGGGAACATCCACTCTGTCTCTGCCCCTCGAACATACATTTCTTTCTTGGGCTCTTCTCCTTTCCCTTTTATTTTTTTTCTTGAGATCCATCGCCGTCTTCAGCTCACCGGTTCTTCACAGCAGCTCCGGAGGTGCCCAGTTTCCCCGCTCTGTACCAGGCGTGTGGAGGAGGGCACTAGGGAGGGACTCATTCTGGGTAAAAGGACAGGGGG intragenic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A up-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_100984 hsa_circ_0002019 11 126142863-126143349 + hg19 FOXRED1 TATTCACAGGCCTCCACTGGGCTCTCAGTAGGTGGGATTTGTCAGCAGTTCTCATTGCCTGAGAACATCCAGCTCTCCCTCTTTTCAGCCAGCTTTCTACGGAACATCAATGAGTACCTGGCCGTAGTCGATGCTCCTCCCCTGGACCTCCGGTTCAACCCCTCGGGCTACCTCTTGCTGGCTTCAGAAAAGGATGCTGCAGCCATGGAGAGCAACGTGAAAGTGCAGAG exonic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A up-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_100367 hsa_circ_0014879 1 160206924-160231148 - hg19 DCAF8 TCCTTCAGTGAATCTACAGACCTATTTTCTCAGGAGCTCAGCCTGGCCTTACTTCAGTGATAAAAGGAGGAAAGGCTGGCTACAGCAAACATCATTCAAGATGTCCAGCAAAGGGAGCAGCACAGATGGCAGAACAGACTTAGCTAATGGAAGCCTGTCTAGCAGTCCAGAGGAGATGTCTGGAGCTGAAGAGGGGAGGGAGACATCCTCAGGCATTGAAGTGGAGGCCTCAGACCTGAGTTTGAGCTTGACTGGGGATGATGGTGGCCCCAACCGCACCAGCACAGAAAGTCGAGGCACAGACACAGAGAGCTCAGGTGAAGATAAGGACTCTGACAGCATGGAGGACACTGGTCATTACTCCATTAATGATGAAAATCGAGTCCATGACCGCTCAGAGGAAGAGGAAGAGGAGGAAGAAGAGGAGGAAGAAGAGCAGCCTCGGCGCCGTGTACAGCGCAAGCGGGCTAACCGTGACCAGGACTCATCAGATGATGAGCGGGCCCTAGAGGACTGGGTGTCCTCAGAAACATCAGCTCTACCCCGACCTCGCTGGCAAGCCCTCCCTGCCCTTCGGGAGCGGGAGCTGGGTTCAAGTGCCCGCTTTGTCTATGAGGCCTGTGGGGCAAGAGTCTTTGTGCAGCGTTTCCGCCTGCAGCATGGGCTTGAGGGCCATACTGGTTGTGTCAATACCCTGCACTTTAACCAGCGCGGCACCTGGCTGGCCAGTGGCAGCGATGACCTGAAGGTGGTGGTGTGGGATTGGGTACGGCGGCAGCCAGTACTGGACTTTGAGAGTGGCCACAAAAGTAATGTGTTCCAGGCCAAGTTTCTTCCTAACAGTGGTGATTCTACTCTGGCCATGTGTGCCCGTGACGGGCAGGTTCGAGTAGCAGAACTGTCTGCCACACAGTGTTGCAAGAATACAAAACGTGTGGCCCAGCACAAGGGAGCGTCCCACAAGTTGGCACTGGAACCAGACTCTCCCTGTACGTTCTTATCTGCAGGTGAAGATGCAGTTGTTTTCACCATTGACCTGAGACAAGACCGCCCAGCGTC exonic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A up-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_101877 hsa_circ_0004519 16 74670243-74671868 - hg19 RFWD3 TTCCCTACTGAAGGAACAGATGCTAAGGAAACAGGCCGAGTTAGAATCAGCACAGTGCCGACTCCAACTGCAGGTCCTCACTGATAAGTGCACTAGGCTTCAAAGGCGTGTTCAGGACTTGCAAAAACTTACGTCACATCAAAGTCAGAATTTACAGCAACCCAGGGGCTCCCAAGCATGGGTCCTGAGCTGCTCACCCTCCAGCCAGGGCCAGCACAAGCACAAGTACCACTTCCAAAAGACCTTCACAGTATCTCAGGCAGGAAACTGCCGGATCATGGCATACTGTGATGCTCTGAGCTGCCTGGTGATATCACAGCCTTCTCCTCAGGCCTCTTTTCTTCCAG exonic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A down-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_102913 hsa_circ_0058058 2 216177220-216190861 + hg19 ATIC CCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTTGCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCTCGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAG exonic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A down-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_000695 hsa_circ_0001336; hsa_circ_000695 3 128102470-128102926 + hg19 EEFSEC GAGAGCAAGGTGGCTGTGCCCTGGCCTGGAAGGCATCAGCCAGCACTTGGCAGGCACCACCCCCTTCCTGGCCTCGTGCCAGGCCCTGAGTCAGAGGTGCTGGGGCCATAGGGCTGGGACAGGAGGGGCTCAGACTCAGATACAGATGCCTTCAAGGGGCAGGCAGGTGACAGAAATGAGGGGAGCCAGTCTCAGGTAAAAGCAGCAGCACATGAGCGGTGACAGAGAGTAGCTGGTGTGCCCAGGGCCCAGCACAGGCCCACGCCAGCCCACTGTGGCAGGGTAGGAATCCAAAGAGAAGTCTTCTAGCTTTTCAAGACAAACTAGAAGTTCAGAACTGTATGTCAAATGTCCTGATTTAAAAGGTGAGTTAGTAGTTCAAATATTTCAAAAATGCCATGGAGGCTAGATTCTACTCCCAAGCTAATATAGTTCTTTTTGATCTTTGTGAAAGTG intronic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A down-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_000167 hsa_circ_0000518 14 20811404-20811554 - hg19 RPPH1 CTCATCAGTGGGGCCACGAGCTGAGTGCGTCCTGTCACTCCACTCCCATGTCCCTTGGGAAGGTCTGAGACTAGGGCCAGAGGCGGCCCTAACAGGGCTCTCCCTGAGCTTCGGGGAGGTGAGTTCCCAGAGAACGGGGCTCCGCGCGAG intragenic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A down-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circRNA_101419 hsa_circ_0032832 14 81837331-81837529 - hg19 STON2 CCCTACCATTGACCATGCCCTGCTGGACATGCCCTTCCTTTGACTCCCTGGGGAGATGCCCTCTGACTTCTGAGAGCAGCTGGACCACCCATTCTGAAGACACCAGCAGTCCTAGCTTTGGATGTTCGTATACAGATCTGCAGCTCATCAATGCTGAGGAGCAGACGAGTGGCCAGGCTTCTGGGGCTGACTCAACTG exonic esophageal cancer Microarray; qRT-PCR KYSE-150 and KYSE-150R cell lines N/A down-regulated N/A N/A N/A N/A GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network. 27465405 2016.7 J Transl Med. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells N/A hsa_circ_0005075 hsa_circRNA_100085 1 21377358-21415706 - hg19 EIF4G3 AATTCCTAGAGGACCTGTGCAACAACCTCTTGAGGATCGAATCTTCACTCCCGCTGTCTCAGCAGTCTACAGCACGGTAACACAAGTGGCAAGACAGCCGGGAACCCCTACCCCATCCCCTTATTCAGCACATGAAATAAACAAGGGGCATCCAAATCTTGCGGCAACGCCCCCGGGACATGCATCGTCCCCTGGACTCTCTCAA exonic hepatocellular carcinoma Microarray; qRT-PCR HCC tissues and paired adjacent nontumorous tissues N/A up-regulated N/A N/A N/A N/A Hsa_circ_0005075 expression levels in HCC tissues were significantly higher than those in corresponding nontumorous tissues. Hsa_circ_0005075 expression correlated with HCC tumor size (P = 0.042), and showed good diagnostic potential (AUROC = 0.94). Gene oncology analysis revealed that hsa_circ_0005075 could participate in cell adhesion during HCC development. 27258521 2016.5 Medicine (Baltimore) Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development N/A hsa_circ_001569 N/A 9 35546426-35548532 + hg19 RUSC2 N/A N/A colorectal cancer in vitro knockdown; in vitro overexpression; qRT-PCR; western blot; ; luciferase reporter assay etc. CRC tissue samples and matched non-tumor normal tissue; SW480, HCT116, SW620 and LOVO cells N/A up-regulated miR-145 E2F5; BAG4; FMNL2 N/A N/A Hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer. Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC tissues, circ_001569 negatively correlated with miR-145, and miR-145 correlated negatively with E2F5, BAG4 and FMNL2 expressions. This study reveals a novel regulatory mechanism of circ_001569 in cell proliferation and invasion in CRC, provides a comprehensive landscape of circ_001569 that will facilitate further biomarker discoveries in the progression of CRC. 27058418 2016.5 Oncotarget Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer identified in PMID:25624062 circHIPK3 hsa_circ_0000284; BCRC-2; hsa_circRNA_100782; hsa_circ_000016; circR-284 11 33307958-33309057 + hg19 HIPK3 ATTATGATTGCCATTTGTGTCCTATTTAAGAAGTGTTTACCTTCCCTAAAGTAACTGTGATATTTTCCTGTTTCCTTTTTAAAGCTTTATTCTTTCACCTTTTACATTTTGATTTGCCACCCATCTGGAATTGATTTTTGTGTATGATATGAGGTAGAGATTAAGATGCATTGTTTTCCCCATGTGGCTATCCCTAAACTGAGCACCATTTATTATTCTACTGCATAACAGTGACAGCTGCCATATTCATGAATCAGATGACCTCATATGTGTGGGTCTGTTTTTGGACTCTTTATTCATCATTTTGACTGTTCTTCTGCCTGTGTCAGTGTCATTACCATAACTGATAGTGTAAATCCTCCTGATTGTTCTTCAAGGGCCTATTTTTTTGTCCTTTGCATTCTAGGTGAATTTTATAAACTGTAAATTTCTGCAAAACTATTTTAATTTCAACGTATATTTTCTCCTAAGTATGTTTTGAGAGTTACTTTCTGTCTGCACTTTAATTACATCATTCCATTTAATTCTGCCTTCTATTATTTCCATAGAAAATTGGCTACTTTGATAGCAATATGTCCTTTTCCCCCCTCTGGCTGCATTTAGGGTTTTTCTTTGTCTTTTGTTTAAGCACTTGATCTACAGGTGTGTGCCTAGGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGATTCTGCTTGGGGTTTATAGAGCTTCTTGAATCTCTTAATAGCTTTCCCCAGTTTTGGAAAATTCTCAGGCAGTGTCTCTGCAAGTATTTCTTTTAACTTTTTTTTTTTTTTTAACATTTTCTCTTTCTCCTTTGCTTCTGGCATTTTAGTTCTATATATATAAGACTTTAAAAATGATCTGTATATTTCTGATGTTTTCCCTCCCCTCAATACTTTTTTTATATTTCCTTTTACTGCTTTTCTGTTTCAATCTGTGTATTTTCAGTCTGGCCTATCTTTTAAAAATTCCTCTTCTCACCAATATTTTACTGTAAAACATTAAAAAAATAGTAATAATAAAATAAAAAGGATGGATTTGTGAACAAAAGTTCTCTGAAAAGGAATTTAGAGGAAAGAGGCTTTATTCGAGTGA exonic liver cancer RNA-seq; Sanger sequencing; FISH; CRISPR/Cas9; RIP; qRT-PCR; luciferase reporter assay; etc. HCC and adjacent non-cancerous liver tissue; HEK-293 T, HeLa, HCT-116 and Huh-7 cytoplasm up-regulated miR-124; miR-152; miR-193a; miR-29a; miR-29b; miR-338; miR-379; miR-584; miR-654 IL6R and DLX2 (miR-124) N/A N/A We generate ribosomal-depletedRNA sequencing data from six normal tissues and seven cancers, and detect at least 27,000 circRNA candidates. Many of these circRNAs are differently expressed between the normal and cancerous tissues. We further characterize one abundant circRNA derived from Exon2 of the HIPK3 gene, termed circHIPK3. The silencing of circHIPK3 but not HIPK3 mRNA significantly inhibits human cellgrowth. Via a luciferase screening assay, circHIPK3 is observed to sponge to 9 miRNAs with 18 potential binding sites. Specifically, we show that circHIPK3 directly binds to miR-124 and inhibits miR-124 activity. Our results provide evidence that circular RNA produced from precursor mRNA may have a regulatory role in human cells. 27050392 2016.4 Nat Commun. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs N/A hsa_circ_001988 hsa_circ_0001451 4 153332454-153333681 - hg19 FBXW7(hCDC4) GATTACTTCCTTAGGATAGATTGCCAGAAGTGGAGTTACTGGGTCAGAGGGTATGAACTTATGAACTTTTTTTTTAAATAAATTTTTTGTTCATTTTCTGTCCAGTCATTTGTAAAAAAATTAAAATAATAATGATTATAATTGTTACCTGCTAGAAAACTGTGTCTGAAGGCAAGATTCTGTGATCAGAAAAGTTTGGGAAATACCCAGGGTAAAAAGCCTTTTAATCTGATTTACCTCAGCATTTCCCAAATTAACTGAACACTGAAAATTTTTTTTGATACACTTCTTAAAATTTTGTGGAAGTTTTATATAGGATATAGTCTATGAACTACTGATGTAAAATTAAAATTGTTTTATTTGCTTGAAATATTATGTTTTATTGGTCAAAGGAATTAAACTATAAATCTTCATGCTAAAAATTATTAAAAGGGATTAGTGTTGTTTACTATGGTTTTTGTGCATGTCTTTATAAAGTCTTATAACTTTTAAAATTGAAATGTTCTATATTGTTTACTAAAGAACATTTTAATGCCTTGGTGGCATCAATACTTTTTTGCAATCATTAATGATATTTAGAAAGTAGACATATAACATGAAAGTAGAACATAATATAGATTGTACAAATCTTGTTTTTTACCCTATTTTCCCCTGCAGAATGTGAAAACCTTTGCATCTTCTGATAGTCTAGCCAAGGTCCAAGAAGTAGCAAGCTGGCTTTTGGAAATGAATCAGGAACTGCTCTCTGTGGGCAGCAAAAGACGACGAACTGGAGGCTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAGATGAAGAACAGATGAATCGTGTGGTAGAGGAGGAACAGCAACAGCAACTCAGACAACAAGAGGAGGAGCACACTGCAAGGAATGGTGAAGTTGTTGGAGTAGAACCTAGACCTGGAGGCCAAAATGATTCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATTTATTTCGGTAGATGAGGACTCCTCAGGAAACCAAGAAGAACAAGAGGAAGATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGAGGAGGAGGAGATGGACCAGGAGAGTGACGATTTTGATCAGTCTGATGATAGTAGCAGAGAAGATGAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTGGACCTGCCCGTTCACCAACTCTCCTCCCCATTCTATACAAAAACAACAAAA N/A colorectal cancer RNA-seq; qRT-PCR matched colorectal cancer tissue and normal colon mucosa N/A down-regulated N/A N/A N/A N/A The expression of hsa_circ_001988 was significantly down regulated in colorectal cancer.The expression of hsa_circ_001988 was significantly correlated with differentiation (P<0.05) and perineural invasion (P<0.05). The area under ROC curve of hsa_circ_001988 was 0.788 (P<0.05). Those results indicate that hsa_circ_001988 may become a novel potential biomarker in the diagnosis of colorectal cancer and a potential novel target for the treatment of colorectal cancer. 26884878 2015.12 Int J Clin Exp Pathol. Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances N/A cZNF609 hsa_circ_0000615; cir-ZNF609; circ-ZNF609 15 64791491-64792365 + hg19 ZNF609 CAATGATGTTGTCCACTGGGCATGTACTGACCAATGTGGCAGGTCTGAGAACATAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAATCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTCCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAATCTCATCATTGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCAAAGGAGGTGGGGATACCGGCTCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTGACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACACTAGCAAACCCACTCCAGGGACTTCCCTGTTCACTCCAAGTGAGGGGGCAGCTAGCAAGAAAGAGGTGCAGGGGCGCTCAGGAGATGGTGCCAATGCTGGAGGCCTGGTTGCTGCTATTGCTCCCAAGGGCTCAGAGAAGGCGGCTAAGGCATCCCGCAGTGTAGCCGGTTCCAAAAAGGAGAAGGAGAACAGCTCATCTAAGAGCAAGAAGGAGAGAAGCGAAGGAGTGGGGACTTGTTCAGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTGGTCAGTATGATGGAAGTGCAGGGGTGGATACAGGAGCTGTGGAGCCACTTGGGAGTATAGCTATTGAGCCTGGGGCAGCGCTCAATCCTTTGGGAACTAAACCGGAGCCAGAGGAAGGGGAGAATGAGTGTCGCCTGCTAAAGAAAGTCAAGTCTGAAAAG N/A vascular dysfunction; high glucose and hypoxia stress qRT-PCR; FISH; in vitro knockdown; in vitro overexpression; in vivo knockdown; dual luciferase activity assay; RIP; etc. endothelial cells including EA.hy.926 cells, HMVECs, HUVECs, RF/6A cells, and HCAECs cytoplasm up-regulated miR-615-5p MEF2A N/A N/A cZNF609 was significantly up-regulated upon high glucose and hypoxia stress in vivo and in vitro. cZNF609 silencing decreased retinal vessel loss and suppressed pathological angiogenesis in vivo. cZNF609 silencing increased endothelial cell migration and tube formation, and protected endothelial cell against oxidative stress and hypoxia stress in vitro. By contrast, transgenic overexpression of cZNF609 showed an opposite effects. cZNF609 acted as an endogenous miR-615-5p sponge to sequester and inhibit miR-615-5p activity, which led to increased MEF2A expression. MEF2A overexpression could rescue cZNF609 silencing-mediated effects on endothelial cell migration, tube formation, and apoptosis. Moreover, dysregulated cZNF609 expression was detected in the clinical samples of the patients with diabetes, hypertension, and coronary artery disease. Intervention of cZNF609 expression is promising therapy for vascular dysfunction. 28824721 2017.7.8 Theranostics. Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction N/A hsa_circ_0006528 hsa_circRNA_103980 5 145197456-145205763 - hg19 PRELID2 GTTTCCACGCTTTGAGAAGGACTGAATGAGATCATGCGCATGGCAGCTTCTCTAGGATAGCACCCTGCGTGAACACAGTAGCTGCTCAGTTAAGTCTTTGATGGGTGTGATCCTGATTCAGCTTGATCAATTCTGCAGTCATACTGGATTGTGTTTGAAAAGGTGTCCAGAAAAACCTGGCCATCTGCCTCCTGTCTTCCCAGTACCCCAACCCCATGGATAAAAATGTCATCTCAGTAAAAATCATGGAGGAAAAAAGAGATGAATCAACAGGGGTCATCTACAGAAAGAGGATTGCAATCTGTCAGAACGTGGTTCCAGAAATTTTAAGGAAGGTGAGCATTTTGAAAGTACCTAATATCCAATTAGAAGAGGAGTCATGGCTCAATCCTCGGGAAAGAAACATGGCCATACGGAGTCACTGCCTTACGTGGACACAGTATGCATCCATGAAGGAAGAGTCTGTCTTCCGGGAAAGTATGGAAAACCCAAATTG exonic breast cancer Microarray; qRT-PCR; in vitro knockdown; western blot; etc. Adriamycin (ADM) resistant MCF-7 breast cancer cells (MCF-7/ADM) and parental MCF-7 cells N/A up-regulated miR-7-5p Raf1 N/A N/A The expression of hsa_circ_00006528 in ADM-resistant human breast cancer tissues and cell lines (MCF-7/ADM and MDA-MB-231/ADM) was obviously higher than that in the ADM-sensitive groups, and downregulation of circ 0006528 significantly increased the sensitivity of ADM-resistant cell lines to ADM.Further verification revealed that circ 0006528 expression was negatively correlated with hsa-miR-7¨C5p (miR-7¨C5p) expression in ADM-resistant human breast cancers and that the Raf1 gene might be a direct target of miR-7¨C5p. 28803498 2017.9 Epigenomics Screening circular RNA related to chemotherapeutic resistance in breast cancer N/A circHIPK3 hsa_circ_0000284; BCRC-2; hsa_circRNA_100782; hsa_circ_000016; circR-284 11 33307958-33309057 + hg19 HIPK3 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG exonic bladder cancer RNA-seq; RT-PCR; Sanger sequencing; northern blot; qRT-PCR; FISH; pull down; in vitro overexpression; in vivo overexpression; IHC; etc. bladder cancer tissues and paired adjacent normal bladder tissues; human metastatic bladder cancer cell line T24T,human invasive bladder cancer cell line UMUC3,human immortalized uroepithelium cell line SV-HUC-1,and endothelial cell line HUVEC cytoplasm down-regulated miR-558 HPSE N/A N/A circHIPK3, also named BCRC-2, is significantly down-regulated in bladder cancer tissues and cell lines, and negatively correlates with bladder cancer grade, invasion as well as lymph node metastasis, respectively. Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppresses bladder cancer growth and metastasis in vivo Mechanistic studies reveal that circHIPK3 contains two critical binding sites for the microRNA miR-558 and can abundantly sponge miR-558 to suppress the expression of heparanase (HPSE). 28794202 2017.9 EMBO Rep. CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells N/A hsa_circ_0071410 N/A 4 169812072-169837178 + hg19 PALLD AGGATTTCCAAAGAAGGCCAGTAGAACTGCTAGAATAGCCTCCGATGAGGAAATTCAAGGCACAAAGGATGCTGTTATTCAAGACCTGGAACGAAAACTTCGCTTCAAGGAGGACCTCCTGAACAATGGCCAGCCGAGGTTAACATACGAAGAAAGAATGGCTCGTCGACTGCTAGGTGCTGACAGTGCAACTGTCTTTAATATTCAGGAGCCAGAAGAGGAAACAGCTAATCAGGACATTGGTTCTCCTCATGCTTCTGTAGGGAGTCCTCTGGATGGTCAAAAGGAATACAAAGTCTCCAGCTGTGAACAGAGACTCATCAGTGAAATAGAGTACAGGCTAGAAAGGTCTCCTGTGGATGAATCAGGTGATGAAGTTCAGTATGGAGATGTGCCTGTGGAAAATGGAATGGCACCATTCTTTGAGATGAAGCTGAAACATTACAAGATCTTTGAGGGAATGCCAGTAACTTTCACATGTAGAGTGGCTGGAAATCCAAAGCCAAAGATCTATTGGTTTAAAGATGGGAAGCAGATCTCTCCAAAGAGTGATCACTACACCATTCAAAGAGATCTCGATGGGACCTGCTCCCTCCATACCACAGCCTCCACCCTAGATGATGATGGGAATTATACAATTATGGCTGCAAACCCTCAGGGCCGCATCAGTTGTACTGGACGGCTAATGGTACAGGCTGTCAACCAAAGAGGTCGAAGTCCCCGGTCTCCCTCAGGCCATCCTCATGTCAGAAGGCCTCGTTCTAGATCAAGGGACAGTGGAGACGAAAATGAACCAATTCAGGAGCGATTCTTCAGACCTCACTTCTTGCAGGCTCCTGGAGATCTGACTGTTCAAGAAGGAAAACTCTGCAGAATGGACTGCAAA N/A liver cancer Microarray; qRT-PCR; western blot; in vitro knockdown; etc. irradiated and normal hepatic stellate cell(HSC) N/A up-regulated miR-9-5p N/A N/A N/A Inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation. In summary, this study revealed the expression profile and potential function of differentially expressed circRNAs in irradiated HSC, which provides novel clues for RILF study. 28774651 2017.9.20 Gene Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation N/A hsa_circ_0072765 N/A 5 68471223-68471364 + hg19 CCNB1 GTTGATGTCGAGCAACATACTTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACATGGTGCACTTTCCTCCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAATGG N/A liver cancer Microarray; qRT-PCR irradiated and normal hepatic stellate cell(HSC) N/A up-regulated N/A N/A N/A N/A N/A 28774651 2017.9.20 Gene Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation N/A hsa_circ_0054345 N/A 2 44139570-44145537 - hg19 LRPPRC AAATAAACGGTGACTGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTTAGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACCACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAGCAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAAGCATT N/A liver cancer Microarray; qRT-PCR irradiated and normal hepatic stellate cell(HSC) N/A up-regulated N/A N/A N/A N/A N/A 28774651 2017.9.20 Gene Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation N/A hsa_circ_0070963 N/A 4 129919028-129964622 - hg19 SCLT1 CTTTTTAGCTCCTCTTGTTACTGAGTATGATAAACACCTAGGAGAACTAAATGGGCAGCTGAAATATTACCAGAAACAGGTGGGTGAGATGAAATTACAACTTGAAAATGTCATCAAGGAAAATGAAAGGTTGCACAGTGAATTAAAAGATGCTGTTGAAAAAAAATTGGAGGCCTTTCCCCTGGGCACAGAGGTAGGAACTGACATATATGCAGATGATGAAACAGTCAGAAACCTTCAAGAACAATTGCAGCTAGCCAATCAAGAAAAAACTCAGGCTGTGGAACTCTGGCAGACTGTTTCTCAGGAGTTGGACAGACTACACAAGCTTTACCAGGAACATATGACTGAGGCCCAGATTCATGTATTTGAAAGTCAAAAACAAAAGGATCAGCTATTTGATTTTCAACAACTGACCAAACAACTTCATGTTACTAATGAGAACATGGAAGTG N/A liver cancer Microarray; qRT-PCR irradiated and normal hepatic stellate cell(HSC) N/A down-regulated N/A N/A N/A N/A N/A 28774651 2017.9.20 Gene Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation N/A hsa_circ_0061893 N/A 21 45153949-45168961 + hg19 PDXK GTTTTGGGATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGGCTATGCCCACTGGAAGGGCCAAGTGCTGAATTCAGATGAGCTCCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTGCTCACAGGTTATACGAGGGACAAGTCGTTCCTGGCCATGGTGGTGGACATTGTGCAGGAGCTGAAGCAGCAGAACCCCAGGCTGGTGTACGTGTGTGATCCAGTCTTGGGTGACAAGTGGGACGGCGAAGGCTCGATGTACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTGGTGCCGCTTGCAGACATTATCACGCCCAACCAGTTTGAGGCCGA N/A liver cancer Microarray; qRT-PCR irradiated and normal hepatic stellate cell(HSC) N/A down-regulated N/A N/A N/A N/A N/A 28774651 2017.9.20 Gene Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation N/A hsa_circ_0013255 N/A 1 97543299-97915779 - hg19 DPYD GACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCACCTCTGGCCCCATGTATGGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATATTGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTTCCAGACAACATTGTGATTGCTAGCATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCAAGAAGTCTGAGGATTCTGGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATGGGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCTGCCGCTGGGTTAGGCAAGCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCACTGATATTGTGAGCATCGCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGTCTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGGGGATTGCAAAGCGAACTACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCCATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAAAGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAGAATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTGAAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAGAAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGACCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAAAATGTAGCTTTTTCACCACTTAAGAGAAACTGTTTTATCCCCAAAAGGCCTATTCCTACCATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAACGTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTACATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCCACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGACTGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCTGTGAATCCGGTGTGTTAAGGTGATTTGTGAAACAGTTGCTGTGAACTTTCATGTCACCTACATATGCTGATCTTTTAAAATCATGATCCTTGTGTTCAGCTCTTTCCAAATTAAAACAAATATACATTTTCTAAATAAAAATATGTAATTTCAAAATACATTTGTAAGTGTAAAAAATGTCTCATGTCAATGACCATTCAATTAGTGGTCATAAAATAGAATAATTCTTTTCTGAGGATAGTAGTTAAATAACTGTGTGGCAGTTAATTGGATGTTCACTGCCAGTTGTCTTATGTGAAAAATTAACTTTTTTGTGGCAATTAGTGTGACAGTTTCCAAATTGCCCTATGCTGTGCTCCATATTTGATTTCTAATTGTAAGTGAAATTAAGCATTTTGAAACAAAGTACTCTTTAACATACAAGAAAATGTATCCAAGGAAACATTTTATCATTAAAAATTACCTTTAATTTTAATGCTGTTTCTAAGAAAATGTAGTTAGCTCCATAAAGTACAAATGAAGAAAGTCAAAAAATTATTTGCTATGGCAGGATAAGAAAGCCTAAAATTGAGTTTGTAGAACTTTATTAAGTAAAATCCCCTTCGCTGAAATTGCTTATTTTTGGTGTTGGATAGAGGATAGGGAGAATATTTACTAACTAAATACCATTCACTACTCATGCGTGAGATGGGTGTACAAACTCATCCTCTTTTAATGGCATTTCTCTTTAAACTATGTTCCTAACAAAATGAGATGATAGGATAGATCCTGGTTACCACTCTTTTGCTGTGCACATACGGGCTCTGACTGGTTTTAATAGTCACCTTCATGATTATAGCAACTAATGTTTGAACAAAGCTCAAAGTATGCAATGCTTCATTATTCAAGAATGAAAAATATAATGTTGATAATATATATTAAGTGTGCCAAATCAGTTTGACTACTCTCTGTTTTAGTGTTTATGTTTAAAAGAAATATATTTTTTGTTATTATTAGATAATATTTTTGTATTTCTCTATTTTCATAATCAGTAAATAGTGTCATATAAACTCATTTATCTCCTCTTCATGGCATCTTCAATATGAATCTATAAGTAGTAAATCAGAAAGTAACAATCTATGGCTTATTTCTATGACAAATTCAAGAGCTAGAAAAATAAAATGTTTCATTATGCACTTTTAGAAATGCATATTTGCCACAAAACCTGTATTACTGAATAATATCAAATAAAATATCATAAAGCATTTTAA N/A liver cancer Microarray; qRT-PCR irradiated and normal hepatic stellate cell(HSC) N/A down-regulated N/A N/A N/A N/A N/A 28774651 2017.9.20 Gene Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation N/A hsa_circRNA_104916 hsa_circ_0008383; circ-104916 9 127064214-127089724 + hg19 NEK6 TTCGTGCCCTCGTGAGGCTGGCATGCAGGATGGCAGGACAGCCCGGCCACATGCCCCATGGAGGGAGTTCCAACAACCTCTGCCACACCCTGGGGCCTGTGCATCCTCCTGACCCACAGAGGCATCCCAACACGCTGTCTTTTCGCTGCTCGCTGGCGGACTTCCAGATCGAAAAGAAGATAGGCCGAGGACAGTTCAGCGAGGTGTACAAGGCCACCTGCCTGCTGGACAGGAAGACAGTGGCTCTGAAGAAGGTGCAGATCTTTGAGATGATGGACGCCAAGGCGAGGCAGGACTGTGTCAAGGAGATCGGCCTCTTGAAGCAACTGAACCACCCAAATATCATCAAGTATTTGGACTCGTTTATCGAAGACAACGAGCTGAACATTGTGCTGGAGTTGGCTGACGCAGGGGACCTCTCGCAGATGATCAAGTACTTTAAGAAGCAGAAGCGGCTCATCCCGGAGAGGACAGTATGGAAGTACTTTGTGCAGCTGTGCAGCGCCGTGGAGCACATGCATTCACGCCGGGTGATGCACCGAGACATCAAGCCTGCCAACGTGTTCATCACAGCCACGGGCGTCGTGAAGCTCGGTGACCTTGGTCTGGGCCGCTTCTTCAGCTCTGAGACCACCGCAGCCCACTCCCTAG exonic gastric cancer Microarray; qRT-PCR; in vitro overexpression; western blot; etc. paired GC tissues and adjacent normal tissues; human GC cell lines (AGS, MKN-28, NCI-N87 and MKN-45) and human gastric mucosa epithelial cells (GES-1) N/A down-regulated N/A N/A N/A N/A The expression of circ-104916 is downregulated in GC tissues and cell lines. A lower expression of circ-104916 appeared in deeper invasion depth, higher tumor stage and more frequent lymphatic metastasis patients. Overexpression of circ-104916 effectively inhibited the proliferation, migration and invasion abilities of GC cells in vitro. Western blot showed that circ-104916 overexpression upregulated E-cadherin and downregulated N-cadherin, Vimentin and Slug, indicating that circ-104916 was involved in the epithelial-mesenchymal transition process. Our results revealed that circ-104916 might be a novel potential tumor suppressor and biomarker of GC. 28761361 2017.7 Onco Targets Ther. Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastriccancer cells N/A circHIPK3 hsa_circ_0000284; BCRC-2; hsa_circRNA_100782; hsa_circ_000016; circR-284 11 33307958-33309057 + hg19 HIPK3 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG exonic non small cell lung cancer qRT-PCR; in vitro knockdown; in vitro overexpression; luciferase reporter assay; western blot; ELISA etc. NCI-H1299,NCI-H2170 cells cytoplasm N/A miR-379 N/A N/A N/A CircHIPK3 was generally expressed in six kinds of NSCLC cells lines we detected, and the expression level was highest in H2170 and lowest in H1299. Overexpression of circHIPK3 obviously promoted NCI-H1299 cell proliferation and knock-down of circHIPK3 inhibited NCI-H2170 cell proliferation. In the luciferase assay, miR-379 was observed to sequester circHIPK3 and IGF1 mRNA with potential binding sites. Furthermore, we found that the overexpression of circHIPK3 could increase the expression levels of IGF1 and knock-down reduced it. Moreover, up-regulation of miR-379 rescued the phenotype induced by overexpression of circHIPK3. 28738961 2017.7 Zhongguo Fei Ai Za Zhi Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1 Chinese hsa_circ_0006633 hsa_circRNA_100246 1 59805629-59844509 + hg19 FGGY AAAGTTGTACAAGGGATTGATTTAAACCAAATTCGAGGACTTGGGTTTGATGCCACGTGTTCTCTGGTTGTTTTGGATAAGCAGTTTCACCCATTACCAGTCAACCAGGAAGGGGATTCCCATCGAAACGTCATCATGTGGCTGGACCATCGAGCAGTCAGTCAAGTTAACAGGATCAATGAGACCAAGCACAGTGTCCTCCAGTACGTCGGGGGGGTGATGTCTGTGGAAATGCAGGCCCCGAAACTTCTGTGGCTGAAAGAGAACTTGAGAGAGATTTGCTGGGATAAGGCGGGACATTTCTTTGATCTCCCGGACTTCTTATCGTGGAAGGCAACAGGTGTCACAGCACG exonic gastric cancer qRT-PCR; IHC gastric cancer tissues and adjacent non-tumorous tissues; human gastric epithelial cell line GES-1 and four gastric cancer cell lines, HGC-27, SGC-7901, MGC-803, and AGS N/A down-regulated N/A N/A N/A N/A Hsa_circ_0006633 expression was not only significantly decreased in gastric cancer tissues and its cell lines but also decreased in dysplasia. The downregulation expression of hsa_circ_0006633 was associated with distal metastasis and tissue CEA level. Moreover, compared with healthy control, plasma hsa_circ_0006633 levels were significantly increased in gastric cancer patients. 28656881 2017.6 Tumour Biol. Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances N/A hsa_circ_0058246 N/A 2 219305444-219305585 + hg19 VIL1 GAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACCTCAGTTCTGGGCCTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGAAGGAG N/A gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A up-regulated N/A N/A N/A N/A The expression of hsa_circ_0058246 was elevated in tumor specimens of patients with poor clinical outcomes. group. We could not observe a statistically significant difference in the expression of hsa_circ_0058246 in the following groups: TNM stage group (IIIA vs IIIB vs IIIC) and T stage group (T2 vs T3 vs T4). Expression of hsa_circ_0058246 was significantly upregulated in group which have more than 16 lymph node invasions examined than the group less than 16 lymph nodes. Interestingly, the patients who suffered recurrence of gastric cancer have a statistically significant increase in the expression of hsa_circ_0058246. 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A hsa_circ_0091742 N/A X 152770695-152775004 + hg19 BGN GTCTGAAGTCTGTGCCCAAAGAGATCTCCCCTGACACCACGCTGCTGGACCTGCAGAACAACGACATCTCCGAGCTCCGCAAGGATGACTTCAAGGGTCTCCAGCACCTCTACGCCCTCGTCCTGGTGAACAACAAGATCTCCAAGATCCATGAGAAGGCCTTCAGCCCACTGCGGAAGCTGCAGAAGCTCTACATCTCCAAGAACCACCTGGTGGAGATCCCGCCCAACCTACCCAGCTCCCTGGTGGAGCTCCGCATCCACGACAACCGCATCCGCAAGGTGCCCAAGGGAGTGTTCAGCGGGCTCCGGAACATGAACTGCATCGAGATGGGCGGGAACCCACTGGAGAACAGTGGCTTTGAACCTGGAGCCTTCGATGGCCTGAAGCTCAACTACCTGCGCATCTCAGAGGCCAAGCTGACTGGCATCCCCAAAGACCTCCCTGAGACCCTGAATGAACTCCACCTAGACCACAACAAAATCCAGGCCATCGAACTGGAGGACCTGCTTCGCTACTCCAAGCTGTACAGGCTGGGCCTAGGCCACAACCAGATCAGGATGATCGAGAACGGGAGCCTGAGCTTCCTGCCCACCCTCCGGGAGCTCCACTTGGACAACAACAAGTTGGCCAGGGTGCCCTCAGGGCTCCCAGACCTCAAGCTCCTCCAGGTGGTCTATCTGCACTCCAACAACATCACCAAAGTGGGTGTCAACGACTTCTGTCCCATGGGCTTCGGGGTGAAGCGGGCCTACTACAACGGCATCAGCCTCTTCAACAACCCCGTGCCCTACTGGGAGGTGCAGCCGGCCACTTTCCGCTGCGTCACTGACCGCCTGGCCATCCAGTTTGGCAACTACAAAAAGTAGAGGCAGCTGCAGCCACCGCGGGGCCTCAGTGGGGGTCTCTGGGGAACACAGCCAGACATCCTGATGGGGAGGCAGAGCCAGGAAGCTAAGCCAGGGCCCAGCTGCGTCCAACCCAGCCCCCCACCTCGGGTCCCTGACCCCAGCTCGATGCCCCATCACCGCCTCTCCCTGGCTCCCAAGGGTGCAGGTGGGCGCAAGGCCCGGCCCCCATCACATGTTCCCTTGGCCTCAGAGCTGCCCCTGCTCTCCCACCACAGCCACCCAGAGGCACCCCATGAAGCTTTTTTCTCGTTCACTCCCAAACCCAAGTGTCCAAGGCTCCAGTCCTAGGAGAACAGTCCCTGGGTCAGCAGCCAGGAGGCGGTCCATAAGAATGGGGACAGTGGGCTCTGCCAGGGCTGCCGCACCTGTCCAGACACACATGTTCTGTTCCTCCTCCTCATGCATTTCCAGCCTTTCAACCCTCCCCGACTCTGCGGCTCCCCTCAGCCCCCTTGCAAGTTCATGGCCTGTCCCTCCCAGACCCCTGCTCCACTGGCCCTTCGACCAGTCCTCCCTTCTGTTCTCTCTTTCCCCGTCCTTCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTGTGCTTCCTCAGACCTTTCTCGCTTCTGAGCTTGGTGGCCTGTTCCCTCCATCTCTCCGAACCTGGCTTCGCCTGTCCCTTTCACTCCACACCCTCTGGCCTTCTGCCTTGAGCTGGGACTGCTTTCTGTCTGTCCGGCCTGCACCCAGCCCCTGCCCACAAAACCCCAGGGACAGCAGTCTCCCCAGCCTGCCCTGCTCAGGCCTTGCCCCCAAACCTGTACTGTCCCGGAGGAGGTTGGGAGGTGGAGGCCCAGCATCCCGCGCAGATGACACCATCAACCGCCAGAGTCCCAGACACCGGTTTTCCTAGAAGCCCCTCACCCCCACTGGCCCACTGGTGGCTAGGTCTCCCCTTATCCTTCTGGTCCAGCGCAAGGAGGGGCTGCTTCTGAGGTCGGTGGCTGTCTTTCCATTAAAGAAACACCGTGCAACGTG N/A gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A up-regulated N/A N/A N/A N/A Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues,indicating that the biochip findings are highly accurate and reproducible 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A hsa_circ_0089548 N/A 9 139399761-139410168 - hg19 NOTCH1 GGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTGCCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAACGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGGACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGCCTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGACGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTGCGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAATGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGGTCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTGCAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAGGCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCTGAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGAGACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCCCGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGACAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGGTGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTGCGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAACTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTGCCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCTGTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCTGGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTACCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTACAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAGCCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGAGGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTGCCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGCCTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCTGCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTTCCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCTGTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGATCGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGACGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTGTGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAA N/A gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A up-regulated N/A N/A N/A N/A Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues,indicating that the biochip findings are highly accurate and reproducible 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A hsa_circ_0003707 N/A 11 35219667-35232996 + hg19 CD44 GTACGTCTTCAAATACCATCTCAGCAGGCTGGGAGCCAAATGAAGAAAATGAAGATGAAAGAGACAGACACCTCAGTTTTTCTGGATCAGGCATTGATGATGATGAAGATTTTATCTCCAGCACCATTTCAACCACACCACGGGCTTTTGACCACACAAAACAGAACCAGGACTGGACCCAGTGGAACCCAAGCCATTCAAATCCGGAAGTGCTACTTCAGACAACCACAAGGATGACTGATGTAGACAGAAATGGCACCACTGCTTATGAAGGAAACTGGAACCCAGAAGCACACCCTCCCCTCATTCACCATGAGCATCATGAGGAAGAAGAGACCCCACATTCTACAAGCACAATCCAGGCAACTCCTAGTAGTACAACGGAAGAAACAGCTACCCAGAAGGAACAGTGGTTTGGCAACAGATGGCATGAGGGATATCGCCAAACACCCAAAGAAGACTCCCATTCGACAACAGGGACAGCTGCAGCCTCAGCTCATACCAGCCATCCAATGCAAGGAAGGACAACACCAAGCCCAGAGGACAGTTCCTGGACTGATTTCTTCAACCCAATCTCACACCCCATGGGACGAGGTCATCAAGCAGGAAGAAGGATGGATATGGACTCCAGTCATAGTATAACGCTTCAGCCTACTGCAAATCCAAACACAGGTTTGGTGGAAGATTTGGACAGGACAGGACCTCTTTCAATGACAACGCAGCAGAGTAATTCTCAGAGCTTCTCTACATCACATGAAGGCTTGGAAGAAGATAAAGACCATCCAACAACTTCTACTCTGACATCAAGCAATAGGAATGATGTCACAGGTGGAAGAAGAGACCCAAATCATTCTGAAGGCTCAACTACTTTACTGGAAGGTTATACCTCTCATTACCCACACACGAAGGAAAGCAGGACCTTCATCCCAGTGACCTCAGCTAAGACTGGGTCCTTTGGAGTTACTGCAGTTACTGTTGGAGATTCCAACTCTAATGTCAATCGTTCCTTATCAG N/A gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A up-regulated N/A N/A N/A N/A Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues,indicating that the biochip findings are highly accurate and reproducible. 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A hsa_circ_0085553 N/A 8 129001407-129082518 + hg19 PVT1 AATCCTGTTACACCTGGGATTTAGGCACTTTCAATCTGAAAAAATACATATCCTTTCAGCACTCTGGACGGACTTGAGAACTGTCCTTACGTGACCTAAAGCTGGAGTATTTTGAGATTGGAGAATTAAGAGCCAGTCTTGGTGCTCTGTGTTCACCTGGTTCATCTGAGGAGCTGCATCTACCCTGCCCATGCCATAGATCCTGCCCTGTTTGCTTCTCCTGTTGCTGCTAGTGGACATGAG N/A gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A up-regulated N/A N/A N/A N/A Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues,indicating that the biochip findings are highly accurate and reproducible 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A hsa_circ_0006022 hsa_circRNA_104627 8 56863017-56866543 + hg19 LYN GCATGGAGAATGGTGGAAAGCAAAGTCCCTTTTAACAAAAAAAGAAGGCTTCATCCCCAGCAACTATGTGGCCAAACTCAACACCTTAGAAACAGAAGAGTGGTTTTTCAAGGATATAACCAGGAAGGACGCAGAAAGGCAGCTTTTGGCACCAGGAAATAGCGCTGGAGCTTTCCTTATTAGAGAAAGTGAAACATTAAAAGGAAGCTTCTCTCTGTCTGTCAGAGACTTTGACCCTGTGCATGGTGATGTTATTAAGCACTACAAAATTAGAAGTCTGGATAATGGGGGCTATTACATCTCTCCACGAATCACTTTTCCCTGTATCAGCGACATGATTAAACATTACCAAAAGCAGGCAGATGGCTTGTGCAGAAGATTGGAGAAGGCTTGTATTAGTCCCAAGCCACAGAAGCCATGGGATAAAGATGCCTGGGAGATCCCCCGGGAGTCCATCAAGTTGGTGAAAAGGCTTGGCGCTGGGCAGTTTGGGGAAGTCTGGATGG exonic gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A up-regulated N/A N/A N/A N/A Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues,indicating that the biochip findings are highly accurate and reproducible 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A hsa_circ_0031979 N/A 14 54884565-54884669 + hg19 CDKN3 TAGCTGCTTGTCTCCTACTATACCTGTCTGACACAATATCACCAGAGCAAGCCATAGACAGCCTGCGAGACCTAAGAGGATCCGGGGCAATACAGACCATCAAG N/A gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A down-regulated N/A N/A N/A N/A Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues,indicating that the biochip findings are highly accurate and reproducible 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A hsa_circ_0069131 N/A 4 7783102-7873807 - hg19 AFAP1 CAATGGAAGAGTTAATAGTTGAACTTCGTCTCTTTCTTGAACTCCTGGACCATGAATATCTAACCTCAACTGTCAGGGAGAAAAAGGCAGTGATAACCAACATTCTGCTAAGAATACAGTCATCCAAAGGTTTTGATGTGAAGGACCATGCTCAGAAGCAGGAGACCGCTAACAGCCTGCCAGCCCCTCCTCAGATGCCCCTGCCGGAGATCCCTCAGCCCTGGCTGCCTCCTGACAGTGGGCCTCCACCATTGCCAACATCCTCCCTCCCAGAAGGTTATTATGAGGAAGCTGTGCCGCTGAGCCCCGGAAAAGCTCCGGAATACATCACATCAAATTATGATTCCGATGCGATGAGCAGCTCTTATGAGTCGTATGATGAAGAGGAGGAGGATGGGAAGGGGAAGAAAACCCGGCACCAGTGGCCCTCCGAGGAGGCCTCCATGGACCTGGTCAAGGACGCCAAAATCTGCGCCTTCCTGCTGCGGAAGAAGCGGTTCGGCCAGTGGACCAAGTTGCTCTGCGTCATCAAAGACACCAAACTGCTGTGCTATAAAAGTTCCAAGGACCAGCAGCCTCAGATGGAACTGCCACTCCAAGGCTGTAACATTACGTACATCCCGAAAGACAGCAAAAAGAAGAAGCACGAGCTGAAGATTACTCAGCAGGGCACGGACCCGCTTGTTCTCGCCGTCCAGAGCAAGGAACAGGCCGAGCAGTGGCTGAAGGTGATCAAAGAAGCCTACAGTGGTTGTAGTGGCCCCGTGGATTCAGAGTGTCCTCCTCCACCAAGCTCCCCGGTGCACAAGGCAGAACTGGAGAAGAAACTGTCTTCAGAGAGACCCAGCTCAGATGGGGAGGGTGTTGTGGAAAATGGAATTACCACATGTAATGGAAAGGAGCAAGTGAAGAGGAAGAAAAGTTCCAAATCAGAGGCCAAGGGCACTGTGTCGAAAGTCACTGGGAAAAAAATCACCAAGATCATCAGTCTGGGAAAGAAAAAGCCGTCCACAGACGAGCAGACCTCCTCAGCTGAGGAAGATGTTCCCACCTGCGGCTATCTGAACGTGCTCTCCAACAGCCGCTGGCGAGAGCGCTGGTGCCGAGTGAAAGATAACAAGCTCATTTTCCACAAGGACAGGACCGACCTGAAGACCCATATTGTGTCTATTCCGCTCCGTGGCTGCGAGGTGATCCCGGGTTTGGATTCTAAACATCCTCTGACGTTCCGGCTGCTGCGCAACGGCCAGGAGGTTGCAGTATTGGAGGCATCTTCTTCTGAAGACATGGGCAGGTGGATTGGGATTTTACTCGCAGAGACGGGATCGTCCACAGACCCGGAGGCTCTGCACTATGACTACATTGATGTGGAGATGTCTGCAAGTGTCATTCAGACAGCCAAACAGACCTTCTGTTTCATGAACAGGCGTGTTATATCTGCTAACCCATATCTAGGGGGCACCTCCAACGGCTATGCCCACCCCAGCGGGACGGCACTTCATTATGACGATGTCCCGTGCATCAACGGCTCGTGGGAACCGGAAGACGGCTTTCCTGCTTCCTGCAGCAGAGGCTTGGGAGAAGAGGTGCTTTATGATAACGCAGGCCTGTACGATAACTTGCCGCCTCCGCACATCTTTGCCCGCTACTCTCCTGCTGACAGAAAGGCCTCTAGGCTGTCTGCTGACAAGCTGTCCTCTAACCATTACAAATACCCTGCCTCCGCTCAGTCTGTCACTAATACCTCTTCTGTGGGGAGGGCGTCTCTCGGGCTCAACTCGCAG N/A gastric cancer Microarray; qRT-PCR III stage gastric cancer and paired adjacent normal mucosa tissues N/A down-regulated N/A N/A N/A N/A Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues,indicating that the biochip findings are highly accurate and reproducible 28639908 2017.6 Tumour Biol. Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses N/A circ-ITCH cir-ITCH; hsa_circ_0001141; hsa_circ_001763; hsa_circRNA_001141 20 33001547-33037285 + hg19 ITCH TTGAAGAAGTAGTTGTGACTTTGCAGCTTGGAGGTGACAAAGAGCCAACAGAGACAATAGGAGACTTGTCAATTTGTCTTGATGGGCTACAGTTAGAGTCTGAAGTTGTTACCAATGGTGAAACTACATGTTCAGAAAGTGCTTCTCAGAATGATGATGGCTCCAGATCCAAGGATGAAACAAGAGTGAGCACAAATGGATCAGATGACCCTGAAGATGCAGGAGCTGGTGAAAATAGGAGAGTCAGTGGGAATAATTCTCCATCACTCTCAAATGGTGGTTTTAAACCTTCTAGACCTCCAAGACCTTCACGACCACCACCACCCACCCCACGTAGACCAGCATCTGTCAATGGTTCACCATCTGCCACTTCTGAAAGTGATGGGTCTAGTACAGGCTCTCTGCCGCCGACAAATACAAATACAAATACATCTGAAGGAGCAACATCTGGATTAATAATTCCTCTTACTATATCTGGAGGCTCAGGCCCTAGGCCATTAAATCCTGTAACTCAAGCTCCCTTGCCACCTGGTTGGGAGCAGAGAGTGGACCAGCACGGGCGAGTTTACTATGTAGATCATGTTGAGAAAAGAACAACATGGGATAGACCAGAACCTCTACCTCCTGGCTGGGAACGGCGGGTTGACAACATGGGACGTATTTATTATGTTGACCATTTCACAAGAACAACAACGTGGCAGAGGCCAACACTGGAATCCGTCCGGAACTATGAACAATGGCAGCTACAGCGTAGTCAGCTTCAAGGAGCAATGCAGCAGTTTAACCAGAGATTCATTTATGGGAATCAAGATTTATTTGCTACATCACAAAGTAAAGAATTTGATCCTCTTGGTCCATTGCCACCTGGATGGG exonic hepatocellular carcinoma qRT-PCR HCC tissue samples and matched adjacent tissues N/A down-regulated N/A N/A N/A N/A rs10485505 (adjusted OR =1.18; 95% CI=1.06-1.31; P value =3.1¡Á10-3) and rs4911154 (adjusted OR =1.27; 95% CI=1.14-1.43; P value =3.7¡Á10-5) were significantly associated with increased HCC risk. The expression level of circ-ITCH was significantly lower in HCC tissues, compared with that in adjacent tissues (P value < 0.001). Cox regression analysis indicated that high expression of circ-ITCH was associated with favorable survival of HCC (HR=0.45; 95% CI=0.29-0.68; P value < 0.001). These results indicate that circ-ITCH may have an inhibitory effect on HCC, and could serve as susceptibility and prognostic biomarkers for HCC patients. 28636993 2017.7 Oncotarget Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma N/A ciRS-7 hsa_circ_0001946; CDR1as; hsa_circRNA_105055; Cdr1as X 139865339-139866824 + hg19 CDR1 GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG antisense gastric cancer qRT-PCR; western blot; in vitro overexpression; in vivo overexpression; etc. primary GC tissues and the matched para-carcinoma tissues; human GC cell lines MGC-803,HGC-27 and normal human gastric epithelial cell line GES-1 N/A up-regulated miR-7 PTEN; PI3K; AKT N/A N/A The expression of ciRS-7 was significantly upregulated in GC tissues compared with the matched para-carcinoma tissues (P = 0.0023), and the upregulation of ciRS-7 was linked to poor survival in the testing (P = 0.0143) and validation cohort (P = 0.0061). Multivariate survival analysis revealed that ciRS-7 was probably an independent risk factor of overall survival (P < 0.05). Furthermore, overexpression of ciRS-7 blocked the miR-7-induced tumor suppression in MGC-803 and HGC-27 cells and led to a more aggressive oncogenic phenotype, via antagonizing miR-7-mediated PTEN/PI3K/AKT pathway. 28608528 2017.6 J Cell Biochem. Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway N/A hsa_circ_0014717 hsa_circRNA_100363 1 156290629-156304709 - hg19 CCT3 ACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGATTCAAGTCCAGCATCCAGCGGCCAAGTCCATGATCGAAATTAGCCGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTCTTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAG exonic gastric cancer Microarray; qRT-PCR gastric cancer tissues and their matched adjacent nontumorous tissues; Gastric juice samples were collected from healthy volunteers, gastric ulcer patients, chronic atrophic gastritis patients, and gastric cancer patients during endoscopic examination N/A down-regulated N/A N/A N/A N/A Hsa_circ_0014717 was significantly downregulated in 77.2% (74/96) gastric cancer tissues. Its levels in gastric cancer tissues were related to tumor stage (P = 0.037), distal metastasis (P = 0.048), tissue carcinoembryonic antigen (P = 0.001), and carbohydrate antigen 19-9 expression (P = 0.021). More importantly, hsa_circ_0014717 can stably exist in human gastric juice; and its nature meets the requirements of clinical detection. 28544609 2017.6 Cancer Med. Global circular RNA expression profile of human gastric cancer and its clinical significance N/A hsa_circ_0058106 N/A 2 216246934-216248907 - hg19 FN1 GAGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCTGGAGTTGATTATACCATCACTGTGTATGCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACCGATGTTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCACTCCCAAAAATGGACCAGGACCAACAAAAACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTTAGTGTCTATGCTCAGAATCCAAGCGGAGAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCA N/A hypopharyngeal squamous cell carcinoma Microarray; qRT-PCR paired HSCC and adjacent normal tissues N/A up-regulated N/A N/A N/A N/A These circRNAs might sponge microRNAs (miRNAs) in predicted circRNA-miRNA-mRNA networks. Bioinformatics analysis was also performed to predict possible pathways in which these networks might be involved. Finally, we analyzed the interaction between validated circRNAs and their potential cancer-related miRNA targets. We are the first to comprehensively delineate the expression profiles of circRNAs in HSCC and to provide potential candidates for future mechanism studies. 28514762 2017.7 Oncotarget Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma N/A hsa_circ_0058107 N/A 2 216246934-216256537 - hg19 FN1 CTGTTCCTCCTCCCACTGACCTGCGATTCACCAACATTGGTCCAGACACCATGCGTGTCACCTGGGCTCCACCCCCATCCATTGATTTAACCAACTTCCTGGTGCGTTACTCACCTGTGAAAAATGAGGAAGATGTTGCAGAGTTGTCAATTTCTCCTTCAGACAATGCAGTGGTCTTAACAAATCTCCTGCCTGGTACAGAATATGTAGTGAGTGTCTCCAGTGTCTACGAACAACATGAGAGCACACCTCTTAGAGGAAGACAGAAAACAGGTCTTGATTCCCCAACTGGCATTGACTTTTCTGATATTACTGCCAACTCTTTTACTGTGCACTGGATTGCTCCTCGAGCCACCATCACTGGCTACAGGATCCGCCATCATCCCGAGCACTTCAGTGGGAGACCTCGAGAAGATCGGGTGCCCCACTCTCGGAATTCCATCACCCTCACCAACCTCACTCCAGGCACAGAGTATGTGGTCAGCATCGTTGCTCTTAATGGCAGAGAGGAAAGTCCCTTATTGATTGGCCAACAATCAACAGTTTCTGATGTTCCGAGGGACCTGGAAGTTGTTGCTGCGACCCCCACCAGCCTACTGATCAGCTGGGATGCTCCTGCTGTCACAGTGAGATATTACAGGATCACTTACGGAGAGACAGGAGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCTGGAGTTGATTATACCATCACTGTGTATGCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACCGATGTTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCACTCCCAAAAATGGACCAGGACCAACAAAAACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTTAGTGTCTATGCTCAGAATCCAAGCGGAGAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCA N/A hypopharyngeal squamous cell carcinoma Microarray; qRT-PCR paired HSCC and adjacent normal tissues N/A up-regulated N/A N/A N/A N/A These circRNAs might sponge microRNAs (miRNAs) in predicted circRNA-miRNA-mRNA networks. Bioinformatics analysis was also performed to predict possible pathways in which these networks might be involved. Finally, we analyzed the interaction between validated circRNAs and their potential cancer-related miRNA targets. We are the first to comprehensively delineate the expression profiles of circRNAs in HSCC and to provide potential candidates for future mechanism studies. 28514762 2017.7 Oncotarget Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma N/A hsa_circ_0024108 N/A 11 102660640-102667893 - hg19 MMP1 GATTGAAAATTACACGCCAGATTTGCCAAGAGCAGATGTGGACCATGCCATTGAGAAAGCCTTCCAACTCTGGAGTAATGTCACACCTCTGACATTCACCAAGGTCTCTGAGGGTCAAGCAGACATCATGATATCTTTTGTCAGGGGAGATCATCGGGACAACTCTCCTTTTGATGGACCTGGAGGAAATCTTGCTCATGCTTTTCAACCAGGCCCAGGTATTGGAGGGGATGCTCATTTTGATGAAGATGAAAGGTGGACCAACAATTTCAGAGAGTACAACTTACATCGTGTTGCAGCTCATGAACTCGGCCATTCTCTTGGACTCTCCCATTCTACTGATATCGGGGCTTTGATGTACCCTAGCTACACCTTCAGTGGTGATGTTCAGCTAGCTCAGGATGACATTGATGGCATCCAAGCCATATATGGACGTTCCCAAAATCCTGTCCAGCCCATCGGCCCACAAACCCCAAAAGCGTGTGACAGTAAGCTAACCTTTGATGCTATAACTACGATTCGGGGAGAAGTGATGTTCTTTAAAGACAGATTCTACATGCGCACAAATCCCTTCTACCCGGAAGTTGAGCTCAATTTCATTTCTGTTTTCTGGCCACAACTGCCAAATGGGCTTGAAGCTGCTTACGAATTTGCCGACAGAGATGAAGTCCGGTTTTTCAAAGGGAATAAGTACTGGGCTGTTCAGGGACAGAATGTGCTACACGGATACCCCAAGGACATCTACAGCTCCTTTGGCTTCCCTAGAACTGTGAAGCATATCGATGCTGCTCTTTCTGAGGAAAACACTGGAAAAACCTACTTCTTTGTTGCTAACAAATACTGGAGGTATGATGAATATAAACGATCTATGGATCCAGGTTATCCCAAAATGATAGCACATGACTTTCCTGGAATTGGCCACAAAGTTGATGCAGTTTTCATGAAAGATGGATTTTTCTATTTCTTTCATGGAACAAGACAATACAAATTTGATCCTAAAACGAAGAGAATTTTGACTCTCCAGAAAGCTAATAGCTGGTTCAACTGCAGGAAAAATTGAACATTACTAATTTGAATGGAAAACACATGGTGTGAGTCCAAAGAAGGTGTTTTCCTGAAGAACTGTCTATTTTCTCAGTCATTTTTAACCTCTAGAGTCACTGATACACAGAATATAATCTTATTTATACCTCAGTTTGCATATTTTTTTACTATTTAGAATGTAGCCCTTTTTGTACTGATATAATTTAGTTCCACAAATGGTGGGTACAAAAAGTCAAGTTTGTGGCTTATGGATTCATATAGGCCAGAGTTGCAAAGATCTTTTCCAGAGTATGCAACTCTGACGTTGATCCCAGAGAGCAGCTTCAGTGACAAACATATCCTTTCAAGACAGAAAGAGACAGGAGACATGAGTCTTTGCCGGAGGAAAAGCAGCTCAAGAACACATGTGCAGTCACTGGTGTCACCCTGGATAGGCAAGGGATAACTCTTCTAACACAAAATAAGTGTTTTATGTTTGGAATAAAGTCAACCTTGTTTCTACTGTTTTATACACTTTC N/A hypopharyngeal squamous cell carcinoma Microarray; qRT-PCR paired HSCC and adjacent normal tissues N/A up-regulated N/A N/A N/A N/A These circRNAs might sponge microRNAs (miRNAs) in predicted circRNA-miRNA-mRNA networks. Bioinformatics analysis was also performed to predict possible pathways in which these networks might be involved. Finally, we analyzed the interaction between validated circRNAs and their potential cancer-related miRNA targets. We are the first to comprehensively delineate the expression profiles of circRNAs in HSCC and to provide potential candidates for future mechanism studies. 28514762 2017.7 Oncotarget Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma N/A hsa_circ_0036722 N/A 15 90019985-90030216 - hg19 RHCG GCTTCCAGGACGTGCACGTGATGGTCTTCGTGGGCTTCGGCTTCCTCATGACTTTCCTGCAGCGCTACGGCTTCAGCGCCGTGGGCTTCAACTTCCTGTTGGCAGCCTTCGGCATCCAGTGGGCGCTGCTCATGCAGGGCTGGTTCCACTTCTTACAAGACCGCTACATCGTCGTGGGCGTGGAGAACCTCATCAACGCTGACTTCTGCGTGGCCTCTGTCTGCGTGGCCTTTGGGGCAGTTCTGGGTAAAGTCAGCCCCATTCAGCTGCTCATCATGACTTTCTTCCAAGTGACCCTCTTCGCTGTGAATGAGTTCATTCTCCTTAACCTGCTAAAGGTGAAGGATGCAGGAGGCTCCATGACCATCCACACATTTGGCGCCTACTTTGGGCTCACAGTGACCCGGATCCTCTACCGACGCAACCTAGAGCAGAGCAAGGAGAGACAGAATTCTGTGTACCAGTCGGACCTCTTTGCCATGATTGGCACCCTCTTCCTGTGGATGTACTGGCCCAGCTTCAACTCAGCCATATCCTACCATGGGGACAGCCAGCACCGAGCCGCCATCAACACCTACTGCTCCTTGGCAGCCTGCGTGCTTACCTCGGTGGCAATATCCAGTGCCCTGCACAAGAAGGGCAAGCTGGACATGGTGCACATCCAGAATGCCACGCTCGCAGGAGGGGTGGCCGTGGGTACCGCTGCTGAGATGATGCTCATGCCTTACGGTGCCCTCATCATCGGCTTCGTCTGCGGCATCATCTCCACCCTGGGTTTTGTATACCTGACCCCATTCCTGGAGTCCCGGCTGCACATCCAGGACACATGTGGCATTAACAATCTGCATGGCATTCCTGGCATCATAGGCGGCATCGTGGGTGCTGTGACAGCGGCCTCCGCCAGCCTTGAAGTCTATGGAAAAGAAGGGCTTGTCCATTCCTTTGACTTTCAAGGTTTCAACGGGGACTGGACCGCAAGAACACAGGGAAAGTTCCAGATTTATGGTCTCTTGGTGACCCTGGCCATGGCCCTGATGGGTGGCATCATTGTGGGGCTCATTTTGAGATTACCATTCTGGGGACAACCTTCAGATGAGAACTGCTTTGAGGATGCGGTCTACTGGGAG N/A hypopharyngeal squamous cell carcinoma Microarray; qRT-PCR paired HSCC and adjacent normal tissues N/A down-regulated N/A N/A N/A N/A These circRNAs might sponge microRNAs (miRNAs) in predicted circRNA-miRNA-mRNA networks. Bioinformatics analysis was also performed to predict possible pathways in which these networks might be involved. Finally, we analyzed the interaction between validated circRNAs and their potential cancer-related miRNA targets. We are the first to comprehensively delineate the expression profiles of circRNAs in HSCC and to provide potential candidates for future mechanism studies. 28514762 2017.7 Oncotarget Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma N/A hsa_circ_0002260 N/A 5 78936673-78964851 + hg19 PAPD4 TTGAGTCAGCAGATACTGGAGTTATTTGAAACATGTCAGCAGCAAATAAGTGATTTAAAGAAGAAAGAACTCTGTCGAACACAGCTGCAGAGAGAAATTCAGCTGTTATTTCCACAAAGCAGACTTTTTTTGGTTGGGTCCTCTTTAAATGGATTTGGTACCCGGAGCAGTGATGGTGATTTATGCCTAGTTGTTAAGGAAGAACCATGTTTTTTTCAGGTAAATCAGAAGACTGAAGCACGGCATATACTCACCTTAGTCCATAAACACTTCTGTACTAGACTTTCGGGCTACATTGAGAGACCTCAGCTGATTCGAGCAAAAGTGCCAATTGTGAAGTTCAGGGATAAAGTCAGTTGTGTGGAGTTTGACTTGAATGTAAACAATATTGTTGGAATAAGAAACACATTCCTTCTCAGAACTTATGCATACCTTGAAAATCGAGTTCGTCCGTTAGTGCTGGTGATTAAGAAGTGGGCAAGTCACCATCAGATAAATGATGCCAGTCGTGGTACTTTAAGCAGCTATAGTCTTGTATTGATGGTTTTGCACTATTTACAAACCCTACCTGAACCCATCCTTCCATCCCTCCAAAAAATTTACCCAGAGTCTTTTAGTCCTGCTATACAGCTGCACCTTGTACATCAAGCTCCATGTAATGTTCCTCCTTACCTCTCAAAGAATGAATCAAACCTTGGGGACCTCTTACTGGGCTTTCTTAAATATTATGCTACAGAATTTGA N/A hypopharyngeal squamous cell carcinoma Microarray; qRT-PCR paired HSCC and adjacent normal tissues N/A down-regulated N/A N/A N/A N/A These circRNAs might sponge microRNAs (miRNAs) in predicted circRNA-miRNA-mRNA networks. Bioinformatics analysis was also performed to predict possible pathways in which these networks might be involved. Finally, we analyzed the interaction between validated circRNAs and their potential cancer-related miRNA targets. We are the first to comprehensively delineate the expression profiles of circRNAs in HSCC and to provide potential candidates for future mechanism studies. 28514762 2017.7 Oncotarget Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma N/A hsa_circ_0001189 hsa_circ_001502 21 37711076-37717005 + hg19 MORC3 ATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTA N/A hypopharyngeal squamous cell carcinoma Microarray; qRT-PCR paired HSCC and adjacent normal tissues N/A down-regulated N/A N/A N/A N/A These circRNAs might sponge microRNAs (miRNAs) in predicted circRNA-miRNA-mRNA networks. Bioinformatics analysis was also performed to predict possible pathways in which these networks might be involved. Finally, we analyzed the interaction between validated circRNAs and their potential cancer-related miRNA targets. We are the first to comprehensively delineate the expression profiles of circRNAs in HSCC and to provide potential candidates for future mechanism studies. 28514762 2017.7 Oncotarget Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma N/A hsa_circ_0003570 hsa_circRNA_100709 10 126370175-126384781 - hg19 FAM53B CACACGCCAAAGAAGATGAGTCAAGGACCTACACTTTTCTCTTGTGGAATTATGGAAAATGACAGATGGCGAGACCTGGACAGGAAATGCCCTCTTCAGATTGACCAACCGAGCACCAGCATCTGGGAATGCCTGCCTGAAAAGGACAGCTCACTATGGCACCGGGAGGCAGTGACCGCCTGCGCTGTGACCAGTCTGATCAAAGACCTCAGCATCAGCGACCACAACGGGAACCCCTCAGCACCCCCTAGCAAGCGCCAGTGCCGCTCACTGTCCTTCTCCGATGAGATGTCCAGTTGCCGGACATCATGGAGGCCCTTGGGCTCCAAAGTCTGGACTCCCGTGGAAAAGAGACGCTGCTACAGCGGGGGCAGCGTCCAGCGCTATTCCAACGGCTTCAGCACCATGCAGAGGAGTTCCAGCTTCAGCCTCCCTTCCCGGGCCAACGTGCTCTCCTCACCCTGCGACCAGGCAGGACTCCACCACCGATTTGGAGGGCAGCCCTGCCAAGGGGTGCCAGGCTCAGCCCCGTGTGGACAGGCAGGTGACACCTGGAGCCCTGACCTGCACCCCGTGGGAGGAGGCCGGCTGGACCTGCAGCGGTCCCTCTCTTGCTCACATGAGCAGTTTTCCTTTGTGGAATACTGTCCTCCCTCAGCCAACAGCACACCTGCCTCAACACCAGAGCTGGCGAGACGCTCCAGCGGCCTTTCCCGCAGCCGCTCCCAGCCGTGTGTCCTTAACGACAAGAAGGTCGGTGTTAAAAGGCGGCGCCCTGAAGAAGTGCAAGAGCAGAGGCCTTCTCTAGACCTTGCCAAGATGGCACAG exonic hepatocellular carcinoma qRT-PCR HCC cell lines, HepG2, SMMC-7721,MHCC97L, MHCC97H, and HCCLM3, and human normal hepatic cell line L02; HCC tissues and adjacent non-tumor tissues; liver biopsy samples from patients with chronic liver diseases N/A down-regulated N/A N/A N/A N/A Hsa_circ_0003570 was not only first found down-regulated in HCC cell lines (P<.001) but also in HCC tissues (P<.001). Moreover, hsa_circ_0003570 was gradually decreased from chronic hepatitis (CH), to liver cirrhosis (LC) and to HCC tissues (P<.01). Its expression levels were significantly correlated with tumor diameter (P=.035), differentiation (P=.013), microvascular invasion (P=.045), Barcelona Clinic Liver Cancer stages (P=.011), tumor-node-metastasis stages (P=.016), and serum alpha-fetoprotein levels (P=.031). The ROC curve demonstrated that hsa_circ_0003570 had poor performance for differentiating HCC from LC and CH, but had relatively good performance for differentiating LC from CH. 28493512 2017.5 J Clin Lab Anal. Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance N/A hsa_circ_0005986 hsa_circRNA_100062 1 14057494-14068652 + hg19 PRDM2 AACACTACTGAGCCTGTGGCGGCCACCGAGACCCTGGCTGAGGTACCCGAACATGTGCTGCGAGGACTTCCGGAGGAAGTGAGGCTTTTCCCTTCTGCTGTTGACAAGACCCGGATTGGTGTCTGGGCCACTAAACCAATTTTAAAAGGCAAAAAATTTGGGCCATTTGTTGGTGATAAGAAAAAAAGATCTCAGGTTAAGAATAATGTATACATGTGGGAGGTGTATTACCCAAATTTGGGATGGATGTGCATTGATGCCACTGATCCAGAGAAGGGAAACTGGCTGCGATATGTGAATTGGGCTTGCTCAGGAGAAGAGCAAAATTTATTCCCACTGGAAATCAACAGAGCCATTTACTATAAAACTTTAAAG exonic hepatocellular carcinoma qRT-PCR; Sanger sequencing; dual luciferase reporter assays; in vitro knockdown; etc. HCC cell lines (HepG2, SMCC7721, and Huh7) and human normal hepatic cell line L02 N/A down-regulated miR-129-5p Notch1 N/A N/A The expression level of hsa_circ_0005986 in HCC was significantly lower than that in adjacent non-tumorous tissues (P < 0.001). Its levels in HCC cell lines, HepG2, SMMC7721, Huh7, MHCC97L, MHCC97H, and HCCLM3 were significantly lower than those in human normal hepatic cell line L02 (P < 0.001). In addition, the low expression level of hsa_circ_0005986 was correlated with chronic hepatitis B family history (P = 0.001), tumor diameters (P < 0.001), microvascular invasion (P = 0.026), and Barcelona Clinic Liver Cancer (BCLC) stage (P < 0.001). Further experiments demonstrated that both hsa_circ_0005986 and Notch1mRNA were targets of miR-129-5p, and that hsa_circ_0005986 downregulation liberated miR-129-5p and decreased the expression level of Notch1mRNA. More importantly, hsa_circ_0005986 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition. We conclude that hsa_circ_0005986 function as microRNA sponge in tumorigenesis and can be used as a novel biomarker for HCC. 28410211 2017.7 Oncotarget Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma N/A hsa_circRNA_103809 hsa_circ_0072088 5 32379220-32388780 - hg19 ZFR CCCTTACGTCGTCCTGACTCATCTGATGACCGTTATGTAATGACAAAACATGCCACCATTTATCCAACTGAAGAGGAGTTACAGGCAGTTCAGAAAATTGTTTCTATTACTGAACGTGCTTTAAAACTCGTTTCAGACAGTTTGTCTGAACATGAGAAGAACAAGAACAAAGAGGGAGATGATAAGAAAGAGGGAGGTAAAGACAGAGCTTTGAAAGGAGTTTTGCGAGTGGGAGTATTGGCAAAAGGATTACTTCTCCGAGGAGATAGAAATGTCAACCTTGTTTTGCTGTGCTCAGAGAAACCTTCAAAGACATTATTAAGCCGTATTGCAGAAAACCTACCCAAACAGCTTGCTGTTATAAGCCCTGAGAAGTATGACATAAAATGTGCTGTATCTGAAGCGGCAATAATTTTGAATTCATGTGTGGAACCCAAAATGCAAGTCACTATCACACTGACATCTCCAATTATTCGAGAAGAGAACATGAGGGAAGGAGATGTAACCTCGGGTATGGTGAAAGACCCACCGGACGTCTTGGACAGGCAAAAATGCCTTGACGCTCTGGCTGCTCTACGCCACGCTAAGTGGTTCCAGGCTAGAGCTAATGGTCTGCAGTCCTGTGTGATTATCATACGCATTCTTCGAGACCTCTGTCAGCGAGTTCCAACTTGGTCTGATTTTCCAAGCTGG exonic colorectal cancer Microarray; qRT-PCR paired CRC tissues and matched adjacent non-cancerous tissue samples N/A down-regulated N/A N/A N/A N/A The expression level of hsa_circRNA_103809 was significantly correlated with lymph node metastasis ( p = 0.021) and tumor-node-metastasis stage ( p = 0.011).The area under receiver operating characteristic curves of hsa_circRNA_103809 was 0.699 ( p < 0.0001). 28349836 2017.3 Tumour Biol. Identification of differentially expressed circular RNAs in human colorectal cancer N/A hsa_circRNA_104700 hsa_circ_0005273 8 141710989-141716304 - hg19 PTK2 CCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTG exonic colorectal cancer Microarray; qRT-PCR paired CRC tissues and matched adjacent non-cancerous tissue samples N/A down-regulated N/A N/A N/A N/A The expression level of hsa_circRNA_104700 was significantly correlated with distal metastasis ( p = 0.036).The area under receiver operating characteristic curves of hsa_circRNA_104700 was 0.616 ( p < 0.0001). 28349836 2017.3 Tumour Biol. Identification of differentially expressed circular RNAs in human colorectal cancer N/A ciRS-7 hsa_circ_0001946; CDR1as; hsa_circRNA_105055; Cdr1as X 139865339-139866824 + hg19 CDR1 GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG antisense colorectal cancer qRT-PCR; in vitro overexpression; ; in vivo overexpression; IHC; western blot; etc. primary colorectal cancers (pCRC), and matched adjacent normal mucosa (NM) tissues; HCT-116 and HT-29 cells N/A up-regulated miR-7 EGFR; RAF1 N/A N/A ciRS-7 was significantly upregulated in colorectal cancer tissues compared with matched normal mucosae (P = 0.0018), and its overexpression was associated with poor patient survival (P = 0.0224 and 0.0061 in the training and validation cohorts, respectively). Multivariate survival analysis revealed that ciRS-7 emerged as an independent risk factor for overall survival (P = 0.0656 and 0.0324 in the training and validation cohorts, respectively). Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 and resulted in a more aggressive oncogenic phenotype, and ciRS-7 overexpression permitted the inhibition of miR-7 and subsequent activation of EGFR and RAF1 oncogenes. 28174233 2017.7 Clin Cancer Res. Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer N/A hsa_circ_0000096 hsa_circRNA_000096; hsa_circ_001013 1 100515464-100535241 + hg19 HIAT1 CCTCAAGGAATAGGTTCTCCTAGTGTCTATCATGCAGTTATCGTCATCTTTTTGGAGTTTTTTGCTTGGGGACTATTGACAGCACCCACCTTGGTGGTATTACATGAAACCTTTCCTAAACATACATTTCTGATGAACGGCTTAATTCAAGGAGTAAAGGGTTTGTTGTCATTCCTTAGTGCCCCGCTTATTGGTGCTCTTTCTGATGTTTGGGGCCGAAAATCCTTCTTGCTGCTAACGGTGTTTTTCACATGTGCCCCAATTCCTTTAATGAAGATCAGCCCATGGTGGTACTTTGCTGTTATCTCTGTTTCTGGGGTTTTTGCAGTGACTTTTTCTGTGGTATTTGCATACGTAGCAGATATAACCCAAGAGCATGAAAGAAGTATGGCTTATGGACTGGTTTCAGCAACATTTGCTGCAAGTTTAGTCACCAGTCCTGCAATTGGAGCTTATCTTGGACGAGTATATGGGGACAGCTTGGTGGTGGTCTTAGCTACAGCAATAGCTTTGCTAGATATTTGTTTTATCCTTGTTGCTGTGCCAGAGTCGTTGCCTGAGAAAATGCGGCCAGCATCCTGGGGAGCACCCATTTCCTGGGAACAAGCTGACCCTTTTGCGTCCTTAAAAAAAGTCGGCCAAGATTCCATAGTGCTGCTGATCTGCATTACAGTGTTTCTCTCCTACCTACCGGAGGCAGGCCAATATTCCAGCTTTTTTTTATACCTCAGACAGATAATGAAATTTTCACCAGAAAGTGTTGCAGCGTTTATAGCAGTCCTTGGCATTCTTTCCATTATTGCACAG exonic gastric cancer qRT-PCR; in vitro knockdown; western blot; in vivo knockdown; IHC; etc. gastric cancer tissues and paired adjacent non-tumorous tissues; human gastric cancer cell lines, AGS, BGC-823,HGC-27, SGC-7901 and MGC-803 and human gastric epithelial cell line GES-1 N/A down-regulated miR-224; miR-200a N/A CDK6; cyclin D1; MMP-2; MMP-9; Ki67; VEGF N/A Hsa_circ_0000096 was found to be significantly downregulated in gastric cancer tissues and gastric cancer cell lines compared with paired adjacent non-tumorous tissues and normal gastric epithelial cells (P<0.001). Moreover, knockdown of hsa_circ_0000096 significantly inhibited cell proliferation and migration in vitro and in vivo. The results of both immunohistochemical and western blot analyses showed that the protein levels of cyclin D1, cyclin-dependent kinase 6 (CDK6), matrix metalloproteinase-2 and MMP-9 were significantly reduced in vitro and in vivo. A gastric cancer xenograft nude mouse model indicated that Ki67 and VEGF were reduced in a dose-dependent manner following knockdown of hsa_circ_0000096. However, the expression of E-cadherin increased. 28081541 2017.2 Br J Cancer. Circular RNA 0000096 affects cell growth and migration in gastric cancer Only miRNA expressions were verified and no evidences about the relationship between miRNA and CDK6,cyclin D1,MMP-2,MMP-9,Ki67 and VEGF were provided. circ-Foxo3 N/A 6 N/A + N/A FOXO3 N/A N/A breast cancer qRT-PCR; in vitro knockdown; in vitro overexpression; in vivo overexpression; northern blot; etc. non-cancerous cell lines Hek293T,BEAS2B, HaCaT, NIH3T3, MEF, and MCF-10A and cancer cell lines MDA-MB-468, MDA-MB-231, 67NR, 66C14,4T07, 4T1, and B16 N/A down-regulated N/A N/A Foxo3; p53; Puma N/A In patient tumor samples and in a panel of cancer cells, circ-Foxo3 was minimally expressed. Interestingly, during cancer cell apoptosis, the expression of circ-Foxo3 was found to be significantly increased. We found that silencing endogenous circ-Foxo3 enhanced cell viability, whereas ectopic expression of circ-Foxo3 triggered stress-induced apoptosis and inhibited the growth of tumor xenografts. Also, expression of circ-Foxo3 increased Foxo3 protein levels but repressed p53 levels. By binding to both, circ-Foxo3 promoted MDM2-induced p53 ubiquitination and subsequent degradation, resulting in an overall decrease of p53. With low binding affinity to Foxo3 protein, circ-Foxo3 prevented MDM2 from inducing Foxo3 ubiquitination and degradation, resulting in increased levels of Foxo3 protein. As a result, cell apoptosis was induced by upregulation of the Foxo3 downstream target PUMA. 27886165 2017.2 Cell Death Differ. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity N/A circ-ITCH cir-ITCH; hsa_circ_0001141; hsa_circ_001763; hsa_circRNA_001141 20 33001547-33037285 + hg19 ITCH TTGAAGAAGTAGTTGTGACTTTGCAGCTTGGAGGTGACAAAGAGCCAACAGAGACAATAGGAGACTTGTCAATTTGTCTTGATGGGCTACAGTTAGAGTCTGAAGTTGTTACCAATGGTGAAACTACATGTTCAGAAAGTGCTTCTCAGAATGATGATGGCTCCAGATCCAAGGATGAAACAAGAGTGAGCACAAATGGATCAGATGACCCTGAAGATGCAGGAGCTGGTGAAAATAGGAGAGTCAGTGGGAATAATTCTCCATCACTCTCAAATGGTGGTTTTAAACCTTCTAGACCTCCAAGACCTTCACGACCACCACCACCCACCCCACGTAGACCAGCATCTGTCAATGGTTCACCATCTGCCACTTCTGAAAGTGATGGGTCTAGTACAGGCTCTCTGCCGCCGACAAATACAAATACAAATACATCTGAAGGAGCAACATCTGGATTAATAATTCCTCTTACTATATCTGGAGGCTCAGGCCCTAGGCCATTAAATCCTGTAACTCAAGCTCCCTTGCCACCTGGTTGGGAGCAGAGAGTGGACCAGCACGGGCGAGTTTACTATGTAGATCATGTTGAGAAAAGAACAACATGGGATAGACCAGAACCTCTACCTCCTGGCTGGGAACGGCGGGTTGACAACATGGGACGTATTTATTATGTTGACCATTTCACAAGAACAACAACGTGGCAGAGGCCAACACTGGAATCCGTCCGGAACTATGAACAATGGCAGCTACAGCGTAGTCAGCTTCAAGGAGCAATGCAGCAGTTTAACCAGAGATTCATTTATGGGAATCAAGATTTATTTGCTACATCACAAAGTAAAGAATTTGATCCTCTTGGTCCATTGCCACCTGGATGGG exonic lung cancer qRT-PCR; in vitro overexpression; western blot; luciferase reporter assay; etc. lung cancer biopsy specimens and paired adjacent normal tissues; human lung cancer cell lines A549 and NCI-H460 N/A down-regulated miR-7; miR-214 ITCH N/A N/A The expression of cir-ITCH was significantly decreased in lung cancer tissues. In cellular studies, cir-ITCH was also enhanced in different lung cancer cell lines, A549 and NIC-H460. Ectopic expression of cir-ITCH markedly elevated its parental cancer-suppressive gene, ITCH, expression and inhibited proliferation of lung cancer cells. Molecular analysis further revealed that cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/¦Â-catenin signaling. Altogether, our results suggested that cir-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression. 27642589 2016.8 Biomed Res Int. Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/¦Â-Catenin Pathway N/A ciRS-7 hsa_circ_0001946; CDR1as; hsa_circRNA_105055; Cdr1as X 139865339-139866824 + hg19 CDR1 GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG antisense hepatocellular carcinoma in vitro knockdown; qRT-PCR; western blot; etc. HCC tissues and adjacent non-tumor tissues; Hep3B, HepG2, SMMC-7721, Bel7402 and HL-7702 cells N/A up-regulated miR-7 CCNE1; PIK3CD N/A N/A Cdr1as expression was upregulated in HCC tissues compared with the adjacent non-tumor tissues. In addtion, miR-7 expression was downregulated in HCC tissues compared with the adjacent non-tumor tissues. Moreover, the expression level of miR-7 was inversely correlated with that in HCC tissues. Knockdown of Cdr1as suppressed the HCC cell proliferation and invasion. Overexpression of miR-7 inhibited the HCC cell proliferation and invasion. Overexpression of miR-7 could suppress the direct target gene CCNE1 and PIK3CD expression. Knockdown of Cdr1as suppressed the expression of miR-7 and also inhibited the CCNE1 and PIK3CD expression. Furthermore, knockdown of Cdr1as suppressed the HCC cell proliferation and invasion through targeting miR-7. These data suggested that Cdr1as acted as an oncogene partly through targeting miR-7 in HCC. 27391479 2016.7 PLoS One The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression N/A circ-Foxo3 N/A 6 N/A + N/A FOXO3 N/A N/A cancer in vitro knockdown; western blot; RT-PCR; qRT-PCR; RIP; pull-down; northern blot non-cancer cell lines of mouse embryo fibroblast (MEF), mouse cardiac fibroblast (MCF),NIH3T3, and cancer cell lines 67NR, 66C14, 4T07, 4T1 and B16 N/A down-regulated N/A N/A p21; CDK2 cyclin A; cyclin B (CDK2) Circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression. Silencing endogenous circ-Foxo3 promoted cell proliferation. Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins cyclin-dependent kinase 2 (also known as cell division protein kinase 2 or CDK2) and cyclin-dependent kinase inhibitor 1 (or p21), resulting in the formation of a ternary complex. Normally, CDK2 interacts with cyclin A and cyclin E to facilitate cell cycle entry, while p21works to inhibit these interactions and arrest cell cycle progression. The formation of this circ-Foxo3-p21-CDK2 ternary complex arrested the function of CDK2 and blocked cell cycle progression. 26861625 2016.4 Nucleic Acids Res. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 N/A circ-Foxo3 N/A 6 N/A + N/A FOXO3 N/A N/A breast carcinoma qRT-PCR; in vitro overexpression; northern blot; western blot; IHC; dual luciferase reporter assay; in vivo overexpression; etc. non-cancerous cell lines BEAS2B, HaCaT and MCF-10A; human breast cancer cell line MDA-MB-231 cytoplasm down-regulated miR-22; miR-136*; miR-138; miR-149*; miR-433; miR-762; miR-3614-5p; miR-3622b-5p Foxo3 N/A N/A Expression of a member of the forkhead family of transcription factors, Foxo3, is regulated by the Foxo3 pseudogene (Foxo3P), and Foxo3 circular RNA, both of which bind to eight miRNAs. We found that the ectopic expression of the Foxo3P, Foxo3 circular RNA and Foxo3 mRNA could all suppress tumor growth and cancer cell proliferation and survival. Our results showed that at least three mechanisms are used to ensure protein translation of Foxo3, which reflects an essential role of Foxo3 and its corresponding non-coding RNAs. 26657152 2016.7 Oncogene Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis N/A hsa_circ_0001649 hsa_circRNA_104206; hsa_circ_001599 6 146209155-146216113 - hg19 SHPRH GGCAGCCATTCTACAAAAGTGGAAGCTGTGGTCAGAACTCTGATGAAAATACAGCTTAGAGATCCAGGGGCCAAAGCACTCGTTTTCTCAACGTGGCAAGATGTATTAGATATTATTTCAAAAGCTCTTACTGACAACAACATGGAATTTGCACAAATCAGTCGTGTTAAGACATTTCAGGAGAACCTTTCAGCATTTAAACGTGATCCCCAAATCAATATTTTGCTGCTGCCCCTGCACACAGGTTCTAATGGATTAACTATCATTGAAGCAACTCATGTTCTCTTGGTGGAGCCCATATTGAACCCTGCCCATGAGCTTCAGGCCATAGGGAGGGTGCACCGAATTGGACAGACAAAACCTACTATTGTACACAGATTCTTAATTAAAGCAACAATAGAAGAAAGAATGCAGGCAATGCTGAAAACTGCTGAGAGAAG exonic hepatocellular carcinoma qRT-PCR; RT-PCR; Sanger sequencing; in vitro knockdown HCC and paired adjacent liver tissues; Immortalized hepatoma cell lines, HCC-LM3 and MHCC-97L N/A down-regulated N/A N/A N/A N/A Hsa_circ_0001649 expression was significantly downregulated in HCC tissues (p = 0.0014) based on an analysis of 89 paired samples of HCC and adjacent liver tissues and the area under the ROC curve (AUC) was 0.63. Furthermore, hsa_circ_0001649 expression was correlated with tumor size (p = 0.045) and the occurrence of tumor embolus (p = 0.017) in HCC. 26600397 2016 Cancer Biomark Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma N/A circ-ITCH cir-ITCH; hsa_circ_0001141; hsa_circ_001763; hsa_circRNA_001141 20 33001547-33037285 + hg19 ITCH TTGAAGAAGTAGTTGTGACTTTGCAGCTTGGAGGTGACAAAGAGCCAACAGAGACAATAGGAGACTTGTCAATTTGTCTTGATGGGCTACAGTTAGAGTCTGAAGTTGTTACCAATGGTGAAACTACATGTTCAGAAAGTGCTTCTCAGAATGATGATGGCTCCAGATCCAAGGATGAAACAAGAGTGAGCACAAATGGATCAGATGACCCTGAAGATGCAGGAGCTGGTGAAAATAGGAGAGTCAGTGGGAATAATTCTCCATCACTCTCAAATGGTGGTTTTAAACCTTCTAGACCTCCAAGACCTTCACGACCACCACCACCCACCCCACGTAGACCAGCATCTGTCAATGGTTCACCATCTGCCACTTCTGAAAGTGATGGGTCTAGTACAGGCTCTCTGCCGCCGACAAATACAAATACAAATACATCTGAAGGAGCAACATCTGGATTAATAATTCCTCTTACTATATCTGGAGGCTCAGGCCCTAGGCCATTAAATCCTGTAACTCAAGCTCCCTTGCCACCTGGTTGGGAGCAGAGAGTGGACCAGCACGGGCGAGTTTACTATGTAGATCATGTTGAGAAAAGAACAACATGGGATAGACCAGAACCTCTACCTCCTGGCTGGGAACGGCGGGTTGACAACATGGGACGTATTTATTATGTTGACCATTTCACAAGAACAACAACGTGGCAGAGGCCAACACTGGAATCCGTCCGGAACTATGAACAATGGCAGCTACAGCGTAGTCAGCTTCAAGGAGCAATGCAGCAGTTTAACCAGAGATTCATTTATGGGAATCAAGATTTATTTGCTACATCACAAAGTAAAGAATTTGATCCTCTTGGTCCATTGCCACCTGGATGGG exonic esophageal squamous cell carcinoma qRT-PCR; in vitro overexpression; luciferase reporter assay; western blot; in vivo overexpression; etc. ESCC tissues and matched noncancerous tissues; Eca-109 and TE-1 cells N/A down-regulated miR-7; miR-17; miR-214 ITCH N/A N/A Cir-ITCH expression was usually low in ESCC compared to the peritumoral tissue. The functional relevance of cir-ITCH was further examined by biochemical assays. As sponge of miR-7, miR-17, and miR-214, cir-ITCH might increase the level of ITCH. ITCH hyper expression promotes ubiquitination and degradation of phosphorylated Dvl2, thereby inhibiting the Wnt/¦Â-catenin pathway. These results indicate that cir-ITCH may have an inhibitory effect on ESCC by regulating the Wnt pathway. 25749389 2015.3 Oncotarget Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/¦Â-catenin pathway N/A circHIPK2 N/A 7 N/A - N/A HIPK2 N/A exonic neuroinflammatory disorders luciferase reporter assay; western blot; qRT-PCR; FISH; in vitro knockdown; in vivo knockdown; etc. A172 cells; primary mouse astrocytes N/A N/A miR-124 SIGMAR1 N/A N/A Circular RNA HIPK2 (circHIPK2) functions as an endogenous microRNA-124 ,resulting in increased sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1) expression.Knockdown of circHIPK2 expression significantly inhibited astrocyte activation via the regulation of autophagy and endoplasmic reticulum (ER) stress through the targeting of MIR124¨C2HG and SIGMAR1. 28786753 2017.8 Autophagy Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG N/A circR-284 hsa_circ_0000284; BCRC-2; hsa_circRNA_100782; hsa_circ_000016; circHIPK3 11 33307958-33309057 + hg19 HIPK3 GGTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG exonic carotid plaque rupture and stroke RT-PCR; Droplet Digital PCR (1) those without a previous cerebrovascular event in the previous 6 months (asymptomatic), (2) patients with either an acute stroke or transient ischemic attack within 5 days of the CEA (urgent), and (3) patients who had a more remote cerebrovascular isc N/A up-regulated miR-221 N/A N/A N/A miR-221 was significantly lower, whereas circR-284 was elevated in the serum of the urgent compared with the asymptomatic group. The ratio of serum circR-284:miR-221 was significantly elevated in the urgent group (P=0.0002) and exhibited favorable characteristics as a biomarker indicative of carotid plaque rupture and stroke. A validation study in 112 patients (47 asymptomatic, 41 urgent, and 24 patients with a cerebrovascular event between 5 and 180 days of the carotid endarterectomy [symptomatic]) confirmed elevation of serum circR-284:miR-221 uniquely in the urgent group (P<0.001) and favorable sensitivity and specificity for detecting plaque rupture and stroke. 28779016 2017.8 Circ Cardiovasc Genet. Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels N/A hsa-circRNA11783-2 N/A N/A N/A N/A N/A N/A N/A N/A type 2 diabetes mellitus Microarray; qRT-PCR peripheral blood from control individuals, coronary artery disease patients, type 2 diabetes mellitus patients and coronary artery disease combined with type 2 diabetes mellitus patients N/A down-regulated N/A N/A N/A N/A In total, 40 circular RNAs differentially expressed between the three experimental groups and the control group were identified by microarray analysis: 13 were upregulated in the experimental groups, while 27 were downregulated. Of the five circular RNAs chosen for further analysis, three were significantly downregulated in the experimental groups. The crude odds ratios and adjusted odds ratios of hsa-circRNA11783-2 showed significant differences in both the coronary artery disease group and type 2 diabetes mellitus group. We then verified hsa-circRNA11783-2 in the third cohort, and it remained closely related to both coronary artery disease and type 2 diabetes mellitus. 28777011 2017.8 Diab Vasc Dis Res. Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus N/A hsa-circRNA11783-2 N/A N/A N/A N/A N/A N/A N/A N/A coronary artery disease Microarray; qRT-PCR peripheral blood from control individuals, coronary artery disease patients, type 2 diabetes mellitus patients and coronary artery disease combined with type 2 diabetes mellitus patients N/A down-regulated N/A N/A N/A N/A In total, 40 circular RNAs differentially expressed between the three experimental groups and the control group were identified by microarray analysis: 13 were upregulated in the experimental groups, while 27 were downregulated. Of the five circular RNAs chosen for further analysis, three were significantly downregulated in the experimental groups. The crude odds ratios and adjusted odds ratios of hsa-circRNA11783-2 showed significant differences in both the coronary artery disease group and type 2 diabetes mellitus group. We then verified hsa-circRNA11783-2 in the third cohort, and it remained closely related to both coronary artery disease and type 2 diabetes mellitus. 28777011 2017.8 Diab Vasc Dis Res. Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus N/A circSLC8A1 N/A 2 40428473-40430301 - GRCh38 SLC8A1 N/A exonic cardiovascular disease RNA-seq; RiboTag RIP-seq; hiPSC-CMs ¦Â-adrenergic stimulation; FACS analyses; Fluorescent microscopy; PLN western-blot; Quantitative real time PCR hiPSC cells; biopsy material from human dilated cardiomyopathy (DCM) and control patients N/A up-regulated N/A N/A N/A N/A Specific circRNAs fromSLC8A1, CHD7, ATXN10 and DNAJ6C showsignificant changes in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). While circRNAs from SLC8A1, CHD7 and ATXN10 increase relative to their host gene expression, circDNA6JC decreases in the disease state. 28676412 2017.8 J Mol Cell Cardiol. Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease N/A circCHD7 N/A 8 60741259-60743097 + GRCh38 CHD7 N/A exonic cardiovascular disease RNA-seq; RiboTag RIP-seq; hiPSC-CMs ¦Â-adrenergic stimulation; FACS analyses; Fluorescent microscopy; PLN western-blot; Quantitative real time PCR hiPSC cells; biopsy material from human dilated cardiomyopathy (DCM) and control patients N/A up-regulated N/A N/A N/A N/A Specific circRNAs fromSLC8A1, CHD7, ATXN10 and DNAJ6C showsignificant changes in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). While circRNAs from SLC8A1, CHD7 and ATXN10 increase relative to their host gene expression, circDNA6JC decreases in the disease state. 28676412 2017.8 J Mol Cell Cardiol. Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease N/A circATXN10 N/A N/A N/A N/A GRCh38 ATXN10 N/A N/A cardiovascular disease RNA-seq; RiboTag RIP-seq; hiPSC-CMs ¦Â-adrenergic stimulation; FACS analyses; Fluorescent microscopy; PLN western-blot; Quantitative real time PCR hiPSC cells; biopsy material from human dilated cardiomyopathy (DCM) and control patients N/A up-regulated N/A N/A N/A N/A Specific circRNAs fromSLC8A1, CHD7, ATXN10 and DNAJ6C showsignificant changes in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). While circRNAs from SLC8A1, CHD7 and ATXN10 increase relative to their host gene expression, circDNA6JC decreases in the disease state. 28676412 2017.8 J Mol Cell Cardiol. Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease N/A circDNAJ6C N/A N/A N/A N/A GRCh38 DNAJ6C N/A N/A cardiovascular disease RNA-seq; RiboTag RIP-seq; hiPSC-CMs ¦Â-adrenergic stimulation; FACS analyses; Fluorescent microscopy; PLN western-blot; Quantitative real time PCR hiPSC cells; biopsy material from human dilated cardiomyopathy (DCM) and control patients N/A down-regulated N/A N/A N/A N/A Specific circRNAs fromSLC8A1, CHD7, ATXN10 and DNAJ6C showsignificant changes in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). While circRNAs from SLC8A1, CHD7 and ATXN10 increase relative to their host gene expression, circDNA6JC decreases in the disease state. 28676412 2017.8 J Mol Cell Cardiol. Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease N/A circANRIL N/A 9 N/A + N/A ANRIL N/A exonic melanoma RT-PCR; qRT-PCR; etc. NZM7 cell line; NZM3 cell; NZM44 cell and NZM55 cell; NZM37 cell lines cytoplasm N/A N/A N/A N/A N/A Hypothesised that ¡°ANRIL¡± has wholly distinct dual sets of functions in melanoma. This reveals the dynamic nature of the locus and constitutes a basis for investigating the functions of ANRIL in melanoma. 28653984 2017.6 Int J Mol Sci. Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing N/A hsa_circ_0005402 hsa_circRNA_101539 15 60648117-60674640 - hg19 ANXA2 CACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAG exonic multiple sclerosis microarray; qRT-PCR peripheral blood leucocytes from multiple sclerosis patients and healthy controls N/A down-regulated N/A N/A N/A N/A We carried out expression profiling of 13.617 circular RNAs in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed (P-value < 0.05, Fold change > 1.5) and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease. 28651352 2017.6 Hum Mol Genet. Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis N/A hsa_circ_0035560 hsa_circRNA_101541 15 60653139-60674640 - hg19 ANXA2 CACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAG exonic multiple sclerosis microarray; qRT-PCR peripheral blood leucocytes from multiple sclerosis patients and healthy controls N/A down-regulated N/A N/A N/A N/A We carried out expression profiling of 13.617 circular RNAs in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed (P-value < 0.05, Fold change > 1.5) and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease. 28651352 2017.6 Hum Mol Genet. Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis N/A hsa_circ_0005870 hsa_circRNA_103339 3 47079155-47088111 - hg19 SETD2 AGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCACAAGGAGTGGTGGTACAGCCAGCCGCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGACAAATAATCTCTTGGATCTGCCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAGAAGGGAAGATTTATTACTACCATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTGAGCATGAAGCTGAGATGGACCTGGGAACTCCAACATATGATGAAAACCCCATGAAG exonic hypertension Microarray; qRT-PCR plasma from five hypertensive patients and five healthy controls N/A down-regulated N/A N/A N/A N/A CircRNA microarrays study identified 13 downregulated and 46 upregulated circRNAs in hypertension patients, where four circRNAs (hsa-circ-0000437, hsa-circ-0008139, hsa-circ-0005870 and hsa-circ-0040809) showed significantly difference. By further validation, hsa-circ-0005870 exhibited significant downregulation in hypertensive patients. Then, we constructed a network of hsa-circ-0005870-targeted miRNAs, including hsa-miR-6807-3p, hsa-miR-5095, hsa-miR-1273g-3p, hsa-miR-5096, hsa-miR-619-5p, and their corresponding mRNAs. Gene oncology and KEGG pathway analysis enriched from specific mRNAs indicated the involvement of hsa-circ-0005870 in hypertension. 28534714 2017 Clin Exp Hypertens. Profiling and bioinformatics analyses reveal differential circular RNA expression in hypertensive patients N/A ciRS-7 hsa_circ_0001946; CDR1as; hsa_circRNA_105055; Cdr1as X 139865339-139866824 + hg19 CDR1 GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG antisense Alzheimer's disease in vitro overexpression; luciferase activity assays; in vitro knockdown; immunoblot; etc. HEK293T and SH-SY5Y cells cytoplasm down-regulated N/A N/A NF-kB UCHL1; BACE1; APP In this study, we report that ciRS-7 has an important role in regulating BACE1 and APP protein levels. Previous studies have shown that ciRS-7, which is highly expressed in the human brain, is down-regulated in the brain of people with AD but the relevance of this finding was not clear. We have found that ciRS-7 is not involved in the regulation of APP and BACE1 gene expression, but instead reduces the protein levels of APP and BACE1 by promoting their degradation via the proteasome and lysosome. Consequently, overexpression of ciRS-7 reduces the generation of A¦Â, indicating a potential neuroprotective role of ciRS-7. Our data also suggest that ciRS-7 modulates APP and BACE1 levels in a nuclear factor-¦ÊB (NF-¦ÊB)-dependent manner: ciRS-7 expression inhibits translation of NF-¦ÊB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation. Additionally, we demonstrated that APP reduces the level of ciRS-7, revealing a mutual regulation of ciRS-7 and APP. Taken together, our data provide a molecular mechanism implicating reduced ciRS-7 expression in AD, suggesting that ciRS-7 may represent a useful target in the development of therapeutic strategies for AD. 28296235 2017.4 FEBS J. The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-¦ÊB-dependent manner N/A hsa_circ_0005105 hsa_circRNA_103944 5 134022479-134023989 + hg19 SEC24A TTACGACCACCTCAGCCTCCAGTGTATCTCTTTGTATTTGATGTGTCTCACAATGCAGTCGAAACTGGATACTTGAATTCAGTTTGCCAGAGTTTGTTAGACAATCTGGATTTGCTTCCTGGCAACACTAGAACAAAAATTGGCTTCATAACATTTGACAGTACAATCCATTTCTACGGTCTTCAGGAAAGTCTCTCTCAACCTCAGATGCTAATAGTTTCAGATATTGAAG exonic osteoarthritis qRT-PCR; in vitro overexpression; in vitro knockdown; dual luciferase reporter assay; western blot; ELISA; etc. human Chondrocytes-articular N/A up-regulated miR-26a NAMPT N/A N/A After stimulating chondrocytes with interleukin-1 beta (IL-1¦Â), hsa_circ_0005105 expression was significantly upregulated, while miR-26a expression was significantly inhibited. Hsa_circ_0005105 did not influence miR-26a expression but inhibited its transcriptional activity so as to upregulate the expression of its target NAMPT. Studies further indicated that hsa_circ_0005105 can inhibit the expression of type II collagen and aggrecan, promote the expression of MMP-13 and ADAMTS-4, and the generation of PGE2, IL-6, and IL-8, but the linear sequence of hsa_circ_0005105 cannot. MiR-26a has the opposite effect, and hsa_circ_0005105 can antagonize the function of miR-26a. When NAMPT expression was downregulated, the above function of hsa_circ_0005105 was significantly weakened. Therefore, hsa_circ_0005105 can promote extracellular matrix (ECM) degradation by regulating the expression of miR-26a target NAMPT. These findings will provide new targets for treatment and prevention of OA and other orthopedic diseases. 28276108 2017.3 Cell Biol Int. CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a N/A GSDMB circRNA N/A N/A N/A N/A N/A GSDMB N/A exonic multiple sclerosis qRT-PCR peripheral blood mononuclear cells of relapsing-remitting MS patients and controls N/A up-regulated N/A N/A N/A N/A We investigated the alternatively-spliced gene encoding Gasdermin B, GSDMB, which was repeatedly associated with susceptibility to asthma and AIDs. The in-depth characterization ofGSDMB AS and backsplicing profiles led us to the identification of an exonic circular RNA (ecircRNA) as well as of novel GSDMB in-frame and out-of-frame isoforms. The non-productive splicing variants were shown to be downregulated by the nonsense-mediated mRNA decay (NMD) in human cell lines, suggesting that GSDMB levels are significantly modulated by NMD. Importantly, both AS isoforms and the identified ecircRNA were significantly dysregulated in peripheral blood mononuclear cells of relapsing-remitting MS patients compared to controls, further supporting the notion that aberrant RNA metabolism is a characteristic feature of the disease. 28272342 2017.3 Int J Mol Sci. The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis N/A circ-TTBK2 hsa_circ_0000594 15 43120125-43164956 - hg19 TTBK2 TTGAGAAAGATTGGGGGTGGGGGCTTTGGAGAAATTTACGATGCCTTGGACATGCTCACCAGGGAAAATGTTGCACTGAAGGTGGAATCAGCTCAACAACCAAAACAAGTTCTGAAAATGGAAGTTGCTGTTTTGAAAAAGCTGCAAGGGAAAGACCATGTTTGTAGATTTATTGGCTGTGGGAGGAATGATCGATTCAACTATGTGGTCATGCAGTTGCAGGGTCGGAATCTGGCAGATCTTCGCCGTAGCCAGTCCCGAGGCACATTCACCATTAGTACCACTCTCCGGCTGGGTAGACAGATTTTGGAGTCTATTGAAAGCATTCATTCTGTGGGATTCTTGCATCGAGACATCAAACCGTCGAACTTCGCTATGGGTCGCTTTCCTAGTACATGTAGGAAATGTTACATGCTTGATTTTGGCTTGGCTCGACAATTTACCAATTCCTGTGGTGACGTCAGACCA N/A glioma FISH; qRT-PCR; IHC; western blot; in vitro knockdown; in vitro overexpression; luciferase reporter assay; RIP; in vivo knockdown glioma tissues and normal brain tissues cytoplasm up-regulated miR-217 HNF1¦Â N/A N/A We found that circ-TTBK2 was upregulated in glioma tissues and cell lines, while linear TTBK2 was not dysregulated in glioma tissues and cells. Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis. MiR-217 was downregulated in glioma tissues and cell lines. We also found that circ-TTBK2, but not linear TTBK2, acted as miR-217 sponge in a sequence-specific manner. In addition, upregulated circ-TTBK2 decreased miR-217 expression and there was a reciprocal negative feedback between them in an Argonaute2-dependent manner. Moreover, reintroduction of miR-217 significantly reversed circ-TTBK2-mediated promotion of glioma progression. HNF1¦Â was a direct target of miR-217, and played oncogenic role in glioma cells. Remarkably, circ-TTBK2 knockdown combined with miR-217 overexpression led to tumor regression in vivo. 28219405 2017.2 J Hematol Oncol. TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1¦Â/Derlin-1 pathway N/A hsa_circ_0124644 N/A 3 76758592-76759779 + hg19 ROBO2 GGAAGGAAAAGCTTCTTCAGAATCTCCAGAAGATTTTCACTTGTATCTCACCGGCCAGAACTGTGTCACATATCAACACATACCTGTGAATGGAGCTGGAAAAGCACGTATTACTTGGACACATTATTGTCAGAACACAGGAAGGATTATGATGCCATAGAAAAGGGGTGAGTGGTTATTTAGTAGGAACTTCAGGGGCTGGACAGGAGATTTGAAGCAGGAAAGTGAGTTCAGCAATGTTATATGCCATAGTGCTCATTACATCATCTGGATTTTCCAGAGCCAGGGTAATTAGTTTTCAGATTAAAATTAGTTTTCAGATTATTTCTTTAAAATGAAGTATATTTGCAAAAATAAAATCATTAAATAGTAAAAAATGTCAATACTGAAAGAGACCTGCTGTTAGAGGCCACACTGTCTATTGCAATGTGGGGCTGCCTCTCAGCCAATGAGAAGTATAACCAGACCACTTCCTTCTGCCAACAGCTCTTCTGAGGACATGGGATAGCAAAGGCTGCAGATCTCAACACAACTTTAGAGGTAGGATTTTGAGGATAAAGAAAACAAGTAAAGAAAGGGGAGGGAGAGAGACACGTGGAGAGAAAGAGACATGGAGAGAGAGGACTAAGGAAAGTGGCTGAGGCCTGCCCCTCTTCCAAACACTTGTCCTTTTCTTTTTCTTTTCTTTTTTTTTTTGAGATAGAGTCTCACTCTGTCGCGCCAAGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCTTGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTAGAGGTCCGCACCACCCTGCCAAGCTTATTTTTGTATTTTTAGCAGACACGGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCCCTTGACCTTGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGTCCAGCATGTCCTATTCTCATATTCAGAAAAAGGCTAGGCTCAGCTAAGAAAAGATAAGAAGACATTATTTAAACTAGTAGTAATTTGTTTGGCCAATTTCCAAGTTAATTACTACTTGACCCTACTGAAAACTGCCTTTTGGATTTGGTTATAGAATGCCTTGGAGTTATGGAGACAGAAGTCAGAATACAGCAGGTTGAGAAGTAACTCGTCAAG N/A coronary artery disease Microarray; qRT-PCR peripheral blood of coronary artery disease (CAD) patients and controls N/A up-regulated N/A N/A N/A N/A We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710-0.827], P < 0.001) to 0.804 ([0.751-0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. 28045102 2017.1 Sci Rep. Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease N/A hsa_circ_0082081 N/A 7 122120905-122377122 - hg19 CADPS2 CTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTGTAAGTTTTGTTAAAAAATAATTTGATTATCAATTAATAGCCTTAATAAGATATAAAATTGAGGCAAATGTATTCAGTATTATAGTTTACATCATTAATTGATTCCTAATTAAATGAAAATAGTTCATATTAGTAGTCACATAATCACTTATCTAATTTTTCACATAAATCTGGAGTAAATGGTACGTGTGGTTTCCAATCATGGATTTGTCAAGCATTAGGGTATTTCTAGAAATCTCAAGAGCACATAAGAAAATTCTCCAAAACTTCTCAAAGGAAAATTTAATTTAGTTTATTGTGATTTTTGACTTAAGTCTCCTATAGATATGGAAAAAGTATTGCAAAATCAAATTTGCTTTGATAGGATTTCAGAATACCAAAATGATGAACCATTACCTTCTAGAATTGTTCTTAATACCCCAGAAGGATAATAGGTCTATTTTTTTGTTGTAGATTGATAAAAATAATAAGTCATAAAGCCAACTTTTTTCCCCTTGTACCTTAAAGACATGTCACTTTTTGAATGCTACCTTAAGTTGTTAAGAACTAAATTTTTAATTTTAAATGACTGATGCTTAATAATTATGGAATAATGGTCAAAACATCTTCAAACCTAGCTTTGATAATCACTAAACCAAGTGTTTTAACTTGTTGTACTCCTTTACAAAGCTTATCCTGTTTTACCTGTAATAAATATTTGTCTTTAACTTTCAGCTCAACTTGTGGCTTTTTATTCTTGAGATTCTTCTCAAAGGGAATAACATCTTGACATGCATTATTTTCTTCTGCTTTTCATGCATCAAGTAACTATTCTCTTCTCTTTTTAGATACCCTTCAGTATCATTTCTGGGCATCCTAAACAAAGGCACTTTAGTTCAAATAATTAAATGTGAACCATGAGCTTTTTATTTCTTTATTTTAGAAACCACAGACCATACTCATAGATTATCGTAATTATTTTGGGGCATATCTTTTATATGTAGTGAAAACTATTTAGGAATATTATAAATTTTTTCATTGATTTAAAATTTCTTCTTTAAAATTAGTAGCATTGTCATCTTAAAAGGTAAAATAAAATAAAAAGAGCACATTCTGATGTTTTCACTGTATTTGAAAATTTAACTCGCTGCTGCTGCCTTCCTCTCACCCTCTGGGTAATACACATAGAGTATGGCACAGCAGATAAGAGTGTTTCATCAGAGCTAAGGTGTACAGAAGTGTAACTTTATTTTTCTACAATTGAACATATCTTAAATTTTAATTTCTAATGTTGCCAAAAAACTTTAACTCGCTAATTCAAAACAACTGAGTCACAGATTATAATTCAATTAATTCAAGATTCTTCCCCCTACTCTTCTTCCATGTGATCCATAGTAAATTAAGTTTCAGAGGGATTGCATAAAACTGTGATATCATTGAATGTAACATCTAGCCTAAGACTATTCTCTGTTCACATGGGCTTAGGCATGACTTCTGTCATTGATTTCATTACTTATGTGCTGGTATGCACTGCTCGTCACCATGGACCTGCCAGGGCACCTGGCAATGAAGTCCATGTAGTCTGTGTCCTCCTTGGATCAACTCCAGACACCTATGAATTCCTTACATCATTTTCATCAGATTCTTGCCACAGTGGTACATAGTAACTTGTTGGGTATTCCCCAGCTATGCACAGGGGTGCTCACTCAGGCGTTTCTCTTGCAGCACAGCTCTTATCCACTGCTTCTTTCCTACTTCAAGTGCCAAATTGGGTATTTATCCCTGGACTGTGCCTGCATTGGGCATCAAAGTATAAGACTCCCTCAACCCCGGGTAGAACTTTTTTCCTCTGGAGCTCTGTTCATTGCTCACCCCCAGCACAACATTAACTCAAGTCAAATCTCTTCCCAAAACCATTTTCTTCCATCCAGCTGATCTATTTTTTTCCCTCCGAGTTTTGATTCTTGTTGTTGAAAACCAAGTTTTTATAAATTTGTTTCTTACCTCTCCATAGGCCAGTCTCTGTCCCTTCCCCTATAAGCTACAGTTCTACAGCATTTAATGTGAATTTCCTGTGTTTTTCATTTTGCAAATTTGCATTTTGTATGTGTGCATTTAGCGTCAATCTCATAAATGGTTTTGTATTCTTTGTCATATTCAGTCTTACTGTTTTTGTTCATCTCTATGTTTTTAAAATTTATCCATGTTTTTATGAATACATCTAATCTCATTCTTCTGATTACTGCATACCATGTAAGTGGGCTTCTGTCTTATGTTACCTGGTCTACTGCACATTTTATTTCTATTCACTCCTCCAGAGATGGAAACATAGAATGCCTCCAGATCCATACCTGTGTAATGTTCAGTTGTCCCAGCCATGACTATGAAATATCCTTTCATTTATTCAAATCTGAGTCCTTTACATTTTAATAATTTTCCATAGAGCTCTTTTTATTCTTGGTTAAGCTAATTTCTAAGCCTTTCATACTTTCCTTGCTATTGCATCTTATATTTTTTATTATATTTTCTAATTGACTATTGCTCATATAGAGAAATGCTATTTTCATGTGCTTTTTTGCTATCCATATTTATTCTTTGGTTATGTATCTCTGCACATACCTTGCCTAATTTGTAATTAGGCTATTTTCTTATTGGGTTTTGAGAGGTCTTTATACAGGCATACCTAGGAGATATTGTGGGTTCAGTTCCAGACCACTGCAATAAGATGAATATCTCAATAAAGTGAGTCACACAAATTCTTTGGTTTCCCAGTGTGTATAAAAGTTATGTTTGGCCGGCGCAGTGGCTCAAGCCTGTAATCCTAGCACTTTGGGAGGTCGAGGTGGGGGGGATCTCTTCAGTTCAGGAGTTCGAGACCAGACTGGGCAACATGATGAAACCCTGTATCTACAAAAAATGCAAAATTAGCTGAGCATGGTGGTACGTGGCTGTAGTCCCAGCACTTGGGAGGCTTGAAGTAGGAGAACTGCTTGAACCCGAGGGGTGGAGGTTGCAGTGAAATAGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAAACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGTTATGTTTATACTACACTGTAGTGTATTAAGCATGCACTAGCATCATGTCTAAAACATAATTTTAAAATTCTTTATTGCTAAAAATAATCACCTGAGACTTCAGTGATTATAGTATTTTTGCTGGTAGAGGGTCTTGCCTCAACATTGATGGCTGCTGACCGATCAGGTTGCTGGTTGTTGAAGGTTGGTGTGGATGTGGCAATTTCTTAAAATAAGACAAGGATGAAGTTTGCTGCAGTGACTGATTCTTTCACGAAAGATTTTCTGGTAGCATGTGATGCTGTTTGCTATCATTTTGCCCAAAGTAGAACTTCTTTGAAAATTGGAGTCAATCCTCTAAAACTTTACCTCTGCTTTACGAACTAAGTTTATGTAATATCCTAAATCATTTGTTGTCCTTTCAACAATGTTCACAGCATCTTCACCAGAAGTAGATTCCATCTCAAAAATCACTTTCTTTGCTTCACCCAAAGGAACCAACTTCTTATCTGTTCAAGTTTTATCATGAGATTGCAGCAATTCAGTCACATCTTCAGGCTGCACTTTTAATTCTGGTTCTTTTGCTATTTTCATGACATCTGCAGTGACTTCCTCCACTCAAGTCTTCAATCCCTTAAAGTTATCCCTGAGGGTTGGAATCAACTTCCTCCAAACTCCTGTAAATGTTGATATTTTTACCTCCGCCCAAGAATCACAAATGTTCTTAATGGCATTTGGAATGATGAATCCTTTCCAGGTTTTCAATTTACTTTTCCCAGATGTCTCATAGGAATTACTATGTATGGCAGCTATAGCCTTATAAAATGTATTTCTTAAATAATAAGACTTGAAAGTTGAAATTACTCCTTGATCTGTGGGCTGCAGAATGGATGTTGGGTTAGCAAGCATGAAAACAACATTAATCTCCTTGTACATCTCCAGCAGAGCTCTTGAGCAACTAGATGCTATGTCAGTGAGCAATAATGCTTCCAACAGATTCTTTTGTTCTAGCATCAGGCCTCAGCAGTGGACTTAAAATATTCAGTAAACTATGCTGTAAACAGATGCACCATCATCTGGGCTTGTTCTTTCAGTTATAGAGCACAGAACAGGGTTGATGTAGCATAGTTTTTAAGGGCTCTGGGATTTTCAAAATGGTTAATAAACATTGGCTTCAACTTAAAGTCACCAGCTGCATTAGCCACTAACAAGAGAGCCTGTACTCTGAAGCTTTGAAGCCAAGCATTGACTTCTCTCTAACTGCGAAAGTCCTGGATGGCATCTTCTTCCAATAGAAGATTATTTTGTCTACACTAAAAATCTGTTATTTAGCATAGCTAACTTCATCAATGATCTTAGCTGGATCTTTTGGATAACTTATTGCCATTTCTGCATCAACCCTTGCTGTTTCACCTTGTACTTTTATGTAATAGAGATGGCTTCTTTTCCTTAACCCTAATGAGCTGACCTCTGCTGGCTTCACAGTTTGCAGAGGCTTCTTCACCTCTCTCAGCTGTCATAGAATCGAAGAAAGGCAGGGCCTTGCTCTGGATTAGGCTTTGGTTTAAGGGAATATTGTGGCTGGTTTGATCTATCCAGACCATTCAAACTTTCTTCATATCAGCAATAAGGCTGTTTTGCTTTCTTATTATTTGTGTGTTCACTGGAGTAGCAACTTTAATTTACTGCAACAACTTTTCCTTTGCATTCACAACTTAGCTACTTGGTGCAAAAGGCCTCGCTTTCAGCCTATCTTGGCTTTTGACATGCCTTGCTCACTAAGCATGATCATTTGTAGCTTTTAATTTAAAGTGAGGGAGATGGGATTCTTTCATTCATTTGAACACTTAGAGATCATTTCAGGTTGTTAGTTAGCCTAATTTTAATATTGTTGTGTGTCAGGAAATAGGGAGGCCCAAGAAAAGGGAGAGAGATGGGGAACAGTCAGAACACATATAACATTTATTAAGTTTACCATCTTATATGGGTGTAGTTTGTGGCACCCCAAAACAATTACAATAATATCAAAGATCACTTTCCACAGATGACCGTGATAGATCTACTAATAATGAAAAAGTTGGAAATACTGTGAGAATTACCATAACATGAAACAGTCATGATATGAGCACGTCATGATATGAGCACGTGTTGTTAAAAAAGTGACACCATGGACTTGCTTGACACAGGGTTGCCACGAACTTTCAATTTATGAAAAACACATCTGCAAAGCACAATAAAATGAAGTTTCCCTGTGTGTTCTGGATACAAGATGTTTGTCAGATACGTGATTTGCAAATATTTTCTCCTAATCTATGGCTTGTCTTTTCACATCTCTTAATAGTGACTTTCAGAAAAAAAAAAAAAGAAATTCTTAATTTTGATGAAGTCCATTTTATCAATTTTTTTCATAGTTGTGCTTTTGATGTTATAACTAAAGGATCTTTGCCTAACCCAAATTGCAAACATTTTCTCCTTTGCTTTCTTCTAGAAATTTTACAATTTTGGCGTTTACATTTTACAACCATTTTCAGTTAATTTTTATATATGGTGAGAGGTATCCATCAGTATTTCTGGATGGCATATGGATGTCCAGTTGTTCTAACACAAAGAGTTGAAGAGATTATCGTACCCTGAATTGCCCTTGCATATTTGTGAAAAATCAATTAACTACATATGAGTTTATTTCTGGGCTATCCTTTCTTTGGTCAGTTTATCTATCTTAATATTATTACCACACTGTCTTGATTACTGTAGCTTGGTAAATCTTACAGTTAGGTAGTCCAAGTCCTCCAAATTGATTTCTCTTATTCAAAAGTATTTTGGCTATTCTATGTCCTTTGCATTTCTCTATGAATTTTTAAAATAAGTTTATTCACTTTTAATTGACAAATAATTGTTTATATATATGGGGTACAATGTAAATTTTTAAAACATCTTGACATTCCTTGCTGGAGATTTTACTGGGAATGCCTTCAATCTATAGGTCAGTCCTTGGAAAATTTTGGAAAACTGACTTCTTAATATTGAGTCTTCCAATCTGTGAATACCATGTATCACTTCATTTGTTTAGGTAGTCTTTAGTTTCTCTTTGGGATGTTTGTAGTTTTCAGTGAACAGATCTAGCACATCTTTTGTCAGATTTATTTCTAGGTATTTCATCTTTGTTGCTTTAGTAAATGGAATTTTTTATTTCAGTCCAATTGTTTTGTTATCTTTGTGATTGCTTTAGAATTTAAAGTATACCCTTTAAATTTATTATATATCTTCATGTATAGTATGCACACTTTACAATAGTAAACTTCTATTTCTCCTCTCTTGGCTTTTGCACTATTCTTGTCATATATTTTACTTCTATATATGTGGTAAATCCCACAATACATTGCTATTATGATTATTGCCTTAGTCAATATCTTTTAAATAAATTAAAAGTGAAAGAAAAATGTTATGTACATGTCCATTTTGTACATGTCCATTATGTACATGTTATGTACATGTACATTACCATTTCCAGTGCCTTTCATCATCTAATATAGATATTTTCACTTCTTGGAGGACCTCCTTTGACTTTTCTTGTAGTGCAGATCTGCTGGTAATGAATACTTTTAGCTTCTTTATATACGAAAAAAAGTATTTATTTTACCCTCATTTTGAAGATATTTTTCTTTTAGTACTTTAAGGTGTTGCTCCACTTTCTTCTAGCTTGCATTTGTTTTTCCAATGAGAAATGTGCTGCTATTTTGGTTTTTTCCTCTATAAATAATGTCCTTTTTTCCTCTAGCTGCTTTAAAGATTTTTCTCTTTAACACTGTTTTTGAGCAATTTGATTATGATGTGCCTTGGTATAGTTTTCTTCATAAAAATGCTTGTTCTGAGACACAGTTAAGTTACTTGGAAACAATTCAATCCTCTCAAGCTTTGCTTTCAAGTTTTGTTAGGGAAGACCAAGCAGTGTTTAGTCCAGGATGCATTTTCCCCATTTCTGGACCAACATCTTTCTTAATACTCTAACTGATAACCTGTGAATTATGAGCTTTTATATTCTTGCTGCTGAAAAGCAGTGCTATTCTAGGCTGTGTGAGTTTGGGGCACTGTCCTCTCGAATCCTTTAGATTGCTTCTTTCCCTTTCTACACATGCATGAGCTGATGGGTAGTCAGCTGAATTCTTGGGGGAGGCCTTCTGTAGATCTTGAGAGTCTCTTGCTGGGCAGCTCTCTTCTCTCCAGTACTCTTTCCTACAAACTCTAGTTACTATCACCCTTCTGAACTGTCAGTTCCATCTTTTGAACTCAGGGAGACCACTGGGCTTTTCCTGGGTTCCTGTTGCTTGTGCCATGGGCTATAGAGTTTCTCCTGGCAGTAACCTGGAGTGACTGTAAGGCTCACCTTGTTTCCCGTCCCTCAGGAATCACGTTGCCCAACGTGCAGCGTTTAATAAACTTTTTGTAAATTTTTTTAGAATACTTAATTCAGGTAGGAGGTTAAGTTTATTCTCAATTATGCCATCATGACCAGAAGCAGAATTTTTTGTAAGTTAAAGCATGGTTTCTCAATTTCAACACTATTGACATTTTGGGCTAGATAATTATTTGTTTTGGGGCAGGGAGTGGAGTAAGGAACTTTTCCTGTGCGTTATGTAATGTTTTACAGCACCCCTGTCCTCTACCCACTAGGTATCAATAGTCTCCCACCTGGTCCCAGGTCAGACAACCAAAAATATCTCTGGACATTGCCAAATGTCCCAGAGGGTAGGGTTGCGGTTGGTGAGGAATCACCCCCAGTTGAGAACCACAGAATTACAGTGACTTAATAACTATTTTTTTTTAATCGCCATCCTCCTTCACTTGTGTTCCCATATTTTTTCTTAACATCCTGAGTGCAAGGAATGCCCGAGGAATGTGTTGAGCTCGTGGCTATTGTTGCTTGCACATAATGGCAAGAAAAGCAGGTAGGAACCACTAGCATAGAACTTTAAGACTGTGGCTGAATAATACAGAATTTTTTTAGACAGAGTCTGCCTCTGGAGAGAGAGGAAGTGCAGTGGTGCCATCTCGCCTCACTGAACCTCTGCCTCCCAGGTTCAAGCCATTCTCGTGCCTCAGCCTCCCAAGTAGCCTCCCAAGTAATCTCAGCAGCCGGGATTACAGGTGTGTGCCACCACACCCACCTAATTTTTGTATTTTTAGTAGAGACAGAGTTTCTCCATGTTGGCCAGGCTAGTCTCAAACTCCTGACCTCAGGTGATCTGCCAGCCTTGGCCTGCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCTGCCTGTAACAAATAATAACAAAACCTTTCTATTATTCGATATCAATTTATTGTCAAGGCAGGACTGATCAGGCTATGGGATTCCCATGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTATGCTACCACACCTGCCTAATTTTTGTCTTTTTAATAGAGATGGGGTTTCTCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTTATCTGCCCACCTCAGCTCCCGAAGTGCTGGGATTACAGGCATGAGCCACAGCGCCCAGCCCTATCATCTGTTTCTAACAAAACCTTTCTGTTATTTGATATCAATTTATTGTCAAGGCAGAATTGATCAGGCTATGAGAACTGAATTTACTTGTTATAACTAAAAAGGGAAACTGTTTCAATTTGTTAACAACAACTGACTTGTATTCCAGGCTGCTAGTAAAGTTTTAAATCAGGGCAGACCTCTGCTGACGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCACGTTCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCAAAAAAAAAAAAAAAAAAAAAAAGAATGAAGAAAGAAAATGTTCTACCTCATCAGAATGAGGGTAGTGACCCTGAACTATCAGAGAAATGCCATGAATTCCTCCAGAGTTCCTCCAGAGAGTAGTTTCATCCATAGTATTTTCCTCCCTCCATTGACTTACATAATCAATTTTTGTTTTCTTTCCTGATGGTCTTTTAGAAAAACAACTTTTAAAATCATGAGTAGAAATTGAGAAAATAAAAAATTAAATGTCTAGTTGTATAAGTATATAGTTCCCAACCCATTTAAATATGCTTTGTTTCTCATTTCTTTGCTGACCTGTAGCTGGTAAAG N/A coronary artery disease Microarray; qRT-PCR peripheral blood of coronary artery disease (CAD) patients and controls N/A up-regulated N/A N/A N/A N/A We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects and 30 CAD patients with different CADS. The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients. 28045102 2017.1 Sci Rep. Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease N/A hsa_circ_0098964 N/A 12 64474065-64521504 + hg19 SRGAP1 AAACTCAGAGAATATTTGGAAGGCAGTAATCTCATCACAAAACTTCAAGCCAAACATGACTTGCTGCAGAGGACCCTGGGAGAAGGTCATAGAGCTGAATATATGACTACAAGGCCTCCAAATGTTCCCCCTAAGCCCCAGAAACACAGGAAGTCCAGGCCCCGCTCACAGTATAATACTAAGTTGTTTAATGGGGATTTGGAAACATTCGTCAAGGACTCAGGACAGGTTATTCCCCTCATTGTGGAAAGCTGTATTCGGTTCATCAATCTCTATGGTCTTCAGCATCAGGGGATTTTCAGAGTGTCTGGTTCCCAGGTGGAAGTCAATGATATTAAAAATTCATTTGAGAGAGGTGAAAATCCTTTGGCTGATGACCAGAGTAACCATGATATTAACTCAGTTGCTGGCGTTCTGAAGCTCTATTTCCGTGGGCTGGAAAACCCCCTCTTTCCTAAGGAAAGATTTAACGATCTGATTTCTTGTATCAGAATAGATAATCTCTATGAGAGGGCGCTTCACATCCGCAAACTCCTCCTGACTTTGCCCAGGTCGGTCCTTATAGTGATGAGGTACCTCTTTGCCTTCCTCAATCATCTATCACAGTACAGCGATGAGAATATGATGGACCCTTATAACCTGGCCATTTGCTTTGGCCCAACATTGATGCCTGTCCCAGAAATACAGGATCAAGTGTCTTGCCAGGCACATGTGAATGAAATTATCAAAACCATCATCATCCACCATGAGACTATTTTCCCAGATGCTAAAGAGCTGGATGGCCCTGTTTATGAGAAATGTATGGCTGGAGATGACTATTGCGACAGCCCATACAGTGAGCACGGTACATTGGAGGAAGTGGACCAAGATGCTGGTACAGAGCCCCACACAAGTGAAGATGAATGTGAGCCAATAGAAGCAATAGCCAAGTTTGACTATGTTGGGCGGTCTGCCAGAGAACTATCCTTCAAGAAGGGTGCCTCCCTGCTGCTGTATCACCGTGCATCTGAGGACTGGTGGGAAGGCAGGCACAACGGGATTGACGGGCTGGTGCCTCACCAGTATATAGTGGTGCAGGATATGGATGATACGTTTTCAGACACTCTGAGCCAAAAAGCCGACAGTGAGGCCAGCAGTGGGCCAGTCACGGAAGACAAGTCCTCATCCAAGGACATGAACTCCCCGACAGACCGTCATCCTGACGGCTATTTAGCCAG N/A coronary artery disease Microarray; qRT-PCR peripheral blood of coronary artery disease (CAD) patients and controls N/A up-regulated N/A N/A N/A N/A We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects and 30 CAD patients with different CADS. The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients. 28045102 2017.1 Sci Rep. Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease N/A hsa_circ_0113854 N/A 1 63246096-63270926 + hg19 ATG4C GAAGGAGATGGATAAGAAATACACTTGATAGAAGTTAAGAAGTAAAAGTGTCCTAACAAAAATCTGGAGCTGCCTCACAATCAATGCTATTAGAATGGTTGGTATACTTTCAAAGTATATGCCTGGAATACGATGACATTTTAGAAAGGGCTTGACTCTTAAGATAAATGTTACCTATATATTATAAATGTGTTTTTTATATATAAGTACACACACACACACACGTATACACAAGTACGCACACACATATACTAAGCAGTGTGTGTGTGTGTGTGTGTATGTAAATTGTTGCTTTCATGATTATTGAATGTGACATTCTGATTATTCTGGTTTTAATAGTTATTTTATTATACAACCTGAATTACTAATTAAAAAAATAAAGCACAAGAGTTAGAAACAGCTTACATTAAAACTACGCAGTATTCATGAAAAGGCAGTTTCGGGGCCTCGGTCATCACTGTGAATTTTTTTTTTTTTTGAGACAGAGTCATGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTAATCTTGGATCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCCCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCACGCCACCACGCCTGGCTAATTTTTCTTGTATTTTTAGTAGAGACGGAGTTTCACCATGTTGTCCAGGCTGGTCTTGAACTCCTGATCTCAAGTGATCCACCCGCCTTGGACTCCCAAAGTACTGAGGTTACAGGCATGAGCTACTGCACCCAGCCTAGTCATCACTGTGAACTTCCACAAACACTCATTGAGAGCCAGTTACTCTGCACAAAGTACTGTGCATAGAGCTGGGAGGGGCACAGATGTTTAAGATGCGGATCCTGCCTTTAAGAAGGTATATTAGCTATTATAAGTTTCAATTAACCAAATGTGTGATGATTATTAAAAGTCAGTGTTACACATATTTACTTTGTTTTCTATTCTGATAAAGCTCATGTATGCTTTTAATTTCCCTTTAAATCTTAACTAATTTCCAAAACTATCAGTGTTTCATAAACAGCTTATAGTGCCCAGACAGAGAGCCTTGCCCTTAGTAGCACTCATCCTATTTTTGTTGAACTAAAACGAACAGCTTCTTCAGTTTTAACTCTTGCATGGTTGGCAATTGGCTGAATTGGAATGTGAAGACACATTTAGAGGAGAGAATGTTCTGTCTGAGTGCTGCAGCTGTAAGAATCTCTTCAAAAAACATAAAGTCTATTACATAAATTATGTACTCTTTAAACTCCCATGTTCATTTACACAATTGATCATGGAAACGACTTTAGAAATATGTGTATCAAATATTTAGCATATTTTTAAAGCTTCCTTAATAACATCACTAATAAGTGGATGCAATTTTGTGTTTATTTACGGCAAACACCTATGAATATCAGATAACCTAATTATAGTTTATCAACATTACCTTTGAATCATTCCAATGGAAATGTCCTCTCTCACTGCATTCATATTGTTTTGGTGCATGAGCATGGAAAACAGCAGATTATTTTCCATGATCATAGATTTTAAATATTTACTTGCTAGCGCTGCATAATTTAACGCACTAGAGTTGGAAAGCAGTTTGTATGACAGCTGATGCCATGTCAGTGTTGCAGAATATAGTTTCCTCCTGTGATTTCTGTGTGAAGTTGTAAAAAGGAAAGGTACTCTACTCCTTTTTTTCTAACCAATTAAAATTTGTTGTGGCAAATCTACAGAAAACCCAAGTCTGTAGTATACACACAATTTACTTTTGTATATATAGTTATTTTAAGAATCCAAGCATTGTTTCTCATGGCCTGTTAATGCACAATACCAAAAATAAAATACATGCATTCTTGTAATCCAGGTCTTTATGAAAGTTACAAAAAGGCATCTAAACAGCTTGTTAGATGCATGCTCTCTCTCCTAAAAAAAATCAAAACAGAGTTTGGGGATTTCGAAACAGGAAACCACAAGCTATGGAATCATGCAAGAAAACTACTTTGCTCACTCTAATAAGTGTGCCATTTGTGATCTTATCATATCCTTTGTTTGTTGTTTTGTTATTTAGCTGTCCAAGTACATGAATAAAAAATAAATAGATCCAGCTACCTGTTTCTGTGAGAATAAAAAAAAATTTAAACCACCAAATCCACTAAAAAATTGAAAAAATTTCAAGTTTAATTTTGAACTTTTCAACTCTTCATTCTTGAAGGTTTTCATTCCCATGTGGTTTCATAGTCCGGTGGCATAGACTTCATATTTTATTTTTAGTTTTTAGTATAATTTCCTATGTAATTCAGAAGCATGTCTGGTAGTCCTTGCTCCAACAAAATCTGCGGTACTGTAAAACGGCATAGGATTACATTTTACAGTAACAGTATTTCTCTTGACATCATTTAGGAGTGAAGATAAAAATTTCCACTTATTTATTTATTTATTTATTTATTTTTACTTTTTTGAGACAGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGAGGCACAATCTTGGCTCACTGAAAACTCCGCCTCCCGAGTTCAAGCGATTCTCCCGCCTCAGCCTCCTGAGTAGTTGGGACTACAGGCGCGCGCCACCGCACCCGGCTAATTTTTTATATTTTTAGTAGAGACGGGATTTCACCATGTTGGCCAGGCTGGTCTGGAACTCCTGGGCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAATGCTGGGATTACAGGCGTCAGCCGCCGCGCCTGGCCAAAAATTTCCACGTTATAAAAAGCATCTTCGGACCGTCCTTTTTTCTTTCTTTCTTTTTCTTTTCCTTCTTTTTTTTTTTTTTTTCCCCACAAAGCCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCTGCTCACTGCAACCTTTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGGCTCCCGAGTAGCTGGAATTACAGGCGCCCGCCGCCACGCCCGGCTAATTTTTTAATTTTTTAACAGAGACGGGCTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCCAACCTCAAGCGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGCGAACCACCGCGCCCGACTGTCCTGTGTTTTAATGCTTGAAAATAATCTGAATATGGAAAATGAGTGCACATATCCCTTGATGTTTTATAAATAACCTACAGTCCTAATAATGGCTTGGCTTAGAGTTCCTTCACAACAGGAAAAGAAGGCATCCTGGCTTTTTTTTTTTTTTTTTTTTTAAATCAAAGTGAGGCTTGGGTTGGCTCTATCTTGGTCCTGAGTGCGAGGAAGGAGGGCCGCAATGCATGCTGGATCTTGCAGTTCCTACGCCAGAGGCAAGGGCGTGATGCTGCATGGCCTGCTGGTAGTTGAAGTCCAAGTGCTCGAGAGGAATTTATGGCAGCCGTAATGTGGTTTGTCTATCAGAGAGACAATGCTCACAGACGGATACTTTCTCTTGGTTCTGCGCTTGCTGCATTGGTGGATTAGCGGCTTGGGGTGGCGAACAGGTGGGAAAAAGGGATGGATAAAGTAAGCATAGCAGAGGCCTTTACGCCGCTGCTATCGCTACTGCCAATCGCAAGGCTTTCGTATCCCGGAAGTGGCTGATCTGTTGGATTTGACGCGGAGGCGGTTCCTCTTACTACGGTGGCCGGGGTGCTCAAAGTACCTGTAGCTGCGGCGCTGAGGTCGGAACGTCTGCGTGTGTGCGGGCTGGTTTTGTGGCGGCTGCTGCTAGAGCTGGAGCATTTGCCGGGTTGGTGGCTCCTGCACATTTTTACAGTTCTCCAGTCCTTCTCTTTCGTCAGTATAAAAGATTAAACTCTACAGAAGAATGCAATCAAGTGATGGCTTTTCCTTTAGAATTTGAATATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAAACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAG N/A coronary artery disease Microarray; qRT-PCR peripheral blood of coronary artery disease (CAD) patients and controls N/A up-regulated N/A N/A N/A N/A We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects and 30 CAD patients with different CADS. The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients. 28045102 2017.1 Sci Rep. Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease N/A hsa_circRNA5974-1 N/A N/A N/A N/A hg19 N/A N/A N/A coronary artery disease Microarray; qRT-PCR peripheral blood of coronary artery disease (CAD) patients and controls N/A up-regulated N/A N/A N/A N/A We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects and 30 CAD patients with different CADS. The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients. 28045102 2017.1 Sci Rep. Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease N/A ciRS-7 hsa_circ_0001946; CDR1as; hsa_circRNA_105055; Cdr1as X 139865339-139866824 + hg19 CDR1 GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG antisense Alzheimer's disease northern blot; miRNA array; western blot; etc. Alzheimer¡¯s disease (AD) and age-matched control human temporal lobe and hippocampal CA1 cytoplasm down-regulated miR-7 UBE2A N/A N/A We provide evidence of a significantly misregulated ciRS-7-miRNA-7-UBE2A circuit in sporadic Alzheimer's disease (AD) neocortex (Brodmann A22) and hippocampal CA1. Deficits in ciRS-7-mediated sponging events, resulting in excess ambient miRNA-7 appear to drive the selective down-regulation in the expression of miRNA-7-sensitive mRNA targets, such as that encoding the ubiquitin conjugating enzyme E2A (UBE2A; chr Xq24). UBE2A, which normally serves as a central effector in the ubiquitin-26S proteasome system, coordinates the clearance of amyloid peptides via proteolysis, is known to be depleted in sporadic AD brain and, hence, contributes to amyloid accumulation and the formation of senile plaque deposits. Dysfunction of circRNA-miRNA-mRNA regulatory systems appears to represent another important layer of epigenetic control over pathogenic gene expression programs in the human CNS that are targeted by the sporadic AD process. 27929395 2016.12 Genes (Basel). Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7) N/A cir-ZNF609 hsa_circ_0000615; cir-ZNF609; cZNF609 15 64791491-64792365 + hg19 ZNF609 GCAATGATGTTGTCCACTGGGCATGTACTGACCAATGTGGCAGGTCTGAGAACATAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAATCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTCCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAATCTCATCATTGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCAAAGGAGGTGGGGATACCGGCTCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTGACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACACTAGCAAACCCACTCCAGGGACTTCCCTGTTCACTCCAAGTGAGGGGGCAGCTAGCAAGAAAGAGGTGCAGGGGCGCTCAGGAGATGGTGCCAATGCTGGAGGCCTGGTTGCTGCTATTGCTCCCAAGGGCTCAGAGAAGGCGGCTAAGGCATCCCGCAGTGTAGCCGGTTCCAAAAAGGAGAAGGAGAACAGCTCATCTAAGAGCAAGAAGGAGAGAAGCGAAGGAGTGGGGACTTGTTCAGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTGGTCAGTATGATGGAAGTGCAGGGGTGGATACAGGAGCTGTGGAGCCACTTGGGAGTATAGCTATTGAGCCTGGGGCAGCGCTCAATCCTTTGGGAACTAAACCGGAGCCAGAGGAAGGGGAGAATGAGTGTCGCCTGCTAAAGAAAGTCAAGTCTGAAAAG exonic Hirschsprung's disease qRT-PCR; in vitro knockdown; in vitro overexpression; western blot; dual luciferase reporter assay; RIP; etc. HSCR colon tissues; Negative controls were from patients affirmed to be without HSCR or other enteric neural malformations; SH-SY5Y cells; 293T cell lines cytoplasm down-regulated miR-150-5p AKT3 N/A N/A We reported that the cir-ZNF609 was down-regulated in HSCR compared with normal bowel tissues. Furthermore, suppression of cir-ZNF609 inhibited the proliferation and migration of cells. We screened out several putative cir-ZNF609 ceRNAs of which the AKT3 transcript was selected. Finally, RNA immunoprecipitation and luciferase reporter assays demonstrated that cir-ZNF609 may act as a sponge for miR-150-5p to modulate the expression of AKT3. In conclusion, these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p. 27903978 2017.1 Oncotarget Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease N/A hsa_circRNA_104871 hsa_circ_0088036 9 114840817-114842445 - hg19 SUSD1 TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG exonic rheumatoid arthritis microarray; qRT-PCR PBMCs from 35 patients with RA and 30 healthy controls N/A up-regulated N/A N/A N/A N/A We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis. 28618429 2017 Cell Physiol Biochem Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients N/A hsa_circRNA_003524 hsa_circ_0003524 2 131829427-131840230 - hg19 FAM168B TTTTTGAAATCATGAATCCTGTTTATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGCTGGTTTTCCCATGGGCTATGCAGCAGCAGCTCCTGCCTATTCTCCTAACATGTATCCTGGAGCGAATCCTACCTTCCAAACAG exonic rheumatoid arthritis microarray; qRT-PCR PBMCs from 35 patients with RA and 30 healthy controls N/A up-regulated N/A N/A N/A N/A We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis. 28618429 2017 Cell Physiol Biochem Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients N/A hsa_circRNA_101873 hsa_circ_0004315 16 74491771-74493687 - hg19 GLG1 ATCTCCAGTCTATGTGCTGAAGAAGCAGCAGCCCAAGAGCAGACAGGTCAGGTGGAGGAGTGCCTCAAGGTCAACCTGCTCAAGATCAAAACAGAATTGTGTAAAAAGGAAGTGCTAAACATGCTGAAGGAAAGCAAAGCAGACATCTTTGTTGACCCGGTACTTCATACTGCTTGTGCCCTGGACATTAAACACCACTGCGCAGCCATCACCCCTGGCCGCGGGCGTC exonic rheumatoid arthritis microarray; qRT-PCR PBMCs from 35 patients with RA and 30 healthy controls N/A up-regulated N/A N/A N/A N/A We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis. 28618429 2017 Cell Physiol Biochem Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients N/A hsa_circRNA_103047 hsa_circ_0060144 20 34389412-34459751 + hg19 PHF20 GAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCCCAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTCAAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGCTTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTCACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCCAAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAAGAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAAGGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAATGACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAAAGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGAAGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAAAACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCAGATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGCCAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAACACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAG exonic rheumatoid arthritis microarray; qRT-PCR PBMCs from 35 patients with RA and 30 healthy controls N/A up-regulated N/A N/A N/A N/A We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis. 28618429 2017 Cell Physiol Biochem Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients N/A ciRS-7 hsa_circ_0001946; CDR1as; hsa_circRNA_105055; Cdr1as X 139865339-139866824 + hg19 CDR1 GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG antisense hepatocellular carcinoma qRT-PCR; microarray; in vitro overexpression; iTRAQ; western blot; immunofluorescent staining; etc. HepG2, Huh7, THLE-3, MCF-7, HeLa, 293T; matched pairs of HCC samples and the matched nontumor tissues N/A down-regulated miR-7 EGFR N/A N/A A quantitative proteomics strategy was employed to globally identify CDR1as-regulated proteins in HCC cells. In total, we identified 330 differentially expressed proteins (DEPs) upon enhanced CDR1as expression in HepG2 cells, indicating that they could be proteins regulated by CDR1as. Bioinformatic analysis revealed that many DEPs were involved in cell proliferation and the cell cycle. Further functional studies of epidermal growth factor receptor (EGFR) found that CDR1as exerts its effects on cell proliferation at least in part through the regulation of EGFR expression. We further confirmed that CDR1as could inhibit the expression of microRNA-7 (miR-7). EGFR is a validated target of miR-7; therefore, CDR1as may exert its function by regulating EGFR expression via targeting miR-7 in HCC cells. Taken together, we revealed novel functions and underlying mechanisms of CDR1as in HCC cells. This study serves as the first proteome-wide analysis of a circRNA-regulated protein in cells and provides a reliable and highly efficient method for globally identifying circRNA-regulated proteins. 28892615 2017.9 J Proteome Res. Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells N/A hsa_circ_0000026 hsa_circRNA_100086 1 21377358-21437876 - hg19 EIF4G3 CAATCCCACAGAGTATTGATGAGGAAACTGAAGTTTGGAGCGATCACATCATTTTCCCAAGAATTCCTAGAGGACCTGTGCAACAACCTCTTGAGGATCGAATCTTCACTCCCGCTGTCTCAGCAGTCTACAGCACGGTAACACAAGTGGCAAGACAGCCGGGAACCCCTACCCCATCCCCTTATTCAGCACATGAAATAAACAAGGGGCATCCAAATCTTGCGGCAACGCCCCCGGGACATGCATCGTCCCCTGGACTCTCTCAA exonic gastric cancer Microarray; qRT-PCR GC and adjacent normal tissues N/A down-regulated N/A N/A N/A N/A The qPCR results were consistent with the findings of the microarray based expression analysis. Of the circRNAs studied, only circRNA 0026 (hsa_circ_0000026) exhibited significantly different expression in GC (2.8 fold, P=0.001). Furthermore, online Database for Annotation, Visualization and Integrated Discovery annotation was used to predict circRNA targeted miRNA gene interactions. The analysis revealed that circRNA 0026 may regulate RNA transcription, RNA metabolism, gene expression, gene silencing and other biological functions in GC. In conclusion, differential expression of circRNAs may be associated with GC tumorigenesis, and circRNA 0026 is a promising biomarker for GC diagnosis and targeted therapy. 28737829 2017.9 Mol Med Rep. Expression profile of circular RNAs in human gastric cancer tissues N/A hsa_circRNA_103783 hsa_circ_0007380 5 6623326-6625782 - hg19 NSUN2 GTATCCTGAAGAACTTGCCTGGCACACAAATTTAAGTCGAAAAATCTTGAGAAAATCGCCACACTTGGAAAAGTTTCATCAGTTTCTAGTTAGTGAAACAGAATCTGGAAATATTAGTCGTCAAGAAGCTGTTAGCATGATCCCACCACTGCTCCTCAACGTGCGGCCTCATCATAAG exonic leukoaraiosis Microarray; qRT-PCR peripheral blood of LA cases and control cases N/A up-regulated N/A N/A N/A N/A The expression of hsa_circ_103783 in the test group was significantly higher compared with the control group, with fold increase in expression of 3.67 (P<0.001).The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research. 28677780 2017.9 Mol Med Rep. Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes N/A hsa_circRNA_102533 hsa_circ_0006186 19 34942885-34957919 + hg19 UBA2 GAGAAGAAACGAATGCATCAGATCAACAGAATGAACCCCAGTTAGGCCTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCATCGAGACTTTGAGAGTTCATTTAGCAGAAAAGGGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCACCTCTGCTGCAAACCTCAGGATGCATATTTTCAGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTGCTATTGCTACTACTAATGCAGTAATTGCTGGGTTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAATTTTTTTGAATAAACAACCAAACCCAAGAAAGAAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCAGCAAGCCAGAGGTGACTGTGCGGCTGAATGTCCATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGGTAGCACCAGATGTCCAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGTTGTCAGAATTTGGAATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTGAAGACCTAGGAAAGGACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCATAACCAATGGCAGTGATGATGGAGCTCAGCCCTCCACCTCCACAG exonic leukoaraiosis Microarray; qRT-PCR peripheral blood of LA cases and control cases N/A up-regulated N/A N/A N/A N/A The expression of hsa_circ_102533 in the test group was significantly higher compared with the control group, with fold increase in expression of 3.52 (P<0.05).The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research. 28677780 2017.9 Mol Med Rep. Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes N/A hsa_circRNA_103827 hsa_circ_0008621 5 43292575-43297268 - hg19 HMGCS1 GGCTTCGTGGGACACATATGCAACATGCCTATGATTTTTACAAGCCTGATATGCTATCTGAATATCCTATAGTAGATGGAAAACTCTCCATACAGTGCTACCTCAGTGCATTAGACCGCTGCTATTCTGTCTACTGCAAAAAGATCCATGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTTACCTTGAATGATTTTGGCTTCATGATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTAGCTCGGATGTTGCTGAATGACTTCCTTAATGACCAGAATAGAGATAAAAATAGTATCTATAGTGGCCTGGAAGCCTTTGGGGATGTTAAATTAGAAGACACCTACTTTGATAGAGATGTGGAGAAGGCATTTATGAAGGCTAGCTCTGAACTCTTCAGTCAGAAAACAAAGGCATCTTTACTTGTATCAAATCAAAATGGAAATATGTACACATCTTCAGTATATGGTTCCCTTGCATCTGTTCTAGCACAGTACTCACCTCAGCAATTAGCAGGGAAGAGAATTGGAGTGTTTTCTTATGGTTCTGGTTTGGCTGCCACTCTGTACTCTCTTAAAGTCACACAAGATGCTACACCGGGGTCTGCTCTTGATAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGGCTTGATTCAAGAACTGGTGTGGCACCAGATGTCTTCGCTGAAAACATGAAGCTCAGAGAGGACACCCATCATTTGGTCAACTATATTCCCCAGGGTTCAATAGATTCACTCTTTGAAGGAACGTGGTACTTAGTTAGGGTGGATGAAAAGCACAGAAGAACTTACGCTCGGCGTCCCACTCCAAATGATGACACTTTGGATGAAGGAGTAGGACTTGTGCATTCAAACATAGCAACTGAG exonic maternal aging Microarray; qRT-PCR granulosa cells(GCs) from in vitro fertilization (IVF) patients with young age (YA, ¡Ü 30 years) and advanced age (AA, ¡Ý 38 years) N/A up-regulated N/A N/A N/A N/A circRNA_103827 and circRNA_104816 levels were positively associated with maternal age (partial r = 0.332, P = 0.045; partial r = 0.473, P = 0.003; respectively). Moreover, circRNA_103827 and circRNA_104816 expressions in GCs were negatively correlated with the number of top quality embryos (r = -0.235, P = 0.036; r = -0.221, P = 0.049; respectively). Receiver operating characteristic (ROC) curve analysis indicated that the performance of circRNA_103827 for live birth prediction reached 0.698 [0.570-0.825], with 77.2% sensitivity and 60.9% specificity (P = 0.006), and that of circRNA_104816 was 0.645 [0.507-0.783] (P = 0.043). Bioinformatics analysis revealed that both circRNAs were potentially involved in glucose metabolism, mitotic cell cycle, and ovarian steroidogenesis. Therefore, age-related up-regulation of circRNA_103827 and circRNA_104816 might be potential indicators of compromised follicular micro-environment which could be used to predict IVF prognosis, and improve female infertility management. 28644873 2017.6 PLoS One Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes N/A hsa_circRNA_104816 hsa_circ_0087493 9 95018961-95048121 - hg19 IARS GTGGGTCTTCAAACAACTCTATGATAAAGGCCTTGTTTATAGAGGTGTGAAAGTCATGCCCTTCTCTACGGCATGTAACACTCCACTTTCCAACTTCGAGTCACACCAGAATTATAAGGATGTTCAAGATCCTTCAGTATTTGTAACTTTCCCTTTGGAAGAAGATGAAACTGTATCTTTAGTTGCTTGGACAACCACTCCCTGGACTCTACCTAGTAACCTTGCTGTGTGTGTTAATCCAGAAATGCAATATGTGAAAATTAAAGATGTTGCCAGAGGACGATTACTCATTTTAATGGAAGCCAGATTGTCAGCCCTCTATAAATTGGAGAGTGACTATGAGATCCTTGAAAGATTTCCTGGTGCCTATCTTAAAGGCAAGAAGTACAGGCCCCTGTTTGACTATTTCCTGAAGTGTAAAGAGAATGGCGCTTTCACTGTGCTTGTTGACAACTATGTGAAGGAAGAAGAAGGCACAGGGGTTGTCCACCAAGCTCCTTACTTCGGTGCTGAGGACTATCGGGTCTGTATGGACTTTAACATTATTCGGAAAGACTCACTCCCTGTTTGCCCTGTGGATGCTTCAGGCTGCTTCACAACGGAGGTGACAGATTTCGCAGGACAGTATGTGAAGGATGCTGACAAAAGTATCATCAGGACTTTGAAGGAACAAGGCCGACTTCTGGTTGCCACCACCTTCACTCACAGCTACCCTTTTTGCTGGAGATCAGACACTCCTCTAATTTACAAAGCAGTGCCCAGCTGGTTTGTGCGAGTGGAGAACATGGTGGACCAGCTCCTAAGGAACAATGACCTGTGCTACTGGGTCCCAGAGTTGGTACGAGAAAAACGATTTGGAAATTGGCTGAAAGATGCACGTGACTGGACAATTTCCAGAAACAGATACTGGGGCACCCCCATCCCACTGTGGGTCAGCGATGACTTTGAGGAGGTGGTATGCATTGGGTCAGTGGCGGAACTTGAAGAACTGTCAGGAGCAAAGATCTCAGATCTCCACAGAGAGAGTGTTGACCACCTGACCATTCCTTCACGCTGTGGGAAGGGATCCTTGCACCGCATCTCTGAAGTGTTTGACTGTTGGTTTGAGAGTGGCAGCATGCCCTATGCTCAGGTTCATTACCCGTTTGAAAACAAGAGGGAGTTTGAGGATGCTTTTCCTGCAGATTTCATTGCCGAGGGCATCGACCAAACCAGAGGATGGTTTTATACCCTGCTGGTGCTGGCCACGGCCCTCTTTGGACAACCGCCTTTCAAGAACGTAATTGTGAATGGGCTTGTCCTGGCAAGTGATGGCCAAAAAATGAGCAAACGGAAAAAGAATTATCCAGATCCAGTTTCCATCATCCAGAAGTATGGTGCTGATGCCCTCAGATTATATCTGATTAACTCCCCTGTGGTGAGAGCAGAAAACCTCCGCTTTAAAGAAGAGGGTGTGCGGGACGTCCTTAAGGATGTACTGCTCCCATGGTACAATGCCTATCGCTTCTTAATCCAGAACGTTCTGAGGCTCCAGAAGGAGGAAGAAATAGAATTTCTCTACAATGAGAACACGGTTAGAGAAAGCCCCAACATTACAGACCGGTGGATCCTGTCCTTCATGCAGTCTCTCATTGGCTTCTTTGAGACTGAAATGGCAG exonic maternal aging Microarray; qRT-PCR granulosa cells(GCs) from in vitro fertilization (IVF) patients with young age (YA, ¡Ü 30 years) and advanced age (AA, ¡Ý 38 years) N/A up-regulated N/A N/A N/A N/A circRNA_103827 and circRNA_104816 levels were positively associated with maternal age (partial r = 0.332, P = 0.045; partial r = 0.473, P = 0.003; respectively). Moreover, circRNA_103827 and circRNA_104816 expressions in GCs were negatively correlated with the number of top quality embryos (r = -0.235, P = 0.036; r = -0.221, P = 0.049; respectively). Receiver operating characteristic (ROC) curve analysis indicated that the performance of circRNA_103827 for live birth prediction reached 0.698 [0.570-0.825], with 77.2% sensitivity and 60.9% specificity (P = 0.006), and that of circRNA_104816 was 0.645 [0.507-0.783] (P = 0.043). Bioinformatics analysis revealed that both circRNAs were potentially involved in glucose metabolism, mitotic cell cycle, and ovarian steroidogenesis. Therefore, age-related up-regulation of circRNA_103827 and circRNA_104816 might be potential indicators of compromised follicular micro-environment which could be used to predict IVF prognosis, and improve female infertility management. 28644873 2017.6 PLoS One Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes N/A circRNAs-MSR hsa_circ_0005567; hsa_circRNA_100226 1 51868106-51874004 - hg19 EPS15 ATCTCTTCTCTGAAAGCTGAATTAACTAGTCAGGAATCGCAGATCTCCACTTACGAAGAAGAATTGGCAAAAGCTAGAGAAGAGCTGAGCCGTCTACAGCAAGAAACAGCAGAATTGGAGGAGAGTGTAGAGTCAGGGAAGGCTCAGTTGGAACCTCTTCAGCAGCACCTACAAGATTCACAACAGGAAATTAGTTCAATGCAAATGAAACTGATGGAAATGAAAGATTTGGAAAATCATAATAGTCAGTTAAATTGGTGCAGTAGCCCACACAGCATTCTTGTAAACGGAGCTACAGATTATTGCAGCCTCAGCACCAGCAGCAGTGAAACAGCCAACCTTAATGAACATGTTGAAGGCCAGAGCAACCTAGAGTCTGAGCCCATACACCAGGAATCTCCAGCAAGAAGTAGTCCTGAACTACTGCCTTCTGGTGTGACTGATGAAAATGAGGTGACTACAGCTGTTACTGAAAAAGTTTGTTCTGAACTCGACAATAATAGACATTCAAAAGAGGAAGATCCATTTAATGTAGACTCAAGTTCGCTGACAGGTCCAGTTGCAGATACAAACTTGGATTTTTTCCAGTCTGATCCTTTTGTTGGCA exonic osteoarthritis Microarray; qRT-PCR; in vitro knockdown; etc. damaged region and intact region of the cartilage in OA N/A up-regulated miR-875 TNF-a(predicted) N/A N/A circRNA-MSR expression increased under mechanical stress in chondrocytes. circRNAs-MSR were silenced using small interfering RNA, and knockdown of circRNAs-MSR could suppress tumor necrosis factor alpha (TNF-¦Á) expression and increase extracellular matrix (ECM) formation. Our results demonstrated that circRNAs-MSR regulated TNF-¦Á expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA. 28624198 2017.6 Mol Ther Nucleic Acids Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis N/A hsa_circRNA_000598 hsa_circ_0000589 15 31645077-31645307 - hg19 KLF13 CCCAGCCCCCTGGCCCAGGGTCCCTTCCCTGTCACTACCTCTGCAGTCCCTCCTCCCCTGGAAGGCCCACCCAGAGCAAGCCGCACACTCCAAGGCGGCATCAACAGAGCCCACAGCCTAGGTGGGCTGCATGGTGGCTGCATACAGACGGGGAGGTGGGTCCAGCCTCGTCATGCTCCACGGTCAAGAAACTGCCCTCCCCACAAAAACTCCAAGTAGCCACCCTGGAG antisense osteoarthritis Microarray; qRT-PCR damaged region and intact region of the cartilage in OA N/A up-regulated N/A N/A N/A N/A To validate the circRNA microarray results, we performed qPCR to analyze the changes in expression among the differentially expressed circRNAs. The data confirmed that circRNA_000598, circRNA_103387, circRNA_101975, and circRNA_100226 (circRNAs-MSR) were overexpressed in the damaged region compared with the intact region of the cartilage in OA. 28624198 2017.6 Mol Ther Nucleic Acids Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis N/A hsa_circRNA_103387 hsa_circ_0065932 3 51675764-51677990 + hg19 RAD54L2 CCAGAGTCTTTCCACCTTGGCTCTCATCGAGGAATTCCTTGGAAAACGAGAAGTACCCTGTCCACCTGGTACCGAGGGGCAAGGAGCACAGAAGTGGGTTCGAAACATCAGCTACTTCCGGCTAGATGGTAGCACCCCTGCCTTTGAGAGGGAGCGGCTTATTAATCAGTTCAATGATCCCAGCAACCTCACCACCTGGCTGTTCCTTCTCTCTACAAG exonic osteoarthritis Microarray; qRT-PCR damaged region and intact region of the cartilage in OA N/A up-regulated N/A N/A N/A N/A To validate the circRNA microarray results, we performed qPCR to analyze the changes in expression among the differentially expressed circRNAs. The data confirmed that circRNA_000598, circRNA_103387, circRNA_101975, and circRNA_100226 (circRNAs-MSR) were overexpressed in the damaged region compared with the intact region of the cartilage in OA. 28624198 2017.6 Mol Ther Nucleic Acids Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis N/A hsa_circRNA_101975 hsa_circ_0008310 17 7849045-7849304 + hg19 CNTROB GCTCCTCCTGCTGGACCCTCCAGCCCCGGGCCTCAGGAGCCCGAGAAGGAGGAGAGGAGGGTCTGGACTATGCCTCCCATGGCCGTGGCCCTGAAGCCTGTATTGCAGCAGAGCCGGGAAGCAAGGGACGAGCTACCTGGAGCGCCTCCTGTTCTTTGCAGTTCCTCCTCAGATCTTAGCCTCCTGTTGGGCCCCTCTTTTCAGAGCCAGCATTCTTTCCAGCCCCTGGAGCCCAAACCAGACCTCACTTCATCCACAG exonic osteoarthritis Microarray; qRT-PCR damaged region and intact region of the cartilage in OA N/A up-regulated N/A N/A N/A N/A To validate the circRNA microarray results, we performed qPCR to analyze the changes in expression among the differentially expressed circRNAs. The data confirmed that circRNA_000598, circRNA_103387, circRNA_101975, and circRNA_100226 (circRNAs-MSR) were overexpressed in the damaged region compared with the intact region of the cartilage in OA. 28624198 2017.6 Mol Ther Nucleic Acids Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis N/A hsa_circ_0010729 N/A 1 22186058-22207328 - hg19 HSPG2 GTGGACTCCTATGGCGGCTCCCTGCGTTACAACGTGCGCTACGAGTTGGCCCGTGGCATGCTGGAGCCAGTGCAGCGGCCGGACGTGGTCCTCATGGGTGCCGGGTACCGCCTCCTCTCCCGAGGCCACACACCCACCCAACCTGGTGCTCTGAACCAGCGCCAGGTCCAGTTCTCTGAGGAGCACTGGGTCCATGAGTCTGGCCGGCCGGTGCAGCGCGCGGAGCTGCTGCAGGTGCTGCAGAGCCTGGAGGCCGTGCTCATCCAGACCGTGTACAACACCAAGATGGCCAGCGTGGGACTTAGCGACATCGCCATGGATACCACCGTCACCCATGCCACCAGCCATGGCCGTGCCCACAGTGTGGAGGAGTGCAGATGCCCCATTGGCTATTCTGGCTTGTCCTGCGAGAGCTGTGATGCCCACTTCACTCGGGTGCCTGGTGGGCCCTACCTGGGCACCTGCTCTGGTTGCAATTGCAATGGCCATGCCAGCTCCTGTGACCCTGTGTATGGCCACTGCCTGAATTGCCAGCACAACACGGAGGGGCCACAGTGCAACAAGTGCAAGGCTGGCTTCTTTGGGGACGCCATGAAGGCCACGGCCACTTCCTGCCGGCCCTGCCCTTGCCCATACATCGATGCCTCCCGCAGATTCTCAGACACTTGCTTCCTGGACACGGATGGCCAAGCCACATGTGACGCCTGTGCCCCAGGCTACACTGGCCGCCGCTGTGAGAGCTGTGCCCCCGGATACGAGGGCAACCCCATCCAGCCCGGCGGGAAGTGCAGGCCCGTCAACCAGGAGATTGTGCGCTGTGACGAGCGTGGCAGCATGGGGACCTCCGGGGAGGCCTGCCGCTGTAAGAACAATGTGGTGGGGCGCTTGTGCAATGAATGTGCTGACGGCTCTTTCCACCTGAGTACCCGAAACCCCGATGGCTGCCTCAAGTGCTTCTGCATGGGTGTCAGTCGCCACTGCACCAGCTCTTCATGGAGCCGTGCCCAGTTGCATGGGGCCTCTGAGGAGCCTGGTCACTTCAGCCTGACCAACGCCGCAAGCACCCACACCACCAACGAGGGCATCTTCTCCCCCACGCCCGGGGAACTGGGATTCTCCTCCTTCCACAGACTCTTATCTGGACCCTACTTCTGGAGCCTCCCTTCACGCTTCCTGGGGGACAAGGTGACCTCCTATGGAGGAGAGCTGCGCTTCACAGTGACCCAGAGGTCCCAGCCGGGCTCCACACCCCTGCACGGGCAGCCGTTGGTGGTGCTGCAAGGTAACAACATCATCCTAGAGCACCATGTGGCCCAGGAGCCCAGCCCCGGCCAGCCCAGCACCTTCATTGTGCCTTTCCGGGAGCAAGCATGGCAGCGGCCCGATGGGCAGCCAGCCACACGGGAGCACCTGCTGATGGCACTGGCAGGCATCGACACCCTCCTGATCCGAGCATCCTACGCCCAGCAGCCCGCTGAGAGCAGGGTCTCTGGCATCAGCATGGACGTGGCTGTGCCCGAGGAAACCGGCCAGGACCCCGCGCTGGAAGTGGAACAGTGCTCCTGCCCACCCGGGTACCGTGGGCCGTCCTGCCAGGACTGTGACACAGGCTACACACGCACGCCCAGTGGCCTCTACCTGGGTACCTGTGAACGCTGCAGCTGCCATGGCCACTCAGAGGCCTGCGAGCCAGAAACAGGTGCCTGCCAGGGCTGCCAGCATCACACGGAGGGCCCTCGGTGTGAGCAGTGCCAGCCAGGATACTACGGGGACGCCCAGCGGGGGACACCACAGGACTGCCAGCTGTGCCCCTGCTACGGAGACCCTGCTGCCGGCCAGGCTGCCCACACTTGTTTTCTGGACACAGACGGCCACCCCACCTGTGATGCGTGCTCCCCAGGCCACAGTGGGCGTCACTGTGAGAGGTGCGCCCCTGGCTACTATGGCAACCCCAGCCAGGGCCAGCCATGCCAGAGAGACAGCCAGGTGCCAGGGCCCATAGGCTGCAACTGTGACCCCCAAGGCAGCGTCAGCAGCCAGTGTGATGCTGCTGGTCAGTGCCAGTGCAAGGCCCAGGTGGAAGGCCTCACTTGCAGCCACTGCCGGCCCCACCACTTCCACCTGAGTGCCAGCAACCCAGACGGCTGCCTGCCCTGCTTCTGTATGGGCATCACCCAGCAGTGCGCCAGCTCTGCCTACACACGCCACCTGATCTCCACCCACTTTGCCCCTGGGGACTTCCAAGGCTTTGCCCTGGTGAACCCACAGCGAAACAGCCGCCTGACAGGAGAATTCACTGTGGAACCCGTGCCCGAGGGTGCCCAGCTCTCTTTTGGCAACTTTGCCCAACTCGGCCATGAGTCCTTCTACTGGCAGCTGCCGGAGACATACCAGGGAGACAAGGTGGCGGCCTACGGTGGGAAGTTGCGATACACCCTCTCCTACACAGCAGGCCCACAGGGCAGCCCACTCTCTGACCCCGATGTGCAGATCACGGGCAACAACATCATGCTAGTGGCCTCCCAGCCAGCGCTGCAGGGCCCTGAGAGGAGGAGCTACGAGATCATGTTCCGAGAGGAATTCTGGCGCCGGCCCGATGGGCAGCCGGCCACACGCGAGCACCTCCTGATGGCACTGGCCGACCTGGATGAGCTCCTGATCCGGGCCACGTTCTCCTCCGTGCCGCTGGCGGCCAGCATCAGCGCAGTCAGCCTGGAGGTCGCCCAGCCGGGGCCCTCAAACAGACCCCGCGCCCTCGAGGTGGAGGAGTGCCGCTGCCCGCCAGGCTACATCGGTCTGTCCTGCCAGGACTGTGCCCCCGGCTACACGCGCACCGGGAGTGGGCTCTACCTCGGCCACTGCGAGCTATGTGAATGCAATGGCCACTCAGACCTGTGCCACCCAGAGACTGGGGCCTGCTCGCAATGCCAGCACAACGCCGCAGGGGAGTTCTGCGAGCTTTGTGCCCCTGGCTACTACGGAGATGCCACAGCCGGGACGCCTGAGGACTGCCAGCCCTGTGCCTGCCCACTGACCAACCCAGAGAACATGTTTTCCCGCACCTGTGAGAGCCTGGGAGCCGGCGGGTACCGCTGCACGGCCTGCGAACCCGGCTACACTGGCCAGTACTGTGAGCAGTGTGGCCCAGGTTACGTGGGTAACCCCAGTGTGCAAGGGGGCCAGTGCCTGCCAGAGACAAACCAAGCCCCACTGGTGGTCGAGGTCCATCCTGCTCGAAGCATAGTGCCCCAAGGTGGCTCCCACTCCCTGCGGTGTCAGGTCAGTGGGAGCCCACCCCACTACTTCTATTGGTCCCGTGAGGATGGGCGGCCTGTGCCCAGCGGCACCCAGCAGCGACATCAAGGCTCCGAGCTCCACTTCCCCAGCGTCCAGCCCTCGGATGCTGGGGTCTACATTTGCACCTGCCGTAATCTCCACCAATCCAATACCAGCCGGGCAGAGCTGCTGGTCACTG exonic angiogenesis Microarray; RT-PCR; qRT-PCR; in vitro knockdown; western blot; dual luciferase reporter assay; etc. hypoxia induced HUVECs and HEK293T cells N/A up-regulated miR-186 HIF-1a N/A N/A Hsa_circ_0010729 was selected as candidate circRNA and which was validated to be significantly up-regulated using RT-PCR. In loss-of-function experiments of HUVECs, hsa_circ_0010729 knockdown suppressed the proliferation and migration ability and enhanced apoptosis. Bioinformatic prediction and luciferase assay revealed that hsa_circ_0010729 and hypoxia inducible factor 1 alpha (HIF-1¦Á) were targeted by miR-186. Validation experiments verified that hsa_circ_0010729 was co-expressed with HIF-1¦Á, being negatively correlated with miR-186. Moreover, rescue experiments demonstrated that miR-186 inhibitor could reverse the role of hsa_circ_0010729 knockdown on HUVECs progression. Overall, the present study identifies the crucial regulation of hsa_circ_0010729 on vascular endothelial cell proliferation and apoptosis via targeting miR-186/HIF-1¦Á axis. 28571741 2017.8 Biochem Biophys Res Commun Circular RNA hsa_circ_0010729 regulates vascular endothelial cell proliferation and apoptosis by targeting the miR-186/HIF-1¦Á axis N/A hsa_circRNA_103110 hsa_circ_0004771 21 16386664-16415895 - hg19 NRIP1 GAAGTGTTTGGATTGTGAGCTATTTCAGAACTGTTCTCAGGACTCATTATTTTAACATTTGGGAGAAACACAGCCAGAAGATGCACACTTGACTGAAGGAGGACAGGGAATCTGAAGACTCCGGATGACATCAGAGCTACTTTTCAACAGCCTTCTCAATTTTCTTTCTCAGAAAGCAGAGGCTCAGAGCTTGGAGACAGACG exonic breast cancer Microarray; qRT-PCR breast cancer and adjacent normal-appearing tissues N/A up-regulated N/A N/A N/A N/A The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements. The area under the receiver operating characteristic curve for distinguishing breast cancer was 0.82 (95% CI: 0.73-0.90) when hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were used in combination. This study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. 28484086 2017.7 Oncotarget Identification of circular RNAs as a promising new class of diagnostic biomarkers for humanbreast cancer N/A hsa_circRNA_104689 hsa_circ_0001824; hsa_circ_001608 8 131164981-131181313 - hg19 ASAP1 TTTCTTTCAAGATGGCTTGAAAACAGCTGATAAGTTGAAACAGTACATTGAAAAACTGGCTGCTGATTTATATAATATAAAACAGACCCAGGATGAAGAAAAGAAACAGCTAACTGCACTCCGAGACTTAATAAAATCCTCTCTTCAACTGGATCAGAAAGAAGATTCTCAGAGCCGGCAAGGAGGATACAGCATGCATCAGCTCCAGGGCAATAAGGAATATGGCAGTGAAAAGAAGGGGTACCTGCTAAAGAAAAGTGACGGGATCCGGAAAGTATGGCAGAGGAGGAAGTGTTCAGTCAAGAATGGGATTCTGACCATCTCACATGCCACA exonic breast cancer Microarray; qRT-PCR breast cancer and adjacent normal-appearing tissues N/A up-regulated N/A N/A N/A N/A The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements. The area under the receiver operating characteristic curve for distinguishing breast cancer was 0.82 (95% CI: 0.73-0.90) when hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were used in combination. This study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. 28484086 2017.7 Oncotarget Identification of circular RNAs as a promising new class of diagnostic biomarkers for humanbreast cancer N/A hsa_circRNA_104821 hsa_circ_0001875; hsa_circ_001209 9 96233422-96261168 + hg19 FAM120A GTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGGTTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGCCCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCGTTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACATCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAACATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAAGAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAG exonic breast cancer Microarray; qRT-PCR breast cancer and adjacent normal-appearing tissues N/A up-regulated N/A N/A N/A N/A The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements. The area under the receiver operating characteristic curve for distinguishing breast cancer was 0.82 (95% CI: 0.73-0.90) when hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were used in combination. This study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. 28484086 2017.7 Oncotarget Identification of circular RNAs as a promising new class of diagnostic biomarkers for humanbreast cancer N/A hsa_circRNA_006054 hsa_circ_0006054 19 34818325-34821252 + hg19 KIAA0355 GCGACATCTAGACTAAGAGAAAGAGGCTGTGATGGTTGCCTGGCAGGAATTGAAGTTCAACAACTCTTTTGTTCTCAAAGTGCAGCAATTCCTGAGCACCAGCTAAAAGAACTGAACATAAAAATCGACAGTGCTTTGCAAGCATATAAGATAGCTCTGGAAAGCTTAGGACACTGTGAATATGCAATGAAAGCCGGCTTCCACCTGAATCCAAAGGCGATTGAAGCAAGTTTGCAGGGCTGCTGCAGCGAGGCGGAAGCCCAGCAGACGGGGCGGAGGCAGACACCCCCGCAGCCCATGCAGTGTGAGCTCCCCACCGTCCCTGTGCAGATAGGATCGCACTTCCTGAAGGGCGTCTCCTTTAATGAGTCGGCCGCCGACAATCTGAAACTTAAGACGCATACAATGTTACAGCTGATGAAGGAGGCAGGCTGCTATAATGGAATCACATCCAGGGATGATTTTCCTGTGACTGAAGTGCTGAACCAGGTTTGCCCTTCCACATGGCGAGGTGCCTGCAAGACGGCGGTGCAGCTGCTGTTTGGCCAGGCTGGACTG exonic breast cancer Microarray; qRT-PCR breast cancer and adjacent normal-appearing tissues N/A down-regulated N/A N/A N/A N/A The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements. The area under the receiver operating characteristic curve for distinguishing breast cancer was 0.82 (95% CI: 0.73-0.90) when hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were used in combination. This study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. 28484086 2017.7 Oncotarget Identification of circular RNAs as a promising new class of diagnostic biomarkers for humanbreast cancer N/A hsa_circRNA_100219 hsa_circ_0004619 1 51121113-51210447 - hg19 FAF1 GAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGGCCAACTTCTGCTACAGACGACTCA exonic breast cancer Microarray; qRT-PCR breast cancer and adjacent normal-appearing tissues N/A down-regulated N/A N/A N/A N/A The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements. The area under the receiver operating characteristic curve for distinguishing breast cancer was 0.82 (95% CI: 0.73-0.90) when hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were used in combination. This study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. 28484086 2017.7 Oncotarget Identification of circular RNAs as a promising new class of diagnostic biomarkers for humanbreast cancer N/A hsa_circRNA_406697 N/A N/A N/A N/A N/A RBM22 N/A N/A breast cancer Microarray; qRT-PCR breast cancer and adjacent normal-appearing tissues N/A down-regulated N/A N/A N/A N/A The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements. The area under the receiver operating characteristic curve for distinguishing breast cancer was 0.82 (95% CI: 0.73-0.90) when hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were used in combination. This study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. 28484086 2017.7 Oncotarget Identification of circular RNAs as a promising new class of diagnostic biomarkers for humanbreast cancer N/A circ-ZNF609 hsa_circ_0000615; circ-ZNF609; cZNF609 15 64791491-64792365 + hg19 ZNF609 N/A N/A Duchenne muscular dystrophy RNA-seq; qRT-PCR; etc. human WT and DMD primary myoblasts cytoplasm up-regulated N/A N/A N/A N/A Circ-ZNF609, which is downregulated during myogenesis in control myoblasts, was instead found at elevated levels in DMD conditions. This is consistent with the delayed differentiation phenotype of dystrophic primary myoblasts and with the persistence of a high proportion of proliferating,non-fusing myoblasts. These data reinforce further the connection of circ-ZNF609 and myoblast proliferation. 28344082 2017.4 Mol Cell Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis N/A circ-BNC2 N/A 9 16435552-16437522 N/A hg19 BNC2 N/A N/A Duchenne muscular dystrophy RNA-seq; qRT-PCR; etc. human control (WT) and Duchenne (DMD) myocytes cytoplasm down-regulated N/A N/A N/A N/A Interestingly, both circ-QKI and circ-BNC2, upregulated during in vitro differentiation of control myoblasts, were downregulated in DMD conditions, well correlating with the notion that dystrophic cells have altered progression into the differentiation process. 28344082 2017.4 Mol Cell Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis N/A circ-QKI N/A 6 163876310-163956157 N/A hg19 QKI N/A N/A Duchenne muscular dystrophy RNA-seq; qRT-PCR; etc. human control (WT) and Duchenne (DMD) myocytes cytoplasm down-regulated N/A N/A N/A N/A Interestingly, both circ-QKI and circ-BNC2, upregulated during in vitro differentiation of control myoblasts, were downregulated in DMD conditions, well correlating with the notion that dystrophic cells have altered progression into the differentiation process. 28344082 2017.4 Mol Cell Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis N/A hsa_circRNA_100395 hsa_circ_0015278 1 173726114-173744981 + hg19 KLHL20 TTGGTGGTTGGTGCAGTGGAGATGCCATTTCCAGTGTTGAACGATATGATCCACAGACCAATGAATGGAGAATGGTGGCTTCAATGAGCAAAAGGAGATGCGGAGTTGGGGTCAGTGTTCTTGATGATCTGTTATATGCAGTAGGAGGCCATGATGGATCCTCTTATCTCAATAGTGTTGAAAGGTATGACCCCAAAACAAACCAGTGGAGCAGTGATGTGGCCCCTACAAGCACCTGCAGGACAAGTGTTGGTGTAGCAGTACTTGGAGGCTTTCTTTATGCTGTGGGTGGCCAGGATGGTGTGTCTTGCCTCAACATTGTTGAGAGGTATGATCCGAAGGAGAACAAGTGGACTCGGGTAGCTTCTATGAGTACCAGAAGACTAGGTGTGGCTGTGGCTGTGTTAGGAGGGTTCTTATATGCTGTAGGTGGCTCTGACGGGACATCTCCTCTCAACACAGTGGAACGTTACAATCCTCAGGAAAACAGATGGCACACTATAGCCCCTATGGGGACCCGGAGGAAACACCTAGGCTGTGCAGTATATCAGGACATGATCTATGCTGTAGGAGGTAGAGATGACACTACAGAGCTGAGCAGTGCTGAGAGATACAACCCCAGAACCAACCAGTGGTCTCCAGTGGTGGCCATGACATCACGCCGTAGTGGA exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A down-regulated miR-141-3p; miR-200a-3p(predicted) N/A N/A N/A One downregulated circRNA (hsa_circRNA_100395) showed interactive potential with two cancer-related miRNAs (miR-141-3p and miR-200a-3p). From this analysis, we identified several promising cancer-related genes that may be targets of the dysregulated hsa_circRNA_100395/miR-141-3p/miR-200a-3p axis in PTC tumors. 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_100777 hsa_circ_0021553 11 30557540-30602041 - hg19 MPPED2 AAATGCACAGCGGTATTGATGAGTAGATCCTTGGATTCAGAGGTTGGCTGAAACGCACCATGCCTGCTTCCATCTTTTGCTCTGTAAAGTTGTGAATTGCTCATGCCTATAGGGAGGAAGGATGGCACATGGGATTCCTTCTCAAGGCAAAGTTACCATAACGGTGGATGAGTACAGCTCAAACCCCACCCAGGCATTCACGCACTACAACATCAACCAGAGCAGATTCCAGCCTCCACATGTACATATGGTCGACCCCATCCCATATGACACTCCAAAACCAGCGGGCCACACGCGGTTTGTCTGCATCTCAGACACACACTCCAGAACAGATGGTATCCAGATGCCTTATGGGGACATCCTTCTCCACACAGGCGATTTCACCGAGCTGGGACTGCCCTCAGAGGTTAAGAAGTTTAATGACTGGTTAG exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A down-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_104348 hsa_circ_0079891 7 37250990-37382367 - hg19 ELMO1 GTATAGACACGTGTGGCCGTTTACGCTGTAGGATCCTCATTCCCACTGGCTTTGAACATTTTGGGGACTTACAATGCCGCCACCCGCGGACATCGTCAAGGTGGCCATAGAATGGCCGGGCGCCTACCCCAAACTCATGGAAATTGATCAGAAAAAACCACTGTCTGCAATAATAAAGGAAGTCTGTGATGGGTGGTCTCTTGCCAACCATGAATATTTTGCACTCCAGCATGCCGATAGTTCAAACTTCTATATCACAGAAAAGAACCGCAATGAGATAAAAAATGGCACTATCCTTCGATTAACCACATCTCCAGCTCAGAACGCCCAGCAGCTCCATGAACGAATCCAGTCCTCGAGTATGGATGCCAAGCTGGAAGCCCTGAAGGACTTGGCCAGCCTCTCCCGGGATGTCACGTTTGCCCAGGAGTTTATAAACCTGGACGGTATCTCTCTCCTCACGCAGATGGTGGAGAGCGGCACTGAGCGATACCAGAAATTGCAGAAGATCATGAAGCCTTGCTTTGGAGACATGCTGTCCTTCACCCTGACGGCCTTCGTTGAGCTGATGGACCATGGCATAGTGTCCTGGGATACATTTTCGGTGGCGTTCATTAAGAAGATAGCAAGTTTTGTGAACAAGTCAGCCATAGACATCTCGATCCTGCAGCGGTCCTTGGCCATTTTGGAGTCGATGGTGCTCAATAGCCATGACCTCTACCAGAAAGTGGCGCAGGAGATCACCATCGGCCAGCTCATTCCACACCTGCAAGGGTCAGATCAAGAAATCCAAACCTATACTATTGCAGTGATTAATGCGCTTTTCCTGAAGGCTCCTGATGAGAGGAGGCAGGAGATGGCGAATATTTTGGCTCAGAAGCAACTGCGTTCCATCATTTTAACACATGTCATCCGAGCCCAGCGGGCCATCAACAATGAGATGGCGCACCAGCTGTATGTTCTACAAGTGCTCACCTTTAACCTCCTGGAAGACAGGATGATGACCAAAATGGACCCCCAGGACCAGGCTCAGAGGGACATCATATTTGAACTTCGAAGAATTGCTTTTGATGCTGAGTCTGAACCTAACAACAGCAGTGGCAGCATGGAGAAACGCAAGTCCATGTACACGCGAGATTATAAGAAGCTTGGGTTCATT exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A down-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_103454 hsa_circ_0067103 3 125032151-125032500 - hg19 ZNF148 GCAGTTATACTTAAGCATGAACATTGACGACAAACTGGAAGGATTGTTTCTTAAATGTGGCGGCATAGACGAAATGCAGTCTTCCAGGACAATGGTTGTAATGGGTGGAGTGTCTGGCCAGTCTACTGTGTCTGGAGAGCTACAGGATTCAGTACTTCAAGATCGAAGTATGCCTCACCAGGAGATCCTTGCTGCAGATGAAGTGTTACAAGAAAGTGAAATGAGACAACAGGATATGATATCACATGATGAACTCATGGTCCATGAGGAGACAGTGAAAAATGATGAAGAGCAGATGGAAACACATGAAAGACTTCCTCAAGGACTACAGTATGCACTTAATGTCCCT exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A down-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_104566 hsa_circ_0004458 8 18656804-18662408 - hg19 PSD3 CAATGCTGGGGTGAAAACAACACGGCTAGAAGCTCATTCTGAAATGGGGAGCACTGAAATTTTGGAAAAGGAGACCCCAGAAAATCTCAGTAATGGTACCAGCAGCAATGTGGAAGCAGCCAAAAGGTTGGCCAAACGCCTTTATCAGCTGGACAGATTCAAAAGATCAGATGTTGCAAAACACCTTGGCAAGAACAACGAATTTAGCAAACTAGTTGCAGAAGAATATCTGAAGTTTTTTGATTTTACAGGAATGACGCTGGATCAGTCACTCAGGTATTTCTTTAAAGCATTCTCTCTTGTGGGAGAAACTCAAGAACGAGAGAGAGTTTTAATACACTTCTCCAATAGATATTTTTATTGTAACCCAGATACCATTGCTTCACAAGATGGAGTCCATTGCCTTACCTGTGCAATAATGCTTCTTAATACCGATCTACATGGCCAC exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_104565 hsa_circ_0002111 8 18622958-18662408 - hg19 PSD3 CAATGCTGGGGTGAAAACAACACGGCTAGAAGCTCATTCTGAAATGGGGAGCACTGAAATTTTGGAAAAGGAGACCCCAGAAAATCTCAGTAATGGTACCAGCAGCAATGTGGAAGCAGCCAAAAGGTTGGCCAAACGCCTTTATCAGCTGGACAGATTCAAAAGATCAGATGTTGCAAAACACCTTGGCAAGAACAACGAATTTAGCAAACTAGTTGCAGAAGAATATCTGAAGTTTTTTGATTTTACAGGAATGACGCTGGATCAGTCACTCAGGTATTTCTTTAAAGCATTCTCTCTTGTGGGAGAAACTCAAGAACGAGAGAGAGTTTTAATACACTTCTCCAATAGATATTTTTATTGTAACCCAGATACCATTGCTTCACAAGATGGAGTCCATTGCCTTACCTGTGCAATAATGCTTCTTAATACCGATCTACATGGCCACAATATTGGAAAGAAGATGACCTGTCAGGAGTTCATTGCAAATCTGCAAGGGGTAAATGAGGGTGTTGATTTCTCCAAGGATCTGCTGAAA exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_104595 hsa_circ_0008016 8 38287199-38287466 - hg19 FGFR1 CCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTGGAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTCAATGTTTCAG exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_103110 hsa_circ_0004771 21 16386664-16415895 - hg19 NRIP1 GAAGTGTTTGGATTGTGAGCTATTTCAGAACTGTTCTCAGGACTCATTATTTTAACATTTGGGAGAAACACAGCCAGAAGATGCACACTTGACTGAAGGAGGACAGGGAATCTGAAGACTCCGGATGACATCAGAGCTACTTTTCAACAGCCTTCTCAATTTTCTTTCTCAGAAAGCAGAGGCTCAGAGCTTGGAGACAGACG exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_105038 hsa_circ_0091894 X 153581139-153581292 - hg19 FLNA GCTATGGTGGGCTCAGCCTGTCCATTGAGGGCCCCAGCAAGGTGGACATCAACACAGAGGACCTGGAGGACGGGACGTGCAGGGTCACCTACTGCCCCACAGAGCCAGGCAACTACATCATCAACATCAAGTTTGCCGACCAGCACGTGCCTG exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_400064 hsa_circ_0092315 21 45545508-45545708 + hg19 PWP2 CCACGCCCCATCGGGGCAGAAGCCCACTGTCCCCTAAATGTTTCTGGGGGAAAGTGTCCTTGGCATTTTCACAAGGGAGTAGACGGCCATCCTCGCTGTGAGCCCCAGCCTTTGTGATGGTGGCAGCAATGCCAGCATGTAGACCTCAGTCCATCCCCCTCCGCAGCCTCCGCACCTGCCCTGCTCCACAGCTTCCACAC intronic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_104268 hsa_circ_0078738 6 170033042-170058454 - hg19 WDR27 CTCCTGTGTCCTACCGACCTCTCCACTGTATCTGGGAATTGCCAAGGAGAAGAGTACCAAGGCTGCTAGTGAACAGCGACGTGCTGCACGGAACGTCATGAAGGACCAACGCCTGGTTTTCCATAGTAAAGTTAGGTCATCTGGTTATGCGTCAGCACCACATGTAACTATGTTTTCACCAAAGACCAACATCAAGAGTGAGGGGAAAGGATCTTCAAGGAGCAGGAGCAGCTGCGCACGGGAGGCATACCCCGTGGAGTGCGCTGTGCCCACCAAGCCCGGCCCCCAGGTCGCTGCCGCCCCCACCTGCACACGTGTATGCTGCATCCAGTACTCAGGAGATGGGCAGTGGCTGGCCTGTGGGTTGGCCAACCATCTGTTACTCGTTTTTGATGCCAGCCTGACTGGGACACCTGCTGTGTTTTCAGGTCACGACGGGGCAGTGAATGCCGTGTGCTGGAGCCAGGACCGGAGGTGGCTGCTCTCTGCGGCCCGGGACGGGACCCTGCGAATGTGGTCGGCTCGTGGGGCAGAGCTCGCACTGCTTCTGGGCAAAGACATGTTTTCTAAACCTATACAGTCTGCACAGTTCTATTATATAGATGCCTTTATATTGTTATCTTCTGGCCCTGAATTTCAGCTACTGAGGTATCACATTGACACTTGCAAAGATGAGATTAAGAGATATAAACAGAAGAGCAAGTCCAAGCTGATTTGCAGGCTCTCCACGACGGGTGCAGTAGACATGACCAGTTTATCGGCAGTCAACGACTTTTATTCCCACATCGTACTCGCAGCTGGCCGGAACAGGACCGTGGAAGTGTTTGACCTCAACGCCGGCTGCAGTGCAGCGGTGATAGCGGAAGCCCACTCACGGCCTGTCCATCAAATCTGCCAAAATAAA exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_103307 hsa_circ_0064557 3 18456602-18462483 - hg19 SATB1 GTGATCTTTAGACAGTGACTGAGTATGGATCATTTGAACGAGGCAACTCAGGGGAAAGAACATTCAGAAATGTCTAACAATGTGAGTGATCCGAAGGGTCCACCAGCCAAGATTGCCCGCCTGGAGCAGAACGGGAGCCCGCTAGGAAGAGGAAGGCTTGGGAGTACAGGTGCAAAAATGCAGGGAGTGCCTTTAAAACACTCGGGCCATCTGATGAAAACCAACCTTAGGAAAGGAACCATGCTGCCAGTTTTCTGTGTGGTGGAACATTATGAAAACGCCATTGAATATGATTGCAAGGAGGAGCATGCAGAATTTGTGCTGGTGAGAAAGGATATGCTTTTCAACCAGCTGATCGAAATGGCATTGCTGTCTCTAGGTTATTCACATAGCTCTGCTGCCCAGGCCAAAGGGCTAATCCAGGTTGGAAAGTGGAATCCAGTTCCACTGTCTTACGTGACAGATGCCCCTGATGCTACAGTAGCAGATATGCTTCAAGATGTGTATCATGTGGTCACATTGAAAATTCAGTTACACAGTTGCCCCAAACTAGAAGACTTGCCTCCCGAACAATGGTCGCACACCACAGTGAGGAATGCTCTGAAGGACTTACTGAAAGATATGAATCAGAGTTCATTGGCCAAGGAGTGCCCCCTTTCACAG exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_001379 hsa_circ_0000516; hsa_circ_001379 14 20811398-20811483 + hg19 RPPH1 TCTGACCTCGCGCGGAGCCCCGTTCTCTGGGAACTCACCTCCCCGAAGCTCAGGGAGAGCCCTGTTAGGGCCGCCTCTGGCCCTA antisense papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_101356 hsa_circ_0004846 14 55168779-55169298 + hg19 SAMD4A GAATCATTAACCAATGGCAACAGGAATCCAAGGATAAAGTGATTTCCCTCCTGTTAACTCATCTGCCTTTGCTGAAGCCAGGAAACCTCGACGCGAAAGTAGAATATATGAAACTGCTGCCCAAAATCCTGGCTCACTCTATTGAACACAACCAGCACATTGAGGAGAGCAGGCAGCTGCTGTCCTATGCTTTGATACATCCAGCCACTTCGTTAGAAGACCGTAGTGCTTTAGCCATGTGGCTGAATCACTTGGAGGACCGCACGTCGACCAGCTTTGGTGGCCAGAACCGAGGCCGCTCAGACTCTGTGGATTATGGACAGACACACTACTATCACCAAAGACAGAACTCTGATGACAAGCTCAATGGGTGGCAGAACTCTCGGGATTCTGGGATTTGCATCAATGCCTCCAACTGGCAGGACAAAAGCATGGGGTGTGAGAATGGCCATGTGCCCCTCTACTCCTCCTCATCTGTCCCCACCACAATCAATACGATTGGAACCAGCACAAGTACAA exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_102002 hsa_circ_0003505 17 20910208-20911309 - hg19 USP22 ATTCACCAGACCAGAGCACTTGGGCAGCAGCGCCAAGATCAAGTGCAGCGGTTGCCATAGCTACCAGGAGTCCACAAAGCAGCTCACTATGAAGAAACTGCCCATCGTAGCCTGTTTTCATCTCAAACGATTTGAACACTCAGCCAAGCTGCGGCGGAAGATCACCACGTATGTGTCCTTCCCCCTGGAGCTGGACATGACCCCTTTCATGGCCTCCAG exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_104433 hsa_circ_0081342 7 98984307-98987635 + hg19 ARPC1B AGATTGCCATCTGCCCCAACAACCATGAGGTGCATATCTATGAAAAGAGCGGTGCCAAATGGACCAAGGTGCACGAGCTCAAGGAGCACAACGGGCAGGTGACAGGCATCGACTGGGCCCCCGAGAGTAACCGTATTGTGACCTGCGGCACAGACCGCAACGCCTACGTGTGGACGCTGAAGGGCCGCACATGGAAGCCCACGCTGGTCATCCTGCGGATCAACCGGGCTGCCCGCTGCGTGCGCTGGGCCCCCAACGAGAACAAGTTTGCTGTGGGCAGCGGCTCTCGTGTGATCTCCATCTGTTATTTCGAGCAGGAGAATGACTGGTGGGTTTGCAAGCACATCAAGAAGCCCATCCGCTCCACCGTCCTCAGCCTGGACTGGCACCCCAACAATGTGCTGCTGGCTGCCGGCTCCTGTGACTTCAAGTGTCG exonic papillary thyroid carcinoma Microarray; qRT-PCR thyroid samples, consisting of 6 PTC tumors, 6 matching contralateral normal samples, and 6 benign thyroid lesions. N/A up-regulated N/A N/A N/A N/A N/A 28288173 2017.3 PLoS One Microarray profiling of circular RNAs in human papillary thyroid carcinoma N/A hsa_circRNA_400071 hsa_circ_0092283 22 36681395-36681695 - hg19 MYH9 CAGGACTTCTCCCACTCTGGGCTCTGGCTGGAGCCACCACGGCAGAGCTGGCCTTGGACCCAGCCGGCAGAAGCACAGGCCAAGTGCCAGCTGCTCCCCAGGCGCTTAGGGGAAAATGTCCAGGCACCTGGACCTGAAAGGTCCCCCTCTGGCTTCTGTGTTGGGTGTTCAGAAGTTTCTAATCTTCCCTTTTCTGGGAGACCCAAGACTCTGGACCCCAAGGGTTTGGTGGGATCCTGCTGCCACCTTCCTCTGGCCCTGCTCATGCCCTCCAGCCAGGGCCCCAGCCCTCCCCAAGGT intronic gastric cancer Microarray; qRT-PCR GC tissues and adjacent tissue N/A up-regulated N/A N/A N/A N/A N/A 28184940 2017.3 Oncol Rep. Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology N/A hsa_circRNA_000792 hsa_circ_0000291; hsa_circ_000792 11 35163017-35163328 + hg19 CD44 AAGAGGGCCCTGGTGGTTTCCCTATAGTCTCTAGGGAAGTTTATTTGTATGTTACCTACCAGTGCCATCTTCTGCTTTGTCTTTGGGCATTCTGACTCCTGACTCCTTCCAACCTGTCTCCCCGTTCCTTCTAAAAGGCCCCACTTCCAAATATTTGGCACTGTCCTAACCCTTGAGGTTCTCCCAGAGACCCGCAGTCTCCCTCCTGCCCCGTGTTTCCACGGCCCCTTTGCGCAGCATCATTTAGAGGAAGTACAATGAAGTGCCAGTAGCAATAACTGCCCCGGCCCTCGCTTTCATGTGCTTGTAAA intronic gastric cancer Microarray; qRT-PCR GC tissues and adjacent tissue N/A up-regulated N/A N/A N/A N/A N/A 28184940 2017.3 Oncol Rep. Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology N/A hsa_circRNA_001959 hsa_circ_0001539; hsa_circ_001959 5 139042473-139043291 - hg19 CXXC5 TCAGGCCAGGCGTGTTGGGTAACCCAGGTCATGGCCCTGGTTCTCTCACCATTTGCTTTTGAGCTCTGAGGCAATCCTTCATGCCTCAGTTTCCCCAGCCCCAAATACAAAGCATTCCCCGTCTAGCCTGCAGGACCATGGGGGGATGGACATGTGGTAGAAGCCTGAAGGTTACAACGAGGGTAGCACCCCACTGGCCAGGCTTGCATCTCCTCTTCTGCCCAAAGGAAGAAGGCCTACCTACACTTCTAGACAGCCTTTCCTCCTACCTCCCTCGCCCTCAGCCCTGCCAGCTCATGTCGGCTCTTCTTAGATCTCCCACAGCCCTGACAGCCCTGCCACAAAGGCACATCCCAAGCCTCTCGCCACCCTGCAAAGGCTCCATTTGCCACCTGGAAGTCCCTGCTCAAGTCTAACATATAGCCTTGCTGTGTGAGCATAGGGGGTGGGAGACAGAGAAAGCCTTGAAACTACAGTCGGCTCTCTCTGCTCCCTCTGATATTAGGAAGCCTCCAGGATTTTCCACCCAACACCCATGGGTTCCTTTGCCCTGGGTCCAACCCATTCCCATCCCTCCCCCAACCCCTGGCCCCCAGCTCAGCCTCTTCACTCAGGTACCTCAGCATCCCCATCTGAGAACAGCCCTAGAGAAGGCTAAATCCAAGACATTCTAATTAAGGAGCCCTTGTTGTGGGATGCCACCCCCAGAAAAATGCCAGGTCTAGTGGAGCAGGTGGAGGGGCATGCTCGCCTGGAGATCCAGGTGACATAATGAGAACTGATGACAACACACCCCACCATCTACTTCAGGTCCTGCG antisense gastric cancer Microarray; qRT-PCR GC tissues and adjacent tissue N/A down-regulated N/A N/A N/A N/A N/A 28184940 2017.3 Oncol Rep. Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology N/A hsa_circRNA_400066 hsa_circ_0092330 22 19965129-19965469 - hg19 ARVCF CGGTCACAGCCTCATACCAAGGGCTGGAGAGACGATCATGCAGGTCCCAGGAGGCTGGAACTGTGGGAGCAGCACAGGGGAATGGGCTTGTGGGTCTGGGGTGGCGTTCTGGGTGTGGCCCGCCTCGCAGTGACCACACTGAAGTGGGCACCGTCCTGCAGGCAGAAGGTGTGCCGTGAGGGCAGAGGCTTCCTCCCATGGACCCTTCCTGGCGGTTACCGCCCTTTTGCTCCCCTCCACTGAGGACTCCCTGTTCCTTTGCTCCCGGTGCCCTCATGCACACCAGCTGTGGCCAGTCTTTCCTGAGGGCCAGCCCTGTGCCTAGGGTGCCCTGCCCCAC intronic gastric cancer Microarray; qRT-PCR GC tissues and adjacent tissue N/A down-regulated N/A N/A N/A N/A N/A 28184940 2017.3 Oncol Rep. Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology N/A hsa_circRNA_001066 hsa_circ_0000627 15 72789131-72848248 + hg19 ARIH1 TGCATATTGGGTACTTCCAGAAGTATGAATTCAGTGATGCAAAGGACAGGCGGGCTGCAGCAGCAAAGGTAGGACAGAATCATTCCAAAGACAAGTCATTAAAAGACCATTAAACACACATACTTACACACAGACATTGGCAACCAGTACCTCATTATTTAAGGGCACATCATTTATCCTATAAATCTTTGTGGGAAAGTTTGTTTTGACATGACAAATGTGATGTACTTGTAAAGGGCACAATTTTATTATTATGTTTTAAACCAGAAGCCTACTTGGCACTTAGGCAACAAAGTAAATGGCATTTGCCACTGTCTTTAAGATGCCGAATAATAGAAGAGATAATTAAATGGAGGATATTAATGGTATTAATTGATTCATGGAGCTGGCTGATTTTCAGAAACTATGATAAAGGATCCTATTTTGTAAACTGGGAGGAGAAACAGAGAAGATAGATTGAGCTATGTGTGTATATTTATGTGTTAATGTTTATTTATATTCCTGACTCTGGAATATTTTGATGAAAATAATCTAAATCTTCCTGTTATTTCGCTGACATCACTATGAGGAAGATTAAGAAATTCTATTTAAATGTTTGTACCATTTACTTAAGTATTTGTATCAGTTTACTTGCTAAATGATAGCAGTTATAATAGCAATTTCTGGCTTAAAAAAAAAACAGGGTTAGGATGGAAGGGCAATAGCATTTTTATACTGAATCCTAAAACATCAGTTATAGGCAAGTTTTAAAACTTAATCATACGTTGCAAACACTTGAAGATGAAATGGAAGGCTTATAAGGTTAAGTGTTAGGTTTTATGTGTCATTCTAGTATTGGCTGAAAAGTGAGTGCTATAGGGATGGTGGAATGATGCAGATATTTGCATCATTTTCTATGCTGTTATGCTTCTAAAAAGAAGAGGCTATGTTTTCCTAAATAGGTTAGTAGAGTGCTTCTCAAGGCTTCCCAAATGAAAAGTCAGACAAAAATATGTATTTGTTCTTCAGTGAAGATTGTTGGGTTTTCAAACCAGCAATCTTAGCTGTAAAACCTAAGATCTTACCACAGCCTAAATTGTGACTCAAATGCTGATGTTAGTTAATACTTTTATAAACTCCATATACTATATTGAGGAGATCTAGTTTCTTGAATGTGGAAGTGAAGCTTCATAATATACCATAGTAGGGATGTTTCGAATCAATAGTGTTAAAATGTTTTGGGTTTTTTAAAGATTTTTTTTCAGCTGGTCTTGGAAACCTTTTCAGTTATCTGTTTTTGATTCTACCAAAGGTATTAGGTATTTAATGCTCCACTAAATAGATCACAAAAGGGGAGTCTTAAGGAGGTGAAGATGTGAACTTCTTGACTAGATGTAAATCACTGCTCAGAAAGATTTGACTTTTTTAAATGATGCATTCTTATGTCAATAGACTTTAATCTGCAACCAAAATGTTTTTTTTTTAAATAAAAATGAGGCACATTTGTGCTTTCTCACTTCTGCTCCAATTCTACCTTATTCTGCAAGTTGCTATTTTTTCCTTTAGCAGTACACTATAGATTTAAAAATTGTATGGTATTTTCTAATATAACCATATCAATTTATCAGTTTTCCTATTGTTGGACATCTAATTCACTCATATTTGTGTCTTCTTCCTTTCCCTTACAGAGTTTTTGTAAAGAAGGCTGAGTGTTTTCAAAAGTTATGTTTATATTTACATGTGTGTGAACTACCATTTTCTGTATACCCTTGCTGATAACTATTAAGAATCTTGGTCTGGCGTGGTGGCTCACGCCTGTGATCCCAGCACTTAGGGAGGCTGAGGCGGTGGATCACCCGAGGTCAGGAATTGGAGACCAGCCTGACCAACATGGCGAAACCCCGTCTCTACTAAAAATACATTAGCTGGGTGTGGTGGTGCATGCCTGTAATCCCAGCTACCTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCAGGAGGCGGAGGTTGCAGGGAGCCAAGATCGTGCCACTGCATTCCAGCCTGGGCAACAAGAGTGAAACACTCCATCTCAAAAATAAAAAAAAAAAAGAACTCTTCAAATTTTTATTAATCTGGTAAAGAAAATACTAGTTGTTTTAATTTACATTTTTCTGAATTGCCTTTTTATGTCGTTTGCACCTTTTCATAAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAAAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTAGTGTGATCTCGGCTCACTGCGACCTCTGCCTCCCGGGTTCAAGCCATTCTCCCGCCTCATCCTCCTGAGTAGCTGGGAGGCGCACGCCACCACACTTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGCCTCGAACTTCTGATCTCAAATGATCCACCTGCCTTGGCCTCCCAAAGTGTTGGCGTGAGCCACTGAGCCCAGCCAGTAATGGTATTTAATGTATAATTATTGTAGCTCTTTCTCCAGTTTGTTATTTGTAAGAAAAAAAAAAAGCAATACATGCATGTGGTAACAAATGTAAATGTTATATCTTACAATGATTACATTTATAGCTTTAATATGTCTCTTCCTTTTGACATTATCTCTTTCCTTTTTCTTCCTCCATCCTTGAGAACCCCACTTTATGCCAGCTATAGTTATATGTTATCAAAATATTTTTGTCTTGTGATTATAACCAAATGTTATTAGTTCGCTTATAGCTTGATTTTTGAAGTGACATCATTGAATGTTTGTTTTTATGGTTTATAAATATCAATGACATTCTAAGTAGTGTATTATGATTACTGTTGCTTTTTGTTTTTAACAGGTCTAATTTCAAATGCTGTGAACCTTCCTAAGAACAGTACTCTGGTAGCAAGATGGTTTGGGTTTATTTATACTCCTTGGAGCCCTTCATTCTGCTCTTGTAATCAGGATGGCTTTCCCTGTAAGCCTCTTACATATAGCTCTCAACCATGGACTTTGCATCATTCTCCTGTGTTGGAGCCTCTGATTCTTAGATACATGTCTTTTTCTTGACTGAATCTCATTGTGCTGGACTGCATCCTTAATTTAACTCTCACAACACTTTTTTCCCCCCTGCAACACTCTTAGGCTGTTACTTATTGTGGCTCTGATAATGTGCTTAATTTTCCTTCAAACTTGATTGCTAGATTGGCTAGGTTGGAAACTCTAGATTAGAATATTTGTGCAAGACATTGCCTTCTGCATTCACTGTTGGTGATAAGACTGATAGTAGTCTGGTTGTCATTTCTCTCTTTTTTTTTTTTGAGTTGGAGTCTTGCTCTGTTGCCAGGCTGGAGTGTAGTGGCACAATCTCGTCTCACTGCAACCTCCACCTCCTGTGTTCAAGCGATTTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCACACCACCACGCCCAGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACTGTGTTGGCCAGGATGATGTCGATCTCTTGACCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTTTATGACTTTATTTATTTATTTATTTTTTAAGTTTCAGCCTTTTCTCTGAAGAGATATGTAAGTGTGAATCTTCTAATCCATTGTGCTGGATCTTCAGTGGACCCTTTCAACTGGAAGACTTGTGTCCTTATAAAGCTTTGGGGAATTAACTTCTGTTACTGCTTTGCTAATTTCATTCCCTCTCTTCTTCTTTTGGAATTCCTATCAGTTGAATGTGAAAAACAATGGATATAACTTAAAATAATGATAAGTTATGGAAGAAAGATTGAGAGGTGCATGTAGCGTGCCAGATCCTCATCTTTCACATTAGGAAGGTGACAGATAATATCTAAAATAGAAAAATAATAACTCCTTGAGCATAAGCATATTATTTAGCATAAAAGTAAATACTAGAAGACACAGAAGAGTTTAAAATGGTTACCTCAGAGGATTAGAAATCAGTAGTGACTGAAGTATGGCAAAGAACACTGTTAAATCTTGCAGTACCATTAACTTCTAAAACTATGTATGTATATTAAATAAAATAACTTAAAAGTGATTTAATGTAATCCTTAAGGTCTACATTTAATGATACCTTCATTCTTTAAAATATCGTCAGGAAGTTTATGTAGACGTGTTCTTAGACCAAATATACACTATCAGCCTTCATGGGAGGAGGTACACACTATGTATTCCTTTGTCATGATTCGTAATTATTGAGCTGTGTATTTTGAGAATAATTGATAGAGAATGTACTGGAGATTTACATGGCCTGTTATTGCTTGGTTTTAAAACTTAAAGGATACAGGGGTATATTTTTGTCTAATTCAAGATCATTTGGATTTATGACTTTTATTAGCTTTAAAGAAGCCTACAATGGCTTTTTTCAAAAATAGAATTTTTCTTAGAAAACAGTTTTTAAGAGACAAATTTATTTAAATGCCCACTCTTTTAAAATAAAGTTAGATGTATGGTTTTCAAATAATCTTATGTTTGTTATTGAACAAAATCTTATTTACTGTATATACAAATATATAGTATGGATGAGTAAGAAGCAGTGAATTGCTAATCAGAATCCCACCACTTATCAGTAAGTGTTTTGAGTTGCACGGTTTGAGAAAGTACTGGTTCAAATGCTGTTAAAAATCAAATTTTTGTATGCTGTCTCTAGATGGTTTGTTGATGACCTAGTGGTTGTGTTAAAGAAGTGGAGTTACATTGAAGTCACGCGAATGTTTTGCTTGTGTGTTTGGTGGAACATTTTTAGTATATGCCACAGCAGATACGTGGAATGCTGATACTTAGGGCTTAACAGTTGGAACCCAGAAGTGAGTATGTGAACAAATAACTGAAAGGTTACAAAATAACTTTAATCATCTCACAATTCTAATCACCACAAAAATAATAAAGTAGCATGAGGTGGTCTATATTTATGGTTTACATTAGCCCCACTGTGCCAGGGCAGTTTGGAATTTAAGTTACCTGGTTCTTGGCTCTACCTTTAGTTTGTACCCTTTTTATCAATAGGGCTTTTTTGCCCCTATAAGGAATAGCCAGTTAAGAGACTGCAACCCAAGAAAATCTTGCCTGAATGGAGTTTCAGGTAACGATAAAAGTTTAAAAACTAGGGTGTTATATATATTAGAAGTGACTTGTCTCTTGATGCAAAGTCATAGACTGCTATTTTAAGTCTTGAGTATTTTTTTTTGATATAACATTGAAGGATACCTTACCTATTGTTTCTATTGTTCATGTAAATATACCCTTCCATTATCTCTCCCCACTTTGGTTTGCCGCTGAATTTTTATGGAAGAAATCAAATGATTATACATAGTGATAACATCCTTCTACTTACAGAAACATTGTATTAAAACACTGATTAAACTCTTGATGTTTTCTAGAGGTGAAATCTTTATATTTGGGATGACATAGAAGGAAGTAATTTCCCTCATAAAATAAATGTGCAAAGAACAGCAAAGCCCAGATGTGTCATTGGCTAGGCACATTTATTAACAAGTTTGGATGCATCAGGATTACATATTTAAATCAAATGCATATCTCAGCAAAATTTCAAATTGTTATGTATTTATAGGATTGCCAACAGTTAATTGAAACTTGTCATTGTTAAATTTTGCTTTAAATAATCTCCAAGAGTAATGAGTGGCTGGGCACTCACTCATGGCTGTAATCCCAGCACTTTGGGAGGCTAAGACAGGCTGATTGCTTCAGCCCAAGAGTTTCAGACCAGCCAGGGCAACATGGCGAAACCCTGTCTCTACAAAAAAATAAAAAAATTAGCCTGGCATCGTGGCACGTGCCTGTAGTCCCAGTTACTTGGGAAGCTGAGGTGAGAGGATTGCCTGAGCCTGGGAGGCAGAAGTTGCAGTGAGCCAAGATCTCGCCACTGTACTCCAGCCTGAGCGACAGAGCCAGACCCTGTCTTAAATAAAATAAAATTAAAAAAAAGAGTGATGAAGGTATGACATTCCTGCCTGCTGAAGTAATCTGAGAAGCCTCTTTAAGGGGGAGTTCTCTCAAGAATATTATCCTCAACATTTTTACCTTTTACCTTCCTTCTCCTGTGGTAGCTTAGAAGTAAATATTCATAACTGGGAAGTTTGATGATCAGTGTTTAGTTGTAAATTCTTTTAAAATGCACATACTTTTAAGCCATCTAGAGATTGTGTGGATTGTCTCCCTTAGCCCCACTAGGTGCTTCTCTGTCCTAAGTAGTCTAGAAGGCCAAAAACTATTTCTCAGACTATTTTGCATTTAGGGTTCTAGATATAAAATAGTTGTGACAATTATAATATATATGTGGGAGATTTGAAGGGAGTTTATGTTTTCTTCGTTTTTGTGGTCTGGGTCATGAAGAAGTGAGATTTTGCCAACAGTAGCAGAAATGCAGCATAGCATTATTTATTCTCCAGCATCTTGAGTTATCAAGAGGCTTTTGTGGTTAAGGCAGCAGCTAGACTGTTTTATTGTGTACATCCCCTAGCTGGGTATTTAGAGGCAGTTGTGACAGTGGCAACTTCCTGATTCAAGCTTTCCAATCCTTGGATCACAGTTATCTGCCATGTGTTCTTGGATTTAGTGGTCCCATTGGTAGCTTCTTATGATTTCAGTTCTGTAGTGTTCTGGTAGTCACTCCTGGAGACATATTCCTATAGCCCCATTCCTCCATTCTTTCCCGTAACTAAGCATCTAATTCCTTTTTAACTCCCCTTTGCTCAGAATATCTAGTGGTTTCTATTCCCTCCACCAAATACTGATTGATCAAAGTCAAGAGCATCCTTTGGTGACAAAATGCTACTCTTACATTTAGTAGATGGTACTGTATGTGATGCAGGATTTTTCTTGACCCCTTCTTTGGACTTGTGATGGAGGTGCCCCATTTACTCTGCTTGCAGCCCTCAACCCCTTGCAGGAGGGAGCACGTGAGCAAGTGAATGCGGGATCTGGCTGGCTGCTTTGGGTGCTGGCAGGAGCAAGTTTCATGTGGGCCCTGCGATGGCACCCAGGTTGGGGTGCCTGCAACCCCTGAAGCCCTAGAGGGCATGTTACAATGCTGTCTTAGCTCCACCGTCTGTGGACAGCGGTGTGTTACCAGCTCAGTAGGCTCCTTGCCTTGTTGCGTGGGGCAGCCGCCCTCCACTAGTGAGGGCAAAGGGCCAGTGTGATAGCCTTTATTTATTTATTTATTTTTTAGATGGAGTTTCGCCCTTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGTCTCTTGAATAGCTGGGATTACAGGTACCCGCCACCATGCCCCACTAATTTTTGTATTTTTAGTAGAGATGGCGTTTTGCCATGTTGGCCAGGCTGGACTCGAGCTTCTGACCTCAGGTTAATCTGCCGTCTCAGCCTCCCAGAGTACTGGGATTACAGTGTGAGCCACCGCACCCAGCCAGACAGCCTTTTTTGGGTACCTGCACTTGGTGGGTCCCAAGTTCTTGTCTGGTGTCCAAGAAAAATGAGGTCCTGCCAGACGCTTGAAGGATGGTGGAGGCGGATAATTTTCTTTAGTGATGAAAATGGCTCTTAGCAGAGAGGGGAGCTAGAGAAGAGACAGGTTGGGCAGGTAATCTTTCCTGAAGTCAAGCTGCCCCTCTGAAGTCCAGGGACCTCTCTCCAGTCAAGCCGCTTCTCTCGTTCGTCTTTATCTGCACAGGATGAGGGGTGGGTTGGCCATCAGTAGTTTTGGAAAAAGCAACATTCGATTGGTAAAAAGACATTATTCGGAAAGAACCAACTGGGAGAGAATCGGCAGACGGAAGTTCTCATTTTGGGCCACAGGTTTCAGGCTTTTTGGTTTGAAGTTGGGGTTTCACTGGGAACCCACCCCTGTCTGCCTAGAATGTCTCTGCTTCCTGCCTCTATCATTGAACTTCAGATATATAAAGAAGTTATTCTATGATATGTCATTGACTAAGCATTAATTATGTTGACCCTTTTAGTGACTCTAAATAAAGAGCTCTCAACAAACCTATACCTTTAAAGGGAAGAAAAACTATACCTGAATTACACATGATAATTTCTTAGAAGGCATTAAGTATTTAATCATATCTGAGGAGAATTTGGAAATGAAACCATTTACAGTTGCAATTTAACCAGCTCTCAAGAGCATTACTTCCTGTAGCTTATATCAGTGCTCCTCAAACTTTAACATGCATACAGATCACCTCAGGAACACTTGAGGGTCTGTTCAAAGTGAAGATTCAGTAGATGGCTGTTGGGACCTGGGATTCTACATTTCTCACAAACTCAGGTGATTGTAATTTTGTGAACCACACTTTAAGTAGCAAAGCCTATAGTATTTACAGTTATAAATAAAGGTAATATTTTACATTTCTATTTATTTGAAATTTCTTTTTGAATATTACCATATCATAGAAATTTACTTTTTTAACACAAAAATGGAATATTGTGCACTACTCAGTAGCTTGTTTTTTTTCGCTCAGTGGTATCTCATGAATAACCTTCCATATTTTTTTAATGGCTGCATAATATTTCAAGTATGAATATAGCATAATTTATAGGCAGTCTCCTCTTGAAAAAATGTATAAATGGGAAAATGCTTTCCCAAATAATGTGGATGTGAAAATTCTTATACTTCTATACTTGGTATTTCTGTTGAGCAGGTTCCTATAATGGGTATTTCTAGGTCCTAGTTCATGTGCATTTTAAATTTTGATCACTTCTGCCAAACTACCCTCAGAAAAGGTTTGACCAAAGTTGCCATCTCATTAACAAATTATGACCTGTTTCTCTTGCCGTTGTCACTGGATAGTGTCTTTTTTTTCTCCCTGAGACGGGGTCTTGCTTTGTTGCCCAGAGGTGGAGTGCAGTGGTGCGATCTTGGTTCACTGCACCCTCTGCCTCCCGAGTTCAAGCAGTTCTCCTTCTTCAGCCTCCCGAGGAGCTGGGATTACAGGCTCGTGCCACCATAGCGGGTAATTTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCATGATCCACCCTCCTTGGCCTTCCAAAGTACTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCAATAGTATCAGCTTTTAAAAACTTAGTCATTGTGGGCCAGGCGCGTGGCTCACGCCTATAATACCAGCACTTGGGGAGGCCGAGGCGGGCGGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACTCTTTCTCTACTAAAAAATACAAAAATATTAGCCAGGCGTGGTGGTGGGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGGGAATGGCGTGCACCCGGGAGGTGGAGCTTGCAATGAGGCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCACAAAAAAAAAAAAAAGAAAAAAAAAAAGAACTTAGTCATTGTGGAAGATTTAAAGCATTCATTGTATTAAGGAGATTGGATATTTTCGTGTGTTTTTCAGCCAATTGTAATATGGGAATTGATGAACTGTCCATTTTTGTTGGATTATTTTCTTTTTTGAGTGGGTATGCTTGCTCATTTTTGTTGTAGCATTTATAAATATTCCTTAGAATACAGATGTTTTTATACTTTGTGACTTTTGAGTTTCTAATATTGTTTAAAAAGTATTAAAAAATTCTCTTTAAATTTTGGACCCATAAGCAGCTCATTTGAGGAGCTTGTAGATTTTATGCAAACATGAGCCCATGCTTCTGTAGGAAAATCTTAAAACTGAGGTTTAAGGTGGTGCCTCTAACCTGTTTAATTCTCGTTCAGATCAAATTCTGAAATAATAAAAAGGTGGGTTTTGGAGGTTTTCTGTGTATGTAAACTGGAATAAAAAAGTGGTTTTTTTTTGTTTTTTTTGTTTGTTTTTTTACTTAGCTTTATCCTAAAATAAGAAAGTTGTCTCTTGAGATTTTTGAAAAAGTAGTTGCCTCCCACTCTGCTAAATATAGGAATGTCATTCAGCAATTTGGTTGTGATTATTTTTATGTATGTATGTATGTATGTATGTATGTATGTATGTATGTATTTATTTATTTATTTTTTGAAACGCAGTCGTGCCCTGTCGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGTGTTTCTCTTGCCTCAGCCTCCCAAGTAGCTAGGACTATAGGCGCACACCACCGTGCCCGGCTAATATTTGTATATTTTTGGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCTGACCTCAAGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCTTTGGTTGTGATTCTACCTGGAGAGTTTGTCATACTCTTGAATATGGGCCTGTCTGCACACATGTGTGCATCCAGATTATGATTCTCCACTGTGACTGCTTATTGGAATCTCTTGGGAGTTTTTGAAAATGGTAATGCCCAGGTGTCCCCCTCAGTCCTCTTCCTCACTCCCCCCATATTCTGATATATTTGGCCTGGGGTTTGTGGCTTGTTTAAAAGCTTCCTAGATGGCTGTGCACAGTGGCTCATTCCTATAATCCCTGTGTTTTGGGAGGCTGAAGCTGGAGGATTGCATGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGCAAGATCCTGTCTTTAAATAAAAATAAATAAATAAATAACAGTCAATTAAGAGCTTATGTGCTACTAAAATTGAGAACTACTTGATCAAAGGATAGGGGATGATGGTGCAATTGATGTTAAAGCTTCAGCTAGGACAGTTGACATAATCAGACTTACTAATCAACTTTTTCAAAATGCAAAACTTTAAAGTAAATACAGCTGCTCTGAGCCTGGAATGTTATTTTCTTTAGATTACTAAAATACTATACTGCCACATTCATGGGAGTTCTACAGATGTACTTTTTCGGAGCCTGTGTAGTGGGAAATTGTTTAGAGCAGTAGTTCCCAGTTCTGTCTGCATGTTAGGATCATCTGGGGACCTTCAGATAAAAATGTTGGATGAAAATATATATATTCATATTCTACCCTTGACAGTTGAATCAGAATTGCTGGGGGCAAAGCCCAATTAATGGTATTTTTTAAGTTCCTCAGGAGATTCTTATATGTAGCCAGAATGGACAGGGGTGGGTGGTACTGATTTAGAGTTATAACTAGACAAGATGTAAGGTTTTAGGTTGTTCTATTGTCCTAAAAGTTAAATGTACTGCTGCTAGTATTAGTACTAGTTTTCTGATTATAGTGATTTTACTCAAACTGTTTTTGTTTGGTTTGTTTATATCCTTTAAAAAGGATGAAGAGCTCTTTATTTCAGCCAAGAGCTTGAATTGGCTTTTCACTGAACTATCAGTTTTGGTGGCACACCGAAGTGAATTTCTCTCCTTTGACAAGTCCTTGTAGGGAGTGGTGCTATAATCATAAATTAAAAAATAATTTCTCCATGTATTCAAATCCTACTAGCCTATTTTATCCTGGACCAAGACACTTAACCTCTGTAACCTCATCTGTAAAATGTAAATCATATCTAACTTGCATAAAATATTGATGTGAGTATTAAATGAAATAATGTATATAAAGTATCTAGCATTGTGCCCGGCACTAAATAATTTCAAATCTATGTTCTCCTTTTCAGCATTCCCTTTTACTCTCATTGTTCTTTCTTTCTTTTTTTTTTTTTTTTGAGACGGAGTCTCTCTCTATCACCCAGGCTGGAGTGTAGTGGTGCAGTCTCGGCTCACTGCAACCTCCACGTCCCGGGTTCAAGCAATTCTCCTGTCTCAGACTCCCGAGTAGCTGGGACTACAGGCATACGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTCACCATATTGGTCAGGCTGGTCTCAAACTCCTGACTTTAGGTGATCTACCCGCCTTAGCTTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCCTTTTTTTTTTTTTTTGAGACTGAGTCTTGCTCTGTTGCCCAGGCTGGGTGCAGTGGCCTGATCTCAGCTCACTGCAACCTCCGCTTCCTGGGTTCAGGTGATTCTCATGCCTCAGCCACCCAAGTAGCTGGGACTACAGGCGTGCATCACCACTCCCAGCTAATGTTTATATTTTTAGTAGAGACAAGGTTTCATCATGTTGGTCAGCCTGGCCTTGAAGTCCTGACCTTAAGTGATCACCTGCCTCGGTCTCCCAAAGTGGTGGGATTACAGGTGTGAGCCACCACACCTGGCCCACATTGTTCTTTTTAAAAGAACTTCACTACAGGTGCTCCAGTGCAGGCTAGATTACGTTTATAGTTGAATACTTTAAGTTTCATACAATAAAATTTACACTGGAGCATACAGTTCTCTGAGTTTTGATAAATGCCTAGAGTTGTGTAAACCACCACCATAGTTAATTTACAGAACAGTTTCCCCTCACCATCACCCCTCAAATTTCTTTCTACCCCATTGTTTAGTCAAACCCTCCCCCACCTTTAATATTTGGCAGCTCTGGATTTGTACCCTATCCTTACTTATTTATTTCTATTTATTTTCACTCATTCATTTAAGACAGGGTCTTACTCTTTCGCCCAGGCTGGAATGCAGTGATGCGATCATAGGTCACTACAGCCTTGTGCTACTGGACTCAAGGGATCCTACTCACCTCAGTCTCTAGAGTAGCTGGGACTACAGGCATGTGTGTCATCATGCCTGGCTAATTTTTTAAAAATTTTTAGTAGAGGTCTTGCTTTGTTGCCCAGGCTAGTCTGAAACTCTTGGGCTCAAGCAGTCCTCCCGCCTTGGCCCCTCAAAGTGTTGGGATTACAGGTGTGACACCAATCGCCCACTCCAGCCCCACCTTTTTTTTTTTTTTTCCCCAAAGAGAGATGGGGCCTCACTGTGTTGTCCAGGCTAGAGTGCAGTGACTGTTCACAGATGGGATCCTAGCACACTACATCTTTGAACTCCTTAGCTCAAGTGATCCTCCTGCCTCAGCCTCCTGAGTACCTGGGACTACAGGGATCTCCCACCTCTTCTGGCCTGAGCCCTGTAATTTTGCCTTTTCCACTGTGTCATTTAAATAGAATTGTAAATCAATTTTTAAAATGGGCTTTTATTTTCTTGTTAGGTTTTTAGATTTTTAAAAAATTATTCTAGGTACAAATTCTTCATCAGAAATGTAATTTGCAGGTATCTTCTCCTAGTCTGTGGTATATCTTGTATTTTCTTAACAGTATCTTTTACTTTCGATGGATTTCAGTGTATCCGTTTTCTCTAATGGATTGTGCTTTTGATGTATGTACGAACTATTTGTGTAACTCAAGGTCACAAACATTTTCTTTAAGTTTTACAGTCTGATTTACATTTGGGTCTGATCCATTATTAATTTTGTATTAAATGTGAGCTAAAGTACATTTTAAAAATATGTACATCTTAATTATTCCAGTACTACCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAAGCCCATCTCTACTAAAAAAATTAGGCGGGCTTGGTGGTGGGCGCCTGTATTCCCAGCTACTGGGGAGGCTGAGGCAGCAGAATGATGTGAATCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGACTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACTTTTTCCCCGTTGAATTGTTTTATCACTTTTGTAAAAGATCACTTTTGCTGTATTTATGTGGGTCTATTTCTGGTCTCCATTCCATTCTTTTGATCTGTATATCTTTTTGCCAGTACTGTAACTTCATAGTTATGTTTTGAAATCAGGTGTTCTGTTTTAAAATTTTTCAAAATTTGGCCACTCTAGTTTCCTTGGTATTCCATATAAAATTTAGAATCACTTTGATGTTTATCCAAAAAATATTTGGAGTTTGATTGGCATTGAGTGGAATCTATAGGTCAGTTTGGGAAGAATTAACATTTTAATTATGTTGTTTTCCAATCCATGAAGATGGCATCTCTCTCCATTATTTAGGTCTTATTAAAATTTCTTTCATCAATATTTTGCAGTTTTCCGTGTACACGTTCTTCACATATTAAATTTATACCTATGTATTTCACGTTTTGGTGCTATTGTAAGTGGCACTTTAAATTTTTTTGATCTTCAGTTATTCATTACTAGTATGTAAAAATATAGCTGATCTTTTCTTTCTTTCTTTCTTTTTTGAGATGGAGTTTTGCTCTTGTTGTCCAGGCTGGAGTGCAGTGGCGCCATCTTGGCTCACTTGTAACCTCCGCTTCCCGGGTTCAAGTGATTGTCCTGCCTCAGTCTCCTGAGTAGCTGAGATTACAGGCGTCTGCCACCATGCCCTGCTAATTTTTTGTATTTTTAGTAGAAATGGGGTTTCATCATGTTGGCCAGGCTGGTCTTGAACTCCTCACCTCAGGTGATCCACACACCTTGGCCTCTCAAAGTGCTAGGATTACAGGCATGAACCACCGTGCCTGGCCCAGCTGATCTTTTTATATTGGCCTTGGACTTCGCTAAACTCATTTCTTCTAGGAATTTTTTGTAGATTAATGGGATTTTCTGCATAGCCACATACATAGTCATCTGATTAGAAACAGCTTTTTTCCTTTCCAATTTCTTTTATTTCTTTTTCTTGCCATATTGTATTTGTAAGACTCCGTCCAGTACAGAGTTGACTGAGAGTGACTGGGCAGCTGGCCTAGAAGTGCCTCTTCTAGGCACTTCTTTTTCGTTTCCTAGTTTGCTGAGAGATTTTTATAGTAGTGGATGTTGAATTTTGTCAAATGCTTTATTTATATCCTATCCTGTGACTTTTCTTCATTAGGCTTTTAGTGTGGTAATTAAATTGAATTTTGAATATTTAAAACTATCCGTGCAATCCCAGGACGAACCCCACTTGATTGTGGTGTAATTATCCTTTTTATATATTGCTAGATTGTATTTCCTAATATTTCATTGAGGATTTTTGCATCTTTGTTCATGTAGTAATTTTCTTGAAATGTCTTTGTCGGATTTTGATATCAGTGTGATCTTATGGAAATTGGGAAGTGGTCCCTCCTATTCTAGTTTTTGGAAGAGTGGTGTAGAATTTTTTTTTTTCTTCCTTGAATGATTAGTAGAATTTTCCAGTGACACCATTTTTGGTCCATGAGTTTTCTTTGTGCAAGAGAGTTAATTACATACTCAGTTTGCTTAATAGATATAGGATCATTCGTGTTGTGTCTTCTTTAGTGAGGTTTAGTAATTTGTGTCTTTAAGAAGTTGGCCTGTTTTATTGAGTTGATGAATTTAATGGGCAAAGAGTTTGTAGTATTTGCTTATCATCCTAGGTAGAGTTTTATTAGTTTCATTGATCTTTAGCACTAGCTTTTGGTTTTGTTTCTCGGTTTTTTTCTTTTTTTTTTTCCTTTTTAATTTCATTGACTTCTGCTGTTTATTATTCCCTTTCTTCTGCTTGCTTTGGGTTTTTCTTTTTCTTTTTTTTCCTGAAGTGTTTGAGATCTTTCTGATTTTCTTACATAAGCATTTAATATGATAAATTTTCCTGTAAACACTGTTATGTCCCACAACTTTGATATGTTGTATTTTCATTTTTGTCTAGTTCAAGATATTTCTAATTTTCTTTGAGATTTCCTCTTTCAAGCTTGGATTTAGCAAAAGATGGTTTAATTTGGAAGTAGGCTGTCTACATATTCAGTGGATTACTGAGAGAGGAGTGTTGAAATCTCTTAAGTATAATTGTGGAATCATCTATTTGATTTCTATCAGTTTTTTCTTTATTTTGAAGTTACTGCTGCTAATTTTTCTTGTTCTGGAGTTTGCTTTGTCTGATAGAAATATGGCCACTGTAGCCTTCATGTGATTAGTGTTTGCGTGATATATCTTTTCCCATCTTTTTACTTTTAATCTGTATATATCAATCATTACATTGAAAACTGAGCTGTTATGGACAGCATAGAGTTTTGCCCTTTTTAAAAAAAAGATCTGAGCGGTTGCCCTGCCTTTTAAATGGTTTGTTTTGAACATTTACACTTGATGTAATTATTTACGTGGTTAGATTTAGGTCTTTTAAAATTACTTTTCTCTTTGTTCCTCCTTTTTCTGCCTTTTGGATTACTTGAAATTTTTAAAATATTCTACTTGATATATTTATTGGCTTTTTAAAAGCTTTTCTCTTGGTCTTACTATTTTAGTGGTTGCTCTAGGGAGTATAATCTAACTCTTGACATTCTAGTTAAGGTAAATATTTTACCTTCTCAAAGTAAAACAGGTTTTTTTCCTAGCCTCTTTATATTACAGTTGTCGTATGTGTTATGTCTAGAAACATTTAACTCTTCCTACCAAGCATGATGTTACAGTTTTTTATTTCAACAGTTTTATAAGTTTTCAAGAATTTAAGTGGAGAAAAATAGTGTATAATATTTACCCAGGTATTTACCATTTCTGTCGCTTTTCCTTCTTTCCTGTAGTTCCAAGTTTACCCCCATATCATTTCCCTTCCACCCAAAGAATTTCTTATAGCTTTTCTTTTAGAGCAGGTTTCAATCTCTCTCTCTCCCTCTCCCTCCCTCCCCCTCTCCCTCCCTCCCTCCCCCTGTCCCTCCTTCCCTCCCTCCCCCTCCCTCCCTCCCCCTCTCCCTCCCTCCCTCCCCCTCTCCCTCCCTCCCCCTCTCCCTCCTTCCCTCCCTCCCCCTCTCCCTCCCCCTCTCCCTCCCTCCCTCTCTGTCTCTCTCCCTCCTTCCCTCTACCCCCCGCCCCGCCTCCGCCAAAGACAGAGTCTTGTCTGAGGCTGGAAGGCTGGAGTGCAGTGGTGTGATCACAGCTCATTGCAACCTCAGCCTCCTCAGCTACTGGGACTAATACGCCACCACGCCCAGCTAATTTTTTGTAGTTTTTGTAGAGATGGGGTCTCACCATGTTGCTCAGACTGGTCTCGAACTCCTGGGCTCAAGTGATCCTCCTGCCTTAGCCTCCCAAAGCACTGAAATTAGAGGCATGAGCCACTGCACCTAGCCTGTTTTTTGCTTTTTTGTCTGATAATGTGTTTGTCTTCATTTCTGAACTATACTTTTAGTGAATACAGAATTCTAGCTTGATACCTTTTGATATCCTATAGGGGCCTGAGAGATTGTTTGTTTTTAAAAAATATTTCTTCTCTCTTTTGTTAAGATTGGATAATTTGTGTTGCCATATCTTCAAGTTCACTGACTCTTCTGTCATCTTCTTTCTGATAGTGAGCCGGTCCAGTGAGTGAGTTCTAAAATTTTCATTTTTTTAAAAAATAGTAAACTCTTTCTTTTTTGAGAATTTCAGACCGGGCTCTGTAATCCCAGCACTTTGGGAGGTCAAGGTGGGAGGATCATTTGAGTCTGGGAGTTCGAGACCAGCTTGGGCGGTATACAAAACCCTGTCGCTACTGAAAATACAAAATATTAGCTGGGCACGGTGGTGCATGCCTGTAGTTCAGCTGCTCAGGAGGCTGAGGTGGGAGAATCACCTGAACCAAGAGGTTGAGGCTGCAGCAAGCTGAGATTGCACCACTGCACTCCATCCTGGACGACAAAGCAAGACCTTGTCTTAAAAAAAAAAAGAGGATTTTGGCCAGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATTTGAGGTCAGGAGTTTGAGACCAGTAGAGGGGGTTTCACCCTCTCTACTAAAAATAAAGAAAATTAGCTGAGTGTGGTGGCATGCCCCTGTAATCCCAGCCACTCAGGAGAATTGCTTGAATCCAGGAGGCAGAGGGTGCAGTGAGCCTAGATCACGCCACTGCACTCCAGCCTGAATGACAGAACAAGACTCCATCAAAAAAACAACAAAAAAGATAATTTCACATTTCATTTGTTTTAAGGTGTTCTTTTTTTACCTAATGGATCATGGTTGTAATAACTGCTGGCCTGTAATCCGAGCACTTTGGGAGGCCGAGGTGGGCAGATCACCTGAGGTCGGGAGTTCGAGACCTGCCTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGACGGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGTTGTGGGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGTCAGCAAGAGTGGAACTACGTCTCGAAAAATAAAAAATAAAAATAAAAAAATATAAAATAACTGCTTTAAAAGTCTTTGATAATTGTAATATCTGGGTCATCTAGGAGTCAGCATCTGTTGATTATCTTCTGCTTTAAGAATTGGTCAGTTTTTTGTTTTTTGTATTTGCTGTGTTTGGTAGTTTAGATTCTATCGCGGACATTTTGAATATTGTATTGTGAGATTCTGAGTCCTGTTGAAGTGCTGTAGAGAAAGTTTAAGATTTGTTTTAGTAGACAAATTGACCTATTTAGTTTATACCTGCAAATTCTTTCTCATCTTACATAGGCAGTGGTTCCATTATCTCTTCAGTTTTCAAAGTCTTTGCCATGTTGTTTGCATTTGCCCCTCCCATTCCCACTTTGGTTGATCTAGCACTTGAGCAGTGATTTATATCCTAATTTTATTGTGAAAGCCTCCCTTACACTTCTTTGGATCTGTTCCATATATATATAGATAGCTTGCAGCTGGGCCCACAGACTTAGGGATCTACTTTTCTGTCTCTTAATCATCAGTGATTTCACCTATATTCTTCAGCTCCCAGGGGCCTTCTTTATTCCCCTAGCCAGAAGCATGGAATTATAGTTTGAGTCTCCTACCTGTCATGCCTCACATGGCAGTGAGCACATTTAGGGAGCCCTTGCCCTAACCATATTAAATAAAAACATGGTGGTGGAAACTAGGAATCTGTTTTAACAAAACTTACCATAGTTACTTTTGATAAACCAATAACAGATTTGGGAACTTGTGGCTAGAAACAATATTTGGCACTAGCAACATCAAGTTATACTCCCTCCCCTCTGTTTTTTCCCTTTTTGCAAGTTGAGGCTCTTAACAATTCCTGAAATAGTTTACCCCAAGCACCCTATCCAGTGGTAGAAAATACAGTGTACTGGATGCCACAAAGTTATAGTCATGCAATTTTAGTTAATAACAGGAGACTTAAGTCTCTTGATTGATGGAGAGACTTAAGATTTAGCTTATTTTACATATAGCTAAATCTAAATTAGTGACTTTATTTCAGTTGTAGGCAAATCCTCTTGTTAAAACTTGTTTTTAATTTCTGAGTTCTTTTAAAAAAAAAGTTTTACATCACATTTCTAAGAGCTGGAGATGACAGTGTCTCTGTTTTCTGTTTTCTCTACAAATAAACGTATAACTTAGGATCAGTTAAAATATTTCTTTTCACATCTTAACTCTTATAGATGGGTGGTGTCTATCAGCAGTGCTCTGTTAAAGACAGATTCTTAGGGGAGTGTGGGTCCAGAGAAGTAAGGAGTACCTAGATTAGCAAAATGTACTAAGGTGAGTAAGTGAGTGTCTGTATCTTTGGCTTTTGGAGGGGAGTATGCATGTGTGTAAATTTTTCTGTAACAAATGGTACTGTCGAAAACAATTGACATACATTTCTTTCATGACACTATTTTTATACAAGATTACTTTAAATCTGTAGCTAACTACGGTCTGCTTGTGGTGAAGTAAAGTGGTTTTAGTCCACAGAGATCTTTTTTGGAAGGTTATTTGATGTAGTAAAATTATATATGAGATAAAAATAAGCAGACACATGTTTGAGTTCCACTTCTGCTATTGTAACTAGCTCTTGTATCTTTGAATGAGTCAGGCCTTGCTGACTTCTTAGGCCCCGTTGCATTTTGAGTTAAAATTTTGTGCACAAATAGTGAGCTCACTAGTTTCATGGGAAATGGAGATATTTGTGACAGCATTGAATGATAAGGCAGTAAACTTTGGTTTTATTTCATAGTGGTAACTTTTCTTTCTTGAAATAGCAGCCTAAAAGTATGCCCTGTAAACTACTATGTGGTACAGTATTTTTTCATTTTGGTTAAATATCTCTGAAGTATCCTTCTAACTTAAAAGTGATTTGAACTCATTTGAACTATTCAGTGTATAAGGTATTAAATTATTTTTTTAAAAGAGACTGGGTCTAACTATGTTGTCCAGGCTTCACTCGAACTCTGGGGCCTGAGATCCTCCTGCCTCAACCTCCTGAGTGGTTAGGACTATAGGCACATGCGATCGTGCCTGAGTGTTGGAAATTTTCCTTTTTTAAAACAAATTTTTTTTTTTTTGAGTCAGAGTCTTGCCCTGTTGCCCAGGCTGGAGTGCAGTGGTGGGATCTTGGCTCACTGCAACCTCCATCTCCCAGGTTCAGGTGATTCTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGTGTACCACTACACCTGGCTAATTTTTGTATTTTTATTAGGGACGGGTTTTGCCTTGTTGCCCAGGCTGGTCACAAACTCCTGAGCTCAAGCAGTCAGCCTGCCTTGGCCTCTCTAAGTGCTGGGATTACAGGTGTGAGCACCCTGCCTGGCTGAAATTTTGATTACATTTAGTGTGCTGATGTGGCAGTCTGCTGAAATTATTTTTTTTTTGCAATTAAGACAGCGCCGGATTTACTATAGTAACTTACTTTCTGTTTAATTTCTTTTTGGCTTATTTTTAATCCTAAAGAAACCTGACATAGTAGTGTGGCAGACTATGTTTAAATAGTCTTGATCTTATCATTCAAATATATTTCCTTAGAGGAATAAAGAAATAACTCTAGGGATGGAAATTTGGGTGGAGTATTGTGGAAATTTAACTTCAACCTAGGAGTTCACTAAATGTCCATGAAGTGCTATTACCTTAAAATGACTTTTTTTCCCCTCCTTCTTTAGAATCCAGCAACTATCACAAGAATACTCCTTAGCCACTTCAATTGGGATAAAGAGAAGCTAATGGAAAGGTACTTTGATGGAAACCTGGAGAAGCTCTTTGCTGAGTGTCATGTAATTAATCCAAGTAAAAAGTCTCGAACACGCCAGATGAATACAAGGTCATCAGCACAGGATATGCCTTGTCAGATCTGCTACTTGAACTACCCTAACTCGTATTTCACTGGCCTTGAATGTGGACATAAGTTTTGTATGCAGTGCTGGAGTGAATATTTAACTACCAAAATAATGGAAGAAGGCATGGGTCAGACTATTTCGTGTCCTGCTCATGGTTGTGATATCTTAGTGGATGACAACACAGTTAT sense overlapping gastric cancer Microarray; qRT-PCR GC tissues and adjacent tissue N/A down-regulated N/A N/A N/A N/A N/A 28184940 2017.3 Oncol Rep. Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology N/A circPABPN1 hsa_circ_0031288; hsa_circRNA_101325 14 23793346-23793498 + hg19 PABPN1 GTGATCCCAAAACGAACCAACAGACCAGGCATCAGCACAACAGACCGGGGTTTTCCACGAGCCCGCTACCGCGCCCGGACCACCAACTACAACAGCTCCCGCTCTCGATTCTACAGTGGTTTTAACAGCAGGCCCCGGGGTCGCGTCTACAG exonic cervical carcinoma RIP; Microarray; qRT-PCR; pull down; in vitro knockdown; etc. HeLa cells N/A N/A N/A N/A HuR PABPN1 This study identified en masse circRNAs binding HuR in human cervical carcinoma HeLa cells. One of the most prominent HuR target circRNAs was hsa_circ_0031288, renamed CircPABPN1 as it arises from the PABPN1 pre-mRNA. Further analysis revealed that HuR did not influence CircPABPN1 abundance; interestingly, however, high levels of CircPABPN1 suppressed HuR binding to PABPN1 mRNA. Evaluation of PABPN1 mRNA polysomes indicated that PABPN1 translation was modulated positively by HuR and hence negatively by CircPABPN1. We propose that the extensive binding of CircPABPN1 to HuR prevents HuR binding to PABPN1 mRNA and lowers PABPN1 translation, providing the first example of competition between a circRNA and its cognate mRNA for an RBP that affects translation. 28080204 2017.3 RNA Biol. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 N/A hsa_circRNA_100284 hsa_circ_0003513 1 94360169-94367225 - hg19 GCLM GAGTTTCCAGATGTCTTGGAATGCACTGTATCTCATGCAGTAGAAAAGATAAATCCTGATGAAAGAGAAGAAATGAAAGTTTCTGCAAAACTGTTCATTGTAGAATCAAACTCTTCATCATCAACTAGAAGTGCAGTTGACATGGCCTGTTCAGTCCTTGGAGTTGCACAGCTGGATTCTGTGATCATTGCTTCACCTCCTATTGAAGATGGAGTTAATCTTTCCTTGGAGCATTTACAGCCTTACTGGGAGGAATTAGAAAACTTAGTTCAGAGCAAAAAGATTGTTGCCATAGGTACCTCTGATCTAGACAAAACACAGTTGGAACAGCTGTATCAGTGGGCACAGGTAAAACCAAATAGTAACCAAGTTAATCTTGCCTCCTGCTGTGTGATGCCACCAGATTTGACTGCATTTGCTAAACAATTTGACATACAGCTGTTGACTCACAATGATCCAAAAG exonic arsenic poisoning; arsenite-induced skin oncogenesis Microarray; RT-PCR; qRT-PCR; western blot; in vitro knockdown; ChIP; etc. HaCaT cells, As-HaCaT cells, and T-HaCaT cells cytoplasm up-regulated miR-217 EZH2 N/A N/A Among the circRNAs up-regulated in both As-HaCaT cells and T-HaCaT cells, circ100284 had the greatest increase. The presence of circ100284 was confirmed in HaCaT cells. In these cells, arsenite induced increases of EZH2 and cyclin D1 and accelerated the cell cycle. miR-217 suppressed the expression of EZH2 was involved in regulation of the cell cycle. Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1. Moreover, knockdown of circ100284 with siRNA inhibited the cell cycle acceleration induced by arsenite, but this inhibition was reversed by co-transfection with circ100284 siRNA and by a miR-217 inhibitor. Knockdown of circ100284 with siRNA or transfected with miR-217 mimic inhibited the capacity of T-HaCaT cells for colony formation, invasion, and migration, effects that were reversed by co-transfection with a miR-217 inhibitor or by epigenetic expression of EZH2. These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation. Thus, circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. This establishes a previously unknown mechanism between arsenite-induced acceleration of the cell cycle and carcinogenesis. 28062277 2017.3 Biochim Biophys Acta. Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis N/A hsa_circ_0054633 N/A 2 55861197-55913579 - hg19 PNPT1 TCAGGTGACACTGCAGTAATGGTCACAGCGGTCAGTAAAACAAAACCTTCCCCTTCCCAGTTTATGCCTTTGGTGGTTGACTACAGACAAAAAGCTGCTGCAGCAGGTAGAATTCCCACAAACTATCTGAGAAGAGAGATTGGTACTTCTGATAAAGAAATTCTAACAAGTCGAATAATAGATCGTTCAATTAGACCGCTCTTTCCAGCTGGCTACTTCTATGATACACAGGTTCTGTGTAATCTGTTAGCAGTAGATGGTGTAAATGAGCCTGATGTCCTAGCAATTAATGGCGCTTCCGTAGCCCTCTCATTATCAGATATTCCTTGGAATGGACCTGTTGGGGCAGTACGAATAGGAATAATTGATGGAGAATATGTTGTTAACCCAACAAGAAAAGAAATGTCTTCTAGTACTTTAAATTTAGTGGTTGCTGGAGCACCTAAAAGTCAGATTGTCATGTTGGAAGCCTCTGCAGAGAACATTTTACAGCAGGACTTTTGCCATGCTATCAAAGTGGGAGTGAAATATACCCAACAAATAATTCAGGGCATTCAGCAGTTGGTAAAAGAAACTGGTGTTACCAAGAGGACACCTCAGAAGTTATTTACCCCTTCGCCAGAGATTGTGAAATATACTCATAAACTTGCTATGGAGAGACTCTATGCAGTTTTTACAGATTACGAGCATGACAAAGTTTCCAGAGATGAAGCTGTTAACAAAATAAGATTAGATACGGAGGAACAACTAAAAGAAAAATTTCCAGAAGCCGATCCATATGAAATAATAGAATCCTTCAATGTTGTTGCAAAGGAAGTTTTTAGAAGTATTGTTTTGAATGAATACAAAAGGTGCGATGGTCGGGATTTGACTTCACTTAGGAATGTAAGTTGTGAGGTAGATATGTTTAAAACCCTTCATGGATCAGCATTATTTCAAAGAGGACAAACACAGGTGCTTTGTACCGTTACATTTGATTCATTAGAATCTGGTATTAAGTCAGATCAAGTTATAACAGCTATAAATGGGATAAAAGATAAAAATTTCATGCTGCACTACGAGTTTCCTCCTTATGCAACTAATGAAATTGGCAAAGTCACTGGTTTAAATAGAAGAGAACTTGGGCATGGTGCTCTTGCTGAGAAAGCTTTGTATCCTGTTATTCCCCGAGATTTTCCTTTCACCATAAGAGTTACATCTGAAGTCCTAGAGTCAAATGGGTCATCTTCTATGGCATCTGCATGTGGCGGAAGTTTAGCATTAATGGATTCAGGGGTTCCAATTTCATCTGCTGTTGCAGGCGTAGCAATAGGATTGGTCACCAAAACCGATCCTGAGAAGGGTGAAATAGAAGATTATCGTTTGCTGACAGATATTTTGGGAATTGAAGATTACAATGGTGACATGGACTTCAAAATAGCTGGCACTAATAAAGGAATAACTGCATTACAGGCTGATATTAAATTACCTGGAATACCAATAAAAATTGTGATGGAGGCTATTCAACAAGCTTCAGTGGCAAAAAAGGAGATATTACAGATCATGAACAAAACTATTTCAAAACCTCGAGCATCTAGAAAAGAAAATGGACCTGTTGTAGAAACTGTTCAGGTTCCATTATCAAAACGAGCAAAATTTGTTGGACCTGGTGGCTATAACTTAAAAAAACTTCAGGCTGAAACAGGTGTAACTATTAGTCAGGTGGATGAAGAAACGTTTTCTGTATTTGCACCAACACCCAGTGCTATGCATGAGGCAAGAGACTTCATTACTGAAATCTGCAAGGATGATCAGGAGCAGCAATTAGAATTTGGAGCAGTATATACCGCCACAATAACTGAAATCAGAGATACTGGTGTAATGGTAAAATTATATCCAAATATGACTGCGGTACTGCTTCATAACACACAACTTGATCAACGAAAGATTAAACATCCTACTGCCCTAGGATTAGAAGTTGGCCAAGAAATTCAGGTGAAATACTTTGGACGTGACCCAGCCGATGGAAGAATGAGGCTTTCTCGAAAAGTGCTTCAGTCGCCAGCTACAACCGTGGTCAGAACTTTGAATGACAGAAGTAGTATTGTAATGGGAGAACCTATTTCACAGTCATCATCTAATTCTCAGTGATTTTTTTTTTTAAAGAGAATTCTAGAATTCTATTTTGTCTAGGGTGATGTGCTGTAGAGCAACATTTTAGTAGTATCTTCCATTGTGTAGATTTCTATATAATATAAATACATTTTAATTATTTGTACTAAAATGCTCATTTACATGTGCCATTTTTTTAATTCGAGTAACCCATATTTGTTTAATTGTATTTACATTATAAATCAAGAAATATTTATTATTAAAAGTAAGTCATTTATACATCTTAGAAAAAATTACATAGTTTTGTTTTTACAATTCTGAAATATATGAAAAACTTAGATAGAATATGTCATATGTTATTATAACAGATCTCTTCCTACATCTTATTTTTCTTCTTTGTATACAGTAGTGACAGTTTACCTTCAGTCATCCTACAGGTCACCTCTGTGCCCAACAACTTTACTTGCCTACAACGGTTCACAAACTGGAACAGGCCATATTCAAAGCCAGTGCCTATTTCTTCAGAACTGTTAACAGATATAGTGAGTTGAGGGAGCTAATCTGATACACTTTTGATAATATAATGCCTTTCAAATTAGTTACCAAATCATAAACAGAGTGGAATAAATATAAATGAGATTCTAACTAGGATGAATGTGGTAGTAATGATGTATATTTTTCAAATTTACCTAAACAGAAAGATTATTGGCTAAGGCAGGCGGATCATGAGATCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAGTGCAAAAATTAGCCGGGCGTGGTGGCGCATGCCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAGAAGAATCACTTCAACCCAGGAGGTGGAGGTTGTAGTGAGCCGAGATTGCGCCATTGCACTCCAGCTCAGGCAACAAGAGCAAAACTCCGTCTCAAAAAAAAAAAAAAAATTGTTTACTTATCAAATTGAACTAGGTCAATTTGAATATGTGTATTGCTCTAATGTATGGAAGTTCTTAGTATAAGAGCTGAAGGATCATGACTTTCGGTTAATAGATGTTTGAAATAGATGTTTAGAGGTTACTGATACACATGTCAAGTTGTTCATTCCCATCATTTAAAATATCACCTTATAATTCCACAGAAAAGTAAATGGTATGTGGACGTCATAATTTAGAATGTGTAATCTTTTTTAAAATCTTATAAAAATACACTGGACTCAGTGGTACGTGCCTGTAGTCCCAGCTACTTGGAAGGCTGAAGTGGGAAGGTCACTAGAGCCCAGAAGTTCGACACTGTAGTGTGCAACAATCATACCTGTGAATAGCTACTGTACTCCAGCCTGGGCAACATAGCAGGACTCTTATCTCTAAAAAAAATTTTAAATCTTATAAAAATGTAGGTATATCTGGCCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGTCAAGGCGGGTAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGCAGAGGTGGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCAAAAAGAGTAAAACTCCATCTCAAAAAAAAAAATGGTGGGCACAGAAGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGTGGATTACATGAGGTCAGGAATTCAAGACCAGCCTGGCCAACACGGTAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAATCCTAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAGCCTGGGAAATGGAGGTTGCAGTGAGCCGAGATTGCGCCATTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCCAGAAAAAAAAAAAAAAAAGGTAAATTCATGACTCAGGGTTAACTAGTTCATAAAATATTACAAATTTATCTGGCTAAACCAAAGATTTTTAAGTCAATAAACATTGATTATATATCTATTGTGTGTAAAATAGCATGTTAGGCAATGTTGATATACTTCTGAAATATTAAAGATTAATTGAAAATGAAAGATTAAATTTATTTGCTTTCTACACTT N/A type 2 diabetes mellitus Microarray; qRT-PCR peripheral blood from healthy individuals, pre-diabetes patients and T2DM patients N/A up-regulated N/A N/A N/A N/A The expression levels of hsa_circ_0054633 was significantly different among the three groups and increased gradually from the control group to the pre-diabetes group to the T2DM group. Hsa_circ_0054633 was found to have the largest area under the curve (AUC). The diagnostic capacity of hsa_circ_0054633 was tested in a third cohort. After introducing the risk factors of T2DM, the hsa_circ_0054633 AUCs for the diagnosis of pre-diabetes and T2DM slightly increased from 0.751 (95% confidence interval [0.666-0.835], P < 0.001) to 0.841 ([0.773-0.910], P < 0.001) and from 0.793 ([0.716-0.871], P < 0.001) to 0.834 ([0.762-0.905], P < 0.001), respectively. 27878383 2017.3 Acta Diabetol. Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus N/A hsa_circ_0068087 N/A 3 179113875-179137293 - hg19 GNB4 ATTACATCAAATATGGACTCTGTGGGTCGAATACAAATGCGAACAAGACGTACACTGAGGGGCCACCTAGCTAAAATCTATGCTATGCATTGGGGATACGATTCCAGGCTGCTAGTCAGTGCTTCTCAAGATGGAAAATTAATTATTTGGGATAGCTATACAACAAATAAGATGCATGCTATTCCTTTGAGGTCCTCCTGGGTGATGACCTGTGCTTATGCTCCCTCTGGTAATTATGTTGCCTGTGGAGGCTTGGACAACATCTGCTCTATATATAACTTAAAGACCAGAGAGGGAAATGTGAGAGTAAGCCGAGAGTTGCCAGGTCACACAGGGTACTTGTCCTGCTGTCGTTTTTTAGATGACAGCCAAATTGTTACAAGTTCAGGAGATACAACTTGTGCTTTATGGGACATCGAAACTGCCCAGCAGACCACCACATTCACTGGGCATTCTGGAGATGTGATGAGTCTTTCTTTGAGTCCTGACATGAGGACTTTTGTTTCTGGTGCTTGTGATGCCTCTTCCAAATTATGGGATATTCGAGATGGAATGTGTAGACAGTCTTTCACGGGACATGTCTCAGATATCAATGCTGTCAGTTTTTTCCCAAATGGATATGCCTTCGCCACTGGCTCTGATGATGCCACTTGCCGGCTCTTTGACCTTCGTGCAGATCAAGAGTTATTATTGTATTCTCATGACAATATCATCTGTGGAATCACTTCTGTAGCCTTCTCAAAAAGTGGGCGTCTCTTGTTGGCTGGTTACGATGACTTTAATTGTAATGTATGGGACACGCTAAAAGGAGATCGTGCAGGTGTCCTTGCTGGTCATGACAACCGTGTGAGCTGCTTAGGTGTAACTGATGATGGCATGGCTGTGGCAACAGGCTCTTGGGACAGTTTTCTTAGAATCTGGAATTAACAGTGTCATACATATTTGTTCTCCATTGATATATCTGGAGAAATCAATGCTACAGCCTATAGCTGTGAAAAAATTCTACCTTATATTTGCAGGTGAAGATTTTTCTATTAGATTATCTACAAAAACAAGCTTTCAGTAAACTACCAAAAAAAAAGTGGGGGTGGAGGAAAAAAGGCAAAGGCGCCTTCTGAGATCAAAAGGACCAGTGTATTAATTTGAGGGGTTGGGTTATTTTAACCTTGGTGAATTGTTGTGTGTACTCAGAGTGTATTTTCTTTGTGTAGAACAGAATGTACACATTATAGCAGCTCGCCATTGTGTTTGCATTTTTTAAGAAGTACATTTTTAACTTTGTATACACAAGAAATGTCATATTTTTGAGTTTTGTAATGGAAGAACCAGGCACAGAAACAGACAGAAATGATACTGTATGTGTGTGTATTTATGTCTGAAGAAAGTCCCCTTGAATTCTGATATCTCTTTGAATCTAAGAGATCCTGATAGCTTCATGTTTAAGAGCATTGACAGGTGGGGCACCTCTGAGGGGAGTTCATTGTTTCTCATGCATCATTTGCCATATACTATTAATCAAAGTGCTTGCTTTCAGTCCTTTGAGGGGACAGATAATCTGAAGGCCAGAGATTAGAGATTTCACTGATATTTTGGACATACATAAGAAACATCATTATAATTAATAAAAAGTAGGTAATAGCATATAAATGGTTCTTGACATTTTAAAAGCCTGGTTATGATCAGTTGACACTTTGAGTACCCCCCTAAATAGCTGGACTTTCCTTTTCATTTCATATTTGGAACTAAGTTTGTAGCGTATACTCATCTTTCAGAAGTTTGGTAAACATTGGGATTGTCCCTGCATCTGAACATCTTTCCCAGTGCTATCAGTATACATCTAGAGAGGAAATGCAATGTGACAGTGTTACATTTGGAGAGAAGTGTGAAATCTAACCAATCGCTAGCACATATTTGTTGTAATACGGTGGTTTATTTCATGTTTGCATACTATAAAATCTGAATTGATGTGAAATATCTGTGCCTTTAAATTTCTTAAACCTTTAAGCTTTTTGTTCTGTTTTGCAACATTTTGTAGTATTTCTTCCCTTCCTTAGCACAAAATACTGGTTTCTAAGTGGTTTTGCTTCAAAGGATGTCTAGATGTAAGTGATTCCACTTAAAGCCAAAATAAAAATTCCTAAAGCAGTTCTTAAAGGAGTTAGAGAGCTATATTAAACAGTTTTTCTGTGGTATAATAATGTGTCTCTTACTAGAAGTCCCCCACGACCAAGTTAAAGATACTTTTCCTGTTGGATTCTCTTTTACAAATAAGTCTAAATGACTGATAATAGAAGATTGTTAGTCTTGCTTGATGGTAAAGTCTTGGATTATTCTGATATATAGACGTGCATTGTTTTGTAACTTAGTTACTTTTCAGATAGGTCTGTGTTAACTTTTGAACATGTGTAACTTAACCTAAATACTCCCAAACTTTACCTCTAAATTTTTGTTTTTATGTTGTGAATGTGCTAATATGTGCATCAACTGTAAAGATGTATCAGTTTTATTAAAATCAGTTGACAATTAGAATAATAAAGTGGATAAAGGCAAATTAAGATATAGGACCAAAACAGAATATTGTAGATGGCAGTTATGAATGTATATTTATATTTTGATTAAGATTTCTATTAACTTTTTGGCTGGGCAGAGTGGCTTACACCTATAATCCCAGCAATTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGTCAGGAGTTCGCGACCAGCCTACCCAACATGGTGAAACCCCATCTCTTCTAAAAATACAAACATTAGCCGGGCGTGGTGGCACATTCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGATTCGCCTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGTGAGACTCCATCTCAAATTGGAAAAAAAAAAAATTATATGAACTTTTGCTATTAATGTTTATTTGTAGGCTATTTATATCACTTCATAAAGAACAGTTCTTTGAGAAAAGAATAAAGGAATGTATTCATTTCCAGAAAAAGAGGGTTGGGGAAAGTTTGCCATGTAGGTTAGTCAGAAGAAAGCAATTCTATTATGCATAAAAATAACCTTAAATATGTAAGAGAGTATCTCCTCTACTTAAAAGTTATTATAGTAGTCACAGGCATACAGACCACAGGAATTCTATGGTCTTAACATATTTTAAAATTACATTTATTTTAATGTTCTTAAAGTTTATGAAGAGGAGTTTAAAGCAATTCCCATAATTAAATATTTACTCGGCAACTAAAAACTATTTAACACTTGTGGTTAATTATACACATAAACAAATGGCGACAGAGTAGCCTCACTACCACAATTACTTCATGGTTACACCTTTGCTTTCTAATAATAGGGGCTCCAGTTGCTAAATATATTTGTTTACTTACAGTTTAAGTTGAGCTGATTGTTGAATTCTGTTATTGTTCCTGAATTCAATGAGTATATAATTTGTAGAGATGTTGAATAGTTTGGATCTTAGTTTTTAAGGCTGAAAAATCTGGCTGGATTTAGTTTTTAAAAATTTGCATCATCAAGAATATTGCAGTTAATGTTCCTTTTTTTTTTTTTTTAAAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGTACAGTGGTGTGATTTTGGCTCATTGCAACCTCAACCTCTGCCTCCTGGGTTCAAGCAATTCTTGTGCCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGTGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGTCTGATCTCGTACTCCTGGCCTCAAGTGATCCACCAGCCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACCGTGCCCAGCCAGGTTTCCTTCTTTACCTTCTAAGAAACATTTAAACATAATGTGCCTGAGAAGGTTAATTTGTTGACTCTGTAGCATGTCAAGAAGAGTAGTTTTTTGAGATCTGGCAAGAATATTTTAGAGATACATATTCTTTTCTAAGTATGTTATCACCCTGTGGTGTTGAGCATATCGTCCCAAAAACCTGCTTCAGCAAGCAGTTCTTGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGAGGTGGGCGCCTGTCAGCTACTCGTGAGGCTGAGGCAGAGAATTACTTGAACTCAGGAGGTGGAGGTTTTGGTGAGCTGAGATGGCGCCACTGCACTCCAACCCGAGCGACAGAGCAAGATTCCGTCCCAAAAAGAAAAAGCAGTTTTTGCCATCAGCAAGGATATCTCCTCCACTTTAATGGACAGGCCTCATTTTTGGCAGCTATGCTGTTTGAGATGTAGACTGAATATCCAAGGTTCCTCCCTAGCTCAAGTTTTTACTTGTGATTACACACACCACATTGAATTCCGTCTTCAGAGGCAAAGATTTGGGCTTCATATCTCAACAGCAAAAGGGCCTGTTCAGCAATTCCCTTCATTTTAGACTCATATGACCTCAGCGATTGCATGATAGTAGTAAACTAGTCTCCTGGAAATAATGGATGTAGGTGCTTCTAGAATATGTTACAGAATTTCAGACTTAACCTATTAATAGATAAATGGATCTTGACTTAAGGTGACAAAATGAAACTTTTATTATTGCTTAAAAATGCTGTGCCAATATTGTATAACTAGCTCCTCTAATACTTTTGGTATTTTGGATTTAATAATAAGACCTTAAGCATTTTAAATGTGAACATGTTCAGGGAAGTATGCTTTGATGTAAATGTCTCAGATCTAAGTTGTAACACAATTGAATACTTGTGGCTTATTCTTGGTTTAACTTAGGAAAACTGGTTAAACAATCCCCCATTTGGGCCTGTCATCATTTTAATAGTGACGATGTTCTTTCTGAAATCTTCAGGGTCGGAGTCAGGCTGAATTTTTTTAAAAATTAAATATTATGTTCAAATTCTTTCCTTTTTGCCATTGTGAAAAAGCAAAATTTTAAATGATTTCTCCTGTTAGAATTTTTAAAAATACCCACAGGTTGGACCATCTTTCTTATGGGTTGCACAATGAATTTATATTTTAAATTAGATTAAGTAGAATGTGAAGTACATTTCAGATTTACTAGTTTTCTTTCCATTGTTCATTTTGGGTTGCCTCAGATTCAGTGTATATTTTAAAATATTGGTTACATAATAGGTACTCAATGAAATGGTTTATAGTAGAATATCTAAGCTAGCACTTTATTTTAAAAAGTAACTTATTAATTAATCACACATTGATGGTACACCTTGTATTTAGCAAATGTTTGCATGTTGATAAAATCTCCTATGTCTTCTTTCTTAAATCCAGTTGCTGATTTTGTAAAATACAGTTGTGATAAAGCAGCATTACGGGGGGGAAAAAGCTATATTCCAACTGGTGTTAAATGTATTCAACAAAATCTTACATCATACAGTATTTATTTCTTAATTAATAGAACTTCAGTGATATACTTGGTAGATATCTCAAGCCTTTTGTCTTTTACACAATGGTGCTCTATCCTATTGTTTTCTTTTCAAAGAAGCATCTGAACACTTGCATTTCTATTTTCCTATCCAAAGGCATCCACATCTAAGTGTGTTTTTAAAGTTGATTAAAATTATTTTTCTGTTAAAGCATTCTGAAAGTGTTTGTCTTTACCTAGAATGATTTGTACACACTCGTGGTCAACTGAACATGAATGTCAGTAGTAGTCTAATTATGGGAAGGGTAAACGTGTTAGATTAAGGCTCTTAAAGCTCTAAACCATATAAACTATGGACTTGTATCATGATTTAACTGTTCTTAGATCTTTCTTACACAGTGATTCATTCCTCTATTTGTACAGTGGCTTTATGAAATGTTGTGAATTGATACTGTAATCAATAAAGTGCTTTTAACCAGA N/A type 2 diabetes mellitus Microarray; qRT-PCR peripheral blood from healthy individuals, pre-diabetes patients and T2DM patients N/A up-regulated N/A N/A N/A N/A The expression levels of hsa_circ_0068087 were significantly different among the three groups and increased gradually from the control group to the pre-diabetes group to the T2DM group. 27878383 2017.3 Acta Diabetol. Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus N/A hsa_circ_0018508 N/A 10 70174795-70229920 - hg19 DNA2 ATTTCAGAAGAAAGTGGTAGCTTCCTTTCCAAGAACAGTTCTGAGCACAGGAATGGATAACCGGTACCTGGTGTTGGCAGTCAATACTGTACAGAACAAAGAGGGAAACTGTGAAAAGCGCCTGGTCATCACTGCTTCACAGTCACTAGAAAATAAAGAACTATGCATCCTTAGGAATGACTGGTGTTCTGTTCCAGTAGAGCCAGGAGATATCATTCATTTGGAGGGAGACTGCACATCTGACACTTGGATAATAGATAAAGATTTTGGATATTTGATTCTGTATCCAGACATGCTGATTTCTGGCACCAGCATAGCCAGTAGTATTCGATGTATGAGAAGAGCTGTCCTGAGTGAAACTTTTAGGAGCTCTGATCCAGCCACACGCCAAATGCTAATTGGTACGGTTCTCCATGAGGTGTTTCAAAAAGCCATAAATAATAGCTTTGCCCCAGAAAAGCTACAAGAACTTGCTTTTCAAACAATTCAAGAAATAAGACATTTGAAGGAAATGTACCGCTTAAATCTAAGTCAAGATGAAATAAAACAAGAAGTAGAGGACTATCTTCCTTCGTTTTGTAAATGGGCAGGAGATTTCATGCATAAAAACACTTCGACTGACTTCCCTCAGATGCAGCTCTCTCTGCCAAGTGATAATAGTAAGGATAATTCAACATGTAACATTGAAGTCGTGAAACCAATGGATATTGAAGAAAGCATTTGGTCCCCTAGGTTTGGATTGAAAGGCAAAATAGATGTTACAGTTGGTGTGAAAATACATCGAGGGTATAAAACAAAATACAAGATAATGCCGCTGGAACTTAAAACTGGCAAAGAATCAAATTCTATTGAACACCGTAGTCAGGTTGTTCTGTACACTCTACTAAGCCAAGAGAGAAGAGCTGATCCAGAGGCTGGCTTGCTTCTCTACCTCAAGACTGGTCAGATGTACCCTGTGCCTGCCAACCATCTAGATAAAAGAGAATTATTAAAGCTAAGAAACCAGATGGCATTCTCATTGTTTCACCGTATTAGCAAATCTGCTACTAGACAGAAGACACAGCTTGCTTCTTTGCCACAAATAATTGAGGAAGAGAAAACTTGTAAATATTGTTCACAAATTGGCAATTGTGCTCTTTATAGCAGAGCAGTTGAACAACAGATGGATTGTAGTTCAGTCCCAATTGTGATGCTGCCCAAAATAGAAGAAGAAACCCAGCATCTGAAGCAAACACACTTAGAATATTTCAGCCTTTGGTGTCTAATGTTAACCCTGGAGTCACAATCGAAGGATAATAAAAAGAATCACCAAAATATCTGGCTAATGCCTGCTTCGGAAATGGAGAAGAGTGGCAGTTGCATTGGAAACCTGATTAGAATGGAACATGTAAAGATAGTTTGTGATGGGCAATATTTACATAATTTCCAATGTAAACATGGTGCCATACCTGTCACAAATCTAATGGCAGGTGACAGAGTTATTGTAAGTGGAGAAGAAAGGTCACTGTTTGCTTTGTCTAGAGGATATGTGAAGGAGATTAACATGACAACAGTAACTTGTTTATTAGACAGAAACTTGTCGGTCCTTCCAGAATCAACTTTGTTCAGATTAGACCAAGAAGAAAAAAATTGTGATATAGATACCCCATTAGGAAATCTTTCCAAATTGATGGAAAACACGTTTGTCAGCAAAAAACTTCGAGATTTAATTATTGACTTTCGTGAACCTCAGTTTATATCCTACCTTAGTTCTGTTCTTCCACATGATGCAAAGGATACAGTTGCCTGCATTCTAAAGGGTTTGAATAAGCCTCAGAGGCAAGCGATGAAAAAGGTACTTCTTTCAAAAGACTACACACTCATCGTGGGTATGCCTGGGACAGGAAAAACAACTACGATATGTACTCTCGTAAGAATTCTCTACGCCTGTGGTTTTAGCGTTTTGTTGACCAGCTATACACACTCTGCTGTTGACAATATTCTTTTGAAGTTAGCCAAGTTTAAAATAGGATTTTTGCGTTTGGGTCAGATTCAGAAGGTTCATCCAGCTATCCAGCAATTTACAGAGCAAGAAATTTGCAGATCAAAGTCCATTAAATCCTTAGCTCTTCTAGAAGAACTCTACAATAGTCAACTTATAGTTGCAACAACATGTATGGGAATAAACCATCCAATATTTTCCCGTAAAATTTTTGATTTTTGTATTGTGGATGAAGCCTCTCAAATTAGCCAACCAATTTGTCTGGGCCCCCTTTTTTTTTCACGGAGATTTGTGTTAGTGGGGGACCATCAGCAGCTTCCTCCCCTGGTGCTAAACCGTGAAGCAAGAGCTCTTGGCATGAGTGAAAGCTTATTCAAGAGGCTGGAGCAGAATAAGAGTGCTGTTGTACAGTTAACCGTGCAGTACAGAATGAACAGTAAAATTATGTCCTTAAGTAATAAGCTGACCTATGAGGGCAAGCTGGAGTGTGGATCAGACAAAGTGGCCAATGCAGTGATAAACCTACGTCACTTTAAAGATGTGAAGCTGGAACTGGAATTTTATGCTGACTATTCTGATAATCCTTGGTTGATGGGAGTATTTGAACCCAACAATCCTGTTTGTTTCCTTAATACAGACAAGGTTCCAGCGCCAGAACAAGTTGAAAAAGGTGGTGTGAGCAATGTAACAGAAGCCAAACTCATAGTTTTCCTAACCTCCATTTTTGTTAAGGCTGGATGCAGTCCCTCTGATATTGGTATTATTGCACCGTACAGGCAGCAATTAAAGATCATCAATGATTTATTGGCACGTTCTATTGGGATGGTCGAAGTTAATACAGTAGACAAATACCAAGGAAGGGACAAAAGTATTGTCCTAGTATCTTTTGTTAGAAGTAATAAGGATGGAACTGTTGGTGAACTCTTGAAAGATTGGCGACGTCTTAATGTTGCTATAACCAGAGCCAAACATAAACTGATTCTTCTGGGGTGTGTGCCCTCACTAAATTGCTATCCTCCTTTGGAGAAGCTGCTTAATCATTTAAACTCAGAAAAATTAATCATTGATCTTCCATCAAGAGAACATGAAAGTCTTTGCCACATATTGGGTGACTTTCAAAGAGAATAA N/A type 2 diabetes mellitus Microarray; qRT-PCR peripheral blood from healthy individuals, pre-diabetes patients and T2DM patients N/A up-regulated N/A N/A N/A N/A The levels of hsa_circ_0018508 expression in the pre-diabetes and T2DM groups did not differ, but both were higher than that of the control group. 27878383 2017.3 Acta Diabetol. Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus N/A hsa_circRNA_100782 hsa_circ_0000284; hsa_circ_000016 11 33307958-33309057 + hg19 HIPK3 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG exonic pre-eclampsia Microarray; qRT-PCR 40 placental tissues from PE patients and 35 placental tissues from gestational age-matched patients who gave premature birth N/A up-regulated N/A N/A N/A N/A The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls. 27606420 2016 Cell Physiol Biochem. Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia N/A hsa_circRNA_102682 hsa_circ_0005442 2 36623756-36749456 + hg19 CRIM1 ATGAGAACTGGACTGATGACCAACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTGCAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCGCTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAGCCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCCGGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTGTCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGATGCGAGTGTCTCTCTGGCTTATGTGGTTTCCCCGTGTGTGAGGTGGGATCCACTCCCCGCATAGTCTCTCGTGGCGATGGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGATACAAAGCCAGCCTGCGTATTTAACAATGTGGAATATTATGATGGAGACATGTTTCGAATGGACAACTGTCGGTTCTGTCGATGCCAAGGGGGCGTTGCCATCTGCTTCACCGCCCAGTGTGGTGAGATAAACTGCGAGAGGTACTACGTGCCCGAAGGAGAGTGCTGCCCAGTGTGTGAAGATCCAGTGTATCCTTTTAATAATCCCGCTGGCTGCTATGCCAATGGCCTGATCCTTGCCCACGGAGACCGGTGGCGGGAAGACGACTGCACATTCTGCCAGTGCGTCAACGGTGAACGCCACTGCGTTGCGACCGTCTGCGGACAGACCTGCACAAACCCTGTGAAAGTGCCTGGGGAGTGTTGCCCTGTGTGCGAAGAACCAACCATCATCACAGTTGATCCACCTGCATGTGGGGAGTTATCAAACTGCACTCTGACAGGGAAGGACTGCATTAATGGTTTCAAACGCGATCACAATGGTTGTCGGACCTGTCAGTGCATAAACACCGAGGAACTATGTTCAGAACGTAAACAAGGCTGCACCTTGAACTGTCCCTTCGGTTTCCTTACTGATGCCCAAAACTGTGAGATCTGTGAGTGCCGCCCAAGGCCCAAGAAGTGCAGACCCATAATCTGTGACAAGTATTGTCCACTTGGATTGCTGAAGAATAAGCACGGCTGTGACATCTGTCGCTGTAAGAAATGTCCAGAGCTCTCATGCAGTAAGATCTGCCCCTTGGGTTTCCAGCAGGACAGTCACGGCTGTCTTATCTGCAAGTGCAGAGAGGCCTCTGCTTCAGCTGGGCCACCCATCCTGTCGGGCACTTGTCTCACCGTGGATGGTCATCATCATAAAAATGAGGAGAGCTGGCACGATGGGTGCCGGGAATGCTACTGTCTCAATGGACGGGAAATGTGTGCCCTGATCACCTGCCCGGTGCCTGCCTGTGGCAACCCCACCATTCACCCTGGACAGTGCTGCCCATCATGTGCAGATGACTTTGTGGTGCAGAAGCCAGAGCTCAGTACTCCCTCCATTTGCCACGCCCCTGGAGGAGAATACTTTGTGGAAGGAGAAACGTGGAACATTGACTCCTGTACTCAGTGCACCTGCCACAGCGGACGGGTGCTGTGTGAGACAGAGGTGTGCCCACCGCTGCTCTGCCAGAACCCCTCACGCACCCAGGATTCCTGCTGCCCACAGTGTACAGATCAACCTTTTCGGCCTTCCTTGTCCCGCAATAACAGCGTACCTAATTACTGCAAAAATGATGAAGGGGATATATTCCTGGCAGCTGAGTCCTGGAAGCCTGACGTTTGTACCAGCTGCATCTGCATTGATAGCGTAATTAGCTGTTTCTCTGAGTCCTGCCCTTCTGTATCCTGTGAAAGACCTGTCTTGAGAAAAGGCCAGTGTTGTCCCTACTGCATAG exonic pre-eclampsia Microarray; qRT-PCR 40 placental tissues from PE patients and 35 placental tissues from gestational age-matched patients who gave premature birth N/A up-regulated N/A N/A N/A N/A The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls. 27606420 2016 Cell Physiol Biochem. Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia N/A hsa_circRNA_104820 hsa_circ_0005218 9 96233422-96259881 + hg19 FAM120A GTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGGTTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGCCCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCGTTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACATCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAACATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAG exonic pre-eclampsia Microarray; qRT-PCR 40 placental tissues from PE patients and 35 placental tissues from gestational age-matched patients who gave premature birth N/A up-regulated N/A N/A N/A N/A The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls. 27606420 2016 Cell Physiol Biochem. Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia N/A hsa_circRNA_101852 hsa_circ_0040039 16 69279504-69318147 + hg19 SNTB2 TCAAGTTCATCCGAGAAGTAACACCATATATCAAGAAGCCATCATTAGTATCAGATCTGCCGTGGGAAGGTGCAGCCCCCCAGTCACCAAGCTTTAGTGGCAGTGAGGACTCTGGTTCGCCAAAACACCAGAACAGCACCAAGGACAGGAAGATCATCCCTCTCAAAATGTGCTTTGCTGCTAGAAACCTAAGCATGCCGGATCTGGAAAACAGATTGATAGAGCTACATTCTCCTGATAGCAGGAACACGTTGATCCTACGCTGCAAAGATACAGCCACAGCACACTCCTGGTTCGTAGCTATCCACACCAACATAATGGCTCTCCTCCCACAGGTGTTGGCTGAACTCAACGCCATGCTTGGGGCAACCAGTACAGCAGGAGGCAGTAAAGAGGTGAAGCATATTGCCTGGCTGGCAGAACAGGCAAAACTAGATGGTGGAAGACAGCAATGGAGACCTGTCCTCATGGCTGTGACTGAGAAGGATTTGCTGCTCTATGACTGTATGCCGTGGACAAGAGATGCCTGGGCGTCACCATGCCACAGCTACCCACTTGTTGCCACCAGGTTGGTTCATTCTGGCTCCGGATGTCGATCCCCCTCCCTTGGATCTGACCTTACATTTGCTACCAGGACAGGCTCTCGACAGGGCATTGAGATGCATCTCTTCAGGGTGGAGACACATCGGGATCTGTCATCCTGGACCAGGATACTTGTTCAGGGTTGCCATGCTGCTGCTGAGCTGATCAAGGAAGTCTCTCTAG exonic intervertebral disc degeneration Microarray; qRT-PCR human normal (cadaveric donors) and degenerative lumbar nucleus pulposus (NP) with patient demographics and IDD grading N/A up-regulated N/A N/A N/A N/A To validate the circRNAs microarray result, two circRNAs were selected for qRT-PCR validation. The expression of has-circRNA-101852 (P < 0.05) was significantly increased in degenerative samples compared with control whereas the expression of has-circRNA-101645 (P < 0.05) was significantly decreased. 27542248 2016.9 Oncotarget Landscape of RNAs in human lumbar disc degeneration N/A hsa_circRNA_101645 hsa_circ_0036763 15 90760670-90763123 + hg19 SEMA4B GCTCTGAAGAGCGGCCATTCCTCAGATTCGAAGCTGAACACATCTCCAACTACACAGCCCTTCTGCTGAGCAGGGATGGCAGGACCCTGTACGTGGGTGCTCGAGAGGCCCTCTTTGCACTCAGTAGCAACCTCAGCTTCCTGCCAGGCGGGGAGTACCAGGAGCTGCTTTGGGGTGCAGACGCAGAGAAGAAACAGCAGTGCAGCTTCAAGGGCAAGGACCCACAGCGCGACTGTCAAAACTACATCAAGATCCTCCTGCCGCTCAGCGGCAGTCACCTGTTCACCTGTGGCACAGCAGCCTTCAGCCCCATGTGTACCTACATC exonic intervertebral disc degeneration Microarray; qRT-PCR human normal (cadaveric donors) and degenerative lumbar nucleus pulposus (NP) with patient demographics and IDD grading N/A down-regulated N/A N/A N/A N/A To validate the circRNAs microarray result, two circRNAs were selected for qRT-PCR validation. The expression of has-circRNA-101852 (P < 0.05) was significantly increased in degenerative samples compared with control whereas the expression of has-circRNA-101645 (P < 0.05) was significantly decreased. 27542248 2016.9 Oncotarget Landscape of RNAs in human lumbar disc degeneration N/A circANRIL hsa_circ_0008574 9 22046749-22056386 + hg19 linANRIL/CDKN2B-AS TGTCCCTTTTGATGAGAAGAATAAGCCTCATTCTGATTCAACAGCAGAGATCAAAGAAAAGACTTCTGTTTTCTGGCCACCAGATATATGTTATCTGTGCTTAAAGAATTGAAAAACACACATCAAAGGAGAATTTTCTTGGAAAGAGAGGGTTCAAGCATCACTGTTAGGTGTGCTGGAATCCTTTCCCGAGTCAGTACTGCTTTCTAGAAGAAAACCGGGGAGATCTATTTGGAATGTATCTAACTCCAAAGAAACCATCAGAGGTAACAGTAGAGACGGGGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCTCGACCTCGTGATTCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGACACCACACCCGGCGGATAGAGAGAATTTTGACAG antisense atherosclerosis qRT-PCR; in vitro overexpression; western blot; northern blot; FISH; IHC; pull down; RIP; etc. healthy and diseased human vascular tissues; smooth muscle cells (SMC) and monocyte/macrophages; blood mononuclear cells and whole blood of patients with different burden of coronary artery disease; HEK-293 cell N/A down-regulated N/A N/A PES1 p53 circANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis. 27539542 2016.8 Nat Commun. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans N/A hsa_circRNA_103636 hsa_circ_0001410 4 52729602-52744020 + hg19 DCUN1D4 ATTTTCAGCTGAACTCTCATCTCTCAACACTGGCAAATATTCATAAGATCTACCACACCCTTAATAAGCTGAACCTAACAGAAGACATTGGCCAAGACGATCACCAAACAGGAAGTCTGCGGTCTTGCAGTTCTTCAGACTGCTTTAATAAAGTGATGCCACCAAGGAAAAAGAGAAGACCTGCCTCTGGAGATGATTTATCTGCCAAGAAAAGTAGACATGATAGCATGTATAGAAAATATGATTCGACTAGAATAAAGACTGAAGAAGAAGCCTTTTCAAGTAAAAGGTGCTTGGAATGGTTCTATGAATATGCAG exonic major depressive disorder Microarray; qRT-PCR peripheral blood mononuclear cells (PBMCs) from MDD patients and healthy controls N/A down-regulated N/A N/A N/A N/A Four differentially expressed circRNAs were identified between MDD patients and controls, and only down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients.ROC curve analysis was employed to evaluate the diagnostic value of hsa_circRNA_103636. The results showed that the area under the curve (AUC) of hsa_circRNA_103636 was 0.632 (95% CI: 0.533¨C0.688), and the sensitivity and specificity were 0.73 and 0.65,respectively. 27404501 2016.9 Biomark Med. hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder N/A circRNA-CER hsa_circRNA_100876; hsa_circ_0023404 11 71668272-71671937 + hg19 RNF121 GTTGATATGTCAGATCTCTCTCCAGAAGAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAAT exonic osteoarthritis Microarray; qRT-PCR; luciferase reporter assay; western blot; etc. OA cartilage and normal cartilage N/A up-regulated miR-136 MMP13 N/A N/A CircRNA-CER expression increased with interleukin-1 and tumor necrosis factor levels in chondrocytes. Silencing of circRNA-CER using small interfering RNA suppressed MMP13 expression and increased ECM formation. CircRNA-CER could compete for miR-136 with MMP13. Our results demonstrated that circRNA-CER regulated MMP13 expression by functioning as a competing endogenous RNA (ceRNA) and participated in the process of chondrocyte ECM degradation. We propose that circRNA-CER could be used as a potential target in OA therapy. 26931159 2016.3 Sci Rep. Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation N/A hsa_circRNA_100086 hsa_circ_0000026; hsa_circRNA_100086 1 21377358-21437876 - hg19 EIF4G3 CAATCCCACAGAGTATTGATGAGGAAACTGAAGTTTGGAGCGATCACATCATTTTCCCAAGAATTCCTAGAGGACCTGTGCAACAACCTCTTGAGGATCGAATCTTCACTCCCGCTGTCTCAGCAGTCTACAGCACGGTAACACAAGTGGCAAGACAGCCGGGAACCCCTACCCCATCCCCTTATTCAGCACATGAAATAAACAAGGGGCATCCAAATCTTGCGGCAACGCCCCCGGGACATGCATCGTCCCCTGGACTCTCTCAA exonic osteoarthritis Microarray; qRT-PCR OA cartilage and normal cartilage N/A up-regulated N/A N/A N/A N/A We selected four circRNAs that exhibited significant changes in expression among the differentially expressed circRNAs and then performed qPCR to analyze the changes in expression. The data confirmed that circRNA_100876 (circRNA-CER), circRNA_100086, circRNA_101178 and circRNA_101914 were overexpressed in OA. 26931159 2016.3 Sci Rep. Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation N/A hsa_circRNA_101178 hsa_circ_0005043; hsa_circRNA_101178 12 121002874-121009094 + hg19 RNF10 GATGTTCGACAGCGTCACAGATATCTCTCTCACTTGCCACTCACCTGTGAGTTCAGCATCTGTGAACTGGCTTTGCAACCTCCTGTGGTCTCTAAGGAAACCCTAGAGATGTTCTCAGATGACATTGAGAAGAGGAAACGTCAGCGCCAAAAGAAGGCTCGGGAGGAACGCCGCCGAGAGCGCAGGATTGAGATAGAGGAGAACAAGAAACAGGGCAAGTACCCAGAAGTCCACATTCCCCTCGAGAATCTACAGCAGTTTCCTGCCTTCAATTCTTATACCTGCTCCTCTGATTCTGCTTTGGGTCCCACCAGCACCGAGGGCCATGGGGCCCTCTCCATTTCTCCTCTCAGCAGAAGTCCAGGTTCCCATGCAGACTTTCTGCTGACCCCTCTGTCACCCACTGCCAGTCAGGGCAGTCCCTCATTCTGCGTTGGGAGTCTGGAAGAAGACTCTCCCTTCCCTTCCTTTGCCCAG exonic osteoarthritis Microarray; qRT-PCR OA cartilage and normal cartilage N/A up-regulated N/A N/A N/A N/A We selected four circRNAs that exhibited significant changes in expression among the differentially expressed circRNAs and then performed qPCR to analyze the changes in expression. The data confirmed that circRNA_100876 (circRNA-CER), circRNA_100086, circRNA_101178 and circRNA_101914 were overexpressed in OA. 26931159 2016.3 Sci Rep. Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation N/A hsa_circRNA_101914 hsa_circ_0041019; hsa_circRNA_101914 16 89824984-89833645 - hg19 FANCA ATTTTGTACAGCAGCAATTTCTTACTCTCTCTGCAAGTTTTCTTCCCAGTCACGAGATACTTTGTGCAGCTGCTTATCTCCAGGCCTTATTAAAAAGTTTCAGTTCCTCATGTTCAGATTGTTCTCAGAGGCCCGACAGCCTCTTTCTGAGGAGGACGTAGCCAGCCTTTCCTGGAGACCCTTGCACCTTCCTTCTGCAGACTGGCAGAGAGCTGCCCTCTCTCTCTGGACACACAGAACCTTCCGAGAGGTGTTGAAAGAGGAAGATGTTCACTTAACTTACCAAGACTGGTTACACCTGGAGCTGGAAATTCAACCTGAAGCTGATGCTCTTTCAGATACTGAACGGCAGGACTTCCACCAGTGGGCGATCCATGAGCACTTTCTCCCTGAGTCCTCGGCTTCAGGGGGCTGTGACGGAGACCTGCAGGCTGCGTGTACCATTCTTGTCAACGCACTGATGGATTTCCACCAAAG exonic osteoarthritis Microarray; qRT-PCR OA cartilage and normal cartilage N/A up-regulated N/A N/A N/A N/A We selected four circRNAs that exhibited significant changes in expression among the differentially expressed circRNAs and then performed qPCR to analyze the changes in expression. The data confirmed that circRNA_100876 (circRNA-CER), circRNA_100086, circRNA_101178 and circRNA_101914 were overexpressed in OA. 26931159 2016.3 Sci Rep. Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation N/A hsa_circRNA_101222 hsa_circ_0029601 13 20067587-20077417 - hg19 TPTE2 TCCACCCACAAATGAATTATCAGGAGTGAACCCAGAGGCACGTATGAATGAAAGTCCACAGACAAACGAATTTAAAGGAACAACCGAGGAGGCACCTGCGAAAGAAAG exonic pre-eclampsia Microarray; qRT-PCR; ELISA blood corpuscles of pregnant women with PE and healthy controls between 8 and 20 weeks of gestation N/A up-regulated N/A N/A N/A N/A The circ_101222 levels in blood corpuscles of patients with PE were significantly higher than those in corresponding healthy women (P < 0.001). Using ENG in combination with circ_101222 resulted in a sensitivity of 0.7073, a specificity of 0.8049, and overall area under the curve of 0.876 (95% confidence interval 0.816-0.922) for the prediction of PE.The performance of each of these factors may be strengthened when plasma proteins are used in combination with circRNA. The results are preliminary and need to be validated in larger studies and other populations. 26846540 2016.12 BJOG. Circular RNA in blood corpuscles combined with plasma protein factor for early prediction of pre-eclampsia N/A hsa_circRNA_100783 hsa_circ_0008887 11 33307958-33350179 + hg19 HIPK3 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAGAGCTCCAGAGATTATATTGGGGTTGCCATTTTGTGAAGCCATAGACATGTGGTCATTGGGATGTGTGATTGCAGAATTATTTCTTGGATGGCCGCTCTACCCAGGAGCCTTGGAGTATGATCAG exonic T cell ageing and global immunosenescence Microarray; qRT-PCR CD28(+)CD8(+) T cells and CD28(-)CD8(+) T cells isolated from healthy elderly or adult control subjects N/A up-regulated N/A N/A N/A N/A Circular RNA100783 was up-regulated in C1 than C4 group. DAVID annotation revealed that a circular RNA100783-targeted miRNA-mRNA network may be involved in alternative splicing, the production of splice variants, and in the regulation of phosphoprotein expression. Considering the hypothesis of splicing-related biogenesis of circRNAs, we propose that circular RNA100783 may play a role in phosphoprotein-associated functions duringCD28-related CD8(+) T cell ageing. 26451160 2015.10 Immun Ageing. Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing N/A cZNF292 hsa_circ_0004383 6 87920168-87928449 + hg19 ZNF292 GCTTGCCCCAGAACACACACTATAGAGCAGATGCAGTAGCCACAAATAACTTTGTGGGGATCTAGTAGCTCCCTTAAAGAATGAGGTGAGGCAGGCTGAAGCGGGCGGATCACGAGGTCAAGAGATCAAGACCATCCTGGCTGACAAGGTGAAACGCCGTCTCTACTAAAAATACAAAAAGTAGCCAGGCTTGGTGGCGGGCGTCTGTAGTCCCAACTACACGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCTGTGAGCCGAGATCATGCCACTGCATTCCAGCCTGGGGAACAGAACAAGACTCTGTCTCAAAAACAAACAAACAAACAAAGAATGAGGTGAGGCATGTAGCACCCACAGAGCCTGTGTCTGATCTCAGTGGGAGATCTTGGGTCATCACTCAGCCCTAGCTAGTTGCCATGCTGGGATGTGGGCCCAAAGTTGCCAATTTTTTTTGTTTTAAAAGAAAAGCCAGAAACCCAAGTTTTTATGTAAAATATATGACTTCTAAATATTAGAAACTAATTCAAATACTTTTTGAACAATGTGCACATCAAAACATCCATGAGCCACTAGTTTATGAACACACACATATACTCACTAGTGTAGTCCCTTCTGGTATGGTGGAGTGTGTCTTTAATATATGACTCCTTTCAGTATCCTCAACTCTGAATCATCTTGCTCCTCTTTGAATAACTTCAGTTCGTGGGCCACCACCTGTCTCAGGAGGCCAACTTGTTCTGTTTTTGGTTTACTCTAATGGTTTGGTAGTTCTGTCTTATAGGAAACAGGAAAGTGTCTCTTTTAAACTTCAACCTAGTGGTCCTGGTATGACCTGTGAGACACACAGAATAAAATTAACTCCTCTCTTATGTGACAAGCCTCTAGATTTGTGAATTTGGCTAATTTAATCTAAAATTTAATCCAAATTTTAAAAATTGGATTTACAAGTCAATTTTTATTTCTCCAGAAATGTATCACATAGTAGTTAAGAATGAACACTCTGAAGTCAGACTATGAGGATTTGAATCCCTTCTCTGCCTTTCCTAGCTCTGTGGTCTTATGGCTTTTTATTTCACTACTTTTGGTTAGTTAATTTTTAATATAAGCATATTACTATAATTTACCTAATTACTGAATAGGTAGTACATGTAAAGCTCTTAGAACAACGCCTAGCACATGGTAAATATTCAGTAAATATTATTTAGTATCCAGATAAAGCATCCCTAGTTCCATCAGTCATTCATCAAAAAACAGTTTTAAATTTTCTTACCATATTTTTCTTACAGGTTACTCATTAATGGAAGCAATATGGTGCATTGCAGGAAGACATTTAGGTTTTGTTCCTTGTCTTTTCCCCTCTATGCCATCTCCCCCCAACTCATCTTCAAACCAGATTACAGTGACATTTATCTTTGTCTGTTCATATGTGTATAAATATAAATATATGTGTATAGACATTCATTCATTCTTGAAGGGGTGTCGTAACAAAAACCATTGGTTTAATGGGGAAAAAAGTGTAGGACTTTGGTCAGATGCCAGTCGCAAGTACCAGGTCCCCAAGTCTGTCCAACTTGGCTACAATGTTAGGGGTTCTCACAACCCCCTCCTCAGGGTCAGTAATTTGCTAGAATAACTCACAGAACTCAGGAAAATGCTATACTTACTATTACAAGGTATTATAAAGGATACAAATGAACAGCCAGATGAAGAAGTACCTAGGGTGAGATCTGAAAGGGTTCCAAGCACCAGAGCCTGTCTCTGTGGAGTTGGGATGTGCCACCTTCCCAGCACATGGATGTGTTTTCCAACTCAGAAGCTCTTAGACTACTGTTGTTTAGGAGGTCTTGTGGAGTACATAGCCATGATTGATCAGATCATTGGCCATTGGTGATTGGGTTCAATCTCTGCCCCTTTACCTCCTGCAAGACTGGGGGGTGGGGCTACAAGTTCCATCTCTCTAATCATGGCATGGTCTTTGTAGTGACCAGTCCCTGTCTTAAAGCTATCTAGAAGCTCCTCAGCCTAATGTTATCTCATTAACATGAAAAAGACACTTACGTAGATTTCAAGGGTTTTAGGAGCTTTGTGCTAAGAACCTAGGACAAAGACCAGTTATTTTTTATTATACCATACTTGTATGCCTGCCAGTGGCACAAACTGAATTCAAAGACTGGTCATGAATCTTAACATCCCTTTTGATTGAATGGTTGCATCATTGAATTCCAAATTTTCTTGTATAATCTTTCCTAGTTCATGTTGGTTCAACCAGGAACTAATCCCAGGTTTTAATTGCTCTAATCAAAATCACCATGCAAGAGAATGTTTTCATTTCTAGCAGTCCATAGTTCTCTGTCATTGTCCTCTGAATCATCTAGCTGGTCAAAAGATTGGAGAGTATAACCATTTCAGATCCATAAGAAATATAAGTTCTTCTTTATTTGAGGGCTGTTTAGAAGAAAGTTAAGAATTCTTCTGTGTAGGGGTCAAAAGAAAACTTCCCTTCATCCTCTGAAGGTTCACTGAAAATCACCTGACAAACAGCAGATTAATAGGAGAAATGGCATACAGATTTATTAATGAAAGGGAGGTGGGGAAATGTGGGTGATTTTAGAGGAGGGTTGTAAATTATTTTTAGGGGAATTCAATGGACTTGAACATACAGTGGCCTGGGACAAAGTCTATTGAGCCTGCTAAGCATTCAGTGGTTTGTGACAAAAGTCTGGCTAGGTGTGTTGACAGACTTCCGTCTTCCTGCCCTATGAGTTCAGTTAATGAAAACTCAGGGAGGGGACTGTTAGAAATGCTTATTCCCGGTGCCACAAAGAAATAGCACTCAAACATAAATTTAATTTTCACAGAAAGGCAATTTTTACTTTCTGCGGAAAGGGTGCTCCTTGCAGATGGAACAATGGTGAGACCACACCCGGACAGGGGAGGGGAAGGAGTTCTTGTTCCTGACGCAGGTATCCCCTACTGCTGTGTCATTCCTGTATTGGCTAGGGTTGGCCCGCACAGTCTAAGCTAATTCCAACTGGCTATTTTAAAAAGAGCAGGGGGTATGAGCCAGAGTGGTAGGGTGAGTAGTTTGGCGGGAAGGATGGTTAGAAACAGGTAACTAAAGGTGACTTAGGTCAGAGCAGGTGACCAGGGGTGACTCAGGTAAAGCAGGTGACCGGGATGAGTCAGGATGGACCAGGTGACCAGGGAACAGATGTGAACTACTGATTAGGACTGGTGGGAAAGTTGTTTACTGAAACTTAGAAGCAAGGGGGTGAAGAGAACCAGGAAGCTAAACTTTAAAATGGAGAATCAAAGAATAAGAGAGCTGAACATACTGACATACTGATTCTTTGAAGAGAAACTTGGGGTTCACTATATTTAACAGGATCAAAGGTAATTTTCTTCTTCTTTGGTGGGCCTGGACTTTAGACAGATAAGGAAACTTCACAGAACAACTTCATACTGTGTTTTGCGAGAAAGAGGATCAAGAGATGGGAAGAAACAGGGGAAGGTCGGAGAGACTCTGAGGCTGCTTCTTCAGCATGTCAAAGTGCCACAGTTTGGGGTATCAGTTTCTGAGCCCCAGCACCTGCAAAAGTGAGTCTCTGGATTGGGATTATATGTATAATAGTGACATGATTAGGCAAATAAAAGGCTTTAATTTCTGTGTTTACATCGAAGCTGAATAATCTTGGATATAATGTAGGCAGCTTGGGTATAATGTAGGCAGCTTCATCTCATGACCAGCTACAATGTCATTTGTTCATCATTACATTTAACAATGCCAAGAGGGTACAGAAACATGGATTCCCCTCTTCCCCAGCATCTCTGTCCCTGCTTGGAACTTAAAAGATCAGGAATAGCTTTACCTTTGGGTTTCATGTGGATTGAGCTAAGGAACTTATCTCTGGTTGTTTTTATCCTCACGTAGAATCTATTTTGTACCATGAAGGTTTGGGATATAATGGGATTGTGAGGTGAGGTGCAAGTGTGGATGAGAGCAAATTTGTTTCAGGGTTCATCTGGGAAAGATTGCAGTGTTTTTTCCTGGATATCTGAGAAACACGTTTTTCCACTTCAACTTTACTGAGAAATTTTGCTGTGGAGTTGGTTTTGGACCTAGTTGAGTATCCCCCGACACCCCATCCTACATCCTGCACTGTGGCTGCAGGTTTTCTGTCCTTTCTGTCTCTAGCAATCAGTATTTGCCCTCACTTCTTAGGGGGAAAGGAAAGGAAAGGATTAGTTGAGAGCCAAGGTCTGTGAATATATGGCTACTCAGTCGGTGAGTAGTTATTTTGTTGCCCTTTAGTTTACCAGCTTACTTTTTCTATTGCTTTCGTCTAATCACTTACTAATTCTGTTAGTTGGAAGTTAGTAGAGAGGTCAAGGTAGTAAGTGCTTTGGTAGTAGAATACAATCCCCCCCACCCCTTCCCTCCCTCCAGTTTTTAAAAGTGCTTCTGTATGCCAGAGGATACAGGCCCTCAGGAAATTTTTTTTTCCTTCAATACCCTATTTTCTAGGAAAAGAAACCTGAATTTCCATATGTTTGATTAAATGAGTCTTAAACCCTGAAGTGTGGAGAGGACCAATTGTGGCAGTCTTCTGTGTTATAAAAACATTTAATTAGAATCTCTCTTCATTTAGCATAACTATAGAACCTTTTAGGTAAGAGTCTTAACATGTGTGTTTCTGTATAACTTATCTTTCCATTATCTCCCATCTCTTATTCAGTAAGATAAATAGCATCTTTTAAAGTAATTCTGATGAGGTAAATTTAAAATATTCACTTAATTGAAAGATGAGAAATATTTTTAATTAAAAAAACACTATTACAAAAATTACTTAACCTTATAATAATTCTTTAATATCTTTAATGTTGATTTTTATATGTTGAAAGTCTTTGGATGACTTTTTAATTGCTAGTGCTTGTCAAAAAATTATTAATTTGTATGTACTGTTATTTTTTTATGGACTGAAAAAGGACACGTCTTTGCTGACCATACATGATTTATTTTGTTGTTCAATATTGAATTTTCTGCTGCTTCTACGAGAAATAGAAAACAGATATTATTTCAAATTCTTCACTGCATGCCTGGTCAACTGTTACTTGCTCAGATGTCTTTTTAAAATAACTTTTAAAACTTACTAGGGAATAGAGGAGATAACTCTTGCCCTATTTAAAACTAGCCTTGATGAAATTATGCTGTTGCTGGATGAATTAATACTAATCTTTTCTCCTACAGAGAGCTGCCAAAAATATGACTATGACTTTATTTCATTTAATATTTTAATCAATATAAACTACTTTTTGTTTTTATAAATAAAAATCTGTATTTTTCAAAATTTTTCAGGAAAAAACAGCTGATGAGTCAATGTATATTTTGATTTACATTTTGAATACTTTTTATTATTCCTTCCAAAACAGACACTCCTAGAATATGCAGAGAAATGGAAAACTTCAGAAGATCCTTTACCTTTATTGGAGGTATACACAGTGGCTATCCAAAGTTATGTTAAAGCCCGACCTTATCTTACCTCTGAATGTGAAAATGTAGCCTTGGTTCTGGAACGCTTGGCATTAAGCTGTGTTGAACTTTTACTGTGTCTGCCTGTTGAGTTATCAGATAAACAGTGGGAACAATTTCAGACACTGGTGCAGGTAGCTCATGAAAAGCTGATGGAGAATGGCAGCTGTGAATTGCATTTTTTAGCTACTCTAGCTCAAGAGACTGGGGTGTGGAAAAACCCGGTACTGTGCACTATTCTTTCCCAGGAACCATTGGATAAGGATAAAG intronic hypoxia RNA-seq; RT-PCR; qRT-PCR; Northern blot; in vitro knockdown; HITS-CLIP Endothelial cells cytoplasm up-regulated not microRNA sponge N/A N/A N/A Cloning of cZNF292 validated the predicted back splicing of exon 4 to a new alternative exon 1A. Silencing of cZNF292 inhibited cZNF292 expression and reduced tube formation and spheroid sprouting of endothelial cells in vitro. The expression of pre-mRNA or mRNA of the host gene was not affected by silencing of cZNF292. No validated microRNA-binding sites for cZNF292 were detected in Argonaute high-throughput sequencing of RNA isolated by cross-linking and immunoprecipitation data sets, suggesting that cZNF292 does not act as a microRNA sponge. 26377962 2015.10 Circ Res. Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA N/A cAFF1 hsa_circ_0001423 4 87967317-87968746 + hg19 AFF1 TTTGTACAATGACGACAGAAACCTGCTTCGAATTAGAGAGAAGGAAAGACGCAACCAGGAAGCCCACCAAGAGAAAGAGGCATTTCCTGAAAAGATTCCCCTTTTTGGAGAGCCCTACAAGACAGCAAAAGGTGATGAGCTGTCTAGTCGAATACAGAACATGTTGGGAAACTACGAAGAAGTGAAGGAGTTCCTTAGTACTAAGTCTCACACTCATCGCCTGGATGCTTCTGAAAATAGGTTGGGAAAGCCGAAATATCCTTTAATTCCTGACAAAGGGAGCAGCATTCCATCCAGCTCCTTCCACACTAGTGTCCACCACCAGTCCATTCACACTCCTGCGTCTGGACCACTTTCTGTTGGCAACATTAGCCACAATCCAAAGATGGCGCAGCCAAGAACTGAACCAATGCCAAGTCTCCATGCCAAAAGCTGCGGCCCACCGGACAGCCAGCACCTGACCCAGGATCGCCTTGGTCAGGAGGGGTTCGGCTCTAGTCATCACAAGAAAGGTGACCGAAGAGCTGACGGAGACCACTGTGCTTCGGTGACAGATTCGGCTCCAGAGAGGGAGCTTTCTCCCTTAATCTCTTTGCCTTCCCCAGTTCCCCCTTTGTCACCTATACATTCCAACCAGCAAACTCTTCCCCGGACGCAAGGAAGCAGCAAGGTTCATGGCAGCAGCAATAACAGTAAAGGCTATTGCCCAGCCAAATCTCCCAAGGACCTAGCAGTGAAAGTCCATGATAAAGAGACCCCTCAAGACAGTTTGGTGGCCCCTGCCCAGCCGCCTTCTCAGACATTTCCACCTCCCTCCCTCCCCTCAAAAAGTGTTGCAATGCAGCAGAAGCCCACGGCTTATGTCCGGCCCATGGATGGTCAAGATCAGGCCCCTAGTGAATCCCCTGAACTGAAACCACTGCCGGAGGACTATCGACAGCAGACCTTTGAAAAAACAGACTTGAAAGTGCCTGCCAAAGCCAAGCTCACCAAACTGAAGATGCCTTCTCAGTCAGTTGAG exonic hypoxia RNA-seq; RT-PCR Endothelial cells cytoplasm up-regulated N/A N/A N/A N/A N/A 26377962 2015.10 Circ Res. Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA N/A cDENND4C hsa_circ_0005684; circDENND4C 9 19286766-19305525 + hg19 DENND4C AGTTCTATATGAAGGGAAAGAACGGCTTATTCCAGGATGTGAAGTGATCCTAGCCACACCCTATGGTCGCTGTGCCAATGTCAACAATAGTTCAACTACTTCACAAAGAATCTTTATCACTTATCGAAGGGCTCCTCCAGTTCGACCCCAGAATTCCTTGGCTGTAACTGATATCTGTGTTATTGTAACCAGTAAAGGAGAAACTCCTCCTCATACCTTCTGCAAAGTTGACAAAAACTTAAATTGTGGAATGGTAAGAATAAAGTTTTCATCTTCAAAGTTTCATATGAAACCAAAAAGGGATACGTTTTGGATTCCTGTTTACTGTTGGGTATATACTCACATTTTATATTTTCATGATGCTTGTTTTTATTTTTCCTAATTTTTATGATTTGTAATAATTTTTAAAGTCCTATCCCATGATTTATAATAATTTCATCTTTAAGTCAGGGATATTTTTGAGGGAGTAAATCCTAATATTGTCTGTGTTACATTAACAAAGGTTTTATTCACTTTTGGATTTCAGTGGTGTCTTCAGGGACAACTGTGGGGTTAGAGTGGGTAGAAGCTCTCCTTACATTCATTTATTCATTCATTCATTCATTTGTTTGCTTTTTTTATTTTTTTGAGACAGGGTCTTGCTTTGTCGCCCAGGCTGGAGTACAGTGGTGCAATCACAGCTCACTGCAGCCTTGACCCCCCACCAGGCTCAAGTGATCTTCCCACCTTAGCCTCCCGAGTAGCTGGGACTACAGGATAGTAGAGACAGGGTTTCATCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTTAAGTGATCCACCTCCCTTGGCCTCCCAAAGTGTTGGAATTACAGGCGTGAGCCACCATGCCCGGCCTGTTTTTGTTTTTGAGACAGGGTCTCCTTAAGTTGCCCAGGATGCTCCTGAACTCTAGGGCTCAAGAGAAAATATTGCAGTTTTGCATACTTATTTTTTTTTTTCAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGTCTCAGCCTCCCAGGTAGCTGGGGCTACGGGCGTGCGCCACTACGCCCACCTAATTTTGTATGTTTAGTAGAGATGAGGTTTCACCATGTTGGTTGGCCAGGATGGTCTTGATCTCTTGACCTTGTGATCCACCTGCCTCAGCTTCCCAAAGTGCTGGGATTACAGGCGCAAGCCACCACACCCAATCCATGCATACTTACTCTTTAAAAGGACTGTAGTGAAGAAGAAAATGAACATAAATGTTTGATTCATAGTTTTTAAAGACTACAGCTTACTTTTGGTTCAGATTTACTTTGAAAAATATCTTCAGGTCAAACTAATATTAGCTTAATGTTGTATAGGCGGAGATGACAAATGCACCCAGAACAATTAGTGAAGACAGGGTTGCCTCTGGAGGTGATGACCTCATAGTCCTCCAGTGACCCAAGTCTTCCCCAATTTGGGCTCCAGTGCACACTCCGTTTTGTGCTGTGTCTTACAAGAAGGGGCAATCTCTGAGTGATTGTGAAATTCTAAATCTTTTGAAATGGCCTTCATATCAGTTTGATTTTTGTAGCATTGTTTTCTTACTCTCTTATTTTAGTGTTCTGAACTTCATGCTTTGCTGTATTTTATACTGCATAGTTCATTATATAAACGTTTTAAATAGACTCTTCTGAGTAAATAAATGAATCTTTAGTTGGTATCCAACAAAATCAATTTCTTTTCACTCTTTTGTCTTTTTTATAAACCTAATTCATGTTTTACAGTGGGGTTCCAGCGTGTTTCTGTGTTATAAGAAGTCTGTACCTGCTTCAAATGCAATAGCATATAAGGCTGGTAAGTGAGTTAAAAAAAATTGTCTCAATTGCTATAGTTATTGGTGCATATTAACATTTGGCTAAAAGAGATAAAGTATGCTCCCTTACATAGTTTGTAGAATTGATCTATTCATAAAATTATCTATAATTTTAGCATATAAAGATATGTGTTTTCTTAAATACATATACAAGATATATTAATACCCCCACCAAACATGCTGTTAATTTAATTTAAACATTTATCTAAAGCAAACATATGTGGAATAAACATTCAAGCTTTTGGTCTACGTTAATAGACTTAACAGTATAATGGAAAGTTGCTGACTCTCTGACCTTTTATATTTTGGCAATCAGAAAGGTGTCAAACTGCGTCTTTACTTCTTATATTTCCTTCTCTTATCTCTTTGTGTCTGATTTGAAACCACATGTTACTTGCCATGAAAGGTGGACTTGCTTCCTTTCTCCTTTGTTGCAAAGAATCAGCTATATGGAGGAGAGGAGGGCCTGAGAAACTTTTCTGCCATGAAGTGTTTGAGAAATCTATCGCCACATTCTTACTGCACATTAAAGTGTCAAGGGCTGTAAAGATTTAAGTGTCACGTCTTCATTCCACTGGTATGGTGGGATAAAAACTGAAAATACAGGTATGCTCCAGTTGTAAATAGAAAAGATACTGGAATACTTCTTTGTGAAAAGAAGCAGTGCTAATTACTATTTGATTATGCACAGTTCTTGAAATAAAGTTTTACTTCAGGGAAGTCAGGCAAATTCATATCCAAAAAATCGTGATTTTCATAAAAACATTCATACTAATGAACCAAACCATTTAATTTATAATATAAAAATAATGGCAACGACTAACGTATAAAATTCAGTATCATTTTAAAATCTGATACTGTAGGCTGGGCATGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGAGTGAGGCGGGCAGATCGCTTGAGGCCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACGCATCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCACGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGTGACAAAGCAAGATCCTGTCTCAAAAAAAAAAAAAAAAAGTGATACTGTTAATACTGCTGTAATATGTTGATTATGTGTGATGTCCTTTTTTTGTTGTTGTTGTTGTTTTTGGTGGAGAAAAGATATCACTTAAAAAACTTATAGAAAGAAACTGTACCAAAGTATTCAGTTATTTGATATGAGACACTTATTTTAGAATAGAGAGTTTTAGATACTGAATTTGGGCTCAAAATTCTACTACTGATTTTGAAGTTTTTCACTTAGAGATGGTCTATATATTGATGACCTTAGAGGCTAATGAACAGATGCCATGTAGCTAATTTATTCTGTGGGTCTTCATTGTGGTTCTCAAAGTGTCACTTGCTCCTACTTTCTGGGTCTCACATACTCTGTACTTAGTCACAGTGTTTCTGTCTCATTTACTTTTCATGTTGCATGCCTTTTACACTGCTTCCCTCTTAAGATGAGTTTAGGGGCTGTGATAATTTCTGTTGCCTCAGCATTATTTCATAACACTTGTCTCTTCCCTGAATTTTTCACAGAAGACTAACTGAAATAGTTGGTAAATTTTTCTGTATGTTTCTTACCATTTTCCACAAGGTGTTGGCATGTGTAGAAGAAAATACATTAAGATTGGTGATCAAGATTGGTTGAATGGAATCTCAACTAGTATATTAATACATTTTAAATGTTACAATGAACTGTAAATTCATGGGTAAAATATCAGGGGTAAACTTATTTTAGTTTCTGTTATAGCAAGGGGGAAATCAATTTTAAAATACCACACAAGTATTGCCATGAAATTCGGCATTAAAATATTCCATTAATACCTATCATATGCAATTTATGGAAAAGTAACTATTTAAAAAATTTATTGTTGTCTCATTCTTCAAAAGGTTTAATTTTTAGATATCCAGAAGAGGACTATGAGTCATTTCCACTCTCAGAATCAGATGTACCTCTTTTCTGCCTTCCTATGGGAGCTACTATTGAGTGCTGGGATCCTGAAACCAAATATCCACTTCCAGTTTTTTCAACTTTTGTCTTGACAGGTTCTTCAGCCAAAAAGGTATATGGAGCTGCCATTCAGTTTTATGAACCTTACTCTCGGGAACTTCTATCAGAGAAACAGCTTATGCACCTGGGCTTGTTGACGCCTGTGGAGAGAAAAATGGTCTCCAAATCCATCAATACAAACAAATGCATTTGTTTACTCTCACACTGGCCTTTTTTTGAAGCTTTTAGGAAATTTCTTATGTTTATCTACAAACTTTCTGTGTCTGGACCACATCCTCTTCCCATTGAAAAGCACATTTCACATTTTATGCAAAACATCCCTTTTCCTTCACCACAAAGACCGAGAATCCTTGTCCAGCTGTCAGTCCATGATGCATTAATATTATCACAGCCAGTTTCTACACCTTTACCACTAAGTGGAGCCAACTTTAGCACCTTGCTAATGAATCTGGGTCCTGAGAATTGTGCAACACTGCTGCTCTTTGTTTTACTTGAGAGTAAAATTCTGCTGCATTCTCTTAGGCCAGCTGTCTTGACTGGGGTAGCTGAAGCTGTTGTAGCTATGATCTTTCCATTTCAGTGGCAATGCCCATATATTCCCCTTTGTCCTCTTTCACTGGCTGCAGTGCTTAGTGCACCTTTACCATTTATAGTTGGAGTTGACTCAAGGTATTTTGATCTTCATGACCCACCACAAGATGTTGTTTGCATTGACTTGGATACGAACATGTTATATGT N/A hypoxia RNA-seq; RT-PCR Endothelial cells cytoplasm up-regulated N/A N/A N/A N/A N/A 26377962 2015.10 Circ Res. Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA N/A cTHSD1 N/A 13 52971366-52976829 - hg19 THSD1 N/A N/A hypoxia RNA-seq; RT-PCR Endothelial cells cytoplasm down-regulated N/A N/A N/A N/A N/A 26377962 2015.10 Circ Res. Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA N/A hsa_circ_002059 hsa_circ_0000140 1 155891165-155895634 - hg19 KIAA0907 ATGCATTATGTTCAAGATAAATTATTTGTGGGTCTAGAACATGCTGTACCCACTTTTAATGTCAAGGAGAAGGTGGAAGGTCCAGGCTGCTCCTATTTGCAGCACATTCAGATTGAAACAGGTGCCAAAGTCTTCCTGCGGGGCAAAGGTTCAGGCTGCATTGAGCCAGCATCTGGCCGAGAAGCTTTTGAACCTATGTATATTTACATCAGTCACCCCAAACCAGAAGGCCTGGCTGCTGCCAAGAAGCTTTGTGAGAATCTTTTGCAAACAGTTCATGCTGAATACTCTAGATTTGTGAATCAGATTAATACTGCTGTACCTTTACCAGGCTATACACAACCCTCTGCTATAAGTAGTGTCCCTCCTCAACCACCATATTATCCATCCAATGGCTATCAGTCTGGTTACCCTGTTGTTCCCCCTCCTCAGCAGCCAGTTCAACCTCCCTACGGAGTACCAAGCATAGTGCCACCAGCTGTTTCATTAGCACCTGGAGTCTTGCCGGCATTACCTACTGGAGTCCCACCTGTGCCAACACAATACCCGATAACACAAGTGCAGCCTCCAGCTAGCACTGGACAG N/A gastric cancer qRT-PCR paired gastric cancer tissues and adjacent nontumorous tissues; paired plasma samples from preoperative and postoperative gastric cancer patients N/A down-regulated N/A N/A N/A N/A Hsa_circ_002059, a typical circular RNA, was first found to be significantly downregulated in gastric cancer tissues compared with paired adjacent nontumorous tissues (p<0.001). Its levels in plasma collected from postoperative gastric cancer patients were found significantly different from those from preoperative gastric cancer patients. The area under the ROC curve was 0.73. Importantly, we further found that lower expression levels were significantly correlated with distal metastasis (P=0.036), TNM stage (P=0.042), gender (P=0.002) and age (P=0.022). The stability of circRNAs and the reproducibility of the qRT-PCR method for detecting circRNA levels were determined.These results suggested that circRNAs are highly stable in mammalian cells and that one specific circRNA, hsa_circ_002059, may be a potential novel and stable biomarker for the diagnosis of gastric carcinoma. 25689795 2015.4 Clin Chim Acta. Using circular RNA as a novel type of biomarker in the screening of gastric cancer N/A cir-GLI2 hsa_circ_0056288 2 121708818-121713006 + hg19 GLI2 GCCCCCTGCCCTCAGCGGCAGCCCTGTCATCTCTGACATCTCCTTGATCCGGCTTTCCCCGCACCCGGCTGGCCCTGGGGAGTCCCCCTTCAACGCCCCCCACCCGTACGTGAACCCCCACATGGAGCACTACCTCCGTTCTGTGCACAGCAGCCCCACGCTCTCCATGATCTCTGCAGCCAGGGGCCTCAGCCCCGCTGATGTGGCCCAGGAGCACCTTAAGGAGAGGGGACTGTTTGGCCTTCCTGCTCCAGGCACCACCCCCTCAGACTATTACCACCAGATGACCCTCGTGGCAGGCCACCCCGCGCCCTACGGGGACCTGCTGATGCAGAGCGGGGGCGCTGCCAGCGCACCCCATCTCCACGACTACCTCAACCCCGTGGACG N/A osteosarcoma qRT-PCR; in vitro knockdown; luciferase reporter assay; etc. osteosarcoma tissues compared to adjacent non-tumor tissue; OS cell lines (MG63, Saos-2, HOS, and U2-OS) and normal human osteoplastic cell line (hFOB) and HEK293 N/A up-regulated miR-125b-5p N/A N/A N/A Cir-GLI2 was significantly upregulated in osteosarcoma tissues compared to adjacent non-tumor tissue. Moreover, cir-GLI2 silencing could effectively suppress the proliferation, migration, and invasion capacity of osteosarcoma cells, indicating the tumor-promoting role. Besides, bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR-125b-5p. In conclusion, our study demonstrated that cir-GLI2 acts as an oncogenic circular RNA in osteosarcoma genesis, providing a novel diagnostic and therapeutic target for osteosarcoma. 28695772 2017.7 Tumour Biol. Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p N/A circCOL3A1-859267 N/A 2 189859267-189861944 + N/A COL3A1 N/A N/A photoaging RNA-seq; qRT-PCR; in vitro knockdown; etc. UVA irradiated and no irradiated human dermal fibroblasts N/A down-regulated N/A N/A Overexpression of circCOL3A1-859267 inhibited UVA-induced decrease of type I collagen expression and silencing of it reduced type I collagen intensity. 28286269 2017.4 Biochem Biophys Res Commun. Circular RNA profiling reveals that circCOL3A1-859267 regulate type I collagen expression in photoaged human dermal fibroblasts N/A hsa_circ_0075828 hsa_circRNA_104083 6 22020567-22020771 + hg19 LINC00340 GATCTGCATTTACTGCTCAACCACATCTAATTTGATGTCCTCTGCAGATTTAAAATGTGTGCCTTCTTTTCCGTCACCAAGTCATCCCTGGGTTACTACTGAACATCCTTCTCAATTCCCCCCGACCCATGGATGGCTGTTCTCCATTGTCTGTTTCACCAGATGTCCTCAAAACAAACAGACAGAAGAAGGAAGTGGCTAATG exonic basal cell carcinoma Microarray; qRT-PCR nodular basal cell carcinoma and nonlesional epithelial skin N/A up-regulated N/A N/A N/A N/A N/A 27097056 2016.5 Epigenomics Circular RNA expression in basal cell carcinoma N/A hsa_circ_0075825 hsa_circRNA_104081 6 21909700-22020771 + hg19 LINC00340 GTGTGAATCATGGCAATACAGTGAAAGACAGTGATTTACTGCTTTTGAGGGCGTGCATGTATATGATTAACGGATGGAAGTGCAGGACTCCAAGATTTACTTCCTTCCCTTTCCAGCAGAATTACCTGAGACGAGTAAAATCTACTGGTGGAGTCACTCCATTATTCTTATCTGTGGAGATCTAGATCTTGATTTGAAAGTTTCTGAGAAAATCTTCAGCTCAGACTTGAGGGTCAACTTTACCAGCTGAAGGATCTGCATTTACTGCTCAACCACATCTAATTTGATGTCCTCTGCAGATTTAAAATGTGTGCCTTCTTTTCCGTCACCAAGTCATCCCTGGGTTACTACTGAACATCCTTCTCAATTCCCCCCGACCCATGGATGGCTGTTCTCCATTGTCTGTTTCACCAGATGTCCTCAAAACAAACAGACAGAAGAAGGAAGTGGCTAATG exonic basal cell carcinoma Microarray; qRT-PCR nodular basal cell carcinoma and nonlesional epithelial skin N/A up-regulated N/A N/A N/A N/A N/A 27097056 2016.5 Epigenomics Circular RNA expression in basal cell carcinoma N/A hsa_circ_0075829 hsa_circRNA_104084 6 22020567-22056919 + hg19 LINC00340 GATCTGCATTTACTGCTCAACCACATCTAATTTGATGTCCTCTGCAGATTTAAAATGTGTGCCTTCTTTTCCGTCACCAAGTCATCCCTGGGTTACTACTGAACATCCTTCTCAATTCCCCCCGACCCATGGATGGCTGTTCTCCATTGTCTGTTTCACCAGATGTCCTCAAAACAAACAGACAGAAGAAGGAAGTGGCTAATGGAGCTGTGGAGTCCAAGTGTGACTGCCAAGAGGAATCCAGCAAAGCCAAAAAGCCCAAGCATGTAGCCCTGCCCGAAGCACGCCACACGCATGGAAAACCCAGAGGAAATGAGTGAGGATCAATGGGAAGAAGAGAGCCAGCCAG exonic basal cell carcinoma Microarray; qRT-PCR nodular basal cell carcinoma and nonlesional epithelial skin N/A up-regulated N/A N/A N/A N/A N/A 27097056 2016.5 Epigenomics Circular RNA expression in basal cell carcinoma N/A circHIPK3 hsa_circ_0000284; BCRC-2; hsa_circRNA_100782; hsa_circ_000016; circR-284 11 33307958-33309057 + hg19 HIPK3 GGTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG exonic retinal vascular dysfunction qRT-PCR; northern blot; ChIP; luciferase reporter assay; FISH; RIP; in vitro knockdown; in vitro overexpression; in vivo knockdown; etc. mouse tissues, including brain, retina, heart, liver, artery, and vein; human retinal vascular endothelial cells (HRVECs); EA.hy.926, human coronary artery endothelial cells (HCAECs), and human umbilical vein endothelial cells (HUVECs); cytoplasm up-regulated miR-30a-3p VEGFC; FZD4; WNT2 N/A N/A circHIPK3 is a novel circular RNA which increases angiogenesis.circHIPK3 is a potential therapeutic target to control the vascular complications of diabetes. 28860123 2017.8 Circulation Circular Non-Coding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus N/A hsa_circRNA_063981 hsa_circ_0063981 22 50904191-50904269 - hg19 SBF1 GTCCTGGACCCGGAGCTGGAGTTGGCTGACCTCGCCTTCCCTCCGCCCACGACATCCACCTCCTCCCTGAAGATGCAG exonic diabetic retinopathy Microarray; qRT-PCR Blood serum samples from T2DR patients (T2DM patients with proliferative DR), T2DM patients without DR (T2DM), and age-matched control subjects (controls) N/A up-regulated N/A N/A N/A N/A N/A 28817829 2017 Ophthalmic Res. Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray N/A hsa_circRNA_404457 N/A 1 23735156-23745632 - hg19 TCEA3 N/A exonic diabetic retinopathy Microarray; qRT-PCR Blood serum samples from T2DR patients (T2DM patients with proliferative DR), T2DM patients without DR (T2DM), and age-matched control subjects (controls) N/A up-regulated N/A N/A N/A N/A N/A 28817829 2017 Ophthalmic Res. Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray N/A hsa_circRNA_100750 hsa_circ_0020929 11 3988781-4080626 + hg19 STIM1 AGTTTTGCCGAATTGACAAGCCCCTGTGTCACAGTGAGGATGAGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATGGTGATGTGGATGTGGAAGAAAGTGATGAGTTCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGGCTGGCTGTCACCAACACCACCATGACAGGGACTGTGCTGAAGATGACAGACCGGAGTCATCGGCAGAAGCTGCAGCTGAAGGCTCTGGATACAGTGCTCTTTGGGCCTCCTCTCT exonic diabetic retinopathy Microarray; qRT-PCR Blood serum samples from T2DR patients (T2DM patients with proliferative DR), T2DM patients without DR (T2DM), and age-matched control subjects (controls) N/A up-regulated N/A N/A N/A N/A N/A 28817829 2017 Ophthalmic Res. Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray N/A hsa_circRNA_406918 N/A 7 23381682-23391205 - hg19 IGF2BP3 N/A exonic diabetic retinopathy Microarray; qRT-PCR Blood serum samples from T2DR patients (T2DM patients with proliferative DR), T2DM patients without DR (T2DM), and age-matched control subjects (controls) N/A up-regulated N/A N/A N/A N/A N/A 28817829 2017 Ophthalmic Res. Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray N/A hsa_circRNA_104387 hsa_circ_0080425 7 70880874-70886091 + hg19 WBSCR17 AGGAGCTGAAGGTCCCCCTAGAGGAGTATGTCCACAAACGCTACCCCGGGCTGGTGAAGGTGGTAAGAAATCAGAAGAGGGAAGGCCTGATCCGCGCTCGCATTGAGGGCTGGAAGGTGGCTACCGGGCAGGTCACTGGCTTCTTTGATGCCCACGTGGAATTCACCGCTGGCTGGGCTGAGCCGGTTCTATCCCGCATCCAGGAAAACCGGAAGCGTGTGATCCTCCCCTCCATTGACAACATCAAACAGGACAACTTTGAGGTGCAGCGGTACGAGAACTCGGCCCACGGGTACAGCTGGGAGCTGTGGTGCATGTACATCAGCCCCCCAAAAGACTGGTGGGACGCCGGAGACCCTTCTCTCCCCATCAG exonic diabetic retinopathy Microarray; qRT-PCR Blood serum samples from T2DR patients (T2DM patients with proliferative DR), T2DM patients without DR (T2DM), and age-matched control subjects (controls) N/A up-regulated N/A N/A N/A N/A N/A 28817829 2017 Ophthalmic Res. Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray N/A hsa_circRNA_103410 hsa_circ_0003266 3 66501982-66512933 - hg19 LRIG1 AAACCTGAGTTACAACAAACTCTCTGAGATTGACCCTGCTGGTTTTGAGGACTTGCCGAACCTACAGGAAGTGTACCTCAATAATAATGAGTTGACAGCGGTACCATCCCTGGGCGCTGCTTCATCACATGTCGTCTCTCTCTTTCT exonic diabetic retinopathy Microarray; qRT-PCR Blood serum samples from T2DR patients (T2DM patients with proliferative DR), T2DM patients without DR (T2DM), and age-matched control subjects (controls) N/A up-regulated N/A N/A N/A N/A N/A 28817829 2017 Ophthalmic Res. Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray N/A hsa_circRNA_100192 hsa_circ_0012107 1 44290402-44303983 + hg19 ST3GAL3 CTCACCGAGGACTCTCTGCACGGTGGTTTTTGGCCTTGACTGCATATTGGAATCACCTGGAGAGCCTAAAAAATTACTGATGCCTGCATCCCACCCTCTAGAGATTTTGAAGTCACTGAGCGAGGACACAGCCTTTGCATTAGGATTTTTAAAGCTGCCCAGGCCTGCTGAATTAGCCACCAAGTACGCAAACTTTTCAGAGGGAGCTTGCAAGCCTGGCTATGCTTCAGCCTTGATGACGGCCATCTTCCCCCG exonic diabetic retinopathy Microarray; qRT-PCR Blood serum samples from T2DR patients (T2DM patients with proliferative DR), T2DM patients without DR (T2DM), and age-matched control subjects (controls) N/A up-regulated N/A N/A N/A N/A N/A 28817829 2017 Ophthalmic Res. Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray N/A hsa_circ_0045714 hsa_circRNA_102195 17 73808192-73809959 + hg19 UNK GTGCCCATTCCTGCACAGAACCACAGGGGACACTGAGCGCAGGTACCACCTTCGTTACTACAAAACTGGAATCTGCATCCACGAGACAGACTCGAAAGGCAACTGCACCAAAAACGGCCTGCACTGCGCTTTTGCCCACGGGCCCCATGACCTCCGCTCCCCTGTCTACGACATCAGGGAGCTTCAGGCCATGGAGGCCTTGCAGAATGGCCAGACCACGGTAGAGGGGAGCATAGAGGGCCAGTCGGCTGGGGCTGCGAGCCATGCCATGATAGAAAAGATCCTCAGCGAGGAGCCTCGGTGGCAAGAGACTGCTTATGTGCTGGGGAACTATAAGACGGAGCCTTGCAAGAAGCCCCCGCGGCTGTGCCGCCAAGGCTATGCCTGTCCCTACTACCACAACAGCAAGGACCGGCGGCGGAGCCCCCGGAAGCACAAATACAGGTCGTCTCCATGTCCAAACGTCAAGCACGGGGATGAGTGGGGAGACCCTGGCAAGTGTGAGAACGGAGACGCCTGCCAGTACTGCCACACCCGCACCGAGCAGCAGTTCCACCCCGAG exonic osteoarthritis qRT-PCR; in vitro knockdown; in vitro overexpression; Dual-luciferase assay; western blot; etc. OA cartilage and normal articular cartilage; chondrocytes-articular N/A down-regulated miR-193b IGF1R N/A N/A Studies have shown that tumor necrosis factor-alpha can inhibit hsa_circ_0045714 expression in chondrocytes so as to upregulate miR-193b expression. Dual-luciferase reporter assay showed that IGF1R is a key target gene of miR-193b. Hsa_circ_0045714 over-expression does not influence miR-193b expression, but can inhibit its transcriptional activity, thereby upregulating IGF1R expression. Hsa_circ_0045714 can promote the expression of type II collagen and aggrecan, and upregulate chondrocyte proliferation, while its linear sequences cannot. IGF1R has similar function, while miR-193b can inhibit the expression of type II collagen and aggrecan, and downregulate chondrocyte proliferation but enhance their apoptosis. IGF1R overexpression can reverse the effect of miR-193b, while miR-193b mimics or IGF1R siRNA can inhibit the function of hsa_circ_0045714. Therefore, hsa_circ_0045714 can regulate extracellular matrix synthesis as well as proliferation and apoptosis of chondrocytes by promoting the expression of miR-193b target gene IGF1R. 28795385 2017.8 Hum Cell. Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R N/A hsa_circRNA_003251 hsa_circ_0003251 12 1003727-1006847 + hg19 WNK1 TTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCAGCAGACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTATCAAGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCCCACAAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTGGGTCGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAACAAGCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAGGCCGCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAATCTAAGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAGCTGCGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTGGGCAAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCTAGTCGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAG exonic diabetes mellitus Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A up-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_015115 hsa_circ_0015115 1 167935866-168020171 + hg19 DCAF6 GTTAATACAATCTGTTGGAATGACACTGGAGAATATATTTTATCTGGCTCAGATGACACCAAATTAGTAATTAGTAATCCTTACAGCAGAAAGGTTTTGACAACAATTCGTTCAGGGCACCGAGCAAACATATTTAGTGCAAAGTTCTTACCTTGTACAAATGATAAACAGATTGTATCCTGCTCTGGAGATGGAGTAATATTTTATACCAACGTTGAGCAAGATGCAGAAACCAACAGACAATGCCAATTTACGTGTCATTATGGAACTACTTATGAGATTATGACTGTACCCAATGACCCTTACACTTTTCTCTCTTGTGGTGAAGATGGAACTGTTAGGTGGTTTGATACACGCATCAAAACTAGCTGCACAAAAGAAGATTGTAAAGATGATATTTTAATTAACTGTCGACGTGCTGCCACGTCTGTTGCTATTTGCCCACCAATACCATATTACCTTGCTGTTGGTTGTTCTGACAGCTCAGTACGAATATATGATCGGCGAATGCTGGGCACAAGAGCTACAGGGAATTATGCAGGTCGAGGGACTACTGGAATGGTTGCCCGTTTTATTCCTTCCCATCTTAATAATAAGTCCTGCAGAGTGACATCTCTGTGTTACAGTGAAGATGGTCAAGAGATTCTCGTTAGTTACTCTTCAGATTACATATATCTTTTTGACCCGAAAGATGATACAGCACGAGAACTTAAAACTCCTTCTGCGGAAGAGAGAAGAGAAGAGTTGCGACAACCACCAGTTAAGCGTTTGAGACTTCGTGGTGATTGGTCAGATACTGGACCCAGAGCAAGGCCGGAGAGTGAACGAGAACGAGATGGAGAGCAGAGTCCCAATGTGTCATTGATGCAGAGAATGTCTGATATGTTATCAAGATGGTTTGAAGAAGCAAGTGAGGTTGCACAAAGCAATAGAGGACGAGGAAGATCTCGACCCAGAGGTGGAACAAGTCAATCAGATATTTCAACTCTTCCTACGGTCCCATCAAGTCCTGATTTGGAAGTGAGTGAAACTGCAATGGAAGTAGATACTCCAGCTGAACAATTTCTTCAGCCTTCTACATCCTCTACAATGTCAGCTCAGGCTCATTCGACATCATCTCCCACAGAAAGCCCTCATTCTACTCCTTTGCTATCTTCTCCAGACAGTGAACAAAGGCAGTCTGTTGAGGCATCTGGACACCACACACATCATCAGTCTGAATTTTTAAGGGGCCCTGAGATAGCTTTGCTTCGTAAGCGCCTGCAACAACTGAGGCTTAAGAAGGCTGAGCAGCAGAGGCAGCAAGAGCTAGCTGCACATACCCAGCAACAGCCTTCCACTTCTGATCAGTCTTCTCATGAGGGCTCTTCACAGGACCCTCATGCTTCAGATTCTCCTTCTTCTGTGGTTAACAAACAGCTCGGATCCATGTCACTTGACGAGCAACAGGATAACAATAATGAAAAGCTGAGCCCCAAACCAGGGACAGGTGAACCAGTTTTAAGTTTGCACTACAGCACAGAAGGAACAACTACAAGCACAATAAAACTGAACTTTACAGATGAATGGAGCAGTATAGCATCAAGTTCTAGAGGAATTGGGAGCCATTGCAAATCTGAGGGTCAGGAGGAATCTTTCGTCCCACAGAGCTCAGTGCAACCACCAGAAGGAGACAGTGAAACAAAAGCTCCTGAAGAATCATCAGAGGATGTGACAAAATATCAGGAAGGAGTATCTGCAGAAAACCCAGTTGAGAACCATATCAATATAACACAATCAGATAAGTTCACAGCCAAGCCATTGGATTCCAACTCAGGAGAAAGAAATGACCTCAATCTTGATCGCTCTTGTGGGGTTCCAGAAGAATCTGCTTCATCTGAAAAAGCCAAGGAACCAGAAACTTCAGATCAGACTAGCACTGAGAGTGCTACCAATGAAAATAACACCAATCCTGAGCCTCAGTTCCAAACAGAAGCCACTGGGCCTTCAGCTCATGAAGAAACATCCACCAGGGACTCTGCTCTTCAGGACACAGATGACAGTGATGATGACCCAGTCCTGATCCCAGGTGCAAGGTATCGAGCAGGACCTGGTGATAGATTTAATATCAGAGGAACAACAATAGGTGATAGAATAATGAG exonic diabetes mellitus Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A up-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_100918 hsa_circ_0023918 11 85701292-85742653 - hg19 PICALM ACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGTGGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTTGTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGAGAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAAACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAATAAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTTTGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGTTGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGCTTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGGTCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCTAAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGCCATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCCATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGATCCTTTCTCTGCTACTGTAGATGCTGTTGATGATGCCATTCCAAGCTTAAATCCTTTCCTCACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACCTACTCATGAAATGTTTGTTG exonic diabetes mellitus Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A up-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_005019 hsa_circ_0005019 15 101775286-101775782 - hg19 CHSY1 AACATGGTCCAAGACAATTCCTGGGAAAGTTCAGTTCTTCTCAAGTGAGGGTTCTGACACATCTGTACCAATTCCAGTAGTGCCACTACGGGGTGTGGACGACTCCTACCCGCCCCAGAAGAAGTCCTTCATGATGCTCAAGTACATGCACGACCACTACTTGGACAAGTATGAATGGTTTATGAGAGCAGATGATGACGTGTACATCAAAGGAGACCGTCTGGAGAACTTCCTGAGGAGTTTGAACAGCAGCGAGCCCCTCTTTCTTGGGCAGACAGGCCTGGGCACCACGGAAGAAATGGGAAAACTGGCCCTGGAGCCTGGTGAGAACTTCTGCATGGGGGGGCCTGGCGTGATCATGAGCCGGGAGGTGCTTCGGAGAATGGTGCCGCACATTGGCAAGTGTCTCCGGGAGATGTACACCACCCATGAGGACGTGGAGGTGGGAAGGTGTGTCCGGAGGTTTGCAGGGGTGCAGTGTGTCTGGTCTTATGAG exonic diabetes mellitus Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A down-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_003251 hsa_circ_0003251 12 1003727-1006847 + hg19 WNK1 TTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCAGCAGACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTATCAAGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCCCACAAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTGGGTCGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAACAAGCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAGGCCGCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAATCTAAGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAGCTGCGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTGGGCAAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCTAGTCGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAG exonic depression Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A up-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_015115 hsa_circ_0015115 1 167935866-168020171 + hg19 DCAF6 GTTAATACAATCTGTTGGAATGACACTGGAGAATATATTTTATCTGGCTCAGATGACACCAAATTAGTAATTAGTAATCCTTACAGCAGAAAGGTTTTGACAACAATTCGTTCAGGGCACCGAGCAAACATATTTAGTGCAAAGTTCTTACCTTGTACAAATGATAAACAGATTGTATCCTGCTCTGGAGATGGAGTAATATTTTATACCAACGTTGAGCAAGATGCAGAAACCAACAGACAATGCCAATTTACGTGTCATTATGGAACTACTTATGAGATTATGACTGTACCCAATGACCCTTACACTTTTCTCTCTTGTGGTGAAGATGGAACTGTTAGGTGGTTTGATACACGCATCAAAACTAGCTGCACAAAAGAAGATTGTAAAGATGATATTTTAATTAACTGTCGACGTGCTGCCACGTCTGTTGCTATTTGCCCACCAATACCATATTACCTTGCTGTTGGTTGTTCTGACAGCTCAGTACGAATATATGATCGGCGAATGCTGGGCACAAGAGCTACAGGGAATTATGCAGGTCGAGGGACTACTGGAATGGTTGCCCGTTTTATTCCTTCCCATCTTAATAATAAGTCCTGCAGAGTGACATCTCTGTGTTACAGTGAAGATGGTCAAGAGATTCTCGTTAGTTACTCTTCAGATTACATATATCTTTTTGACCCGAAAGATGATACAGCACGAGAACTTAAAACTCCTTCTGCGGAAGAGAGAAGAGAAGAGTTGCGACAACCACCAGTTAAGCGTTTGAGACTTCGTGGTGATTGGTCAGATACTGGACCCAGAGCAAGGCCGGAGAGTGAACGAGAACGAGATGGAGAGCAGAGTCCCAATGTGTCATTGATGCAGAGAATGTCTGATATGTTATCAAGATGGTTTGAAGAAGCAAGTGAGGTTGCACAAAGCAATAGAGGACGAGGAAGATCTCGACCCAGAGGTGGAACAAGTCAATCAGATATTTCAACTCTTCCTACGGTCCCATCAAGTCCTGATTTGGAAGTGAGTGAAACTGCAATGGAAGTAGATACTCCAGCTGAACAATTTCTTCAGCCTTCTACATCCTCTACAATGTCAGCTCAGGCTCATTCGACATCATCTCCCACAGAAAGCCCTCATTCTACTCCTTTGCTATCTTCTCCAGACAGTGAACAAAGGCAGTCTGTTGAGGCATCTGGACACCACACACATCATCAGTCTGAATTTTTAAGGGGCCCTGAGATAGCTTTGCTTCGTAAGCGCCTGCAACAACTGAGGCTTAAGAAGGCTGAGCAGCAGAGGCAGCAAGAGCTAGCTGCACATACCCAGCAACAGCCTTCCACTTCTGATCAGTCTTCTCATGAGGGCTCTTCACAGGACCCTCATGCTTCAGATTCTCCTTCTTCTGTGGTTAACAAACAGCTCGGATCCATGTCACTTGACGAGCAACAGGATAACAATAATGAAAAGCTGAGCCCCAAACCAGGGACAGGTGAACCAGTTTTAAGTTTGCACTACAGCACAGAAGGAACAACTACAAGCACAATAAAACTGAACTTTACAGATGAATGGAGCAGTATAGCATCAAGTTCTAGAGGAATTGGGAGCCATTGCAAATCTGAGGGTCAGGAGGAATCTTTCGTCCCACAGAGCTCAGTGCAACCACCAGAAGGAGACAGTGAAACAAAAGCTCCTGAAGAATCATCAGAGGATGTGACAAAATATCAGGAAGGAGTATCTGCAGAAAACCCAGTTGAGAACCATATCAATATAACACAATCAGATAAGTTCACAGCCAAGCCATTGGATTCCAACTCAGGAGAAAGAAATGACCTCAATCTTGATCGCTCTTGTGGGGTTCCAGAAGAATCTGCTTCATCTGAAAAAGCCAAGGAACCAGAAACTTCAGATCAGACTAGCACTGAGAGTGCTACCAATGAAAATAACACCAATCCTGAGCCTCAGTTCCAAACAGAAGCCACTGGGCCTTCAGCTCATGAAGAAACATCCACCAGGGACTCTGCTCTTCAGGACACAGATGACAGTGATGATGACCCAGTCCTGATCCCAGGTGCAAGGTATCGAGCAGGACCTGGTGATAGATTTAATATCAGAGGAACAACAATAGGTGATAGAATAATGAG exonic depression Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A up-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_100918 hsa_circ_0023918 11 85701292-85742653 - hg19 PICALM ACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGTGGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTTGTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGAGAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAAACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAATAAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTTTGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGTTGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGCTTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGGTCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCTAAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGCCATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCCATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGATCCTTTCTCTGCTACTGTAGATGCTGTTGATGATGCCATTCCAAGCTTAAATCCTTTCCTCACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACCTACTCATGAAATGTTTGTTG exonic depression Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A up-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_005019 hsa_circ_0005019 15 101775286-101775782 - hg19 CHSY1 AACATGGTCCAAGACAATTCCTGGGAAAGTTCAGTTCTTCTCAAGTGAGGGTTCTGACACATCTGTACCAATTCCAGTAGTGCCACTACGGGGTGTGGACGACTCCTACCCGCCCCAGAAGAAGTCCTTCATGATGCTCAAGTACATGCACGACCACTACTTGGACAAGTATGAATGGTTTATGAGAGCAGATGATGACGTGTACATCAAAGGAGACCGTCTGGAGAACTTCCTGAGGAGTTTGAACAGCAGCGAGCCCCTCTTTCTTGGGCAGACAGGCCTGGGCACCACGGAAGAAATGGGAAAACTGGCCCTGGAGCCTGGTGAGAACTTCTGCATGGGGGGGCCTGGCGTGATCATGAGCCGGGAGGTGCTTCGGAGAATGGTGCCGCACATTGGCAAGTGTCTCCGGGAGATGTACACCACCCATGAGGACGTGGAGGTGGGAAGGTGTGTCCGGAGGTTTGCAGGGGTGCAGTGTGTCTGGTCTTATGAG exonic depression Microarray; qRT-PCR whole blood samples from patients with T2DM with current major depressive episodes or without major depressive episodes N/A down-regulated N/A N/A N/A N/A KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy. 28779132 2017.8 Sci Rep. Relationships of circular RNA with diabetes and depression N/A hsa_circRNA_103809 circZFR; hsa_circ_0072088 5 32379220-32388780 - hg19 ZFR CCCTTACGTCGTCCTGACTCATCTGATGACCGTTATGTAATGACAAAACATGCCACCATTTATCCAACTGAAGAGGAGTTACAGGCAGTTCAGAAAATTGTTTCTATTACTGAACGTGCTTTAAAACTCGTTTCAGACAGTTTGTCTGAACATGAGAAGAACAAGAACAAAGAGGGAGATGATAAGAAAGAGGGAGGTAAAGACAGAGCTTTGAAAGGAGTTTTGCGAGTGGGAGTATTGGCAAAAGGATTACTTCTCCGAGGAGATAGAAATGTCAACCTTGTTTTGCTGTGCTCAGAGAAACCTTCAAAGACATTATTAAGCCGTATTGCAGAAAACCTACCCAAACAGCTTGCTGTTATAAGCCCTGAGAAGTATGACATAAAATGTGCTGTATCTGAAGCGGCAATAATTTTGAATTCATGTGTGGAACCCAAAATGCAAGTCACTATCACACTGACATCTCCAATTATTCGAGAAGAGAACATGAGGGAAGGAGATGTAACCTCGGGTATGGTGAAAGACCCACCGGACGTCTTGGACAGGCAAAAATGCCTTGACGCTCTGGCTGCTCTACGCCACGCTAAGTGGTTCCAGGCTAGAGCTAATGGTCTGCAGTCCTGTGTGATTATCATACGCATTCTTCGAGACCTCTGTCAGCGAGTTCCAACTTGGTCTGATTTTCCAAGCTGG exonic liver cancer Microarray; qRT-PCR liver cancer tissues and their paired adjacent normal liver tissues N/A up-regulated N/A N/A N/A N/A ROC analysis showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively. 28727484 2017.7 Cell Cycle Construction and analysis of circular RNA molecular regulatory networks In liver cancer N/A hsa_circRNA_101368 circFUT8; hsa_circ_0003028 14 66028054-66028484 + hg19 FUT8 CATGTAGAGCGCATGAAGTACAGGACAATAAAGCTTCCTACACATATCACCAGGAGGATCTCTTTGAAAGATTCACTGCAGGACTACCAGAGAGAATAATTTGTCTGAAGCATCATGTGTTGAAACAACAGAAGTCTATTCACCTGTGCACTAACTAGAAACAGAGTTACAATGTTTTCAATTCTTTGAGCTCCAGGACTCCAGGGAAGTGAGTTGAAAATCTGAAAATGCGGCCATGGACTGGTTCCTGGCGTTGGATTATGCTCATTCTTTTTGCCTGGGGGACCTTGCTGTTTTATATAGGTGGTCACTTGGTACGAGATAATGACCATCCTGATCACTCTAGCCGAGAACTGTCCAAGATTCTGGCAAAGCTTGAACGCTTAAAACAACAGAATGAAGACTTGAGGCGAATGGCCGAATCTCTCCG exonic liver cancer Microarray; qRT-PCR liver cancer tissues and their paired adjacent normal liver tissues N/A up-regulated N/A N/A N/A N/A ROC analysis showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively. 28727484 2017.7 Cell Cycle Construction and analysis of circular RNA molecular regulatory networks In liver cancer N/A hsa_circRNA_103847 circIPO11; hsa_circ_0007915 5 61745753-61747760 + hg19 IPO11 TGCTCTCTCAGAGGAGGAGAAAACTACTCTGCGTGCAGGGCTCATCACCAACTTCAATGAACCAATAAACCAGATTGCAACTCAGATTGCAGTGCTCATTGCAAAAGTTGCTAGATTGGATTGTCCCAGACAGTGGCCTGAACTAATTCCCACTCTTATAGAGTCTGTTAAAGTCCAGGATGATCTTCGACAGCACAGAGCATTACTTACCTTCTATCATGTTACCAAGACACTGGCATCTAAACGACTTGCTGCTGATAGAAAACTATTTTATGAT exonic liver cancer Microarray; qRT-PCR liver cancer tissues and their paired adjacent normal liver tissues N/A up-regulated N/A N/A N/A N/A ROC analysis showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively. 28727484 2017.7 Cell Cycle Construction and analysis of circular RNA molecular regulatory networks In liver cancer N/A hsa_circRNA_002082 hsa_circ_0002082 11 65271199-65272066 + hg19 MALAT1 AAACTTTGTCTGCGAACACTCTTTAATGGACCAGATCAGGATTTGAGCGGAAGAACGAATGTAACTTTAAGGCAGGAAAGACAAATTTTATTCTTCATAAAGTGATGAGCATATAATAATTCCAGGCACATGGCAATAGAGGCCCTCTAAATAAGGAATAAATAACCTCTTAGACAGGTGGGAGATTATGATCAGAGTAAAAGGTAATTACACATTTTATTTCCAGAAAGTCAGGGGTCTATAAATTGACAGTGATTAGAGTAATACTTTTTCACATTTCCAAAGTTTGCATGTTAACTTTAAATGCTTACAATCTTAGAGTGGTAGGCAATGTTTTACACTATTGACCTTATATAGGGAAGGGAGGGGGTGCCTGTGGGGTTTTAAAGAATTTTCCTTTGCAGAGGCATTTCATCCTTCATGAAGCCATTCAGGATTTTGAATTGCATATGAGTGCTTGGCTCTTCCTTCTGTTCTAGTGAGTGTATGAGACCTTGCAGTGAGTTTATCAGCATACTCAAAATTTTTTTCCTGGAATTTGGAGGGATGGGAGGAGGGGGTGGGGCTTACTTGTTGTAGCTTTTTTTTTTTTTACAGACTTCACAGAGAATGCAGTTGTCTTGACTTCAGGTCTGTCTGTTCTGTTGGCAAGTAAATGCAGTACTGTTCTGATCCCGCTGCTATTAGAATGCATTGTGAAACGACTGGAGTATGATTAAAAGTTGTGTTCCCCAATGCTTGGAGTAGTGATTGTTGAAGGAAAAAATCCAGCTGAGTGATAAAGGCTGAGTGTTGAGGAAATTTCTGCAGTTTTAAGCAGTCGTATTTGTGATTGAAGCTGAGTACATTTTGCTGGTGTATTTTTAG sense overlapping hepatic steatosis Microarray; qRT-PCR HepG2 cellsj treatmented with FFA or not N/A down-regulated N/A N/A N/A N/A Six circRNAs among these filtered ones were validated to be significantly different between the normal and model groups. In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183were downregulated in the model group rather than the normal one, while hsa_circRNA_007850,hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern. 28717649 2017 Biomed Res Int. Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis N/A hsa_circRNA_004183 hsa_circ_0004183 10 13701322-13717044 - hg19 FRMD4A GTTCTCAGGAATCAGATAGCTCGCAGTCGGCCAAGAAGGACATGCTGGCTGCCTTGAAGTCCAGGCAGGAAGCTCTGGAGGAAACCCTGCGTCAGAGGCTGGAGGAACTGAAGAAGCTGTGTCTCCGAGAAGCTGAGCTCACGGGCAAGCTGCCAGTAGAATATCCCCTGGATCCAGGGGAGGAACCACCCATTGTTCGGAGAAGAATAGGAACAGCCTTCAAACTGGATGAACAGAAAATCCTGCCCAAAGGAGAGGAAGCTGAGCTGGAACGCCTGGAACGAGAGTTTGCCATTCAGTCCCAGATTACGGAGGCCGCCCGCCGCCTAGCCAGTGACCCCAACGTCAGCAAAAAACTGAAGAAACAAAGGAAAACCTCGTATCTGAATGCACTGAAGAAACTGCAGGAGATTGAAAATGCAATCAATGAGAACCGCATCAAGTCTGGGAAGAAACCCACCCAGAGGGCTTCGCTGATCATAGACGATGGAAACATTGCCAGTGAAGACAGCTCCCTCTCAGATGCCCTTGTTCTTGAGGATGAAGACTCTCAGGTTACCAGCACAATATCCCCCCTACATTCTCCTCACAAGGGACTCCCTCCTCGGCCACCGTCGCACAACAGGCCTCCTCCTCCCCAGTCCCTGGAGGGACTCCGACAGATGCACTATCACCGCAACGACTATGACAAGTCACCCATCAAGCCCAAAATGTGGAGTGAGTCCTCTTTAGATGAACCCTATGAGAAGGTCAAGAAGCGCTCCTCTCACAGCCATTCCAGCAGCCACAAGCGCTTCCCCAGCACAGGAAGCTGTGCGGAAGCCGGCGGAGGAAGCAACTCCTTGCAGAACAGCCCCATCCGCGGCCTCCCGCACTGGAACTCCCAGTCCAGCATGCCGTCCACGCCAGACCTGCGGGTCCGGAGTCCCCACTACGTCCATTCCACGAG exonic hepatic steatosis Microarray; qRT-PCR HepG2 cellsj treatmented with FFA or not N/A down-regulated N/A N/A N/A N/A Six circRNAs among these filtered ones were validated to be significantly different between the normal and model groups. In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183were downregulated in the model group rather than the normal one, while hsa_circRNA_007850,hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern. 28717649 2017 Biomed Res Int. Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis N/A hsa_circRNA_000367 hsa_circ_0000367 11 124517260-124518071 - hg19 SIAE GTCCATTCCATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAG exonic hepatic steatosis Microarray; qRT-PCR HepG2 cellsj treatmented with FFA or not N/A down-regulated N/A N/A N/A N/A Six circRNAs among these filtered ones were validated to be significantly different between the normal and model groups. In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183were downregulated in the model group rather than the normal one, while hsa_circRNA_007850,hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern. 28717649 2017 Biomed Res Int. Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis N/A hsa_circRNA_007850 hsa_circ_0007850 9 2804256-2812362 - hg19 KIAA0020 GAAATTATCAGTTCATTGCCTAGCATAGTAAATGACAAATATGGAAGGAAGGTCCTATTGTACTTACTAAGCCCCAGAGATCCTGCACATACAGTACGAGAAATCATTGAAGTTCTGCAAAAAGGAGATGGAAATGCACACAGTAAGAAAGATACAGAGGTCCGCAGACGGGAGCTCCTAGAATCCATTTCTCCAGCTTTGTTAAGCTACCTGCAAGAACACGCCCAAGAAGTGGTGCTAGATAAGTCTGCGTGTGTGTTGGTGTCTGACATTCTGGGATCTGCCACTGGAGACGTTCAGCCTACCATGAATGCCATCGCCAGCTTGGCAGCAACAGGACTGCATCCTGGTGGCAAGGACGGAGAGCTTCACATTGCAGAACATCCTGCAGGACATCTAGTTCTGAAGTGGTTAATAGAGCAAGATAAAAAGATGAAAGAAAATGGGAGAGAAGGTTGTTTTGCAAAAACACTTGTAGAGCATGTTGGTATGAAGAACCTGAAGTCCTGGGCTAGTGTAAATCGAGGTGCCATTATTCTTTCTAGCCTCCTCCAGAGTTGTGACCTGGAAGTTGCAAACAAAGTCAAAGCTGCACTGAAAAGCTTGATTCCTACATTGGAAAAAACCAAAAGCACCAGCAAAGGAATAGAAATTCTACTTGAAAAACTGAGCACATAGGTGGAAAGAGTTAAGAGCAAGATGGAATGATTTTTTCTGTTCTCTGTTCTGTTTCCCAATGCAGAAAAGAAGGG sense overlapping hepatic steatosis Microarray; qRT-PCR HepG2 cellsj treatmented with FFA or not N/A up-regulated N/A N/A N/A N/A Six circRNAs among these filtered ones were validated to be significantly different between the normal and model groups. In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183were downregulated in the model group rather than the normal one, while hsa_circRNA_007850,hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern. 28717649 2017 Biomed Res Int. Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis N/A hsa_circRNA_004121 hsa_circ_0004121 2 102027080-102038934 - hg19 RFX8 TGTGAAGATCATTCACCGATGAAGACAGACCCAGTTGGATCCCCTTTGTCTGAATTCAGGAGATGTCCATTTCTGGAGCAAGAACAGGCAAAGAAATACTCCTGTAATATGATGGCCTTCCTTGCTGACGAATACTGCAACTATTGTCGAGACATTTTACGAAATGTGGAGGACTTGCTTACTTCCTTCTGGAAGTCTCTGCAGCAAGACACAGTCATGCTGATGTCATTGCCTGACGTGTGCCAGCTCTTTAAATGCTACGACGTCCAGCTGTACAAGGGAATTGAGGATGTTCTCCTTCATGACTTCTTGGAAGATGTTTCTATTCAGTACCTGAAATCTGTGCAGTTATTTAGTAAGAAATTTAAGCTGTGGCTCCTTAATGCTTTGGAAGGTGTTCCAGCCCTCTTGCAGATCTCCAAACTCAAAGAAGTTACTCTATTTGTCAAAAGACTAAGAAGAAAGACGTACCTTTCCAACATGGCTAAGACTATGCGAATGGTATTGAAAAGTAAGAGGCGTGTCAGCGTTTTGAAGTCAGATCTACAGGCCATCATCAATCAAGGCACTTTGGCTACTTCTAAGAAAGCCCTGGCAAGTGACCGGAGTGGCGCAGATGAACTGGAGAACAACCCAGAGATGAAATGTTTAAGAAACTTAATTTCTTTGCTGGGAACATCAACAGATCTCAGGGTATTCCTCAGCTGTCTGTCTTCACATCTCCAAGCATTTGTGTTCCAG exonic hepatic steatosis Microarray; qRT-PCR HepG2 cellsj treatmented with FFA or not N/A up-regulated N/A N/A N/A N/A Six circRNAs among these filtered ones were validated to be significantly different between the normal and model groups. In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183were downregulated in the model group rather than the normal one, while hsa_circRNA_007850,hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern. 28717649 2017 Biomed Res Int. Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis N/A hsa_circRNA_014724 hsa_circ_0014724 1 156303337-156305679 - hg19 CCT3 GCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACATCAATGCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGATTCAAGTCCAGCATCCAGCGGCCAAGTCCATGATCGAAATTAGCCGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTCTTG exonic hepatic steatosis Microarray; qRT-PCR HepG2 cellsj treatmented with FFA or not N/A up-regulated N/A N/A N/A N/A Six circRNAs among these filtered ones were validated to be significantly different between the normal and model groups. In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183were downregulated in the model group rather than the normal one, while hsa_circRNA_007850,hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern. 28717649 2017 Biomed Res Int. Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis N/A hsa_circRNA_101308 hsa_circ_0031027 13 114164552-114193822 + hg19 TMCO3 GTGTGGAAGATTTCCTTACAAGGGCCGTGTTACATGACACTGTTAATGATTGCATTTGGCTTGCTGTGGGGGCATCTCTTGCGGATCAAACCCACGCAGAGCGTCTTCATTTCCACGTGTCTGTCCTTGTCAAGCACACCCCTCGTGTCCAGGTTCCTCATGGGCAGTGCTCGGGGTGACAAAGAAGGCGACATTGACTACAGCACCGTGCTCCTCGGCATGCTGGTGACGCAGGACGTGCAGCTCGGGCTCTTCATGGCCGTCATGCCGACTCTCATACAGGCGGGCGCCAGTGCATCTTCTAGCATTGTCGTGGAAGTTCTCCGAATCCTGGTTTTGATTGGTCAGATTCTTTTTTCACTAGCGGCGGTTTTTCTTTTATGTCTTGTTATAAAGAAGTATCTCATTGGACCCTATTATCGGAAGCTGCACATGGAAAGCAAGGGGAACAAAGAAATCCTGATCTTGGGAATATCTGCCTTTATCTTCTTAATGTTAACGGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAGATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAG exonic stage III gastric cancer Microarray; qRT-PCR gastric cancer(recurrent cancer tissues and non-recurrent cancer tissues) and adjacent normal tissues N/A up-regulated N/A N/A N/A N/A qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. We then constructed a four-circRNA-based classifier to evaluate the risk of early recurrence and distinguished patients with a high risk from those with a low risk. The areas under the receiver operator characteristic curve (ROC) of this classifier were 0.763 and 0.711 in the two cohorts, respectively. A new formula could be established by combined the circRNA classifier with TNM stages. The areas under the ROC curve were 0.866 and 0.818 of the two cohorts, respectively. Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 28206972 2017.4 Oncotarget Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery N/A hsa_circRNA_104423 hsa_circ_0001721; hsa_circ_000457 7 90355880-90356126 + hg19 CDK14 ATATGTGTCACAAAGATGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGACACAGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCTCCACTGGCAAAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCG exonic stage III gastric cancer Microarray; qRT-PCR gastric cancer(recurrent cancer tissues and non-recurrent cancer tissues) and adjacent normal tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. We then constructed a four-circRNA-based classifier to evaluate the risk of early recurrence and distinguished patients with a high risk from those with a low risk. The areas under the receiver operator characteristic curve (ROC) of this classifier were 0.763 and 0.711 in the two cohorts, respectively. A new formula could be established by combined the circRNA classifier with TNM stages. The areas under the ROC curve were 0.866 and 0.818 of the two cohorts, respectively. Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 28206972 2017.4 Oncotarget Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery N/A hsa_circRNA_104916 hsa_circ_0008383; circ-104916 9 127064214-127089724 + hg19 NEK6 TTCGTGCCCTCGTGAGGCTGGCATGCAGGATGGCAGGACAGCCCGGCCACATGCCCCATGGAGGGAGTTCCAACAACCTCTGCCACACCCTGGGGCCTGTGCATCCTCCTGACCCACAGAGGCATCCCAACACGCTGTCTTTTCGCTGCTCGCTGGCGGACTTCCAGATCGAAAAGAAGATAGGCCGAGGACAGTTCAGCGAGGTGTACAAGGCCACCTGCCTGCTGGACAGGAAGACAGTGGCTCTGAAGAAGGTGCAGATCTTTGAGATGATGGACGCCAAGGCGAGGCAGGACTGTGTCAAGGAGATCGGCCTCTTGAAGCAACTGAACCACCCAAATATCATCAAGTATTTGGACTCGTTTATCGAAGACAACGAGCTGAACATTGTGCTGGAGTTGGCTGACGCAGGGGACCTCTCGCAGATGATCAAGTACTTTAAGAAGCAGAAGCGGCTCATCCCGGAGAGGACAGTATGGAAGTACTTTGTGCAGCTGTGCAGCGCCGTGGAGCACATGCATTCACGCCGGGTGATGCACCGAGACATCAAGCCTGCCAACGTGTTCATCACAGCCACGGGCGTCGTGAAGCTCGGTGACCTTGGTCTGGGCCGCTTCTTCAGCTCTGAGACCACCGCAGCCCACTCCCTAG exonic stage III gastric cancer Microarray; qRT-PCR gastric cancer(recurrent cancer tissues and non-recurrent cancer tissues) and adjacent normal tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. We then constructed a four-circRNA-based classifier to evaluate the risk of early recurrence and distinguished patients with a high risk from those with a low risk. The areas under the receiver operator characteristic curve (ROC) of this classifier were 0.763 and 0.711 in the two cohorts, respectively. A new formula could be established by combined the circRNA classifier with TNM stages. The areas under the ROC curve were 0.866 and 0.818 of the two cohorts, respectively. Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 28206972 2017.4 Oncotarget Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery N/A hsa_circRNA_100269 hsa_circ_0013048 1 82302569-82372915 + hg19 LPHN2 ATATGAAGATCAATGATGCAGACTGATGGTTTTGATGAAGCTGGGCATTTATAACTAGATTCATTAAGGAATACAAAGAAAATACTTAAAGGGATCAATAATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTGTAATCAGCTTCTTACCAAATACAGAAGGTTTCAGCAGAGCAGCTTTACCATTTGGGCTGGTGAGGCGAGAATTATCCTGTGAAGGTTATTCTATAGATCTGCGATGCCCGGGCAGTGATGTCATCATGATTGAGAGCGCTAACTATGGTCGGACGGATGACAAGATTTGTGATGCTGACCCATTTCAGATGGAGAATACAGACTGCTACCTCCCCGATGCCTTCAAAATTATGACTCAAAG exonic stage III gastric cancer Microarray; qRT-PCR gastric cancer(recurrent cancer tissues and non-recurrent cancer tissues) and adjacent normal tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. We then constructed a four-circRNA-based classifier to evaluate the risk of early recurrence and distinguished patients with a high risk from those with a low risk. The areas under the receiver operator characteristic curve (ROC) of this classifier were 0.763 and 0.711 in the two cohorts, respectively. A new formula could be established by combined the circRNA classifier with TNM stages. The areas under the ROC curve were 0.866 and 0.818 of the two cohorts, respectively. Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery. 28206972 2017.4 Oncotarget Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery N/A circ-FBXW7 novel_circ_022705 4 N/A - N/A FBXW7 GATTACTTCCTTAGGATAGATTGCCAGAAGTGGAGTTACTGGGTCAGAGGAATGTGAAAACCTTTGCATCTTCTGATAGTCTAGCCAAGGTCCAAGAAGTAGCAAGCTGGCTTTTGGAAATGAATCAGGAACTGCTCTCTGTGGGCAGCAAAAGACGACGAACTGGAGGCTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAGATGAAGAACAGATGAATCGTGTGGTAGAGGAGGAACAGCAACAGCAACTCAGACAACAAGAGGAGGAGCACACTGCAAGGAATGGTGAAGTTGTTGGAGTAGAACCTAGACCTGGAGGCCAAAATGATTCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATTTATTTCGGTAGATGAGGACTCCTCAGGAAACCAAGAAGAACAAGAGGAAGATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGAGGAGGAGGAGATGGACCAGGAGAGTGACGATTTTGATCAGTCTGATGATAGTAGCAGAGAAGATGAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTGGACCTGCCCGTTCACCAACTCTCCTCCCCATTCTATACAAAAACAACAAAA exonic glioma RNA-seq; qRT-PCR; FISH; northern blot; in vitro overexpression; in vitro knockdown; luciferase reporter assay; in vivo overexpression; etc. glioblastoma and their paired periphery normal brain tissues; HEK293T, U251, U373, Hs683 and SW1783 cells cytoplasm down-regulated N/A N/A N/A N/A Circ-FBXW7 is abundantly expressed in the normal human brain (reads per kilobase per million mapped reads [RPKM] = 9.31). The spanning junction open reading frame in circ-FBXW7 driven by internal ribosome entry site encodes a novel 21-kDa protein, which we termed FBXW7-185aa. Upregulation of FBXW7-185aa in cancer cells inhibited proliferation and cell cycle acceleration, while knockdown of FBXW7-185aa promoted malignant phenotypes invitro and invivo. FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization. Moreover, circ-FBXW7 and FBXW7-185aa levels were reduced in glioblastoma clinical samples compared with their paired tumor-adjacent tissues (P < .001). Circ-FBXW7 expression positively associated with glioblastoma patient overall survival (P = .03).Endogenous circRNA encodes a functional protein in human cells, and circ-FBXW7 and FBXW7-185aa have potential prognostic implications in brain cancer. 28903484 2017.8 J Natl Cancer Inst. Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis N/A hsa_circ_0016347 N/A 1 211092981-211192598 - hg19 KCNH1 GTCCTACAGCTGGGCTCAGACATCCTTCCCCAGTACAAGCAAGAGGCACCAAAGACTCCCCCTCACATCATCTTACATTATTGTGTTTTTAAGACCACGTGGGATTGGATCATCTTGATCTTGACCTTCTATACAGCCATCTTGGTCCCTTATAATGTCTCCTTCAAAACCAGGCAGAATAATGTGGCCTGGCTGGTTGTTGATAGCATCGTGGATGTTATCTTTTTGGTGGACATTGTGCTCAATTTTCATACCACCTTTGTTGGACCAGCAGGGGAGGTGATTTCTGACCCCAAACTTATCCGCATGAACTACCTGAAGACGTGGTTTGTGATTGACCTTCTGTCCTGTTTGCCATATGATGTCATCAACGCTTTTGAGAACGTGGATGAGGTTAGTGCCTTTATGGGTGATCCAGGGAAGATTGGTTTTGCTGATCAGATTCCACCACCACTGGAGGGGAGAGAGAGTCAGGGCATCAGCAGCCTGTTCAGCTCTCTAAAAGTTGTCCGGCTGCTCCGTCTTGGGCGAGTGGCCCGTAAGCTGGACCACTACATTGAATATGGAGCTGCTGTGCTGGTCCTGCTGGTGTGTGTGTTTGGGCTGGCTGCACACTGGATGGCCTGCATCTGGTACAGCATTGGGGACTATGAGATCTTTGACGAGGACACCAAGACAATCCGCAACAACAGCTGGCTGTACCAACTAGCGATGGACATTGGCACCCCTTACCAGTTTAATGGGTCTGGCTCAGGGAAGTGGGAAGGTGGTCCCAGCAAGAATTCTGTCTACATCTCCTCGTTGTATTTCACAATGACCAGCCTCACCAGTGTGGGCTTTGGGAACATCGCCCCATCCACAGACATTGAGAAGATCTTTGCAGTGGCCATCATGATGATTGGCT NA osteosarcoma qRT-PCR; in vitro knockdown; in vivo knockdown; in vivo overexpression; luciferase reporter assay; western blot; IHC etc. osteosarcoma tissues and adjacent non-tumor tissues; human osteosarcoma cell lines Saos-2 and MG-63 and the human osteoblast cell line hFOB (OB3) NA up-regulated miR-214 caspase-1 N/A N/A We demonstrated that circ-0016347 acted as a positive regulator in osteosarcoma cells proliferation and invasion. Moreover, circ-0016347 was identified as a sponge of miR-214 that upregulated the expression of caspase-1, which is the functional target of miR-214. Our study provides novel insight into the regulatory mechanism of circ-0016347 and its downstream targets in proliferation, invasion and metastasis of osteosarcoma cells, which will facilitate further development in the therapy of osteosarcoma. 28424426 2017.4 Oncotarget Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells N/A hsa_circ_0000181 hsa_circ_002099 1 212977661-212981190 + hg19 TATDN3 GTTGGACTAGATTTCTCCCCCAGATTTGCTGGCACTGGTGAACAGAAGGAAGAGCAAAGACAAGTCCTAATCAGACAGATCCAGTTAGCCAAAAGACTAAATTTGCCTGTAAATGTGCACTCACGCTCTGCTGGAAGACCTACCATCAACCTTTTACAAGAGCAAGGTGCTGAGAAGGTACTGCTGCATGCATTTGATGGTCGGCCATCTGTAGCCATGGAAGGAGTAAGAGCTGGGTACTTCTTCTCAATTCCCCCTTCTATCATAAGAAGTGGACAG N/A gastric cancer qRT-PCR gastric cancer tissues and paired adjacent non-tumorous tissues, and plasmas from patient with gastric cancer and health people down-regulated N/A N/A N/A N/A Hsa_circ_0000181 levels in gastric cancer tissues and plasma from gastric cancer patients were significantly decreased than those in paired adjacent non-tumorous tissues (P < .001) and healthy people (P < .001), respectively. Furthermore, hsa_circ_0000181 expression in gastric cancer tissues was significantly correlated with tumor diameter (P = .027), lymphatic metastasis (P = .044), distal metastasis (P = .023), and carbohydrate antigen 19-9 (P = .031). Its decreased levels in patients' plasma were significantly associated with differentiation (P = .038) and carcinoembryonic antigen (P = .037). The areas under ROC curve were 0.756. The specificity of tissue hsa_circ_0000181 and sensitivity of plasma hsa_circ_0000181 were 85.2% and 99.0%, respectively. 28940688 2017.9 J Clin Lab Anal. Clinical values of circular RNA 0000181 in the screening of gastric cancer N/A hsa_circ_0004018 hsa_circRNA_101940 17 1703150-1704318 - hg19 SMYD4 ACGTGTCTTAAAGACATTAACAGAGCACAGACACATGGGTATCCAGAAAGGTTGCAACCCAAGATTATGTTACGTAAAGCAGAATGTCTGGTGGCCCTGGGGAGACTGCAGGAGGCAAGCCAGACCATCAGTGATCTTGAAAGGAACTTCACAGCCACACCAGCCCTAGCAGATGTCCTCCCTCAGACTCTGCAGAGAAACCTCCATCGTCTGAAAATGAAGATGCAAGAAAAGGACAGTCTCACAGAAAGCTTCCCAGCAGCTCTGGCCAAAACCCTTGAGGATGCAGCGCTGAGGGAGGAGAATGAACAACTTTCCAATGCCTCATCATCCATCGGCTTATGCGTAGATCCTTTAAAAGGTCGCTGTCTCGTTGCCACAAAAGATATTCTCCCAGGAGAGCTCCTGGTGCAGGAGGATGCTTTTGTGAGTGTTCTCAACCCAGGAGAACTGCCACCACCGCATCACGGCCTAGACAGCAAATGGGACACCAGAGTCACCAATGGGGACCTCTATTGTCACCGATGTTTGAAGCACACTTTGGCCACAGTTCCGTGTGACGGATGCAGTTATGCCAAGTATTGCAGCCAGGAGTGTTTGCAGCAGGCCTGGGAGCTCTACCACAGGACAGAATGTCCTCTGGGAGGGCTGCTTCTCACACTGGGTGTCTTTTGCCACATTGCCCTGAGGTTGACTCTTTTGGTGGGATTTGAGGATGTTCGCAAAATCATAACGAAGCTTTGTGATAAGATTAGTAACAAGGACATCTGTTTACCTGAAAGCAACAATCAGGTCAAGACACTTAATTATGGCCTAGGGGAGAGTGAGAAAAATGGCAACATCGTTGAGACCCCAATTCCTGGATGCGATATTAATGGGAAGTATGAAAATAATTATAATGCTGTCTTCAACCTTTTGCCCCACACTGAAAACCATAGCCCAGAGCACAAATTCCTCTGTGCTCTCTGTGTTTCTGCACTGTGCAGACAGCTAGAAGCAGCCAGTTTACAGGCCATCCCAACTGAGAGGATTGTGAACTCCTCTCAGCTTAAAGCAGCAGTGACACCTGAATTGTGTCCTGACGTGACTATTTGGGGAGTGGCGATGCTGAGACACATGTTACAGCTTCAGTGTAACGCTCAGGCGATGACCACCATACAACACACAG exonic hepatocellular carcinoma Microarray; qRT-PCR; etc. HCC cell lines, HepG2, Huh7, SMMC-7721, MHCC97H and HCCLM3, and human normal hepatic cell line L02 N/A down-regulated N/A N/A N/A N/A The expression levels of hsa_circ_0004018 in HCC were significantly lower compared with para-tumorous tissue (P<0.001). Our data further showed that lower expression ofhsa_circ_0004018 was correlated with serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer stage and Tumor-node-metastasis stage. More importantly, we detected liver tissues from chronic hepatitis, cirrhosis and HCC patients; and found that hsa_circ_0004018 harbored HCC-stage-specific expression features in diverse chronic liver diseases (P<0.001). The area under receiver operating characteristic curve was up to 0.848 (95% CI=0.803-0.894, P<0.001). The sensitivity and specificity were 0.716 and 0.815, respectively. Finally, hsa_circ_0004018 might be involved in cancer-related pathways via interactions with miRNAs. 28938566 2017.8 Oncotarget Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma N/A circGFRA1 hsa_circRNA_005239 10 117849251¨C117856275 N/A hg19 GFRA1 N/A N/A triple negative breast cancer Microarray; qRT-PCR; in vitro knockdown; luciferase reporter assay; Nuclear-cytoplasmic fractionation; western blot; etc. human mammary epithelial (HME) cell lines (MCF10A and 184A1) and breast cancer cell lines (SKBR3, T47D, BT474, MCF-7, BT-483, BT-20, BT549, MDA-MB-468 and MDA-MB-231) cytoplasm up-regulated miR-34a GFRA1 N/A N/A Microarray analysis and qRT-PCR verified a circRNA termed circGFRA1 that was upregulated in TNBC. Kaplan-Meier survival analysis showed that upregulated circGFRA1 was correlated with poorer survival. Knockdown of circGFRA1 inhibited proliferation and promoted apoptosis in TNBC. Via luciferase reporter assays, circGFRA1 and GFRA1 was observed to directly bind to miR-34a. Subsequent experiments showed that circGFRA1 and GFRA1 regulated the expression of each other by sponging miR-34a. 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circRNA_007255 hsa_circ_0007255 X 69549254-69553539 + hg19 N/A GTATTAATATTAACCGAGGCCTCCTATGCTTGGGAAATGTAATCAGTGCTCTTGGAGATGACAAAAAGGGTGGCTTTGTGCCCTACAGAGATTCCAAGTTGACTCGACTGCTTCAAGATTCTCTAGGAGGTAATAGCCATACTCTTATGATAGCCTGTGTGAGTCCTGCTGACTCCAATCTAGAGGAAACATTAAATACCCTTCGCTATGCTGACAGAGCAAGAAAAATCAAGAACAAACCTATTGTTAATATTGATCCCCAGACAGCTGAACTTAATCATCTAAAGCAACAGGTACAACAGCTACAAGTCTTGTTGCTACAGGCCCATGGAGGTACCCTGCCTGGATCTATAAC exonic triple negative breast cancer Microarray; qRT-PCR human mammary epithelial (HME) cell lines (MCF10A) and breast cancer cell lines (BT549, MDA-MB-468 and MDA-MB-231) N/A up-regulated N/A KIF4A N/A N/A N/A 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circRNA_104169 hsa_circ_0001633 6 107824860-107827631 + hg19 SOBP AACTTTGCAGAAAACACCATGAATGAACTCCTTGGCTGGTATGGCTATGATAAGGTTGAATTAAAAGATGGTGAGGATATTGAATTCAGGAGCTACCCTACAGATGGGGAGAGCCGGCAGCACATTTCTGTTCTCAAAGAAAATTCTTTGCCAAAACCAAAATTACCCGAGGACAGTGTTATTTCACCATACAATATAAGCACAGGCTATTCAGGGCTTGCCACTGGAAATGGACTCAGTGACTCACCTGCAGGGTCAAAGGATCATGGCAGTGTGCCCATTATTGTACCTTTAATTCCACCACCTTTCATAAAGCCACCAGCAG exonic triple negative breast cancer Microarray; qRT-PCR human mammary epithelial (HME) cell lines (MCF10A) and breast cancer cell lines (BT549, MDA-MB-468 and MDA-MB-231) N/A up-regulated N/A N/A N/A N/A N/A 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circRNA_089763 hsa_circ_0089763 M 8366-14149 - hg19 None TTATGTGATTAGGAGTAGGGTTAGGATGAGTGGGAAGAAGAAAGAGAGGAAGTAAAGTTTAATTATGCCTTTTTGGGTTGAGGTGATGATGGAGGTGGAGATTTGGTGCTGTGAAATTGTTTTAGGTAATAGCTTTTCTAGTCAGGTTAGGTCTAGGAGGAGTAGGGGCAGGTTTTGGCTCGTAAGAAGGCCTAGATAGGGGATTGTGCGGTGTGTGATGCTAGGGTAGAATCCGAGTATGTTGGAGAAATAAAATGTGCATAGTGGGGATTTTATTTTAAGTTTGTTGGTTAGGTAGTTGAGGTCTAGGGCTGTTAGAAGTCCTAGGAAAGTGACAGCGAGGGCTGTGAGTTTTAGGTAGAGGGGGATTGTTGTTTGGAAGGGGGATGCGGGGGAAATGTTGTTAGTAATGAGAAATCCTGCGAATAGGCTTCCGGCTGCCAGGCGTTTAATGGGGTTTAGTAGGGTGGGGTTATTTTCGTTAATGTTAGTAAGGGTGGGGAAGCGAGGTTGACCTGTTAGGGTGAGAAGAATTATTCGAGTGCTATAGGCGCTTGTCAGGGAGGTAGCGATGAGAGTAATAGATAGGGCTCAGGCGTTTGTGTATGATATGTTTGCGGTTTCGATGATGTGGTCTTTGGAGTAGAAACCTGTGAGGAAAGGTATTCCTGCTAATGCTAGGCTGCCAATGGTGAGGGAGGTTGAAGTGAGAGGTATGGTTTTGAGTAGTCCTCCTATTTTTCGAATATCTTGTTCATTGTTAAGGTTGTGGATGATGGACCCGGAGCACATAAATAGTATGGCTTTGAAGAAGGCGTGGGTACAGATGTGCAGGAATGCTAGGTGTGGTTGGTTGATGCCGATTGTAACTATTATGAGTCCTAGTTGACTTGAAGTGGAGAAGGCTACGATTTTTTTGATGTCATTTTGTGTAAGGGCGCAGACTGCTGCGAACAGAGTGGTGATAGCGCCTAAGCATAGTGTTAGAGTTTGGATTAGTGGGCTATTTTCTGCTAGGGGGTGGAAGCGGATGAGTAAGAAGATTCCTGCTACAACTATAGTGCTTGAGTGGAGTAGGGCTGAGACTGGGGTGGGGCCTTCTATGGCTGAGGGGAGTCAGGGGTGGAGACCTAATTGGGCTGATTTGCCTGCTGCTGCTAGGAGGAGGCCTAGTAGTGGGGTGAGGCTTGGATTAGCGTTTAGAAGGGCTATTTGTTGTGGGTCTCATGAGTTGGAGTGTAGGATAAATCATGCTAAGGCGAGGATGAAACCGATATCGCCGATACGGTTGTATAGGACTGCTTGAATGGCTGCTGTGTTGGCATCTGCTCGGGCGTATCATCAACTGATGAGCAAGAAGGATATAATTCCTACGCCCTCTCAGCCGATGAACAGTTGGAATAGGTTGTTAGCGGTAACTAAGATTAGTATGGTAATTAGGAAAATGAGTAGATATTTGAAGAACTGATTAATGTTTGGGTCTGAGTTTATATATCACAGTGAGAATTCTATGATGGACCATGTAACGAACAATGCTACAGGGATGAATATTATGGAGAAGTAGTCTAGTTTGAAGCTTAGGGAGAGCTGGGTTGTTTGGGTTGTGGCTCAGTGTCAGTTCGAGATAATAACTTCTTGGTCTAGGCACATGAATATTGTTGTGGGGAAGAGACTGATAATAAAGGTGGATGCGACAATGGATTTTACATAATGGGGGTATGAGTTTTTTTTGTTAGGGTTAACGAGGGTGGTAAGGATGGGGGGAATTAGGGAAGTCAGGGTTAGGGTGGTTATAGTAGTGTGCATGGTTATTACTTTTATTTGGAGTTGCACCAAAATTTTTGGGGCCTAAGACCAATGGATAGCTGTTATCCTTTAAAAGTTGAGAAAGCCATGTTGTTAGACATGGGGGCATGAGTTAGCAGTTCTTGTGAGCTTTCTCGGTAAATAAGGGGTCGTAAGCCTCTGTTGTCAGATTCACAATCTGATGTTTTGGTTAAACTATATTTACAAGAGGAAAACCCGGTAATGATGTCGGGGTTGAGGGATAGGAGGAGAATGGGGGATAGGTGTATGAACATGAGGGTGTTTTCTCGTGTGAATGAGGGTTTTATGTTGTTAATGTGGTGGGTGAGTGAGCCCCATTGTGTTGTGGTAAATATGTAGAGGGAGTATAGGGCTGTGACTAGTATGTTGAGTCCTGTAAGTAGGAGAGTGATATTTGATCAGGAGAACGTGGTTACTAGCACAGAGAGTTCTCCCAGTAGGTTAATAGTGGGGGGTAAGGCGAGGTTAGCGAGGCTTGCTAGAAGTCATCAAAAAGCTATTAGTGGGAGTAGAGTTTGAAGTCCTTGAGAGAGGATTATGATGCGACTGTGAGTGCGTTCGTAGTTTGAGTTTGCTAGGCAGAATAGTAATGAGGATGTGAGTCCGTGGGCGATTATGAGAATGACTGCGCCGGTGAAGCTTCAGGGGGTTTGGATGAGAATGGCTGTTACTACGAGGGCTATGTGGCTGATTGAAGAGTATGCAATGAGCGATTTTAGGTCTGTTTGTCGTAGGCAGATGGAGCTTGTTATAATTATGCCTCATAGGGATAGTACAAGGAAGGGGTAGGCTATGTGTTTTGTCAGGGGGTTGAGAATGAGTGTGAGGCGTATTATACCATAGCCGCCTAGTTTTAAGAGTACTGCGGCAAGTACTATTGACCCAGCGATGGGGGCTTCGACATGGGCTTTAGGGAGTCATAAGTGGAGTCCGTAAAGAGGTATCTTTACTATAAAAGCTATTGTGTAAGCTAGTCATATTAAGTTGTTGGCTCAGGAGTTTGATAGTTCTTGGGCAGTGAGAGTGAGTAGTAGAATGTTTAGTGAGCCTAGGGTGTTGTGAGTGTAAATTAGTGCGATGAGTAGGGGAAGGGAGCCTACTAGGGTGTAGAATAGGAAGTATGTGCCTGCGTTCAGGCGTTCTGGCTGGTTGCCTCATCGGGTGATGATAGCCAAGGTGGGGATAAGTGTGGTTTCGAAGAAGATATAAAATATGATTAGTTCTGTGGCTGTGAATGTTATAATTAAGGAGATTTGTAGGGAGATTAGTATAGAGAGGTAGAGTTTTTTTCGTGATAGTGGTTCGCTGGATAAGTGGCGTTGGCTTGCCATGATTGTGAGGGGTAGGAGTCAGGTAGTTAGTATTAGGAGGGGGGTTGTTAGGGGGTCGGAGGAAAAGGTTGGGGAACAGCTAAATAGGTTGTTGTTGATTTGGTTAAAAAATAGTAGGGGGATGATGCTAATAATTAGGCTGTGGGTGGTTGTGTTGATTCAAATTATGTGCTTTTTGGAAAGTCATGTCAGTGGTAGTAATATAATTGTTGGGACGATTAGTTTTAGCATTGGAGTAGGTTTAGGTTATGTACGTAGTCTAGGCCATATGTGTTGGAGATTGAGACTAGTAGGGCTAGGCCCACCGCTGCTTCGCAGGCGGCAAAGACTAGTATGGCAATAGGCACAATATTGGCTAAGAGGGAGTGGGTGTTGAGGGTTATGAGAGTAGCTATAATGAACAGCGATAGTATTATTCCTTCTAGGCATAGTAGGGAGGATATGAGGTGTGAGCGATATACTAGTATTCCTAGAAGTGAGATGGTAAATGCTAGTATAATATTTATGTAAATGAGGGGCATTTGGTAAATATGATTATCATAATTTAATGAGTCGAAATCATTCGTTTTGTTTAAACTATATACCAATTCGGCTCAGTCTAATCCTTTTTGTAGTCACTCATAGGCCAGACTTAGGGCTAGGATGATGATTAATAAGAGGGATGACATAACTATTAGTGGCAGGTTAGTTGTTTGTAGGGCTCATGGTAGGGGTAAAAGGAGGGCAATTTCTAGATCAAATAATAAGAAGGTAATAGCTACTAAGAAGAATTTTATGGAGAAAGGGACGCGGGCGGGGGATATAGGGTCGAAGCCGCACTCGTAAGGGGTGGATTTTTCTATGTAGCCGTTGAGTTGTGGTAGTCAAAATGTAATAATTATTAGTAGTAAGGCTAGGAGGGTGTTGATTATTAAAATTAAGGCGAAGTTTATTACTCTTTTTTGAATGTTGTCAAAACTAGTTAATTGGAAGTTAACGGTACTATTTATACTAAAAGAGTAAGACCCTCATCAATAGATGGAGACATACAGAAATAGTCAAACCACATCTACAAAATGCCAGTATCAGGCGGCGGCTTCGAAGCCAAAGTGATGTTTGGATGTAAAGTGAAATATTAGTTGGCGGATGAAGCAGATAGTGAGGAAAGTTGAGCCAATAATGACGTGAAGTCCGTGGAAGCCTGTGGCTACAAAAAATGTTGAGCCGTAGATGCCGTCGGAAATGGTGAAGGGAGACTCGAAGTACTCTGAGGCTTGTAGGAGGGTAAAATAGAGACCCAGTAAAATTGTAATAAGCAGTGCTTGAATTATTTGGTTTCGGTTGTTTTCTATTAGACTATGGTGAGCTCAGGTGATTGATACTCCTGATGCGAGTAATACGGATGTGTTTAGGAGTGGGACTTCTAGGGGATTTAGCGGGGTGATGCCTGTTGGGGGCCAGTGCCCTCCTAGTTGGGGGGTAGGGGCTAGGCTGGAGTGGTAAAAGGCTCAGAAAAATCCTGCGAAGAAAAAAACTTCTGAGGTAATAAATAGGATTATCCCGTATCGAAGGCCTTTTTGGACAGGTGGTGTGTGGTGGCCTTGGTATGTGCTTTCTCGTGTTACATCGCGCCACCATTGGTATATGGTTAGTGTGTTGGTTAGTAGGCCTAGTATGAGGAGCGTTATGGAGTGGAAGTGAAATCACATGGCTAGGCCGGAGGTCATTAGGAGGGCTGAGAGGGCCCCTGTTAGGGGTCATGGGCTGGGTTTTACTATATGATAGGCATGTGATTGGTGGGTCATTATGTGTTGTCGTGCAGGTAGAGGCTTACTAGAAGTGTGAAAACGTAGGCTTGGATTAAGGCGACAGCGATTTCTAGGATAGTCAGTAGAATTAGAATTGTGAAGATGATAAGTGTAGAGGGAAGGTTAATGGTTGATATTGCTAGGGTGGCGCTTCCAATTAGGTGCATGAGTAGGTGGCCTGCAGTAATGTTAGCGGTTAGGCGTACGGCCAGGGCTATTGGTTGAATGAGTAGGCTGATGGTTTCGATAATAACTAGTATGGGGATAAGGGGTGTAGGTGTGCCTTGTGGTAAGAAGTGGGCTAGGGCATTTTTAATCTTAGAGCGAAAGCCTATAATCACTGCGCCCGCTCATAAGGGGATGGCCATGGCTAGGTTTATAGATAGTTGGGTGGTTGGTGTAAATGAGTGAGGCAGGAGTCCGAGGAGGTTAGTTGTGGCAATAAAAATGATTAAGGATACTAGTATAAGAGATCAGGTTCGTCCTTTAGTGTTGTGTATGGCTATCATTTGTTTTGAGGTTAGTTTGATTAGTCATTGTTGGGTGGTGATTAGTCGGTTGTTGATGAGATATTTGGAGGTGGGGATCAATAGAGGGGGAAATAGAATGATCAGTACTGCGGCGGGTAGGCCTAGGATTGTGGGGGCAATGAATGAAGCGAACAGATTTTCGTTCATTTTGGTTCTCAGGGTTTGTTATAATTTTTTATTTTTATGGGCTTTGGTGAGGGAGGTAGGTGGTAGTTTGTGTTTAATATTTTTAGTTGGGTGATGAGGAATAGTGTAAGGAGTATGGGGGTAATTATGGTGGGCCATACGGTAGTATTTAGTTGGGGCAT exonic triple negative breast cancer Microarray; qRT-PCR human mammary epithelial (HME) cell lines (MCF10A) and breast cancer cell lines (BT549, MDA-MB-468 and MDA-MB-231) N/A up-regulated N/A N/A N/A N/A N/A 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circRNA_004666 hsa_circ_0004666 X 154645235-154649223 - hg19 TCONS_00017391 AGTGCTTCGCTCCTGGTGCTCTACAAGGACTATAGAGGCAACGTCAAAAGAAATAAAACTCTACATTGTTTGCAGATACAGCTACTTTGGGGAAACCTTGTTTCCCAGGAGTAAAGAAACAGTTACAAGCCTCCCACACATTTGTGCCTATAAAGCTGCTGCAACAAACAGACCATGGCTCAGTGGAGTGTTTTACACAATCTGATTATATACATG sense overlapping triple negative breast cancer Microarray; qRT-PCR human mammary epithelial (HME) cell lines (MCF10A) and breast cancer cell lines (BT549, MDA-MB-468 and MDA-MB-231) N/A up-regulated N/A N/A N/A N/A N/A 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circRNA_004674 hsa_circ_0004674 7 87593948-87607727 + hg19 ADAM22 ATTCAGATGTTTTTGAAGTCAGAATCCCAGAAGACCATATACCAGATACAGGTAATGCAGTACCTATAACAAAAATTTTCATTTTGGATGTTAGTATTTTCTCTCAAACATGAATTGTGGATGGATTCTTTCAACCTTCCTGGAACTCAAGGGCAAGGAGTTACTCTTCAAAGCAGCTTGGAGACACCAGCTGGTAGTATGTGGAAGCCTCTGAGTTTAAGAATTTGGGGGCAGATTTATGTCATACTGAATCACTGTTAAAGATTCTTGCTATTTTCTAACCTATGTGTGCATTGCAAGACTACATGGTTTTAAGACATGGTTTTCTCAGAGAGGGCTGGTAGTCTGTTTTCTCTCTTTCTTTCTCTTACAGACACACACCACAATCCCATCTTCTTTCTTTACTGTGGTAGTTAAGATAGCTATAGGTAGTGTGTTCTTCCTACCAGTCTTCATTCTAGCCCACTGGCAAACAAAAAAAAATGAAATATTTTTGCGGTGGTTCTTGTCGCTAGAATTCTCTTGTTTGGTGTCCCAATAAAGGAAGCCTTTGGTTAAAAGAAAGAAAGGAAGAAAGTCTCTGGTGTTTGACAGTCAAGTCATAGGTGAAAACCTGTCGTTTGCATATCCTTAACATTAGGGACTTAACTGCTTTTATTTTTCTCTTCTTTTTTAGCAGGTACTTTGCTCTTAGAGTATTTCTTGACTATATCCTTGGAAAACTTTTAGACGAGTGAGATATGTTAGTAAAGAAGGCATATGGTCCTATGTTTAAAGTTTGAAACATAGTTCCATAGTTTATTATATGTAAATGTGTGAGCAGAACATCCTTTAGAATTATATAGTTTCATTCCTTAGTCCTAGGAGAAAAGGCCTTTATACACCATGTGAAATTGTTTCCCAAAGGAAATGCTATGGAATTTATTTGTGCTAGCTATTTATTATGGGATTTTGTACAACATTATTTCCTATTTTTCTTTCTTCAGACACTTGGAGCTAGCCCTTTAGTAAAAGTGAGCCTTTACTCTCAGATACATCTAATGTCTATATAAGCAAATAAAATCAGGGAAAGAAAAATCCATTGATATTACAGAACTGGGTGAAGTAAACCTTGATGTGAAGAACTCACCATTCTTAGTTTTATTATTTGGACATGGCTTACTCCTGAAGTTGCCTCCAGGAGAGATTGTGACCCAGCTGGCAGAGACAATTCTTATTTCTAATTCTGTTTTTAAAATTACCTGATTTAGAGCTAAACTGACTAGTTATTCATGTGAGAGTGTAGTGGCTTGACAGCCATTTACTCATTTTTCCTCTTCTCTGCTTTTTACCTTTTGATAGTTACATTAGTCTCTGCAATGAGCTTTTATATACTCTCTTCACCATAAACAAAAATGTTGTGTTTTTCTCACAGCATTCTGTAATTGTGACTATTTTCAGCTTGCATATGGGGAAAAACAAGATGAAGATGAAAGTTTTCCTAACTCTACTCTAATGAAATATCAAGCCAATAGTGGGGCTGGGAAGAGCTCTTGTCTCATTTCTCCCCGGCCTTTTCTGTACCAGAAAAGAGTATCCATTTCCCAGGGCTGATTTGTCGGAGGGATTTTTGTCTGCTGATTTTGTTGCATCTAAATGTTAGGGTTCCTTGCACTCAGATTTAATTATAGCTCGATACAACTATACTATATTGTGTTGTTCTCAGACTACTAAATATCTTAAAGGTCTGCTTTGACTTTCAGGATTATGTGAGTAAGCATTTTCTTGTTCAGGCCTTAAATTGAAGGCCTAGTAATGGGCAGTTAATGGCCAAGATGATGGAGAGACTGATTTATCAGAAGATAGCTGAAGCATAAATAGGTAATGAGGCTGCCTGACTTCCTGAATGGAGATGAGAAAATAGGAGCTGGTGCCAGTGTCAGCATAGTCTGTCTTTTTGTCTTTGCCTCTGGTTTGTTGGAGCAGGGACCACCTTGGCAGCCAGGGAATCACAAGAGTTCCGGGCTTTTAGTGCCTTCAGAACTGGAAATGTAGCAAGGTAAATTCGGGGAATGCCTCTCAAGAGTTCATCTTATCCAAGGAAAGCCGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGTGGCATGTGTAGCCTTCATCTAGGAATTCCTGGGTAGTGAGATCTACATGATGTAATCTCTGTCCTAGGAAAATGCATCCCAAAACAAGGGCAAGAAATTGTTTACATCAGTTGTGATATGGTTTGGCTGTGTCCCCGCCCACATCTCATCTTGAATTGTAGTTCCCGTAATCCCAACATGTCATGGGAGGGACCTGGTGGGAGGTAATTGAATGATGGGGATGGTTACCTCCATGCTATTCTCATGATAGTGAGTGAGTTCTCACGAGATCTGATGGTTTTATAAGGGGCTTTTCCCTCACTTCACTCTGTACTTCTTGCTGCTGGCATGTGAAGAAGGATGTGTTTGCTTCCCCTTCTGCCATGACTGTAAGTTTCCTGAGGCCTCCCCACCCCTGTGAACTGAGTCAATTAAACCTCTTTCCTTTATAAATTACCCAGTCTCAGGTATTTCTTCATACCAGCATGAGAACAGACTAATACAAGTTATAAATTTTTTCATGTAAAATAAAATCAACAGCAAGAATGGAAATTTGACTTGGAAAGCAAGTATAAGTAGATAAGAATTCCATGAGAATTGGCCATACTTTAGACTCACATGAAGTAGCTCTTTAAAAAATATGGGCTTGGAGGCCAAAGTAGAAAGATTGCTTGAGCTCAGGACTTTGAGACCAGCCTGGGCAATGTAGTAAGGTCCTGTCTCAAAAAGAATAAAAATACCATGGGAATTCCAATATTTTGCTCCTTTTCATGCCTCATTTAAAAAAACAGTATAGGCTGGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGTCAGATCATGAGGTCAGGAGTTCGAGACCAGCCTTCCCAGATGGTGAAACCCGTCTCTACTAAAAATACAAAGAATTAGCCAGGTATGGTGGCGTGTGCCTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATTGCTTGAGCCCTAGAGGCAGAGGTTGCAGTGAGCTAAGATCGCACCACTGCACTCCAGCCTGAGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAGTATATTGAGGTTCTACTTTGTGACAAAGTGTGCCAAGGTGCTTACAGAGATATTGGCCCTCAATTTAGCTGGAAAGACTATCTGACTGAATTTCTTTTTCTTCCTTTTGTCTTTCTCTTACTCATTCCCTCCTTTTAGAAAAAACTTTTAAAACTTTTATTATTTTGGTTGAACTCAACACCAAAATGTAGGTAGTAAATTGTCATAAGAACATACATTTTACTTTTAAGAAATAATGCAGGAATTTAGTAAGTAAATATTCAGTTTTGAAAGTTAAACATATTTTGTCATAAATAGTGAAGGCAAGGGGAGAGAGCTATTTTTATTGGACATGTATTATCACAAAGGTCTTTAATCCATTTTTATGGCTTTCAAGATAAGGAGGGCATTTCTTAGGTTGGTTTAGAATATTGCTTTTCAACTGTTGGCTATACCTTAGAATGACATTGATGGCTCTTTAAAAAATGTTGATGCCTGGGATCCACTGCAGACCAAGTGTATCAGAATCGCTGAATTTGAGGCATAGGCACTAGTATTTTTTAAAAAGTTTCCCAAGGTAGTCTGGGTGTGGTGGCTCATGCTTGTAATCCCAACGAATCAGGAGACTGAGGTAGGAGAATTGCTTGAGCCCAGGAGTTTGAGGCTGCAGTGACCTATGATCGCATCTCTGAATAGCCACTGCACTCCAGCCTGGGCAACACAGTGAGATTCTGTCTCTACAAAAAATTTAAAAAATAGAAATAGCTGAGTATGGTGGCACATGCTTATAGTCCCAGCTACTCAGAGGGGCTGAGGTGGCAGGATCACTTGAGCCCAGGAATTTGAGGTTACAGTGAGCTGTGACTGTGCAACTGCACTCCAGACTGAGAAAAAGAGCATGACCCTATCTCTAAGGGGGAAAAAGAAAAGCTTCCCAAGTGTATTAGTCTGTTCTTACACTGCTATAACGAAATACCTGAAACTGGGTAATTTTTAAGAAAAGAGGGTTAGTTGGCTTATGGTTCTGCAGGCTGTACAGGCTTTTGCTTCTGGGGAGACCTCAGGAAACTTAAAATCATGGCAGAAGGTGAAGGGGAAGCTGGCATGTCTTACATGGTCAGAGCAGAAGGAAGAGAGAGAGAGAAGGGGGAGATGCTACACACTTTTAAACAACCAGAGCTCCTGAGAACTCACTCACTATCACAAGAACTGCAAGGAGGAAAGTCCACCTCCATGATGTAGTCACTGTGCACCAGGCCTCTCCTCCAACACTGGGGATTACAATTCTACATGTGATTTGGGTGGGGATGCAAATCCTAACCATATCACCAAAGAAGTCTAATGTGGAACCAGGATTGAGAATAACCAGTTTAGAAGTTCTTTGATGTCTTTACTTCCATCTTGATCTTCCATAATAGATCAGTAACATATAGCGTGCCTTGTAATTTCCTGATTGTGCTGAGCTGTTTGCTGTTTTTGTGCCTTTGTTGTTCCTGTTTCCTGGAGTGCTTTCCCTTACATTGTCAATCTGAGGAGCACCAATGCATTCCTCGGTATCCCTACAGTTGAAGGACTGCTGTTGTATTTTATACATATACCTACTGTTAGACTTACACTCATTTTGTAATAATTTGTTTAGTACCTTCCTCTTGTGACTGTGAGTTTCCTGAGTGCAAGAGCCGTATCCAACTCATCTTTCTTTCCCAGAGCCTGGTATGATCAGCACTCTAAAAGTGTCGAATGGACTATCACTTATTTAATTATTACAGCAAATCTACAAAGTGTGTATTATTATTTTTGCTCTTTAAGAGATGAGGACTTTCAGTTCAGAAACATGAAACAACCTGCTCTAGTTTATTCCACTGGTAAATGGAAGACCTAGAATTCAAATGTACCTCAGCTCTTTAAAGTTTGTTCTTTAAAAATTGTGCTATTTTGTTTTGTTTCATTTTGTTTTAAAATGTCCTGTTGCCAGGCACTGTTCTACTTCTTGTAATACTAAATGCAGATGGTTGGATTTCAAGAACAGTTTGGTTTAAAGATAATGTGTAAATTAGATACAATATATAATCAGCTTATGAAAACTGTGGGTGTTACTGAGATGGAAAAGGGAGAGTAACATGGAGTCATAAGTATAGAAATACAGACAGAAAACACTAATGTTCTTACATTTATCATACCAATTTACATATAGGTAGACCTGTTGGGTAGAACTCTCTGTTAACAGATGCCATTGTAATACAGTTCTGCTTCACAAAATTAATCCCATATCTTGATGTGGCCACAACAAATTCTAGAATGAGAAACCTTCATCTGAAATAGAGATATAGTATCAATCCTTTGCAGCTCTTTTGCCAGAAGTTCTCATAAGGCTATGGTGATTTTTCAGTTGCCTTTTCCGATGTAGAAAAGAGGGATCATATATACAAGCCATATATATATATATGTATTTATTAAACTGAAGATGTTAGACTTCCAAGAATTATACTTGTAGTTTTTTTAAACTGAGCTGAAAGAGTCAAATGGCAAATATGTGTTTAGGACGCAGTACCTAAAGTACTGTTACATGCATTAACTCTTATTTTTAATAATATTAATTACTTTCACAGTTATCTTATTGTATACTACCATTTGATTGGTAATATTCCCACCCCATTGGTAAACATCAATTCGTTATTCAGGTTGGACTTAATTAAAAACCTAAAGTACCTCATCTTTCTCCTTGTGTCAGAGTTCTGATTCTACTATGAATGTTGTACTGCTAACTTTGCTTTAAAAATTGGTTATCAGTAAGGCAGTCTTAAAAAGTTCCTTTGTGTTTGATCTCTGGGATAGGTAGGTTGGCCCTGGTTCATTGACTCTAGAAGATATGAGGAGAAGAGGACAGGCTGCCACAAAGCAAAATGCATGAGAAACGAGTGTTATATTAATTCCGCATTTTAATTTCAGCTATTGCCCATGAATAATAAATAGGCTCCAATCTGGGGATTGTATCATGTTCTTATGGTCCTAAAATTCTGTGATTCATTTTTGAATTTAGAATTTAGAATTATCTTTATGTAATTATACTGATTTATTAAGAGTTCCTGCCATTTGGAGAGTTATTTTATATTTTTGCATTTTTCCCTTGAATCTTTTGTTTCACAGCTTCTATAAATGTCAGCCTCACTGCTTGCCTCAATCTCTAAAGCACATACATACTGCAAGCACATACTTTACCATATCCATGTAATTTCTTTTCCTTAAGTGACAGACATATATATATATGTTTAACTATAACTCTGAGTTTGTAAGGTTGTTATCAAATTGGCCTTAGGACATGTGCTGTGTGTCAGCTATGGTCATGTTATTAACTTTTAGATGGAAATGGAATTCTAAAGATTGTTTTTTATGTTTTGATTTTCTTGTCATATCTTCTAAAAATGCTCTTTAGAGTATTTTCATGATACTGAAATAACTTCTATTATAATATTTATTCATTAGAACCCAGTAAAACCTGCAAGTACCTCCAAGCTGTAGGATGAAAGCAAGGAGTTGAAATATGATGAAAAAGGCCTACCAGGAGGTGAGATGCCTACTCTACCACCAAATATGTGACTTTGGAAGTGACTTTTGCCCACACTGGCCTCAGTGTCCCTAGTTATATACTAAGGATCTTGTATTATGTGACCTCTAGGAATCTCTCAATATTATTCTGTAATACCTGAAGTACCTGTTTAATAGTTTTTAAAATCACAATTCATTCTTATGTAGTAATTTGAAAGATGGCATTTCTGCAAAATTACGTTTTTCCAGTATCTGTGAGGGGTATTACTACTTTTTCATCTTCAACTTAAAGTTAATAAATATTGGAATTTTTCCTTGACAGTACCTTAGCCTGTGTCCCCCACCAAAGGAAATTCTTGGTATTATACTGATTCTCTCTTCTCAAACATACCTTTTTCCTTAAACTAAAAAGGCAGGGTCTAAGAGTAACTTTCTGAGAGCCATCCTGGCTCACTTCAGTGGTGTTGAATAATAAGCCTGATAATATAGCAACTCAGTGTAGTTCATTTACTTTATTCCTTCTCCAAGATAACCTTAAGAAGCAACCATATTGGCCGGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCTGTCTCTACTCAGGGATGCCCTCTGTCACCACTCCTATTCAACATAGTGTTGGAAGTTCTGGCCAGGGCAATCAGGCAGGAGAAGGAAATAAAGGGTATTCAATTAGGAAAAGAGGAAGTCAAATTGTCCCTGTTTGCAGACGACATGATTGTATATCTAGAAAACCCCATTGTCTCAGCCCAAAATCTCCTTAAGTTGTTAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAAAATCACAAGCATTCTTATACACCAATAACAGACAAACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAACTTACAAGGGATGTGAAGGACCTCTTCAAGGAGAACTACAAACCACTGCTCAATGAAATAAAAGAGGATACAAACAAATGGAAGAACGTTCCATGCTCATGGGTAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGGAAAAACTACTTTAAAGTTCATATGGAACCAAAAAAGAGCCCGCATCGCCAAGTCAATCCTAAGCCAAAAGAACAAAGCCAGAGGCATCACGCTACCTGACTTCACACTATACCTACAAAGCTACAGTAACCAAAACAGCATGGTACTGGTACCAAAACAGAGGTATAGATCTATAGATCAATGGAACAGAACAGAGCCCTCAGAAATAACACCGCATATCTACAACTATCTGATCTTTGACAAACCTGAGAAAAACCAGCAATGGGGAAAGGATTCCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGCCATATGTAGAAAGCTGAAACTGGATCCCTTCCTTACACCTTATACAAAAATTAATTCAAGATGGATTAAAGACTTAAATGGTAAACCTAAAACCATAAACTCCCTAGAAGAAAACCTAGGCAATACCATTCAGGACATAGGCACGGGCAGACTTCATGTCTCAAACCCCCAAAGCAATGGCAACAAAAGCCAAAATTGACAAATCGGATCTAATTAAGCTAAAGAGCTTCTGCACAGCAAAAGAAACCACCATCAGAGTGAACAAGAAACCTACAGAATGGGAGAAAATTTTTGCAACCTACTTATCTGACAAAGGGCTAATATCCAGAATCTACAACGAACTCAAACAAATTTACAAGAAAAAAACAAACCCATCAAAAAGTGGGCAAAGGATATGAACAGACACTTCTCAAAAGAAGACATTTATGCAGCCAAAAAACACATGGAGAAGTGCTCACCATCACTGGCCATCAGAGAAATGCAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCGATCATTAAAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGATTATAAATCGTGCTGCTATAAAGACACATGCACACGTATGTTTATTGTGGCACTATTCACAATAGCAAAGAGTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATGCAGCCATGAAAAATGATGAGCTCATGTCCTTTGTAGGGACATGGATGAAGCTGGAAACCATCATTCTCAGCAAACTATCGTGAGGACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGAACACATGAACACAAGAAGGGGAACATCACACACCGGGGACTGTTGTGGGGTAGGGGTAGGGGGTGGGATAGCATTAGGAGATATACCTAATGCTAAATGACGAGTTAATGGGTGCAGCACACCAACATGGCACATGTATACATATGTAACAAAGCTGCACGTTGTGCACATGTACCCTAAAACTTAAAGTATAATAATAATAAAATTAAAAAAAAAAAAAGAGAAACCTTGTCTCTACTAAAAAGAAAAAAATACAAAAAAATTAGCCAGCCGTGGTGGCGGGTGTCTGTAGTCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCGAGATCGTGCCACTGCCCTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAGAAAAAAAATAAAAGAAAAGAAGCACCATATTTCTTCTCTTTGGCCTATTTATCAGCCAGAAACATGGGGAAGGTAGGTTCCTGAATATTGGAAGACCACAGAAAATGCGAAGAAACCAGGCTCACATTTATTTTAGTGACCACCACTGCAAGTTTGGTTTGGGTGAGAAGTCCTGTGTTTTGGGTTTGATCCTTGAGGCCTCATGAGTTTCAGCCCTGCTGCTGAAAGTGTCTTGGTTTTAGCCAAACTGTGGAGGAAAGTGACATTGAATACTGGTGCAATGAACTCATTGGAGCTGCTTTTCAAAATGTTCAGAGACAGTGTCAGTGATGCTGTATTAGTTTCCTGGTGCTTCTATAACACATTAGCAGAAACTTCGTTGCCTGAAACAACAACAACTTATTGTCTTACAACTGTGGAGGTCAGAAGCCTGAAATAGGTCTTACAAGGATAAGATGAAGTATTGGCAGTGCTTTGCTCCTTTTGGAGGCCCTAAGGGAGATTCATTCCTTGCCTTTTCTAGTTTCTAGAGGCTGTCTGCATTCCTTGGTTCCTGCCCTCTTCCTCTTAGCACTCTGATCTCTACTTCCACCATCATACCTTCTTCTCTGGTTTTAACCCTGTTGCCTTCCACTTATAAGGACTCATGTAATTAGATTGAGCCCATCCAGATAATCCAGGATAATCTCCCCAAGTCAAGGTCCTTAACAATATCTGCACAGTCCCTTTTTCCATGTGAGGTAACATGTTCGTAGGTTCTGGATATTAGGGTGTAGGCATATTTAGGGGTCATTATTTTCCCTACCGCAGATTCCTTCTAGTTATTAATGTTGTTACCTGGATATTACCTCCTTCTGGAGGCCTTCTGAGACACCCTTAGACCTCCATCTTCCCTGGTCATTCTCGACAGCATTTCTCTGTTTTATTAAGTCTGAGAATACTATGTTTATTTTCTAAACTTATTTTTAATTTAATTGTTCATTTTCTGTCTCCTCTACTATCAGATAAACTCCACAGGAGCAGAAACATGATCAGTTTTCTTCACTACTTTGTCCCCCAAATCTAAATAGCTCCCAGCACTTGGTAGGCTCTCAGAAGAAGGTTATTGAATGAATCAATCTGTATATAGTCTAAGAAAGCTTGCCTTATATTAAAACTATGTTAACATACTCCTGTTCCTATTACTATCAATAATGCAAACATTCTTACTAAGCAGTAGTTAAGCATTCTGTCAATGGATTTTCTTTTGAATTTAAGTACATGAGTTTCTCATTGGGACATAACTGAGATCAATAAAATAAGATACCAGATGTAAAATGGAGCTGCAGGAAAAAGAATTATAATTAATGCAGACAGTAAATACCTTGCCAAGAAGAATTTTAACATTACCTCAATCCAAGCTGTAATCATGATACCAAGGTGAATAACACGTGGCCCTTGTGTTTTTCACCACAAATTTGCAACATTAATATTTCTGATTCAAAGGAAATTGAGGTAAGAGCTTTAATAGTCCTACAATAAGGATGGAGGAGGGAGAGGTTCATTTTAACTGAAACATCATTTCTGGTAAGCAGAGGCTCTTCCCAAAACACAGTTGTTAGCACTCTAGGAAACTCAAAGAGCTTTAGGTAGAGGGAGTGATGTTATCCATTGACATCACATTAAAAGCAACTCTGATGGAAAGAGTGTCTTTCTATAAGCAGTTAACTTATAGCTGTTCAGTTGTTGTTCATTTATACATCCAGGGGATTGATAACAACCTTCGAATGAATCAGGCAATCAGAAGATCAACTAAGTACCTGGTGCTGGTCAAGTACTGAGGTCTTGATGTGATATTGACCTGTAGTGAGGAGGAGATGAGGAGGCTAGACGAGGTTGGAAAGGCTTCATGGAAGAGGGGTGCTATGCACTGAATTATGCCCTCCCCACATTTAAATGTTGAAACTCTAACCCCCAACATGACTGTGTTTGGAGATGGGAGACCTTTAAGAGGTGATTAAGATTACATGAGGTCATAAGGGTGGGACCCTAATCCAATATGACTGGTGTCCTTATAAGAAGAGAAAGAGACACCAGGCATGTGCACTTACAAAGAAAAGGCTATGTGAGGACACAGAGAGAAAATGGCCATTTCCAGGCCAAGGAGACAGGCCTCAGGAGAAACCAAATCTACCAACACCTTAACCTTGGACTTCCAGCCTCCAGAACTGCAAGAAAATAAATTTCTATTTAGGCCACCCAGTCTGTGGTATTTTGTTTTGGCAGTCCTAGACGACTATAGGTGGAACTTGATCTAAATCTTGAAGGATGAGTAGGGCCGTTTCTGGGAAACAGCTTTGGGGAAGTGTCTAGTTCAGGAAAGGTCTCAGCAAAATTAATGAATGAAAAAGCCACAGAAAATGTTGGAATGAACATAGCTTTTGAACTAAAGAGCAGAAGAGAGAACTGAGTGTAGGTGGGCTATGGGTAGGTGCTTATGTACCATTATGCCTGGGGTGGGGAAGGTGATTATGGAAGATCCTGAAATCCAGGGAGAAGGGTTTTTTATTTCTTTTTTTTTTTTTGATACAGTAGAAAATCTAGGGCTTACATTTGGGGTTTTGATAAGGAGCCAACTTTAGAAAGATCGGGGGATATGATGTATGGCAGAGGTGGAAATGAAGGGTAAGGTGTGGCTCCAAGAACTACCATAAAAAAAGAAAACAGATTTAGTTGGGGCTGGGTATTAGTTGAGAAGAGTTAAGAGTTATAGTTGAATGGTTCATGAGGCTGAGAGGTACCCAGGTAGTTCTTAATTTTTGAAGTTTTATGAGGATTAGAATGTGTTAGCAACAGAAGTACAAGATTCTCCCATACCTACTTCTTTAGGAGGATAGACTTTAAAACAGAAGAATTATCCTTTCTTTCCAAAAAGTCTTATTATTATTAATCAGACTCTCTCCTTTCACCTAATCTCATAGTTTACTGTGTGTGAAATCCCAGGGATGGTTGAGGTCACCTGTGGCCCCACAGAATCCTAAGATGTCCGTTCTGGGATGTGCTGGTTCTCAGGGAGCAGCAGCACTGTTGGCCTCACATACTATGTGCAGTTGCTCATGTGGCTTTTAATCTCTAAAATAATGTTTGTCACGTTTCTCATTTTAGTGATTATACATATTGATTTTAGAGGTTTGGATACTGTAGAAACATAAACACGAAAAATTCCAATAATTTGGAGTCCTACTGTTTGGATATAGCTACTGTTCATATTTGGTGAGTCGAATGGAACACACAGTTTTGCTTCCTCCTTTCTTTTCAGTTAATTCACATGATTATTCAGTATGCAAATATTAGTGCTATGGGAAACACTATATTTTTTAGTTTAGAGTCCCTTGTGGTTTTCTCTGGGAGTTCCTAGGATAGCATAGGAAATAGTGAATTTTTTTTTTCTAACACAAGAACATTTTGATAGGTGATATTGGCAGTAGATGTGCAGAGGTTTAATTTTGCTTTTAGGAAGATGTGGAAACCTTGATGAAATTATGTCTGGTAAATTATAAAGGAAATACTATTTTTAAAGTATATCTTTGTGATAAGCGAAAAAGGATTTTTTGGAGGTTTAGATATCTTCTTTCTAAATAGATCATATTCACCATATTATTTTATTCTTGAATTGAGCATATTTTACTTATTTTCTTTCCAAATGTACAAAACTTTATTTTAAAGGAGCTAGTCACTTAAAATCAGATAAGATGAATGAAGTGCAGTCATCTTAGAAATGAAATGCTTAACCACTTGAGGTAAACTAGAAAAGTAGGGCACTTGTCCTCTTTGATTGGGTGGTAATTTACTTCACATTGGTGAATGCTTGGCTTCTAAGAAGGTGTAAATTTTACTTTAATATGTTTTCACTTATTCTCCATGTTGAATTATTTTCTTATGATATTGTAAGTGTTTTGAAATAATCATAAGAAAGACTAATTGTCTGATTAGTATGGCTGAGTAATAAATAACCTTTTTTCTTTTTGATATTGTAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAATCA exonic triple negative breast cancer Microarray; qRT-PCR human mammary epithelial (HME) cell lines (MCF10A) and breast cancer cell lines (BT549, MDA-MB-468 and MDA-MB-231) N/A up-regulated N/A N/A N/A N/A N/A 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circRNA_405198 N/A 14 34394823-34400421 - hg19 N/A N/A sense overlapping triple negative breast cancer Microarray; qRT-PCR human mammary epithelial (HME) cell lines (MCF10A) and breast cancer cell lines (BT549, MDA-MB-468 and MDA-MB-231) N/A up-regulated N/A N/A N/A N/A N/A 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circRNA_405679 N/A N/A N/A N/A hg19 N/A N/A N/A triple negative breast cancer Microarray; qRT-PCR human mammary epithelial (HME) cell lines (MCF10A) and breast cancer cell lines (BT549, MDA-MB-468 and MDA-MB-231) N/A up-regulated N/A N/A N/A N/A N/A 29037220 2017.10.16 J Exp Clin Cancer Res. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a N/A hsa_circ_0047905 N/A 18 61156579-61172318 + hg19 SERPINB5 GAGTTCATCAGCTCTACGAAGAGACCGTATGCAAAGGAATTGGAAACTGTTGACTTCAAAGATAAATTGGAAGAAACGAAAGGTCAGATCAACAACTCAATTAAGGATCTCACAGATGGCCACTTTGAGAACATTTTAGCTGACAACAGTGTGAACGACCAGACCAAAATCCTTGTGGTTAATGCTGCCTACTTTGTTGGCAAGTGGATGAAGAAATTTTCTGAATCAGAAACAAAAGAATGTCCTTTCAGAGTCAACAAGACAGACACCAAACCAGTGCAGATGATGAACATGGAGGCCACGTTCTGTATGGGAAACATTGACAGTATCAATTGTAAGATCATAGAGCTTCCTTTTCAAAATAAGCATCTCAGCATGTTCATCCTACTACCCAAGGATGTGGAGGATGAGTCCACAGGCTTGGAGAAGATTGAAAAACAACTCAACTCAGAGTCACTGTCACAGTGGACTAATCCCAGCACCATGGCCAATGCCAAGGTCAAACTCTCCATTCCAAAATTTAAGGTGGAAAAGATGATTGATCCCAAGGCTTGTCTGGAAAATCTAGGGCTGAAACATATCTTCAGTGAAGACACATCTGATTTCTCTGGAATGTCAGAGACCAAGGGAGTGGCCCTATCAAATGTTATCCACAAAGTGTGCTTAGAAATAACTGAAGATGGTGGGGATTCCATAGAGGTGCCAGGAGCACGGATCCTGCAGCACAAGGATGAATTGAATGCTGACCATCCCTTTATTTACATCATCAGGCACAACAAAACTCGAAACATTATTTTCTTTGGCAAATTCTGTTCTCCTTAAGTGGCATAGCCCATGTTAAGTCCTCCCTGACTTTTCTGTGGATGCCGATTTCTGTAAACTCTGCATCCAGAGATTCATTTTCTAGATACAATAAATTGCTAATGTTGCTGGATCAGGAAGCCGCCAGTACTTGTCATATGTAGCCTTCACACAGATAGACCTTTTTTTTTTTTCCAATTCTATCTTTTGTTTCCTTTTTTCCCATAAGACAATGACATACGCTTTTAATGAAAAGGAATCACGTTAGAGGAAAAATATTTATTCATTATTTGTCAAATTGTCCGGGGTAGTTGGCAGAAATACAGTCTTCCACAAAGAAAATTCCTATAAGGAAGATTTGGAAGCTCTTCTTCCCAGCACTATGCTTTCCTTCTTTGGGATAGAGAATGTTCCAGACATTCTCGCTTCCCTGAAAGACTGAAGAAAGTGTAGTGCATGGGACCCACGAAACTGCCCTGGCTCCAGTGAAACTTGGGCACATGCTCAGGCTACTATAGGTCCAGAAGTCCTTATGTTAAGCCCTGGCAGGCAGGTGTTTATTAAAATTCTGAATTTTGGGGATTTTCAAAAGATAATATTTTACATACACTGTATGTTATAGAACTTCATGGATCAGATCTGGGGCAGCACCCTATAAATCAACACCTTAATATGCTGCAACAAAATGTAGAATATTCAGACAAAATGGATACATAAAGACTAAGTAGCCCATAAGGGGTCAAAATTTGCTGCCAAATGCGTATGCCACCAACTTACAAAAACACTTCGTTCGCAGAGCTTTTCAGATTGTGGAATGTTGGATAAGGAATTATAGACCTCTAGTAGCTGAAATGCAAGACCCCAAGAGGAAGTTCAGATCTTAATATAAATTCACTTTCATTTTTGATAGCTGTCCCATCTGGTCATTTGGTTGGCACTAGACTGGTGGCAGGGGCTTCTAGCTGACTTGCACAGGGATTCTCACAATAGCCGATATCAGAATTTGTGTTGAAGGAACTTGTCTCTTCATCTAATATGATAGCGGGAAAAGGAGAGGAAACTACTGCCTTTAGAAAATATAAGTAAAGTGATTAAAGTGCTCACGTTACCTTGACACATAGTTTTTCAGTCTATGGGTTTAGTTACTTTAGATGGCAAGCATGTAACTTATATTAATAGTAATTTGTAAAGTTGGTTGGATAAGCTATCCGTGTTGCAGGTTCATGGATTACTTCTCTATAAAAAATATGTATTTACCAAAAATTTTGTGACATTCCTTCTCCCATCTCTTCCTTGACCTGCATTGTAAATAGGTTCTTCTTGTTCTGAGATTCAATATTGAATTTTTCCTATGCTATTGACAATAAAATATTATTGAACTACA N/A gastric cancer Microarray; qRT-PCR; FISH; in vitro knockdown; western blot; etc. 31 GC tissue and paired adjacent noncancerous mucosal tissue; human GC cell line AGS cytoplasm up-regulated N/A N/A N/A N/A We examined differentially-expressed circRNAs and mRNAs in GC tissues and paired noncancerous mucosa tissues using circRNA and mRNA microarrays. Next, we built gene co-expression networks according to the degree of correlation to predict the critical circRNAs in GC. Through bioinformatics analysis, we observed three newly identified circRNAs that are substantially upregulated in GC: hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15. Additionally, hsa_circ_0047905 and hsa_circ_0138960 positively correlated with their parental gene mRNA. Knockdown of hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 in GC cells, resulted in downregulation of parental gene expression. Functional assays suggested that inhibition of these three circular RNAs suppresses GC cell proliferation and invasion in vitro. Those findings suggest that hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 might act as tumor promoters in the pathogenesis of gastric cancer. 28980874 2017.10.5 Cell Cycle Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastriccancer N/A hsa_circ_0138960 N/A 9 74817486-74828907 + hg19 GDA TGAGTTCTTCATGCCTGGGCTGGTTGATACACACATCCATGCCTCTCAGTATTCCTTTGCTGGAAGTAGCATAGACCTGCCACTCTTGGAGTGGCTGACCAAGTACACATTTCCTGCAGAACACAGATTCCAGAACATCGACTTTGCAGAAGAAGTATATACCAGAGTTGTCAGGAGAACACTAAAGAATGGAACAACCACAGCTTGTTACTTTGCAACAATTCACACTGACTCATCTCTGCTCCTTGCCGACATTACAGATAAATTTGGACAGCGGGCATTTGTGGGCAAAGTTTGCATGGATTTGAATGACACTTTTCCAGAATACAAGGAGACCACTGAGGAATCGATCAAGGAAACTGAGAG N/A gastric cancer Microarray; qRT-PCR; FISH; in vitro knockdown; western blot; etc. 31 GC tissue and paired adjacent noncancerous mucosal tissue; human GC cell line AGS cytoplasm up-regulated N/A N/A N/A N/A We examined differentially-expressed circRNAs and mRNAs in GC tissues and paired noncancerous mucosa tissues using circRNA and mRNA microarrays. Next, we built gene co-expression networks according to the degree of correlation to predict the critical circRNAs in GC. Through bioinformatics analysis, we observed three newly identified circRNAs that are substantially upregulated in GC: hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15. Additionally, hsa_circ_0047905 and hsa_circ_0138960 positively correlated with their parental gene mRNA. Knockdown of hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 in GC cells, resulted in downregulation of parental gene expression. Functional assays suggested that inhibition of these three circular RNAs suppresses GC cell proliferation and invasion in vitro. Those findings suggest that hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 might act as tumor promoters in the pathogenesis of gastric cancer. 28980874 2017.10.5 Cell Cycle Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastriccancer N/A hsa-circRNA7690-15 N/A N/A N/A N/A N/A GDA N/A N/A gastric cancer Microarray; qRT-PCR; FISH; in vitro knockdown; western blot; etc. 31 GC tissue and paired adjacent noncancerous mucosal tissue; human GC cell line AGS cytoplasm up-regulated N/A N/A N/A N/A We examined differentially-expressed circRNAs and mRNAs in GC tissues and paired noncancerous mucosa tissues using circRNA and mRNA microarrays. Next, we built gene co-expression networks according to the degree of correlation to predict the critical circRNAs in GC. Through bioinformatics analysis, we observed three newly identified circRNAs that are substantially upregulated in GC: hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15. Additionally, hsa_circ_0047905 and hsa_circ_0138960 positively correlated with their parental gene mRNA. Knockdown of hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 in GC cells, resulted in downregulation of parental gene expression. Functional assays suggested that inhibition of these three circular RNAs suppresses GC cell proliferation and invasion in vitro. Those findings suggest that hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 might act as tumor promoters in the pathogenesis of gastric cancer. 28980874 2017.10.5 Cell Cycle Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastriccancer N/A circUBAP2 N/A N/A N/A N/A N/A UBAP2 N/A N/A osteosarcoma Microarray; qRT-PCR; in vitro knockdown; in vitro overexpression; in vivo overexpression; RIP; western blot; etc. osteosarcoma tissue and matched adjacent normal tissue; human osteoblastic cell line hFOB 1.19, osteosarcoma cell lines MG63 and U2OS N/A up-regulated miR-143 Bcl-2 N/A N/A We found that circRNA UBAP2 (circUBAP2) expression is significantly increased in human osteosarcoma tissues as compared to those in matched controls. Increased circUBAP2 expression was significantly correlated with human osteosarcoma progression and prognosis. Furthermore, increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both in vitroand in vivo. Mechanistically, circUBAP2 was found to inhibit the expression of microRNA-143 (miR-143), thus enhancing the expression and function of anti-apoptotic Bcl-2, which is a direct target of miR-143. Together, our results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy. 28977896 2017.6.27 Oncotarget Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression N/A circWDR77 hsa_circ_0013509 1 111984646-111986543 - hg19 WDR77 GACAATAGAATTTTACTCTGGGATACCCGCTGTCCCAAGCCAGCATCACAGATTGGCTGCAGTGCGCCTGGCTACCTTCCTACCTCGCTGGCTTGGCATCCTCAGCAAAGTGAAGTCTTTGTCTTTGGTGATGAGAATGGGACAGTCTCCCTTGTGGACACCAAGAGTACAAGCTGTGTCCTGAGCTCAGCTGTACACTCCCAGTGTGTCACTGGGCTGGTGTTCTCCCCACACAGTGTTCCCTTCCTGGCCTCTCTCAGTGAAGACTGCTCACTTGCTGTGCTGGACTCAAGCCTTTCTGAGTT N/A diabetes mellitus correlated vasculopathy Microarray; qRT-PCR; western blot; RIP; dual luciferase reporter assay; etc. human VSMCs treatmented with high glucose and normal glucose; HEK 293T cells N/A up-regulated miR-124 FGF-2 N/A N/A We performed circRNAs microarray analysis to present the circRNAs expression profiles in high glucose induced VSMCs in vitro. Results showed that total of 983 circRNAs were discovered to be differentially expressed, and of these, 458 were upregulated and 525 were downregulated. Moreover, 31 circRNAs were up-regulated and 22 circRNAs were down-regulated with 2 fold change (P < 0.05). One of an up-regulated circRNA, circWDR77, was identified. In vitro cell assay, circWDR77 silencing significantly inhibited the proliferation and migration. Bioinformatics methods discovered that miR-124 and FGF-2 were downstream targets of circWDR77. The RNA sequence complementary binding was validated by RIP and/or luciferase reporter assay. Further function validation experiments revealed that circWDR77 regulated VSMCs proliferation and migration via targeting miR-124/FGF2. Taken together, present study firstly reveals the circRNAs expression profiles in high glucose induced VSMCs and identifies the role of circWDR77-miR-124-FGF2 regulatory pathway in VSMCs proliferation and migration, which might provide a new theoretical basis for diabetes mellitus correlated vasculopathy. 29042195 2017.10.14 Biochem Biophys Res Commun. Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124 N/A hsa_circRNA_100914 hsa_circ_0023903 11 85692171-85742653 - hg19 PICALM ACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGTGGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTTGTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGAGAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAAACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAATAAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTTTGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGTTGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGCTTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGGTCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCTAAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGCCATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCCATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGATCCTTTCTCTGCTACTGTAGATGCTGTTGATGATGCCATTCCAAGCTTAAATCCTTTCCTCACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACCTACTCATGAAATGTTTGTTGGATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGCTGGCCTTAATGTTGACTTTGAATCTGTGTTTGGAAATAAATCTACAAATGTTATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACTTCTCAAACCAACAGTGGCCTCTCAGAACCAGAACCTTCCTGTTGCCAAACTCCCACCTAGCAAGTTAGTATCTGATGACTTGGATTCATCTTTAGCCAACCTTGTGGGCAATCTTGGCATCGGAAATGGAACCACTAAGAATGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAACTGGGGGATCTAACTGGCAACCAAAGGTTGCACCAACAACCGCTTGGAATGCTGCAACAATG exonic Moyamoya disease Microarray; qRT-PCR blood from MMD and control samples N/A down-regulated N/A N/A N/A N/A To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. 28991692 2017.10.15 J Neurol Sci. Altered expression of circular RNAs in Moyamoya disease N/A hsa_circRNA_103343 hsa_circ_0002569 3 47098310-47108608 - hg19 SETD2 GAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAAGGGATGCTGTTGGCTTCAGAGATCAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATAAAGAGAAAAGGAAACGAAGAAGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACACCAACTTCTAAAAAGAAAGTACGAATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAACGGGAGGCTCAGAAACAACAGCAACAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATCATCCCTTTGCTGGTTACCCACCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACACCCAGCATGGACCCAGTGTGTTCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCACCAGTACCAGTGGTGCCACATGTGGCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACTCCAGCGTTGCTGTCTTGCCAGTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTGTACAGCAGCAGTACTCTCCTGCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTTATTCACAGACAACTCCACCAATTGTACAG exonic Moyamoya disease Microarray; qRT-PCR blood from MMD and control samples N/A down-regulated N/A N/A N/A N/A To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. 28991692 2017.10.15 J Neurol Sci. Altered expression of circular RNAs in Moyamoya disease N/A hsa_circRNA_050898 hsa_circ_0050898 19 39138266-39219794 + hg19 ACTN4 AGGCGCGGGCGGAGGGCGGGCTGAAGCAGCTGAAGCGGCGGTAGCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCGGAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCGGTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAAGCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCATCCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGTGCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCTGAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGACATCGTGAACACGGCCCGGCCCGACGAGAAGGCCATAATGACCTATGTGTCCAGCTTCTACCATGCCTTTTCAGGAGCGCAGAAGGCTGAAACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCTCCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGCCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGACATCAACAATGGCTGGCAGCACTTGGAGCAGGCTGAGAAGGGCTACGAGGAGTGGCTGCTGAATGAGATCCGCAGGCTGGAGCGGCTCGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGACGGGAAGGAAGCCATGCTGAAGCACCGGGACTACGAGACGGCCACACTATCGGACATCAAAGCCCTCATTCGCAAGCACGAGGCCTTCGAGAGCGACCTGGCTGCGCACCAGGACCGCGTGGAGCAGATCGCCGCCATTGCCCAGGAGCTCAACGAGCTGGATTACTACGACTCCCACAATGTCAACACCCGGTGCCAGAAGATCTGTGACCAGTGGGACGCCCTCGGCTCTCTGACACATAGTCGCAGGGAAGCCCTGGAGAAAACAGAGAAGCAGCTGGAGGCCATCGACCAGCTGCACCTGGAATACGCCAAGCGCGCGGCCCCCTTCAACAACTGGATGGAGAGCGCCATGGAGGACCTCCAGGACATGTTCATCGTCCATACCATCGAGGAGATTGAGGGCCTGATCTCAGCCCATGACCAGTTCAAGTCCACCCTGCCGGACGCCGATAGGGAGCGCGAGGCCATCCTGGCCATCCACAAGGAGGCCCAGAGGATCGCTGAGAGCAACCACATCAAGCTGTCGGGCAGCAACCCCTACACCACCGTCACCCCGCAAATCATCAACTCCAAGTGGGAGAAGGTGCAGCAGCTGGTGCCAAAACGGGACCATGCCCTCCTGGAGGAGCAGAGCAAGCAGCAGTCCAACGAGCACCTGCGCCGCCAGTTCGCCAGCCAGGCCAATGTTGTGGGGCCCTGGATCCAGACCAAGATGGAGGAGATCGGGCGCATCTCCATTGAGATGAACGGGACCCTGGAGGACCAGCTGAGCCACCTGAAGCAGTATGAACGCAGCATCGTGGACTACAAGCCCAACCTGGACCTGCTGGAGCAGCAGCACCAGCTCATCCAGGAGGCCCTCATCTTCGACAACAAGCACACCAACTATACCATGGAGCACATCCGCGTGGGCTGGGAGCAGCTGCTCACCACCATTGCCCGCACCATCAACGAGGTGGAGAACCAGATCCTCACCCGCGACGCCAAGGGCATCAGCCAGGAGCAGATGCAGGAGTTCCGGGCGTCCTTCAACCACTTCGACAAGGATCATGGCGGGGCGCTGGGGCCCGAGGAGTTCAAGGCCTGCCTCATCAGCCTGGGCTACGACGTGGAGAACGACCGGCAGGGTGAGGCCGAGTTCAACCGCATCATGAGCCTGGTCGACCCCAACCATAGCGGCCTTGTGACCTTCCAAGCCTTCATCGACTTCATGTCGCGGGAGACCACCGACACGGACACGGCTGACCAGGTCATCGCTTCCTTCAAGGTCTTAGCAGGGGACAAG exonic Moyamoya disease Microarray; qRT-PCR blood from MMD and control samples N/A down-regulated N/A N/A N/A N/A To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. 28991692 2017.10.15 J Neurol Sci. Altered expression of circular RNAs in Moyamoya disease N/A hsa_circRNA_101720 hsa_circ_0002078 16 16126965-16130460 + hg19 ABCC1 AATCCCTGCCCAGAGTCCAGCGCTTCCTTCCTGTCGAGGATCACCTTCTGGTGGATCACAGGGTTGATTGTCCGGGGCTACCGCCAGCCCCTGGAGGGCAGTGACCTCTGGTCCTTAAACAAGGAGGACACGTCGGAACAAGTCGTGCCTGTTTTGGTAAAGAACTGGAAGAAGGAATGCGCCAAGACTAGGAA exonic Moyamoya disease Microarray; qRT-PCR blood from MMD and control samples N/A up-regulated N/A N/A N/A N/A To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. 28991692 2017.10.15 J Neurol Sci. Altered expression of circular RNAs in Moyamoya disease N/A hsa_circRNA_067209 hsa_circ_0067209 3 127965678-127983624 + hg19 EEFSEC GGGCCCAGATCATTGATCTGATGATGCTGGTCATCGATGTGACCAAGGGGATGCAGACCCAGTCAGCGGAATGCCTTGTGATCGGCCAGATTGCCTGCCAGAAGCTGGTCGTGGTGCTGAACAAAATAGACCTCTTACCTGAAGGAAAGAGACAGGCAGCAATTGATAAAATGACCAAGAAAATGCAGAAGACCCTAGAGAACACCAAGTTCCGAGGTGCACCGATTATACCCGTGGCGGCCAAGCCGGGGGGACCAGAGGCCCCCGAAACTGAAGCTCCACAGGGCATTCCAGAGCTCATTGAGCTCCTGACGTCCCAGATTTCCATCCCAACGAGAGATCCCTCGGGACCGTTCCTCATGTCTGTGGACCACTGTTTCTCCATCAAAGGCCAAGGCACTGTGATGACAGGGACCATCCTTTCAGGCTCCATCAGCCTCGGTGACAGTGTGGAGATCCCTGCCCTCAAG exonic Moyamoya disease Microarray; qRT-PCR blood from MMD and control samples N/A up-regulated N/A N/A N/A N/A To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. 28991692 2017.10.15 J Neurol Sci. Altered expression of circular RNAs in Moyamoya disease N/A hsa_circRNA_104194 hsa_circ_0004712 6 136468488-136476896 + hg19 PDE7B GTACAACATACTCAGGGGAGATTGGCACCAAGAAAAAGGTGAAAAGACTATTAAGCTTTCAAAGATACTTCCATGCATCAAGGCTGCTTCGTGGAATTATACCACAAGCCCCTCTGCACCTGCTGGATGAAGACTACCTTGGACAAGCAAGGCATATGCTCTCCAAAGTGGGAATGTGGGATTTTGACATTTTCTTGTTTGATCGCTTGACAAATGGAAACAGCCTGGTAACACTGTTGTGCCACCTCTTCAATACCCATGGACTCATTCACCATTTCAAGTTAGATATGGTGACCTTACACCGATTTTTAGTCATGGTTCAAGAAGATTACCACAGCCAAAACCCGTATCACAATGCTGTTCACGCAGCCGACGTCACCCAGGCCATGCACTGCTACCTGAAAGAGCCAAAGCTTGCCAGCTTCCTCACGCCTCTGGACATCATGCTTGGACTGCTGGCTGCAGCAGCACACGATGTGGACCACCCAGGGGTGAACCAGCCATTTTTGATAAAAACTAACCACCATCTTGCAAACCTATATCAG exonic rheumatoid arthritis Microarray; qRT-PCR PBMC from twenty RA patients and healthy people N/A up-regulated N/A N/A N/A N/A A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA. 28983619 2017.9.27 Mol Med Rep. Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology N/A hsa_circRNA_104593 hsa_circ_0083964 8 37985808-37986469 + hg19 ASH2L CTCCCCAGTTAAAGATCTCAGATGACCGGCTGACTGTGGTTGGAGAGAAGGGCTACTCTATGGTGAGGGCCTCTCATGGAGTACGGAAAGGTGCCTGGTATTTTGAAATCACTGTGGATGAGATGCCACCAGATACCGCTGCCAGACTGGGTTGGTCCCAGCCCCTAGGAAACCTTCAAGCTCCTTTAGGTTATGATAAATTTAGCTATTCTTGGCGGAGCAAAAAGGGAACCAAGTTCCACCAGTCCATTGGCAAACACTACTCTTCTGGCTATGGACAGGGAGACGTCCTGGGATTTTATATTAATCTTCCTGAAGACACAGAGACAGCCAAGTCATTGCCAGACACATACAAAGATAAG exonic rheumatoid arthritis Microarray; qRT-PCR PBMC from twenty RA patients and healthy people N/A up-regulated N/A N/A N/A N/A A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA. 28983619 2017.9.27 Mol Med Rep. Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology N/A hsa_circRNA_103334 hsa_circ_0064996 3 43341245-43373802 + hg19 SNRK GAAAAAGAAGCAACTAACAAAACACTGTGATAATAAGGATTATTCAGTATGCAGTTTGCAGGATATCCATGACGACATTGAAAATGAATTTTTTGTATTCACCAGATATTCTTATATGAGAAGATCTATTTTAAACAGTCTAAATATTTTTTCTTCTGTTGGACCAGCATGGCAGGATTTAAGCGAGGGTATGATGGAAAGATTGCTGGATTATATGATCTGGATAAAACCTTGGGTCGAGGCCATTTTGCCGTGGTTAAACTTGCCAGGCATGTCTTTACGGGTGAAAAGGTGGCAGTAAAAGTTATTGACAAGACAAAACTGGACACTCTAGCTACTGGTCATCTTTTCCAGGAAGTGAGATGCATGAAACTAGTGCAGCATCCTAACATCGTCCGCCTTTATGAAGTTATTGACACCCAGACCAAACTATATCTTATTCTAGAACTTGGGGATGGAGGAGATATGTTTGATTATATAATGAAACATGAGGAGGGTCTTAATGAAGACTTGGCCAAGAAGTATTTTGCTCAGATAGTTCATGCTATATCTTATTGCCATAAACTCCATGTGGTTCACAGAGACTTAAAACCAGAGAATGTAGTCTTCTTTGAAAAACAAGGTCTTGTAAAGTTGACAGACTTTGGGTTCAGCAACAAATTTCAACCAGGGAAGAAGCTCACTACAAGCTGTGGATCTCTTGCATATTCCGCTCCAGAAATTCTGCTTGGTGATGAGTATGATGCACCTGCAGTAGATATTTGGAGTCTGGGAGTGATCCTTTTCATGTTGGTGTGTGGGCAGCCGCCCTTTCAAGAAGCCAATGACAGTGAAACACTGACAATGATCATGGATTGCAAATATACAGTACCATCCCATGTGTCTAAAGAGTGTAAAGA exonic rheumatoid arthritis Microarray; qRT-PCR PBMC from twenty RA patients and healthy people N/A up-regulated N/A N/A N/A N/A A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA. 28983619 2017.9.27 Mol Med Rep. Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology N/A hsa_circRNA_101407 hsa_circ_0032683 14 75590748-75590926 - hg19 NEK9 GATGACTCACTGGTTGTGTGGAAGGAAGTCGATTTGACCCGGCTGTCTGAGAAGGAACGTCGTGATGCCTTGAATGAGATTGTTATTCTGGCACTGCTGCAGCACGACAACATTATTGCCTACTACAATCACTTCATGGACAATACCACGCTGCTGATTGAGCTGGAATATTGTAATG exonic rheumatoid arthritis Microarray; qRT-PCR PBMC from twenty RA patients and healthy people N/A up-regulated N/A N/A N/A N/A A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA. 28983619 2017.9.27 Mol Med Rep. Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology N/A hsa_circRNA_102594 hsa_circ_0052012 19 50902107-50902741 + hg19 POLD1 GATGGATGGCAAGCGGCGGCCAGGCCCAGGGCCCGGGGTGCCCCCAAAGCGGGCCCGTGGGGGCCTCTGGGATGATGATGATGCACCTCGGCCATCCCAATTCGAGGAGGACCTGGCACTGATGGAGGAGATGGAGGCAGAACACAGGCTGCAGGAGCAGGAGGAGGAGGAGCTGCAGTCAGTCCTGGAGGGGGTTGCAGACGGGCAGGTCCCACCATCAGCCATAGATCCTCGCTGGCTTCGGCCCACACCACCAGCGCTGGACCCCCAGACAGAGCCCCTCATCTTCCAACAGTTGGAGATTGACCATTATGTGG exonic rheumatoid arthritis Microarray; qRT-PCR PBMC from twenty RA patients and healthy people N/A down-regulated N/A N/A N/A N/A A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA. 28983619 2017.9.27 Mol Med Rep. Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology N/A hsa_circ_0000745 hsa_circRNA_101996 17 20107645-20109225 + hg19 SPECC1 GGGCCTTTACAACAACTAAACGGACAGGCATTCCAGCCCCACGGGAATTTTCAGTAACTGTCTCAAGAGAGAGGTCTGTGCCACGTGGTCCCTCCAACCCCAGGAAATCAGTGTCCAGTCCAACTTCTTCCAACACTCCCACTCCTACGAAACACCTGAGGACCCCTTCCACAAAGCCCAAGCAAGAGAATGAAGGTGGAGAAAAGGCTGCGCTTGAGTCCCAAGTTCGGGAACTTTTGGCAGAAGCCAAAGCAAAAGATAGTGAAATTAACAGGCTTCGAAGTGAACTAAAGAAATACAAAGAGAAAAGGACTCTGAACGCTGAGGGGACTGATGCTTTGGGCCCAAATGTCGATGGAACATCAGTCTCCCCAGGTGACACGGAACCTATGATAAGAGCTCTTGAGGAGAAGAACAAGAACTTTCAGAAAGAGCTTTCCGATCTAGAGGAAGAAAACCGGGTCCTGAAGGAGAAACTGATCTATCTTGAGCACTCCCCAAATTCAGAAGGGGCAGCAAGTCACACTGGCGACAGCAGCTGCCCAACATCCATAACTCAAGAGTCAAGCTTCGGAAGCCCAACTGGAAATCAGATGTCCAGTGACATTGATGAGTATAAAAAAAACATACATGGAAATGCATTACGGACATCAGGCTCCTCAAGTAGCGATGTTACCAAAGCTTCTTTGTCGCCAGATGCTTCCGACTTTGAGCACATTACAGCAGAGACACCCTCAAGGCCCCTGTCCTCCACCAGTAACCCCTTTAAGAGTTCAAAGTGTTCTACTGCTGGGAGTTCCCCAAACAGCGTAAGTGAATTGTCCCTGGCTTCCCTCACAGAGAAGATACAAAAGATGGAAGAAAACCACCATAGCACTGCAGAAGAACTACAGGCTACTCTACAAGAATTATCAGACCAGCAACAAATGGTACAGGAATTGACAGCTGAAAATGAGAAGCTGGTGGATGAAAAGACGATTTTAGAGACATCCTTTCATCAGCATCGAGAGAGGGCAGAGCAGCTAAGTCAAGAAAATGAGAAGCTGATGAATCTTTTACAAGAGCGAGTAAAGAATGAAGAGCCCACCACTCAGGAAGGAAAAATTATTGAACTGGAGCAGAAGTGCACAGGTATTCTTGAACAGGGCCGCTTTGAAAGAGAGAAGCTACTCAACATTCAGCAGCAGTTGACCTGTAGCTTGCGGAAGGTTGAGGAAGAAAACCAAGGAGCTTTAGAAATGATTAAACGTCTGAAGGAAGAAAATGAAAAACTGAATGAGTTTCTAGAACTGGAACGGCATAATAATAACATGATGGCCAAAACTTTGGAAGAGTGTAGAGTTACCTTGGAAGGGCTAAAAATGGAGAATGGATCTTTGAAGTCTCATTTGCAGGGTGAGAAGCAGAAAGCCACAGAGGCCAGTGCTGTGGAGCAGACGGCAGAGAGCTGCGAAGTTCAAGAAATGTTGAAAGTAGCCCGAGCAGAGAAAGATCTACTGGAACTGTCTTGCAATGAGCTCAGACAAGAATTACTAAAGGCAAACGGTGAAATTAAACATGTTTCCAGTCTGCTGGCCAAG exonic gastric cancer qRT-PCR gastric tissues and normal tissues; 60 plasma samples from GC patients and 60 plasma samples from healthy controls N/A down-regulated N/A N/A N/A N/A Hsa_circ_0000745 was down-regulated in GC tissues vs non-tumorous tissues (P < 0.001) and in plasma samples from patients with GC vs healthy controls (P < 0.001). The expression level of hsa_circ_0000745 in GC tissues correlated with tumor differentiation, while the expression level in plasma correlated with tumor-node-metastasis stage. The area under the ROC curve (AUC) of hsa_circ_0000745 in plasma was 0.683, suggesting good diagnostic value. Plasma hsa_circ_0000745 level combined with carcinoembryogenic antigen (CEA) level increased the AUC to 0.775. 28974900 2017.9.14 World J Gastroenterol. Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer N/A hsa_circ_0081146 N/A 7 94045716-94057789 + hg19 COL1A2 GGGGAACGCGGTCCCCCAGGTGAGAGTGGTGCTGCCGGTCCTACTGGTCCTATTGGAAGCCGAGGTCCTTCTGGACCCCCAGGGCCTGATGGAAACAAGGGTGAACCTGGTGTGGTTGGTGCTGTGGGCACTGCTGGTCCATCTGGTCCTAGTGGACTCCCAGGAGAGAGGGGTGCTGCTGGCATACCTGGAGGCAAGGGAGAAAAGGGTGAACCTGGTCTCAGAGGTGAAATTGGTAACCCTGGCAGAGATGGTGCTCGTGGTGCTCCTGGTGCTGTAGGTGCCCCTGGTCCTGCTGGAGCCACAGGTGACCGGGGCGAAGCTGGGGCTGCTGGTCCTGCTGGTCCTGCTGGTCCTCGGGGAAGCCCTGGTGAACGTGGTGAGGTCGGTCCTGCTGGCCCCAATGGATTTGCTGGTCCTGCTGGTGCTGCTGGTCAACCTGGTGCTAAAGGAGAAAGAGGAGCCAAAGGGCCTAAGGGTGAAAACGGTGTTGTTGGTCCCACAGGCCCCGTTGGAGCTGCTGGCCCAGCTGGTCCAAATGGTCCCCCCGGTCCTGCTGGAAGTCGTGGTGATGGAGGCCCCCCTGGTATGACTGGTTTCCCTGGTGCTGCTGGACGGACTGGTCCCCCAGGACCCTCTGGTATTTCTGGCCCTCCTGGTCCCCCTGGTCCTGCTGGGAAAGAAGGGCTTCGTGGTCCTCGTGGTGACCAAGGTCCAGTTGGCCGAACTGGAGAAGTAGGTGCAGTTGGTCCCCCTGGCTTCGCTGGTGAGAAGGGTCCCTCTGGAGAGGCTGGTACTGCTGGACCTCCTGGCACTCCAGGTCCTCAGGGTCTTCTTGGTGCTCCTGGTATTCTGGGTCTCCCTGGCTCGAGAGGTGAACGTGGTCTACCAGGTGTTGCTGGTGCTGTGGGTGAACCTGGTCCTCTTGGCATTGCCGGCCCTCCTGGGGCCCGTGGTCCTCCTGGTGCTGTGGGTAGTCCTGGAGTCAACGGTGCTCCTGGTGAAGCTGGTCGTGATGGCAACCCTGGGAACGATGGTCCCCCAGGTCGCGATGGTCAACCCGGACACAAGGGAGAGCGCGGTTACCCTGGCAATATTGGTCCCGTTGGTGCTGCAGGTGCACCTGGTCCTCATGGCCCCGTGGGTCCTGCTGGCAAACATGGAAACCGTGGTGAAACTGGTCCTTCTGGTCCTGTTGGTCCTGCTGGTGCTGTTGGCCCAAGAGGTCCTAGTGGCCCACAAGGCATTCGTGGCGATAAGGGAGAGCCCGGTGAAAAGGGGCCCAGAGGTCTTCCTGGCTTAAAGGGACACAATGGATTGCAAGGTCTGCCTGGTATCGCTGGTCACCATGGTGATCAAGGTGCTCCTGGCTCCGTGGGTCCTGCTGGTCCTAGGGGCCCTGCTGGTCCTTCTGGCCCTGCTGGAAAAGATGGTCGCACTGGACATCCTGGTACAGTTGGACCTGCTGGCATTCGAGGCCCTCAGGGTCACCAAGGCCCTGCTGGCCCCCCTGGTCCCCCTGGCCCTCCTGGACCTCCAGGTGTAAGCGGTGGTGGTTATGACTTTGGTTACGATGGAGACTTCTACAGGGCTGACCAGCCTCGCTCAGCACCTTCTCTCAGACCCAAGGACTATGAAGTTGATGCTACTCTGAAGTCTCTCAACAACCAGATTGAGACCCTTCTTACTCCTGAAGGCTCTAGAAAGAACCCAGCTCGCACATGCCGTGACTTGAGACTCAGCCACCCAGAGTGGAGCAGTGGTTACTACTGGATTGACCCTAACCAAGGATGCACTATGGATGCTATCAAAGTATACTGTGATTTCTCTACTGGCGAAACCTGTATCCGGGCCCAACCTGAAAACATCCCAGCCAAGAACTGGTATAGGAGCTCCAAGGACAAGAAACACGTCTGGCTAGGAGAAACTATCAATGCTGGCAGCCAG N/A gastric cancer Microarray; qRT-PCR GC and non-GC tissues N/A up-regulated N/A N/A N/A N/A qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC. 28831102 2017.8.22 Sci Rep. Circular RNAs expression profiles in human gastric cancer N/A hsa_circ_0084720 N/A 8 70475773-70501376 + hg19 SULF1 GACCCTATCTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGCCTTTTTTGGAAAATACCTCAATGAATATAATGGCAGCTACATCCCCCCTGGGTGGCGAGAATGGCTTGGATTAATCAAGAATTCTCGCTTCTATAATTACACTGTTTGTCGCAATGGCATCAAAGAAAAGCATGGATTTGATTATGCAAAGGACTACTTCACAGACTTAATCACTAACGAGAGCATTAATTACTTCAAAATGTCTAAGAGAATGTATCCCCATAGGCCCGTTATGATGGTGATCAGCCACGCTGCGCCCCACGGCCCCGAGGACTCAGCCCCACAGTTTTCTAAACTGTACCCCAATGCTTCCCAACACAT N/A gastric cancer Microarray; qRT-PCR GC and non-GC tissues N/A up-regulated N/A N/A N/A N/A qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC. 28831102 2017.8.22 Sci Rep. Circular RNAs expression profiles in human gastric cancer N/A hsa_circ_0060108 N/A 20 34166977-34190529 - hg19 FER1L4 GCTTTCCATTCGCAGACCCTCCCCTTTATGGCCACCCGGATAGGCACCTTCAGGATGGACCTGGGCATCATCTTGGACCAGCCAGATGGCCAGTTCTACCAAAGATGGGTTCCGCTGCATGATCCCCGAGACACCCGCGCCGGGACCAAGGGTTTCATTAAGGTCACCTTGTCCGTGAGGGCGCGCGGGGACCTGCCCCCTCCAATGCTACCCCCGGCCCCAGGGCACTGTTCGGACATCGAGAAGAACCTGCTCCTGCCGCGCGGGGTGCCCGCCGAGAGGCCATGGGCGCGGCTCCGCGTGCGCCTGTACCGCGCCGAGGGGCTTCCCGCGCTGCGCCTGGGGCTGCTGGGCAGCCTGGTCCGCGCCCTGCACGACCAGCGCGTCCTGGTGGAGCCCTATGTGCGGGTGTCTTTCCTGGGGCAGGAGGGCGAGACGTCGGTGAGCGCCGAGGCGGCGGCGCCCGAATGGAACGAGCAGCTGAGCTTCGTGGAGCTCTTCCCGCCGCTGACGCGCAGCCTCCGCCTGCAGCTGCGGGACGACGCGCCCCTGGTCGACGCGGCACTCGCTACGCACGTGCCGGACCTGAGGCGGATCTCCCATCCGGGCCGCGCGGCGGGGTTTAACCCTACCTTCGGCCCGGCCTGGGTGCCCCTCTATGGCTCGCCCCCCGGCGCGGGGCTCCGGGATAGTCTTCAAGGTCTCAACGAAGGCGTTGGCCAAGGCATTTGGTTCCGCGGCCGCCTTCTGCTGGCTGTGTCCATGCAGGTGTTGGAAGGGAGAGCTGAACCTGAGCCTCCCCAGGCCCAGCAGGGGTCCACGTTGTCCCGGCTCACCCGAAAGAAGAAAAAGAAAGCCAGAAGGGATCAGACCCCAAAGGCGGTTCCGCAGCACTTGGACGCCAGCCCCGGTGCCGAGGGGCCTGAGATCCCCCGTGCCATGGAGGTGGAGGTGGAGGAGCTGCTGCCGCTGCCAGAGAATGTCCTGGCGCCCTGTGAAGATTTCCTGCTTTTCGGTGTGCTCTTCGAGGCCACCATGATCGACCCCACCGTGGCCTCCCAGCCCATCAGCTTCGAGATCTCCATTGGTCGCGCAGGCCGTCTGGAGGAGCAATTGGGCCGAGGGTCCAGGGCTGGGGAGGGAACTGAGGGTGCAGCCGTGGAGGCTCAGCCTCTGCTGGGAGCCAGGCCAGAGGAGGAGAAAGAGGAGGAAGAACTGGGGACCCATGCTCAGCGGCCTGAGCCCATGGACGGCAGTGGGCCATACTTCTGCTTGCCCCTCTGTCACTGCAAGCCATGCATGCATGTGTGGAGTTGCTGGGAGGACCACACCTGGCGCCTGCAGAGCAGCAACTGCGTGCGCAAAGTGGCCGAGAGGCTGGACCAGGGGCTGCAGGAGGTTGAGAGACTGCAGCGCAAGCCGGGGCCTGGCGCCTGTGCACAGCTCAAGCAGGCACTGGAAGTACTGGTGGCTGGGAGCAGACAGTTTTGCCACGGTGCCGAGCGCAGGACGATGACCCGGCCCAATGCCCTGGATCGATGCCGAGGGAAACTCCTGGTGCACAGCCTGAACCTTTTGGCTAAGCAAGGACTGCGACTTCTACGCGGCCTGAGACGGCGCAATGTGCAAAAGAAGGTGGCACTGGCCAAGAAGCTCCTGGCAAAACTGCGCTTTCTGGCTGAGGAGCCCCAGCCACCCCTCCCCGATGTGCTGGTCTGGATGCTCAGCGGGCAGCGCCGTGTGGCCTGGGCCCGGATCCCTGCCCAGGATGTGCTGTTCTCTGTGGTTGAGGAGGAACGGGGCCGAGACTGTGGGAAGATCCAGAGTCTAATGCTCACGGCACCCGGGGCAGCCCCTGGTGAGGTCTGTGCCAAGCTGGAGCTCTTCCTGCGGCTGGGCCTGGGCAAGCAAGCCAAGGCCTGCACCTCTGAGCTGCCCCCGGATTTGCTGCCCGAGCCCTCAGCCGGGCTGCCCTCCAGCCTACACCGGGACGGTCCTGGAGCAGACGCTGAGCCCTCTGTGGGATGAACTCCTGGTATTTGAGCAGTTGATCGTGGATGGGAGGAGGGAGCACCTGCAGGAGGAGCCTCCATTAGTGATCATCAATGTATTTGACCACAATAAGTTTCCCTCAGTGCCCAGTGAGGTGGAGCCCCAGGATCTGGCACCCCTGGTTGAGCCCCACTCTGGACGCCTGTCCCTTCCACCCAACGTGTGCCCAGTGCTCAGGGAGTTCCGTGTTGAGGTGCTGTTCTGGGGTCTTAGGGGACTTGGTCGTGTGCATCTGCTCGAGGTGGAGCAGCCCCAGGTTGTACTGGAGGTGGCTGGGCAAGGTGTGGAGTCTGAGGTCCTGGCCAGCTACCGTGAGAGCCCCAATTTCACTGAGCTTGTCAGGCATCTGACAGTGGACTTGCCGGAGCAGCCTTACTTGCAGCCTCCACTCAGCATCTTGGTGATTGAGCGCCGGGCCTTTGGCCACACAGTCCTTGTGGGTTCCCACATTGTCCCCCACATGCTGCGATTCACATTTCGGGGTCATGAGGATCCTCCTGAGGAGGAAGGAGAGATGGAGGAGACAGGGGATATGATGCCCAAGGGACCTCAAGGACAGAAGTCCCTGGATCCCTTCTTGGCTGAAGCGGGTATATCCAGACAGCTCCTGAAG N/A gastric cancer Microarray; qRT-PCR GC and non-GC tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC. 28831102 2017.8.22 Sci Rep. Circular RNAs expression profiles in human gastric cancer N/A hsa_circ_0057104 N/A 2 173433468-173457776 + hg19 PDK1 CAAAATCACCAGGACAGCCAATACAAGTGGTTTATGTACCATCCCATCTCTATCACATGGTGTTTGAACTTTTCAAGAATGCAATGAGAGCCACTATGGAACACCATGCCAACAGAGGTGTTTACCCCCCTATTCAAGTTCATGTCACGCTGGGTAATGAGGATTTGACTGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAG N/A gastric cancer Microarray; qRT-PCR GC and non-GC tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC. 28831102 2017.8.22 Sci Rep. Circular RNAs expression profiles in human gastric cancer N/A hsa_circ_0054971 hsa_circRNA_102746 2 65228581-65237897 + hg19 SLC1A4 AAACCTGTTTCCCTCCAATCTTGTGGTTGCAGCTTTCCGTACGTATGCAACCGATTATAAAGTCGTGACCCAGAACAGCAGCTCTGGAAATGTAACCCATGAAAAGATCCCCATAGGCACTGAGATAGAAGGGATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTAGGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTGCTGGTGTCCTGGATTATGTG N/A gastric cancer Microarray; qRT-PCR GC and non-GC tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC. 28831102 2017.8.22 Sci Rep. Circular RNAs expression profiles in human gastric cancer N/A hsa_circ_0063561 N/A 22 41903794-41920972 + hg19 ACO2 ACTGAACCGGCCGCTGACACTCTCGGAGAAGATTGTGTATGGACACCTGGATGACCCCGCCAGCCAGGAAATTGAGCGAGGCAAGTCGTACCTGCGGCTGCGGCCGGACCGTGTGGCCATGCAGGATGCGACGGCCCAGATGGCCATGCTCCAGTTCATCAGCAGCGGGCTGTCCAAGGTGGCTGTGCCATCCACCATCCACTGTGACCATCTGATTGAAGCCCAGGTTGGGGGCGAGAAAGACCTGCGCCGGGCCAAGGACATCAACCAGGAAGTTTATAATTTCCTGGCAACTGCAGGTGCCAAATATGGCGTGGGCTTCTGGAAGCCTGGATCTGGAATCATTCACCAGATTATTCTGGAAAACTATGCGTACCCTGGTGTTCTTCTGATTGGCACTGACTCCCACACCCCCAATGGTGGCGGCCTTGGGGGCATCTGCATTGGAGTTGGGGGTGCCGATGCTGTGGATGTCATGGCTGGGATCCCCTGGGAGCTGAAGTGCCCCAAGGTGATTGGCGTGAAGCTGACGGGCTCTCTCTCCGGTTGGTCCTCACCCAAAGATGTGATCCTGAAGGTGGCAGGCATCCTCACGGTGAAAGGTGGCACAGGTGCAATCGTGGAATACCACGGGCCTGGTGTAGACTCCATCTCCTGCACTGGCATGGCGACAATCTGCAACATGGGTGCAGAAATTGGGGCCACCACTTCCGTGTTCCCTTACAACCACAGGATGAAGAAGTACCTGAGCAAGACCGGCCGGGAAGACATTGCCAATCTAGCTGATGAATTCAAGGATCACTTGGTGCCTGACCCTGGCTGCCATTATGACCAACTAATTGAAATTAACCTCAGTGAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGG N/A gastric cancer Microarray; qRT-PCR GC and non-GC tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC. 28831102 2017.8.22 Sci Rep. Circular RNAs expression profiles in human gastric cancer N/A hsa_circ_0058766 N/A 2 234344463-234346125 + hg19 DGKD TGTGCAAATTTAAGGCCCACAAGCGCTGTGCTGTGCGTGCAACCAATAACTGCAAGTGGACCACACTGGCCTCGATCGGGAAGGACATCATTGAAGATGCAGATGGGATTGCAATGCCCCACCAGTGGTTGGAAGGAAACCTACCTGTGAGCGCCAAGTGCACTGTGTGCGACAAGACCTGTGGCAGTGTGCTGCGCCTGCAGGACTGGCGCTGCCTCTGGTGCAAGGCCATGGTTCACACATCGTGTAAAGAATCCTTGCTGACCAAGTGCCCACTTGGCCTGTGCAAAGTGTCAGTCATCCCACCCACGGCTCTCAACAGCATCGACTCCGATG N/A gastric cancer Microarray; qRT-PCR GC and non-GC tissues N/A down-regulated N/A N/A N/A N/A qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC. 28831102 2017.8.22 Sci Rep. Circular RNAs expression profiles in human gastric cancer N/A hsa_circ_0003573 N/A 11 33604883-33640208 + hg19 C11orf41 CCGTGGTGAAGAACCCGCCCAATAACCTGTGGATCATCGCTGCAGTGCTGGCGCCCATTGCCGTGGTCACGGTCATCATCATCATCATCACTGCCGTGCTCTGCAGGAAGAACAAGAACGACTTCAAGCCTGACACCATGATAAACCTGCCGCAGAGAGCAAAGCCTGTGCAAGGCTTTGATTATGCCAAGCAACACCTGGGCCAGCAAGGGGCAGATGAGGAGGTCATCCCTGTGACTCAGGAGACAGTGGTTCTCCCACTGCCCATTAGAGATGCTCCTCAGGAAAGAGACGTCGCTCAGGATGGAAGCACCATCAAGACCGCCAAATCCACTGAAACCAGGAAGAGCAGGTCGCCCAGTGAGAATGGCTCTGTCATCAGCAACGAATCAGGGAAGCCCAGCTCAGGGAGACGCTCACCCCAGAATGTAATGGCACAGCAGAAAGTGACAAAGGAGGAGGCAAGGAAGAGAAATGTGCCAGCGAGTGACGAAGAGGAGGGAGCGGTTCTATTTGACAACTCCAGCAAGGTGGCCGCTGAACCCTTTGACACATCTTCTGGGTCTGTGCAGCTCATTGCCATAAAACCCACAGCCCTCCCCATGGTGCCCCCCACCTCGGACAGGAGCCAGGAGTCATCGGCAGTCCTCAACGGCGAGGTGAACAAAGCCCTGAAGCAGAAGTCAGACATCGAGCACTATCGGAACAAGCTGCGCCTCAAAGCCAAGAGGAAGGGATATTACGACTTCCCTGCAGTGGAGACGAGCAAGGGTCTGACCGAAAGAAAGAAGATGTATGAAAAAGCCCCGAAGGAAATGGAGCATGTTTTGGATCCAGATTCAGAACTCTGTGCTCCATTCACCGAGTCTAAAAACAGGCAACAGATGAAGAACTCTGTCTACAGAAGCCGGCAGTCTCTGAACAGCCCGAGTCCAGGGGAAACCGAGATGGACCTTCTGGTGACTCGGGAGCGACCCCGGCGTGGAATCCGCAACAGCGGATACGAT N/A atherosclerosis Microarray; qRT-PCR; in vitro knockdown; etc. HUVECs treated with or not oxLDL N/A up-regulated N/A N/A N/A N/A Human circRNA microarray analysis revealed that total 943 differently expressed circRNAs were screened with 2 fold change. Hsa_circ_0003575 was validated to be significantly up-regulated in oxLDL induced HUVECs. Loss-of-function experiments indicated that hsa_circ_0003575 silencing promoted the proliferation and angiogenesis ability of HUVECs. Bioinformatics online programs predicted the potential circRNA-miRNA-mRNA network for hsa_circ_0003575. In summary, circRNA microarray analysis reveals the expression profiles of HUVECs and verifies the role of hsa_circ_0003575 on HUVECs, providing a therapeutic strategy for vascular endothelial cell injury of atherosclerosis. 28946214 2017.11 Biomed Pharmacother. Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis N/A hsa_circ_0003204 N/A 17 76798405-76800060 - hg19 USP36 GGCTGTGTCACCTGCTCCCCAATCATCCAGCCGCCTGCAACCCCCCTTCAGCCCCCACCCCACATTGCTGTCCAGTACCCCCAAGCCCCCAGGGACGTCAGAACCACGGAGCTGCTCCTCCATCTCGACGGCGCTGCCTCAGGTCAACGAGGACCTTGTGTCTCTTCCACACCAGTTGCCAGAGGCCAGTGAGCCCCCCCAGAGCCCCTCTGAGAAGAGGAAAAAGACCTTTGTGGGAGAGCCGCAGAGGCTGGGCTCAGAGACGCGCCTCCCACAGCACATCAGGGAGGCCACTGCGGCTCCCCACGGGAAGAGGAAGAGGAAGAAGAAGAAGCGCCCGGAGGACACAGCTGCCAGCGCCCTGCAGGAGGGGCAGACACAGAGACAGCCTGGGAGCCCCATGTACAGGAGGGAGGGCCAGGCACAGCTGCCCGCTGTCAGACGGCAGGAAGATGGCACACAGCCACAGGTGAATGGCCAGCAGGTGGGATGTGTTACGGACGGCCACCACGCGAGCAGCAGGAAGCGGAGGAGGAAAGGAGCAGAAGGTCTTGGTGAAGAAGGCGGCCTGCACCAGGACCCACTTCGGCACAGCTGCTCTCCCATGGGTGATGGTGATCCAGAGGCCATGGAAGAGTCTCCAAGGAAAAAGAAAAAGAAAAAAAGAAAGCAGGAGACACAGCGGGCAGTAGAAGAGGATGGGCATCTCAAATGCCCAAGGAGTGCCAAGCCCCAAGATGCTGTTGTCCCCGAGTCCAGCAGCTGCGCACCATCCGCGAATGGCTGGTGTCCTGGGGACCGCATGG N/A atherosclerosis Microarray; qRT-PCR; in vitro knockdown; etc. HUVECs treated with or not oxLDL N/A up-regulated N/A N/A N/A N/A Human circRNA microarray analysis revealed that total 943 differently expressed circRNAs were screened with 2 fold change. Hsa_circ_0003575 was validated to be significantly up-regulated in oxLDL induced HUVECs. Loss-of-function experiments indicated that hsa_circ_0003575 silencing promoted the proliferation and angiogenesis ability of HUVECs. Bioinformatics online programs predicted the potential circRNA-miRNA-mRNA network for hsa_circ_0003575. In summary, circRNA microarray analysis reveals the expression profiles of HUVECs and verifies the role of hsa_circ_0003575 on HUVECs, providing a therapeutic strategy for vascular endothelial cell injury of atherosclerosis. 28946214 2017.11 Biomed Pharmacother. Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis N/A hsa_circ_0004264 N/A 3 160942717-160953000 + hg19 NMD3 CTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATG N/A atherosclerosis Microarray; qRT-PCR; in vitro knockdown; etc. HUVECs treated with or not oxLDL N/A down-regulated N/A N/A N/A N/A Human circRNA microarray analysis revealed that total 943 differently expressed circRNAs were screened with 2 fold change. Hsa_circ_0003575 was validated to be significantly up-regulated in oxLDL induced HUVECs. Loss-of-function experiments indicated that hsa_circ_0003575 silencing promoted the proliferation and angiogenesis ability of HUVECs. Bioinformatics online programs predicted the potential circRNA-miRNA-mRNA network for hsa_circ_0003575. In summary, circRNA microarray analysis reveals the expression profiles of HUVECs and verifies the role of hsa_circ_0003575 on HUVECs, providing a therapeutic strategy for vascular endothelial cell injury of atherosclerosis. 28946214 2017.11 Biomed Pharmacother. Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis N/A hsa_circ_0000345 hsa_circRNA_000345 11 77409531-77413540 - hg19 RSF1 AGGAACAGAAAGAAAGTGAAAAGATGAAAAGTGAGGAGCAGCCTATGGATTTAGAAAACCGTTCTACAGCCAATGTTCTAGAAGAGACTACTGTGAAAAAAGAAAAAGAAGATGAAAAGGAACTTGTGAAACTGCCAGTCATAGTGAAGCTAGAAAAACCTTTGCCAGAAAATGAAGAAAAAAAGATTATCAAAGAAGAAAGTGATTCCTTCAAGGAAAATGTCAAACCCATTAAAGTTGAGGTGAAGGAATGTAGAGCAGATCCTAAAGATACCAAAAGTAGCATGGAGAAGCCAGTGGCACAGGAGCCTGAAAGGATCGAATTTGGTGGCAATATTAAATCTTCTCACGAAATTACTGAGAAATCTACTGAAGAAACTGAGAAACTTAAAAATGACCAGCAGGCCAAGATACCACTAAAAAAACGAGAAATTAAACTGAGTGATGATTTTGACAGTCCAGTCAAGGGACCTTTGTGTAAATCAGTTACTCCAACAAAAGAGTTTTTGAAAGATGAAATAAAACAAGAGGAAGAGACTTGTAAAAGGATCTCTACAATCACTGCTTTGGGTCATGAAGGGAAACAGCTGGTAAATGGAGAAGTTAGTGATGAAAGGGTAGCTCCAAATTTTAAGACAGAACCAATAGAGACAAAGTTTTATGAGACAAAGGAAGAGAGCTATAGCCCCTCTAAGGACAGAAATATCATCACGGAGGGAAATGGAACAGAGTCCTTAAATTCTGTCATAACAAGTATGAAAACAGGTGAGCTTGAGAAAGAAACAGCCCCTTTGAGGAAAGATGCAGATAGTTCAATATCAGTCTTAGAGATCCATAGTCAAAAAGCACAAATAGAGGAACCCGATCCTCCAGAAATGGAAACTTCTCTTGATTCTTCTGAGATGGCAAAAGATCTCTCTTCAAAAACTGCTTTATCTTCCACCGAGTCGTGTACCATGAAAGGTGAAGAGAAGTCTCCCAAAACTAAGAAGGATAAGCGCCCACCAATCCTAGAATGTCTTGAAAAGTTAGAGAAGTCCAAAAAGACTTTTCTTGATAAGGACGCACAAAGATTGAGTCCAATACCAGAAGAAGTTCCAAAGAGTACTCTAGAGTCAGAAAAGCCTGGCTCTCCTGAGGCAGCTGAAACTTCTCCACCATCTAATATCATTGACCACTGTGAGAAACTAGCCTCAGAAAAAGAAGTGGTAGAATGCCAGAGTACAAGTACTGTTGGTGGCCAGTCTGTGAAAAAAGTAGACCTAGAAACCCTAAAAGAGGATTCTGAGTTCACAAAGGTAGAAATGGATAATCTGGACAATGCCCAGACCTCTGGCATAGAGGAGCCTTCTGAGACAAAGGGTTCTATGCAAAAAAGCAAATTCAAATATAAGTTGGTTCCTGAAGAAGAAACCACTGCCTCAGAAAATACAGAGATAACCTCTGAAAGGCAGAAAGAGGGCATCAAATTAACAATCAGGATATCAAGTCGGAAAAAGAAGCCCGATTCTCCCCCCAAAGTTCTAGAACCAGAAAACAAGCAAGAGAAGACAGAAAAGGAAGAGGAGAAAACAAATGTGGGTCGTACTTTAAGAAGATCTCCAAGAATATCTAGACCCACTGCAAAAGTGGCTGAGATCAGAGATCAGAAAGCTGATAAAAAAAGAGGGGAAGGAGAAGATGAGGTGGAAGAAGAGTCAACAGCTTTGCAAAAAACTGACAAAAAGGAAATTTTGAAAAAATCAGAGAAAGATACAAATTCTAAAGTAAGCAAGGTAAAACCCAAAGGCAAAGTTCGATGGACTGGTTCTCGGACACGTGGCAGATGGAAATATTCCAGCAATGATGAAAGTGAAGGGTCTGGCAGTGAAAAATCATCTGCAGCTTCAGAAGAGGAGGAAGAAAAGGAAAGTGAAGAAGCCATCCTAGCAGATGATGATGAACCATGCAAAAAATGTGGCCTTCCAAACCATCCTGAGCTA N/A atherosclerosis Microarray; qRT-PCR; in vitro knockdown; etc. HUVECs treated with or not oxLDL N/A down-regulated N/A N/A N/A N/A Human circRNA microarray analysis revealed that total 943 differently expressed circRNAs were screened with 2 fold change. Hsa_circ_0003575 was validated to be significantly up-regulated in oxLDL induced HUVECs. Loss-of-function experiments indicated that hsa_circ_0003575 silencing promoted the proliferation and angiogenesis ability of HUVECs. Bioinformatics online programs predicted the potential circRNA-miRNA-mRNA network for hsa_circ_0003575. In summary, circRNA microarray analysis reveals the expression profiles of HUVECs and verifies the role of hsa_circ_0003575 on HUVECs, providing a therapeutic strategy for vascular endothelial cell injury of atherosclerosis. 28946214 2017.11 Biomed Pharmacother. Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis N/A hsa_circ_0008305 hsa_circRNA_104703 8 141799572-141840625 - hg19 PTK2 AAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAG exonic intervertebral disc degeneration qRT-PCR human normal (cadaveric donors) and degenerative lumbar nucleus pulposus (NP) with patient demographics and IDD grading N/A up-regulated N/A N/A N/A N/A Hsa_circ_0008305 upregulation and hsa_circ_0041946 downregulation were validated in IDD using reverse transcription quantitative polymerase chain reaction. 28990083 2017.10.4 Mol Med Rep. Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration N/A hsa_circ_0041946 N/A 17 7573926-7577608 - hg19 TP53 GTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAGTGGTAATCTACTGGGACGGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGAGACCGGCGCACAGAGGAAGAGAATCTCCGCAAGAAAGGGGAGCCTCACCACGAGCTGCCCCCAGGGAGCACTAAGCGAGCACTGCCCAACAACACCAGCTCCTCTCCCCAGCCAAAGAAGAAACCACTGGATGGAGAATATTTCACCCTTCAGGACCAGACCAGCTTTCAAAAAGAAAATTGTTAAAGAGAGCATGAAAATGGTTCTATGACTTTGCCTGATACAGATGCTACTTGACTTACGATGGTGTTACTTCCTGATAAACTCGTCGTAAGTTGAAAATATTATCCGTGGGCGTGAGCGCTTCGAGATGTTCCGAGAGCTGAATGAGGCCTTGGAACTCAAGGATGCCCAGGCTGGGAAGGAGCCAGGGGGGAGCAGGGCTCACTCCAG N/A intervertebral disc degeneration qRT-PCR human normal (cadaveric donors) and degenerative lumbar nucleus pulposus (NP) with patient demographics and IDD grading N/A down-regulated N/A N/A N/A N/A Hsa_circ_0008305 upregulation and hsa_circ_0041946 downregulation were validated in IDD using reverse transcription quantitative polymerase chain reaction. 28990083 2017.10.4 Mol Med Rep. Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration N/A